Cited by 2,048Angiogenesis and VEGF in CancerBarrier Structure and Function StudiesLymphatic System and Diseases

The DOI matches its Crossref record; 134 of the 134 references it cites were found in a registry or an index.

Endothelial/Pericyte Interactions

Armulik, Annika, Abramsson, Alexandra, Betsholtz, Christer·2005·Circulation Research

Open this paper in CoChat — free account

Abstract

Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor β, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.

Integrity signals

Registry

Crossref · 10.1161/01.res.0000182903.16652.d7

Cites

134 of 134 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Self-citation
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Joutel, A., Corpechot, C., Ducros, A., Vahedi, K., Chabriat, H., Mouton, P., Alamowitch, S., Domenga, V., Cécillion, M., Maréchal, E., et al. (1996) · Nature · doi:10.1038/383707a0 · Cited by 2,068
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.14.3047 · Cited by 1,734
Self-citation
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
McAllister, K. A., Grogg, K. M., Johnson, D. W., Gallione, C. J., Baldwin, M. A., Jackson, C. E., Helmbold, E. A., Markel, D. S., McKinnon, W. C., Murrel, J., et al. (1994) · Nature Genetics · doi:10.1038/ng1294-345 · Cited by 1,475
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
Bergers, G., Song, S., Meyer-Morse, N., Bergsland, E. K., & Hanahan, D. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17929 · Cited by 1,361
Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350

Show all 134 references

Research works printed but not linked: 5

10.1161/circ.105.1.112 · DOI
10.1161/res.80.4.444 · DOI
10.1161/circ.103.11.1522 · DOI
10.1172/JCI200318549 · DOI
10.1172/JCI200317929 · DOI

