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Endothelial/Pericyte Interactions
Abstract
Interactions between endothelial cells and mural cells (pericytes and vascular smooth muscle cells) in the blood vessel wall have recently come into focus as central processes in the regulation of vascular formation, stabilization, remodeling, and function. Failure of the interactions between the 2 cell types, as seen in numerous genetic mouse models, results in severe and often lethal cardiovascular defects. Abnormal interactions between the 2 cell types are also implicated in a number of human pathological conditions, including tumor angiogenesis, diabetic microangiopathy, ectopic tissue calcification, and stroke and dementia syndrome CADASIL. In the present review, we summarize current knowledge concerning the identity, characteristics, diversity, ontogeny, and plasticity of pericytes. We focus on the advancement in recent years of the understanding of intercellular communication between endothelial and mural cells with a focus on transforming growth factor β, angiopoietins, platelet-derived growth factor, spingosine-1-phosphate, and Notch ligands and their respective receptors. We finally highlight recent important data contributing to the understanding of the role of pericytes in tumor angiogenesis, diabetic retinopathy, and hereditary lymphedema.
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“pericyte-derived angiopoietin acts on endothelial Tie2 receptor and maintains BBB function (26, 570, 648);”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [26]
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Metadata
- Authors
- Armulik, A., Abramsson, A., & Betsholtz, C.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Betsholtz, Christer
- Venue
- Circulation Research
- Published
- 2005-09-16
- Volume
- 97
- Issue
- 6
- Pages
- 512-523
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2115390024
- Cited by
- 2,048
- References
- 134
- Citations by year
- 2026: 39 · 2025: 62 · 2024: 97 · 2023: 108 · 2022: 90 · 2021: 116 · 2020: 121 · 2019: 101 · 2018: 92 · 2017: 110 · 2016: 117 · 2015: 131 · 2014: 122 · 2013: 120 · 2012: 114
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Keywords
- pericytes, endothelial cells, pericyte-endothelial interactions, vascular remodeling, intercellular communication, TGF-beta, angiopoietins, platelet-derived growth factor, sphingosine-1-phosphate, Notch signaling, tumor angiogenesis, diabetic retinopathy, hereditary lymphedema, CADASIL, vascular calcification, cardiovascular defects
- MeSH terms
- Becaplermin, Animals, Calcinosis, Cell Communication, Cell Differentiation, Humans, Lysophospholipids, Membrane Proteins, Muscle, Smooth, Vascular, Platelet-Derived Growth Factor, Sphingosine, Signal Transduction, Transforming Growth Factor beta, Pericytes, Proto-Oncogene Proteins c-sis, Receptor, Platelet-Derived Growth Factor beta, Angiopoietin-1, Endothelial Cells, Receptor, TIE-2, Receptors, Lysosphingolipid, Receptors, Notch
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