Cited by 226Iron Metabolism and DisordersNutritional Studies and DietTrace Elements in Health

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Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies

Danesh, John, Appleby, Paul·1999·Circulation

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Abstract

BACKGROUND: Studies of iron status and coronary heart disease (CHD) have yielded conflicting results. In a systematic review ("meta-analysis"), we quantitatively assessed epidemiological associations reported in prospective studies. METHODS AND RESULTS: Studies were identified by computer-assisted searches of the published literature, scanning of relevant reference lists, hand searching of relevant journals, and discussions with relevant authors. The following was abstracted: size and type of cohort, mean age, mean duration of follow-up, assay methods, degree of adjustment for confounders, and relationship of CHD risk to the baseline assay results. Twelve studies were identified, involving a total of 7800 CHD cases, with several reporting on >1 marker of iron status. For serum ferritin, with 570 CHD cases in 5 studies, comparison of individuals with baseline values >/=200 versus <200 microg/L yielded a combined risk ratio of 1.0 (95% CI, 0.8 to 1.3). For transferrin saturation, with 6194 CHD cases in 5 studies, comparison of individuals in the top third with those in the bottom third of the baseline measurements yielded a combined risk ratio of 0.9 (95% CI, 0.7 to 1.1). Comparisons of individuals in top and bottom thirds of baseline measurements also yielded nonsignificant risk ratios in combined analyses of studies involving total iron-binding capacity (combined risk ratio, 1.0; 95% CI, 0.7 to 1.5), serum iron (0.8; 95% CI, 0.7 to 1.0), and total dietary iron (0.8; 95% CI, 0.7 to 1.1). CONCLUSIONS: Published prospective studies do not provide good evidence to support the existence of strong epidemiological associations between iron status and CHD.

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Authors: Danesh, J., & Appleby, P.
Affiliations: University of Oxford (GB)
ORCID: Danesh, John
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1999-02-23
Volume: 99
Issue: 7
Pages: 852-854
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.99.7.852
OpenAlex: W2072848251
Cited by: 226
References: 19
Citations by year: 2024: 3 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 10 · 2012: 12
FWCI: 7.00
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: coronary artery disease, iron status, serum ferritin, transferrin saturation, total iron binding capacity, serum iron, dietary iron, cardiovascular risk factors, prospective cohort
MeSH terms: Coronary Disease, Diet, Ferritins, Humans, Iron, Prospective Studies, Transferrin

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Coronary Heart Disease and Iron Status: Meta-Analyses of Prospective Studies

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