Sorted by citations

Items 601–700 of 1,000

Interplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases
Arndt, P., Khoshneviszadeh, M., Jandke, S., Schreiber, S., & Dityatev, A. E. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14887 · Cited by 60
Interleukin-1β induces pericyte apoptosis via the NF-κB pathway in diabetic retinopathy
Yun, J. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.108 · Cited by 65
Imaging aspects of the tumor stroma with therapeutic implications
Narunsky-Haziza, L., Oren, R., Bochner, F., & Neeman, M. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.003 · Cited by 59
The complexity of cell composition of the intima of large arteries: focus on pericyte-like cells
Orekhov, A. N., Bobryshev, Y. V., & Chistiakov, D. A. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu168 · Cited by 61
Netrin-4 promotes mural cell adhesion and recruitment to endothelial cells
Lejmi, E., Bouras, I., Camelo, S., Roumieux, M., Minet, N., Déan, C., Merkulova‐Rainon, T., Autret, G., Vayssettes, C., Clémеnt, O., et al. (2014) · Vascular Cell · doi:10.1186/2045-824x-6-1 · Cited by 61
The roles and role-players in thyroid cancer angiogenesis
Rajabi, S., Dehghan, M. H., Dastmalchi, R., Mashayekhi, F. J., Salami, S., & Hedayati, M. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej18-0537 · Cited by 63
Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor β signaling
Ishimura, A., Ng, J. K., Taira, M., Young, S. G., & Osada, S. (2006) · Development · doi:10.1242/dev.02538 · Cited by 61
Multiscale profiling of protease activity in cancer
Amini, A. P., Kirkpatrick, J. D., Wang, C. S., Jaeger, A. M., Su, S., Naranjo, S., Zhong, Q., Cabana, C. M., Jacks, T., & Bhatia, S. N. (2022) · Nature Communications · doi:10.1038/s41467-022-32988-5 · Cited by 60
Penetration and differentiation of cephalic neural crest‐derived cells in the developing mouse telencephalon
Yamanishi, E., Takahashi, M., Saga, Y., & Osumi, N. (2012) · Development Growth & Differentiation · doi:10.1111/dgd.12007 · Cited by 62
Membrane‐type 4 matrix metalloproteinase (MT4‐MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture
Chabottaux, V., Ricaud, S., Host, L., Blacher, S., Paye, A., Thiry, M., Garofalakis, A., Pestourie, C., Gombert, K., Bruyére, F., et al. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00764.x · Cited by 60
Basic Components of Vascular Connective Tissue and Extracellular Matrix
Halper, J. T. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.012 · Cited by 60
Microvascular maturity elicited in tissue treated with cytokine-loaded hyaluronan-based hydrogels
Hosack, L. W., Firpo, M. A., Scott, J., Prestwich, G. D., & Peattie, R. A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.01.033 · Cited by 59
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration
Morioka, S., Inagaki, M., Komatsu, Y., Mishina, Y. M., Matsumoto, K., & Ninomiya‐Tsuji, J. (2012) · Blood · doi:10.1182/blood-2012-03-416198 · Cited by 60
The angiopoietin pathway is modulated by PAR‐1 activation on human endothelial progenitor cells
Smadja, D. M., Laurendeau, I., Avignon, C., Vidaud, M., Aiach, M., & Gaussem, P. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.02101.x · Cited by 59
Gene therapy for ischemic heart disease
Hinkel, R., Trenkwalder, T., & Kupatt, C. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.570749 · Cited by 59
Essential Role for Thymosin β4 in Regulating Vascular Smooth Muscle Cell Development and Vessel Wall Stability
Rossdeutsch, A., Smart, N., Dubé, K. N., Turner, M., & Riley, P. R. (2012) · Circulation Research · doi:10.1161/circresaha.111.259846 · Cited by 59
Occludin controls HIV transcription in brain pericytes via regulation of SIRT‐1 activation
Castro, V., Bertrand, L., Lüthen, M., Dabrowski, S., Lombardi, J., Morgan, L., Sharova, N. P., Stevenson, M., Blasig, I. E., & Toborek, M. J. (2015) · The FASEB Journal · doi:10.1096/fj.15-277673 · Cited by 59
A 3D Vascularized Bone Remodeling Model Combining Osteoblasts and Osteoclasts in a CaP Nanoparticle-Enriched Matrix
Bongio, M., Lopa, S., Gilardi, M., Bersini, S., & Moretti, M. (2016) · Nanomedicine · doi:10.2217/nnm-2015-0021 · Cited by 59
Human kidney pericytes produce renin
Stefańska, A., Kenyon, C. J., Christian, H., Buckley, C., Shaw, I., Mullins, J. J., & Péault, B. (2016) · Kidney International · doi:10.1016/j.kint.2016.07.035 · Cited by 60
Mesenchymal stem cells-derived MFG-E8 accelerates diabetic cutaneous wound healing
Uchiyama, A., Motegi, S., Sekiguchi, A., Fujiwara, C., Perera, B., Ogino, S., Yokoyama, Y., & Ishikawa, O. (2017) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2017.02.285 · Cited by 58
Bioactive Poly(ethylene Glycol) Acrylate Hydrogels for Regenerative Engineering
Moore, E., & West, J. L. (2018) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-018-0074-y · Cited by 62
Intravenous infusion of mesenchymal stem cells improves impaired cognitive function in a cerebral small vessel disease model
