The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Intracellular Trafficking and Secretion of VLDL
Open accessAbstract
Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density lipoprotein, which are metabolic products of very low-density lipoprotein (VLDL). VLDLs are synthesized and secreted by the liver. In this review, we discuss various stages through which VLDL particles go from their biogenesis to secretion in the circulatory system. Once VLDLs are synthesized in the lumen of the endoplasmic reticulum, they are transported to the Golgi. The transport of nascent VLDLs from the endoplasmic reticulum to Golgi is a complex multistep process, which is mediated by a specialized transport vesicle, the VLDL transport vesicle. The VLDL transport vesicle delivers VLDLs to the cis -Golgi lumen where nascent VLDLs undergo a number of essential modifications. The mature VLDL particles are then transported to the plasma membrane and secreted in the circulatory system. Understanding of molecular mechanisms and identification of factors regulating the complex intracellular VLDL trafficking will provide insight into the pathophysiology of various metabolic disorders associated with abnormal VLDL secretion and identify potential new therapeutic targets.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Membrane Fusion: Grappling with SNARE and SM Proteins
Südhof, T. C., & Rothman, J. E. (2009) · Science · doi:10.1126/science.1161748 · Cited by 2,027
Diabetic dyslipidaemia: from basic research to clinical practice*
Taskinen, M.-R. (2003) · Diabetologia · doi:10.1007/s00125-003-1111-y · Cited by 888
Etiology of Insulin Resistance
Petersen, K. F., & Shulman, G. I. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.01.009 · Cited by 825 · cited 1×
“Of particular interest is insulin resistance, which is generally described as decreased physiological response to circulating insulin by the liver, skeletal muscle, and adipose tissue.(14) Insulin resistance leads to enhanced VLDL synthesis and secretion;(12,13) however, its effects on intracellular VLDL trafficking h…”
Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance
Choi, S. H., & Ginsberg, H. N. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.04.007 · Cited by 418
New Perspectives on Atherogenesis: Role of Abnormal Triglyceride-Rich Lipoprotein Metabolism
Ginsberg, H. N. (2002) · Circulation · doi:10.1161/01.cir.0000035280.64322.31 · Cited by 255 · cited 1×
“Enhanced production of VLDLs and their eventual secretion into the circulatory system constitute one of the major risk factors for the development of atherosclerosis.(1,2) Higher concentrations of VLDLs in the blood are often translated into higher levels of atherogenic particles, low-density lipoproteins (LDLs).”
New variation on the translocation of proteins during early biogenesis of apolipoprotein B
Chuck, S. L., Yao, Z., Blackhart, B. D., McCarthy, B. J., & Lingappa, V. R. (1990) · Nature · doi:10.1038/346382a0 · Cited by 100
Research works printed but not linked: 92
- 10.1097/00041433-199410000-00006 · DOI
- 10.1194/jlr.M800248-JLR200 · DOI
- 10.1074/jbc.R100068200 · DOI · Paper page
- 10.1016/0005-2760(94)90249-6 · DOI
- 10.1016/S1050-1738(01)00071-8 · DOI · Paper page
- 10.1074/jbc.M008885200 · DOI
- 10.1074/jbc.M107460200 · DOI
- 10.1083/jcb.69.2.241 · DOI · Paper page
- 10.1111/j.1365-2796.2005.01556.x · DOI · Paper page
- 10.1194/jlr.R800090-JLR200 · DOI · Paper page
- 10.1186/1743-7075-7-35 · DOI · Paper page
- 10.1073/pnas.82.14.4597 · DOI
- 10.1016/S0021-9258(19)39221-X · DOI
- 10.1126/science.3659919 · DOI · Paper page
- 10.1073/pnas.77.5.2465 · DOI · Paper page
- 10.1152/ajpgi.00123.2007 · DOI
- 10.1146/annurev-physiol-021909-135801 · DOI · Paper page
- 10.1073/pnas.86.2.500 · DOI
- 10.1016/S0022-2275(20)30267-4 · DOI · Paper page
- 10.1021/bi011757l · DOI
- 10.1016/0092-8674(92)90202-N · DOI
- 10.1016/S0022-2275(20)39874-6 · DOI
- 10.1093/jn/129.2.463S · DOI
- Shelness GS, Ingram MF, Huang XF, DeLozier JA. Apolipoprotein B in the rough endoplasmic reticulum: translation, translocation and the initiation of lipoprotein assembly. J Nutr. 1999;129:456S–462S.