Nakazaki, M., Sasaki, M., Kataoka-Sasaki, Y., Oka, S., Suzuki, J., Sasaki, Y., Nagahama, H., Hashi, K., Kocsis, J. D., & Honmou, O. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.04.018 · Cited by 58
Differential expression of capillary VEGF isoforms following traumatic brain injury
Dore‐Duffy, P., Wang, X., Mehedi, A., Kreipke, C. W., & Rafols, J. A. (2007) · Neurological Research · doi:10.1179/016164107x204729 · Cited by 59
Transforming growth factor β family members in regulation of vascular function: In the light of vascular conditional knockouts
Jakobsson, L., & van Meeteren, L. A. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.02.015 · Cited by 58
Cell-microenvironment interactions and architectures in microvascular systems
Bersini, S., Yazdi, I. K., Talò, G., Shin, S. R., Moretti, M., & Khademhosseini, A. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.07.002 · Cited by 60
The origin and mechanisms of smooth muscle cell development in vertebrates
Donadon, M., & Santoro, M. M. (2021) · Development · doi:10.1242/dev.197384 · Cited by 61
The Active Role of Pericytes During Neuroinflammation in the Adult Brain
Medina‐Flores, F., Hurtado‐Alvarado, G., Deli, M. A., & Gómez‐González, B. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01208-5 · Cited by 63
Angiogenesis: The role of PDGF-BB on Adiopse-tissue derived Stem Cells (ASCs)
Gehmert, S., Gehmert, S., Hidayat, M., Sultan, M., Berner, A., Klein, S., Zellner, J., Müller, M., & Prantl, L. (2011) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-2011-1397 · Cited by 59
PDGF , Pericytes and the Pathogenesis of Idiopathic Basal Ganglia Calcification ( IBGC )
Betsholtz, C., & Keller, A. (2014) · Brain Pathology · doi:10.1111/bpa.12158 · Cited by 61
Self-citation
TGF-β suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB
Risinger, G. M., Updike, D. L., Bullen, E. C., Tomasek, J. J., & Howard, E. W. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00417.2008 · Cited by 59
Biology of the renal pericyte
Smith, S. W., Chand, S., & Savage, C. O. S. (2012) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfs134 · Cited by 58
Comparison of organ-specific endothelial cells in terms of microvascular formation and endothelial barrier functions
Uwamori, H., Ono, Y., Yamashita, T., Arai, K., & Sudo, R. (2018) · Microvascular Research · doi:10.1016/j.mvr.2018.11.007 · Cited by 61
The Blood–Brain Barrier, an Evolving Concept Based on Technological Advances and Cell–Cell Communications
Menaceur, C., Gosselet, F., Fénart, L., & Saint‐Pol, J. (2021) · Cells · doi:10.3390/cells11010133 · Cited by 64
Ultrastructure of Islet Microcirculation, Pericytes and the Islet Exocrine Interface in the HIP Rat Model of Diabetes
Hayden, M. R., Karuparthi, P. R., Habibi, J., Lastra, G., Patel, K., Wasekar, C., Manrique, C. M., Özerdem, U., Stas, S. N., & Sowers, J. R. (2008) · Experimental Biology and Medicine · doi:10.3181/0709-rm-251 · Cited by 57
Mesangial Cell Integrin αvβ8 Provides Glomerular Endothelial Cell Cytoprotection by Sequestering TGF-β and Regulating PECAM-1
Khan, S., Lakhe-Reddy, S., McCarty, J. H., Sorenson, C. M., Sheibani, N., Reichardt, L. F., Kim, J. H., Wang, B., Sedor, J. R., & Schelling, J. R. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.10.031 · Cited by 59
Platelet-derived growth factor receptors regulate mesenchymal stem cell fate: implications for neovascularization
Ball, S. G., Shuttleworth, C. A., & Kielty, C. M. (2009) · Expert Opinion on Biological Therapy · doi:10.1517/14712590903379510 · Cited by 57
Quantitative assessment of angiogenesis and pericyte coverage in human cell-derived vascular sprouts
Eglinger, J., Karsjens, H., & Lammert, E. (2017) · Inflammation and Regeneration · doi:10.1186/s41232-016-0033-2 · Cited by 58
The pericyte as a cellular regulator of penile erection and a novel therapeutic target for erectile dysfunction
Yin, G. N., Das, N. D., Choi, M. J., Song, K., Kwon, M., Ock, J., Limanjaya, A., Ghatak, K., Kim, W. J., Hyun, J. S., et al. (2015) · Scientific Reports · doi:10.1038/srep10891 · Cited by 55
Molecular Mechanisms of Pulmonary Vascular Development
Galambos, C., & deMello, D. E. (2006) · Pediatric and Developmental Pathology · doi:10.2350/06-06-0122.1 · Cited by 58
Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras
Perrot, C. Y., Herrera, J. L., Fournier-Goss, A. E., & Komatsu, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68019-w · Cited by 62
Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy
Li, C., Maishi, N., Annan, D. A., Young, M. F., Morimoto, H., Morimoto, M., Nam, J.-M., Hida, Y., & Hida, K. (2021) · Breast Cancer Research · doi:10.1186/s13058-021-01423-w · Cited by 59
Myocardial Oedema: Pathophysiological Basis and Implications for the Failing Heart
Vasques‐Nóvoa, F., Angélico‐Gonçalves, A., Alvarenga, J. M., Nóbrega, J., Cerqueira, R. J., Mâncio, J., Leite-Moreira, A. F., & Roncon‐Albuquerque, R. (2022) · ESC Heart Failure · doi:10.1002/ehf2.13775 · Cited by 62
The impact of genetic manipulation of laminin and integrins at the blood–brain barrier
Halder, S. K., Sapkota, A., & Milner, R. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00346-8 · Cited by 58
Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor
Carrion, B., Kong, Y. P., Kaigler, D., & Putnam, A. J. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.09.007 · Cited by 56
TLR-2/TLR-4 TREM-1 Signaling Pathway Is Dispensable in Inflammatory Myeloid Cells during Sterile Kidney Injury
Campanholle, G., Mittelsteadt, K. L., Nakagawa, S., Kobayashi, A., Lin, S., Gharib, S. A., Heinecke, J. W., Hamerman, J. A., Altemeier, W. A., & Duffield, J. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068640 · Cited by 58
Blood vessel maturation, vascular phenotype and angiogenic potential in malignant melanoma: One step forward for overcoming anti‐angiogenic drug resistance?
Helfrich, I., & Schadendorf, D. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.01.003 · Cited by 58
Impaired Endothelium-Mesenchymal Stem Cells Cross-talk in Systemic Sclerosis: a Link Between Vascular and Fibrotic Features
Cipriani, P., Benedetto, P. D., Ruscitti, P., Campese, A. F., Liakouli, V., Carubbi, F., Pantano, I., Berardicurt, O., Screpanti, I., & Giacomelli, R. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0442-z · Cited by 57
ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds
Alabi, R. O., Glomski, K., Haxaire, C., Weskamp, G., Monette, S., & Blobel, C. (2016) · Circulation Research · doi:10.1161/circresaha.115.307738 · Cited by 58
Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity
Castro, V., Skowrońska, M., Lombardi, J., He, J., Seth, N., Velichkovska, M., & Toborek, M. J. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17720816 · Cited by 55
The three-phase enriched environment paradigm promotes neurovascular restorative and prevents learning impairment after ischemic stroke in rats
Zhan, Y., Li, M.-Z., Yang, L. J., Feng, X.-F., Lei, J., Zhang, N., Zhao, Y., & Zhao, H. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105091 · Cited by 55
The Role of Biofactors in Diabetic Microvascular Complications
Ziegler, D., Porta, M., Παπάνας, Ν., Moța, M., Jermendy, G., Beltramo, E., Mazzeo, A., Caccioppo, A., Striglia, E., Serhiyenko, V. A., et al. (2021) · Current Diabetes Reviews · doi:10.2174/1871527320666210825112240 · Cited by 58
Stroke-induced damage on the blood–brain barrier
Xue, S., Zhou, X., Yang, Z., Si, X., & Sun, X. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1248970 · Cited by 58
Continued dysfunction of capillary pericytes promotes no-reflow after experimental stroke in vivo
Shrouder, J. J., Calandra, G. M., Filser, S., Varga, D. P., Besson‐Girard, S., Mamrak, U., Dorok, M., Bulut-Impraim, B., Şeker, F. B., Gesierich, B. G., et al. (2023) · Brain · doi:10.1093/brain/awad401 · Cited by 60
Human Aortic Smooth Muscle Cells Promote Arteriole Formation by Coengrafted Endothelial Cells
Shepherd, B. R., Jay, S. M., Saltzman, W. M., Tellides, G., & Pober, J. S. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0010 · Cited by 55
Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells
Castilho–Fernandes, A., de Almeida, D. C., Fontes, A. M., Melo, F. U. F., Picanço‐Castro, V., de Freitas, M. C. C., Orellana, M. D., Palma, P. V. B., Hackett, P. B., Friedman, S. L., et al. (2011) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2011.09.002 · Cited by 56
Maintenance of vascular integrity by pericytes is essential for normal kidney function
Lemos, D. R., Marsh, G. A., Huang, A., Campanholle, G., Aburatani, T., Dang, L. T. H., Gomez, I. G., Fisher, K., Ligresti, G., Peti‐Peterdi, J., et al. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00030.2016 · Cited by 55
Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction
Gaskill, C. F., Carrier, E. J., Kropski, J. A., Bloodworth, N. C., Menon, S., Foronjy, R., Taketo, M. M., Hong, C. C., Austin, E. D., West, J. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88629 · Cited by 53
Pericytes: The Role of Multipotent Stem Cells in Vascular Maintenance and Regenerative Medicine
Ahmed, T. A., & El‐Badri, N. (2017) · Advances in experimental medicine and biology · doi:10.1007/5584_2017_138 · Cited by 54
Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells
Gerli, M., Moyle, L. A., Benedetti, S., Ferrari, G., Ucuncu, E., Ragazzi, M., Constantinou, C., Louca, I., Sakai, H., Ala, P., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.01.007 · Cited by 55
Control of cerebrovascular patterning by neural activity during postnatal development
Lacoste, B., & Gu, C. (2015) · Mechanisms of Development · doi:10.1016/j.mod.2015.06.003 · Cited by 58
Cellular Source and Amount of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor in Tumors Determine Response to Angiogenesis Inhibitors