- 10.1194/jlr.R200014-JLR200 · DOI · Paper page
- 10.1074/jbc.273.40.25612 · DOI
- 10.1074/jbc.M100294200 · DOI
- 10.1002/hep · DOI
- 10.1016/S0021-9258(19)49411-8 · DOI
- 10.1016/S0022-2275(20)37125-X · DOI
- 10.1074/jbc.273.42.27225 · DOI
- 10.1074/jbc.M100633200 · DOI
- 10.1074/jbc.273.38.24649 · DOI · Paper page
- 10.1074/jbc.M705216200 · DOI
- 10.1172/JCI6576 · DOI · Paper page
- 10.1016/j.cmet.2008.12.013 · DOI
- 10.1016/S0167-4889(98)00047-0 · DOI
- 10.1016/S0092-8674(00)81577-9 · DOI · Paper page
- 10.1016/0092-8674(94)90138-4 · DOI · Paper page
- 10.1016/j.febslet.2009.10.038 · DOI
- 10.1016/j.cub.2005.11.076 · DOI
- 10.1083/jcb.125.1.51 · DOI · Paper page
- 10.1038/365347a0 · DOI · Paper page
- 10.1016/S0021-9258(18)54015-1 · DOI
- 10.1074/jbc.C000449200 · DOI
- 10.1038/nature01040 · DOI · Paper page
- 10.1083/jcb.200106039 · DOI
- 10.1038/34438 · DOI · Paper page
- 10.1083/jcb.152.1.213 · DOI
- 10.1006/meth.2000.0954 · DOI
- 10.1038/nature04339 · DOI · Paper page
- 10.1073/pnas.191359398 · DOI
- 10.1074/jbc.M306898200 · DOI
- 10.1042/BJ20071469 · DOI
- 10.1242/jcs.00215 · DOI
- 10.1097/00041433-200404000-00012 · DOI
- 10.1016/j.ymgme.2007.08.120 · DOI
- 10.1186/1750-1172-6-1 · DOI
- 10.1016/j.jprot.2010.01.010 · DOI
- 10.1161/atvbaha.111.233908 · DOI
- 10.1038/372055a0 · DOI · Paper page
- 10.1247/csf.21.407 · DOI
- 10.1016/S0955-0674(97)80026-9 · DOI · Paper page
- 10.1038/nrm2002 · DOI · Paper page
- 10.1038/362318a0 · DOI · Paper page
- 10.1091/mbc.e07-03-0193 · DOI
- 10.1073/pnas.95.26.15781 · DOI · Paper page
- 10.1016/S0092-8674(00)81404-X · DOI
- 10.1016/S0092-8674(00)80191-9 · DOI
- 10.1091/mbc.10.2.435 · DOI
- 10.1074/jbc.M102786200 · DOI
- 10.1091/mbc.e02-09-0556 · DOI
- 10.1242/jcs.02803 · DOI
- 10.1074/jbc.M601401200 · DOI
- 10.1042/BJ20100336 · DOI
- 10.1074/jbc.M200249200 · DOI
- 10.1016/S0021-9258(19)79016-4 · DOI
- 10.1016/j.jprot · DOI
- 10.1073/pnas.87.7.2390 · DOI
- 10.1016/S0021-9258(18)37867-0 · DOI
- 10.1083/jcb.47.3.745 · DOI · Paper page
- 10.1016/S0022-5320(81)80119-0 · DOI
- 10.1016/S0021-9258(18)53730-3 · DOI
- 10.1074/jbc.M306920200 · DOI
- 10.1016/S0021-9258(18)49269-1 · DOI · Paper page
- 10.1074/jbc.M202015200 · DOI
- 10.1016/0014-5793(88)80780-4 · DOI
- 10.1074/jbc.M700475200 · DOI
- 10.1016/0014-4800(77)90055-7 · DOI
- 10.1074/jbc.M610765200 · DOI
- 10.1194/jlr.M005611 · DOI
- 10.1194/jlr.M002758 · DOI
Cited by
Lipid droplet biogenesis and functions in health and disease
Zadoorian, A., Du, X., & Yang, H. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00845-0 · Cited by 617
Wolska, A., Dunbar, R. L., Freeman, L. A., Ueda, M., Amar, M. J., Sviridov, D. O., & Remaley, A. T. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.10.025 · Cited by 231
The cell biology of APOE in the brain
Windham, I. A., & Cohen, S. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.09.004 · Cited by 103
Modification of lipoprotein metabolism and function driving atherogenesis in diabetes
Luciani, L., Pedrelli, M., & Parini, P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117545 · Cited by 72
Lipid droplets as signaling platforms linking metabolic and cellular functions
Arrese, E. L., Saudale, F. Z., & Soulages, J. L. (2014) · Lipid Insights · doi:10.4137/lpi.s11128 · Cited by 54
Metadata
- Authors
- Tiwari, S., & Siddiqi, S. A.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2012-05
- Volume
- 32
- Issue
- 5
- Pages
- 1079-1086
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2151276108
- Cited by
- 256
- References
- 6
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Intracellular Trafficking and Secretion of VLDL. https://app.cochat.ai/papers/10.1161/atvbaha.111.241471
- The paper
- Tiwari, S., & Siddiqi, S. A. (2012). Intracellular Trafficking and Secretion of VLDL. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/atvbaha.111.241471
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