Sennino, B., Kuhnert, F., Tabruyn, S. P., Mancuso, M. R., Hu‐Lowe, D. D., Kuo, C. J., & McDonald, D. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3779 · Cited by 55
Protective role of vitamin D against oxidative stress in diabetic retinopathy
Valle, M. S., Russo, C., & Malaguarnera, L. (2021) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3447 · Cited by 58
Lack of Cyp1b1 promotes the proliferative and migratory phenotype of perivascular supporting cells
Palenski, T. L., Sorenson, C. M., Jefcoate, C. R. E., & Sheibani, N. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.55 · Cited by 53
TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins
Tigges, U., Boroujerdi, A., Welser-Alves, J. V., & Milner, R. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-33 · Cited by 55
Pulmonary vascular development in congenital diaphragmatic hernia
Mous, D. S., Kool, H. M., Wijnen, R. M. H., Tibboel, D., & Rottier, R. J. (2018) · European Respiratory Review · doi:10.1183/16000617.0104-2017 · Cited by 54
Human Glioblastoma-Derived Mesenchymal Stem Cell to Pericytes Transition and Angiogenic Capacity in Glioblastoma Microenvironment
Yi, D., Xiang, W., Zhang, Q., Cen, Y., Su, Q., Zhang, F., Lu, Y., Zhao, H., & Fu, P. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488429 · Cited by 57
Systems biology of angiogenesis signaling: Computational models and omics
Zhang, Y., Wang, H., Oliveira, R. H. D. M., Zhao, C., & Popel, A. S. (2021) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1550 · Cited by 54
Contextual role for angiopoietins and TGFβ1 in blood vessel stabilization
Ramsauer, M., & D'Amore, P. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.003533 · Cited by 53
Perivascular-Like Cells Contribute to the Stability of the Vascular Network of Osteogenic Tissue Formed from Cell Sheet-Based Constructs
Mendes, L. F., Pirraco, R. P., Szymczyk, W., Frias, A. M., Santos, T. C., Reis, R. L., & Marques, A. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041051 · Cited by 53
Visualization and contractile activity of cochlear pericytes in the capillaries of the spiral ligament
Dai, M., Nuttall, A. L., Yang, Y., & Shi, X. (2009) · Hearing Research · doi:10.1016/j.heares.2009.04.018 · Cited by 53
Increased Vascular Delivery and Efficacy of Chemotherapy after Inhibition of Platelet-Derived Growth Factor-B
Falcón, B. L., Pietras, K., Chou, J., Chen, D., Sennino, B., Hanahan, D., & McDonald, D. M. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.02.019 · Cited by 53
Neonatal Brain Hemorrhage (NBH) of Prematurity: Translational Mechanisms of the Vascular-Neural Network
Lekic, T., Klebe, D. W., Poblete, R. A., Krafft, P. R., Rolland, W. B., Tang, J., & Zhang, J. H. (2015) · Current Medicinal Chemistry · doi:10.2174/0929867322666150114152421 · Cited by 53
Low on energy? An energy supply-demand perspective on stress and depression
Østergaard, L., Jørgensen, M. B., & Knudsen, G. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.08.007 · Cited by 53
Integrin-linked kinase controls vascular wall formation by negatively regulating Rho/ROCK-mediated vascular smooth muscle cell contractionPreprint
Kogata, N., Tribe, R., Fässler, R., Way, M., & Adams, R. H. (2009) · Genes & Development · doi:10.1101/gad.535409 · Cited by 58
Perivascular cell-specific knockout of the stem cell pluripotency gene Oct4 inhibits angiogenesis
Hess, D. L., Kelly‐Goss, M. R., Cherepanova, O. A., Nguyen, A. T., Baylis, R. A., Tkachenko, S., Annex, B. H., Peirce, S. M., & Owens, G. K. (2019) · Nature Communications · doi:10.1038/s41467-019-08811-z · Cited by 52
Angiogenesis and targeted therapy in the tumour microenvironment: From basic to clinical practice
Yang, S., Fang, Y., Ma, Y., Wang, F., Wang, Y., Jia, J., Yang, Y., Sun, W., Zhou, Q., & Li, Z. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70313 · Cited by 61
Pilot Study on “Pericytic Mimicry” and Potential Embryonic/Stem Cell Properties of Angiotropic Melanoma Cells Interacting with the Abluminal Vascular Surface
Lugassy, C., Wadehra, M., Li, X., Corselli, M., Akhavan, D., Binder, S. W., Péault, B., Cochran, A. J., Mischel, P. S., Kleinman, H. K., et al. (2012) · Cancer Microenvironment · doi:10.1007/s12307-012-0128-5 · Cited by 52
STAT1-mediated Bim expression promotes the apoptosis of retinal pericytes under high glucose conditions
Shin, E. S., Huang, Q., Gürel, Z., Palenski, T. L., Zaitoun, I. S., Sorenson, C. M., & Sheibani, N. (2014) · Cell Death and Disease · doi:10.1038/cddis.2013.517 · Cited by 53
Engineering clinically relevant volumes of vascularized bone
Roux, B. M., Cheng, M., & Brey, E. M. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12569 · Cited by 52
A Modular Tissue Engineering Construct Containing Smooth Muscle Cells and Endothelial Cells
Leung, B. M., & Sefton, M. V. (2007) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9380-0 · Cited by 52
Collagen VI Ablation Retards Brain Tumor Progression Due to Deficits in Assembly of the Vascular Basal Lamina
You, W., Bonaldo, P., & Stallcup, W. B. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.11.006 · Cited by 52
An Accessible Organotypic Microvessel Model Using iPSC‐Derived Endothelium
Ingram, P., Hind, L. E., Jiménez‐Torres, J. A., Huttenlocher, A., & Beebe, D. J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700497 · Cited by 54
Effects of pericytes and colon cancer stem cells in the tumor microenvironment
Garza-Treviño, E. N., González, P. D., Salgado, C. I. V., & Garza, A. M. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0888-9 · Cited by 53
SGLT2 Inhibitors, GLP-1 Agonists, and DPP-4 Inhibitors in Diabetes and Microvascular Complications: A Review
Mouhayyar, C. E., Riachy, R., Khalil, A. B., Eid, A. A., & Azar, S. T. (2020) · International Journal of Endocrinology · doi:10.1155/2020/1762164 · Cited by 54
Resident mesenchymal cells and fibrosis
Hutchison, N., Fligny, C., & Duffield, J. S. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.015 · Cited by 51
Pericyte‐secreted IGF2 promotes breast cancer brain metastasis formation
Molnár, K., Mészáros, Á., Fazakas, C., Kozma, M., Győri, F., Reisz, Z., Tiszlavicz, L., Farkas, A. E., Nyúl‐Tóth, Á., Haskó, J., et al. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12752 · Cited by 53
Pericyte coverage of differentiated vessels inside tumor vasculature is an independent unfavorable prognostic factor for patients with clear cell renal cell carcinoma
Cao, Y., Zhang, Z., Zhou, M., Elson, P. J., Rini, B. I., Aydın, H., Feenstra, K., Tan, M., Berghuis, B. D., Tabbey, R., et al. (2012) · Cancer · doi:10.1002/cncr.27746 · Cited by 51
In Vivo Optical Imaging of Tumor and Microvascular Response to Ionizing Radiation
Maeda, A., Leung, M. K. K., Conroy, L., Chen, Y., Bu, J., Lindsay, P. E., Mintzberg, S., Virtanen, C., Tsao, J., Winegarden, N. A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042133 · Cited by 51
Cellular and molecular basis of the imbalance between vascular damage and repair in ageing and age-related diseases: As biomarkers and targets for new treatments
Madonna, R., Novo, G., & Balistreri, C. R. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.03.005 · Cited by 52
Stromal contributions to the carcinogenic process
Spaw, M. C., Anant, S., & Thomas, S. M. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22583 · Cited by 54
Osteopontin-integrin engagement induces HIF-1α–TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer
Fan, C.-S., Chen, W.-S., Chen, L.-L., Chen, C.-C., Hsu, Y.-T., Chua, K. V., Wang, H., & Huang, T. (2017) · Oncotarget · doi:10.18632/oncotarget.23578 · Cited by 51
Cardiac Fibroblast Physiology and Pathology
Dostal, D. E., Glaser, S. S., & Baudino, T. A. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140053 · Cited by 54
Coronary vessel development and insight towards neovascular therapy
Smart, N., Dubé, K. N., & Riley, P. R. (2009) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2009.00646.x · Cited by 51
The Role of Activated Microglia and Resident Macrophages in the Neurovascular Unit during Cerebral Ischemia: Is the Jury Still Out?
Barakat, R., & Redzic, Z. B. (2015) · Medical Principles and Practice · doi:10.1159/000435858 · Cited by 51
Brain pericyte plasticity as a potential drug target in CNS repair
Lange, S., Trost, A., Tempfer, H., Bauer, H., Bauer, H., Rohde, E., Reitsamer, H. A., Franklin, R. J. M., Aigner, L., & Rivera, F. J. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.12.007 · Cited by 50
Renal ischemia-reperfusion induces a dysbalance of angiopoietins, accompanied by proliferation of pericytes and fibrosis
Khairoun, M., van der Pol, P., de Vries, D. K., Lievers, E., Schlagwein, N., de Boer, H. C., Bajema, I. M., Rotmans, J. I., van Zonneveld, A. J., Rabelink, T. J., et al. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00542.2012 · Cited by 53
Pericytes as targets in hereditary hemorrhagic telangiectasia
Thalgott, J. H., Dos-Santos-Luis, D., & Lebrin, F. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00037 · Cited by 51
Soluble forms of VEGF receptor‐1 and ‐2 promote vascular maturation via mural cell recruitment
Lorquet, S., Berndt, S., Blacher, S., Gengoux, E., Peulen, O., Maquoi, E., Noël, A., Foidart, J., Munaut, C., & Péqueux, C. (2010) · The FASEB Journal · doi:10.1096/fj.09-149070 · Cited by 50
Nuclear Deformation During Neutrophil Migration at Sites of Inflammation
Salvermoser, M., Begandt, D., Alon, R., & Walzog, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02680 · Cited by 52
In Vitro Conditioning Determines the Capacity of Dental Pulp Stem Cells to Function as Pericyte-Like Cells
Monache, S. D., Martellucci, S., Clementi, L., Pulcini, F., Santilli, F., Mei, C., Piccoli, L., Angelucci, A., & Mattei, V. (2019) · Stem Cells and Development · doi:10.1089/scd.2018.0192 · Cited by 51

Authors: Armulik, A., Abramsson, A., & Betsholtz, C.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Betsholtz, Christer
ORCID: Abramsson, Alexandra
Betsholtz, Christer
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2005-09-16
Volume: 97
Issue: 6
Pages: 512-523
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.0000182903.16652.d7
OpenAlex: W2115390024
Cited by: 2,048
References: 134
Citations by year: 2026: 39 · 2025: 62 · 2024: 97 · 2023: 108 · 2022: 90 · 2021: 116 · 2020: 121 · 2019: 101 · 2018: 92 · 2017: 110 · 2016: 117 · 2015: 131 · 2014: 122 · 2013: 120 · 2012: 114
FWCI: 5.70
Type: journal article
Language: en
Open access: closed
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: pericytes, endothelial cells, pericyte-endothelial interactions, vascular remodeling, intercellular communication, TGF-beta, angiopoietins, platelet-derived growth factor, sphingosine-1-phosphate, Notch signaling, tumor angiogenesis, diabetic retinopathy, hereditary lymphedema, CADASIL, vascular calcification, cardiovascular defects
MeSH terms: Becaplermin, Animals, Calcinosis, Cell Communication, Cell Differentiation, Humans, Lysophospholipids, Membrane Proteins, Muscle, Smooth, Vascular, Platelet-Derived Growth Factor, Sphingosine, Signal Transduction, Transforming Growth Factor beta, Pericytes, Proto-Oncogene Proteins c-sis, Receptor, Platelet-Derived Growth Factor beta, Angiopoietin-1, Endothelial Cells, Receptor, TIE-2, Receptors, Lysosphingolipid, Receptors, Notch

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endothelial/Pericyte Interactions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks