Cited by 122Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsClinical practice guidelines implementation

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2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

Writing Committee Members, Blumenthal, Roger S., Morris, Pamela B., Gaudino, Mario, Johnson, Heather M., Anderson, Timothy S., Bittner, Vera A., Blankstein, Ron, Brewer, LaPrincess C., Cho, Leslie, de Ferranti, Sarah D., Gianos, Eugenia, Gluckman, Ty J., Gradney, Kristen F., Isiadinso, Ijeoma, Lloyd-Jones, Donald M., Marrs, Joel C., Martin, Seth S., McLain, Kellie H., Mehta, Laxmi S., Mora, Samia, Mulugeta, Wudeneh M., Natarajan, Pradeep, Navar, Ann Marie, Orringer, Carl E., Polonsky, Tamar S., Reynolds, Harmony R., Saseen, Joseph J., Shapiro, Michael D., Soffer, Daniel E., Tynes, Sheila A., Villavaso, Chloé D., Virani, Salim S., Wilkins, John T., Rohatgi, Anand, Kim, Samuel M., Alexander, Karen P., Anderson, Cheryl, Benziger, Catherine P., Dixon, Dave L., Duprez, Daniel, Ferdinand, Keith C., Goldberg, Anne Carol, Joshi, Parag, Knowles, Joshua W., Lavie Jr, Carl (Chip) J., Linderbaum, Jane A., McEvoy, John William, Mehta, Anurag, Merz, C. Noel Bairey, Nambi, Vijay, Orkaby, Ariela R., Peña,, Jessica M., Rosenson, Robert, Ruisinger, Janelle, Sandner, Sigrid E., Schott, Stacey L., Sperling, Laurence (Larry), Stone, Neil J., Toth, Peter, Ware, Adam L., Whelton, Seamus Paul, Young, James·2026·Circulation

DOI 10.1161/cir.0000000000001423

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Abstract

AIM: The “2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia” retires and replaces the “2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol.” METHODS: A comprehensive literature search was conducted from October 2024 to December 2024 to identify clinical studies, systematic reviews and meta-analyses, and other evidence conducted on human participants that were published in English from MEDLINE (through PubMed), EMBASE, the Cochrane Library, Agency for Healthcare Research and Quality, and other selected databases relevant to this guideline. STRUCTURE: The focus of this clinical practice guideline is to address the evaluation, management, and monitoring of individuals with dyslipidemias, including high blood cholesterol, hypertriglyceridemia, and elevated lipoprotein(a).

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Association of Acculturation with Cardiovascular Risk Factors in Asian-American Subgroups
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Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results
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Harmonization of Lipoprotein(a) Immunoassays Using A Serum Panel Value Assigned with The IFCC-Endorsed Mass Spectrometry-Based Reference Measurement Procedure as A First Step Towards Apolipoprotein Standardization
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Dietary Fats and Atherosclerosis From Childhood to Adulthood
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Patient Preference Distribution for Use of Statin Therapy
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Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure
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Trends of Elevated Low-Density Lipoprotein Cholesterol, Awareness, and Screening Among Young Adults in the US, 2003-2020
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Effect of Exercise on Vascular Function and Blood Lipids in Postmenopausal Women: A Systematic Review and Network Meta-Analysis
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Residential greenness and dyslipidemia risk: Dose-response relations and mediation through BMI and air pollution
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Lipoprotein Metabolism, Dyslipidemia, and Lipid-Lowering Therapy in Women: A Comprehensive Review
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Predictors in Youth of Adult Cardiovascular Events
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Relationship between intake of fruit separately from vegetables and triglycerides - A meta-analysis
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Omega-3 fatty acid supplements and risk of atrial fibrillation and ‘micro-atrial fibrillation’: A secondary analysis from the OMEMI trial
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Million Hearts Cardiovascular Disease Risk Reduction Model
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Garlic consumption can reduce the risk of dyslipidemia: a meta-analysis of randomized controlled trials
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Trends in Lipid-Lowering Prescriptions: Increasing Use of Guideline-Concordant Pharmacotherapies, U.S., 2017‒2022
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Cardiovascular Disease Mortality Among Native Hawaiian and Pacific Islander Adults Aged 35 Years or Older, 2018 to 2022
Woodruff, R. C., Kaholokula, J. K., Riley, L., Tong, X., Richardson, L. C., Diktonaite, K., Loustalot, F. V., Vaughan, A. S., Imoisili, O. E., & Hayes, D. (2024) · Annals of Internal Medicine · doi:10.7326/m24-0801 · Cited by 18
Preventive Health in Cancer Survivors: What Should We Be Recommending?
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Coenzyme Q10 Supplementation for the Treatment of statin-associated Muscle Symptoms
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Combination of low- or moderate-intensity statin and ezetimibe vs. high-intensity statin monotherapy on primary prevention of cardiovascular disease and all-cause death: a propensity-matched nationwide cohort study
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Adherence to lipid monitoring and its impact on treatment intensification of LDL-C lowering therapies at an urban academic medical center
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Pitavastatin, Procollagen Pathways, and Plaque Stabilization in Patients With HIV
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Non–high-density lipoprotein cholesterol reporting and goal attainment in primary care
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Effect of short term aerobic exercise on fasting and postprandial lipoprotein subfractions in healthy sedentary men
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Cardiovascular medication use and risks of colon cancer recurrences and additional cancer events: a cohort study
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Low-Density Lipoprotein Cholesterol Trajectories and Prevalence of High Low-Density Lipoprotein Cholesterol Consistent With Heterozygous Familial Hypercholesterolemia in US Children
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Safety and Efficacy of the Consumption of the Nutraceutical “Red Yeast Rice Extract” for the Reduction of Hypercholesterolemia in Humans: A Systematic Review and Meta-Analysis
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Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease
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Both low-fat and low-carbohydrate diets reduce triglyceride concentration in subjects with multifactorial chylomicronemia syndrome: a randomized crossover study
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Clinical characteristics and treatment patterns in patients with atherosclerotic cardiovascular disease with hypercholesterolemia: a retrospective analysis of a large US real-world database cohort
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Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors
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Statin use in cancer survivors versus the general population: cohort study using primary care data from the UK clinical practice research datalink
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Statin Use in Cancer Patients with Acute Myocardial Infarction and Its Impact on Long-Term Mortality
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Importance of Age and Sex in Carotid Artery Plaque Detection and Cardiovascular Disease Risk
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Effect of High-Intensity Strength and Endurance Training in the Form of Small Circuits on Changes in Lipid Levels in Men Aged 35–40 Years
Ambroży, T., Rydzik, Ł., Obmiński, Z., Spieszny, M., Szczepanik, A., Ambroży, D., Basiaga-Pasternak, J., Spieszny, J., Niewczas, M., & Jaszczur-Nowicki, J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175146 · Cited by 13
Changes in chronic medication adherence in older adults with cancer versus matched cancer-free cohorts
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Clinical conundrums involving statin drug-drug interactions
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Effects of Cinnamon Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
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The association between the triglyceride–glucose index and vulnerable plaques in patients with type 2 diabetes mellitus: insights from coronary computed tomography angiography
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The role of statins in the regulation of breast and colorectal cancer and future directions
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Incidence of cardiovascular events and changes in the estimated risk and treatment of familial hypercholesterolemia: the SAFEHEART registry
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Association of dietary patterns and components with atherosclerosis risk biomarkers in familial hypercholesterolemia
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Pregnancy in homozygous familial hypercholesterolemia—A case series
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Measurement of apolipoprotein B levels helps in the identification of patients at risk for hypertriglyceridemic pancreatitis
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The Effects of Exclusive Walking on Lipids and Lipoproteins in Women with Overweight and Obesity: A Systematic Review and Meta-Analysis
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Physical Activity Assessment and Promotion in Clinical Settings in the United States: A Scoping Review
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Utility of non-HDL-C and apoB targets in the context of new more aggressive lipid guidelines
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Effect of proprotein convertase subtilisin/kexin type 9 inhibition on cancer events: A pooled, post hoc, competing risk analysis of alirocumab clinical trials
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Accuracy of incidental visual coronary artery calcium assessment compared with dedicated coronary artery calcium scoring
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Statin Eligibility According to Atherosclerotic Cardiovascular Disease Risk in the US
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Association of physical activity volume and hypercholesterolemia in US adults
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Analysis of apoB Concentrations Across Early Adulthood and Predictors for Rates of Change Using CARDIA Study Data
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The Effectiveness of Physical Exercise in Reducing Common Risk Factors of Atherosclerosis: A Systematic Review
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Against reflexive recalibration: towards a causal framework for addressing miscalibration
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Colesevelam hydrochloride does not cause maternal or fetal toxicity in rats and rabbits
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Quantification of Utilization Management Barriers for Patients Initiating Therapy to Lower Lipid Levels
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High‐Intensity Statin Reduces the Risk of Mortality Among Chronic Liver Disease Patients With Atherosclerotic Cardiovascular Disease: A Population‐Based Cohort Study
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Improving Cardiovascular Health in a Pediatric Preventive Cardiology Practice
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Detecting familial hypercholesterolemia: An observational study leveraging mandatory universal pediatric total cholesterol screening in Slovakia
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Use of Dietary Supplements Among People With Atherosclerotic Cardiovascular Disease in the United States: A Population‐Based Analysis From NHANES
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Metabolic outcomes in women 6 months and 2 years after preeclampsia versus normotensive pregnancy: A P4 study
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Evaluating the effect of bempedoic acid on kidney function: call for cautious implementation – Authors' reply
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Burden of Atherosclerotic Disease Risk Factors in Patients With and Without Rheumatologic Disease: A Retrospective Cohort Study
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The value of incorporating medical nutrition therapy by a registered dietitian nutritionist in clinical practice
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Review of referral criteria to lipid clinics and outcomes of treatment in four UK centres
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Integrating Diet Screening Into Routine Clinical Care: The Time Is Now
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Efficacy and Safety of Lomitapide in Homozygous Familial Hypercholesterolaemia: A Systematic Review
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Statin Drug‐Drug Interactions: Pharmacokinetic Basis of FDA Labeling Recommendations and Comparison Across Common Tertiary Clinical Resources
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Effect of concomitant medications on treatment response and survival in non-metastatic castrate resistant prostate cancer: Exploratory analysis of the SPARTAN trial
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Clinical Significance of Diabetes in Asymptomatic Individuals With Zero Coronary Artery Calcium Score
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Socioeconomic inequalities and dyslipidaemia in adult population of the Ravansar Non-Communicable Disease Cohort Study: the role of sex and age
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Analysis of Insulin Resistance Among Children and Adolescents in Slovenia With Hypercholesterolemia After Treatment With Statins
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Differences in treatment strategies for LDL-cholesterol reduction in a university lipid clinic vs. standard care apart from the use of PCSK9 inhibitors
Pinsdorf, D., Messiha, D., Petrikhovich, O., Bahar, M., Steinmetz, M., Mahabadi, A. A., Dykun, I., Lortz, J., Rassaf, T., & Rammos, C. (2023) · Journal of clinical lipidology · doi:10.1016/j.jacl.2023.05.100 · Cited by 5
Association between statin use and second cancer risk in breast cancer patients: a nationwide population-based cohort study
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A tool to help patients visualize ASCVD risk and the potential impact of risk-lowering interventions
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Authors: Writing Committee Members, Blumenthal, R. S., Morris, P. B., Gaudino, M., Johnson, H. M., Anderson, T. S., Bittner, V. A., Blankstein, R., Brewer, L. C., Cho, L., de Ferranti, S. D., Gianos, E., Gluckman, T. J., Gradney, K. F., Isiadinso, I., Lloyd-Jones, D. M., Marrs, J. C., Martin, S. S., McLain, K. H., Mehta, L. S., Mora, S., Mulugeta, W. M., Natarajan, P., Navar, A. M., Orringer, C. E., Polonsky, T. S., Reynolds, H. R., Saseen, J. J., Shapiro, M. D., Soffer, D. E., Tynes, S. A., Villavaso, C. D., Virani, S. S., Wilkins, J. T., Rohatgi, A., Kim, S. M., Alexander, K. P., Anderson, C., Benziger, C. P., Dixon, D. L., Duprez, D., Ferdinand, K. C., Goldberg, A. C., Joshi, P., Knowles, J. W., Lavie Jr, C. (. J., Linderbaum, J. A., McEvoy, J. W., Mehta, A., Merz, C. N. B., Nambi, V., Orkaby, A. R., Peña, Rosenson, R., Ruisinger, J., Sandner, S. E., Schott, S. L., Sperling, L. (., Stone, N. J., Toth, P., Ware, A. L., Whelton, S. P., & Young, J.
Affiliations: American Hospital Association (US)
Former ACC/AHA Joint Committee on Clinical Practice Guidelines member; current member during the writing effort.
American Geriatrics Society (US)
American Association of Cardiovascular and Pulmonary Rehabilitation representative.
ACC/AHA Task Force on Performance Measures liaison.
Patient representative.
Association of Black Cardiologists (US)
American Pharmacists Association (US)
American College of Preventive Medicine (US)
National Lipid Association (US)
American Society for Preventive Cardiology representative.
AHA/ACC Guidelines Staff Consultant.
Preventive Cardiovascular Nurses Association representative.
American Diabetes Association (US)
ORCID: Blumenthal, Roger S.
Gaudino, Mario
Johnson, Heather M.
Anderson, Timothy S.
Bittner, Vera A.
Blankstein, Ron
Brewer, LaPrincess C.
Cho, Leslie
de Ferranti, Sarah D.
Gianos, Eugenia
Gluckman, Ty J.
Isiadinso, Ijeoma
Marrs, Joel C.
Mehta, Laxmi S.
Mora, Samia
Mulugeta, Wudeneh M.
Natarajan, Pradeep
Orringer, Carl E.
Polonsky, Tamar S.
Reynolds, Harmony R.
Saseen, Joseph J.
Soffer, Daniel E.
Wilkins, John T.
Rohatgi, Anand
Alexander, Karen P.
Benziger, Catherine P.
Dixon, Dave L.
Ferdinand, Keith C.
Goldberg, Anne Carol
Knowles, Joshua W.
Linderbaum, Jane A.
McEvoy, John William
Nambi, Vijay
Orkaby, Ariela R.
Peña,, Jessica M.
Rosenson, Robert
Ruisinger, Janelle
Sandner, Sigrid E.
Schott, Stacey L.
Stone, Neil J.
Toth, Peter
Ware, Adam L.
Whelton, Seamus Paul
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2026-04-28
Volume: 153
Issue: 17
Pages: e1154-e1276
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/cir.0000000000001423
OpenAlex: W7135196205
Cited by: 122
References: 752
Citations by year: 2026: 122
FWCI: 769.87
Type: journal article
Language: en
Update notices: correction (2026-06-22)
correction (2026-09-08)
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Clinical practice guidelines implementation
Keywords: dyslipidemia, dyslipidemia management, hypercholesterolemia, hypertriglyceridemia, serum cholesterol, lipid-lowering therapy, cardiovascular risk, lipid monitoring
MeSH terms: American Heart Association, Hypolipidemic Agents, Cardiology, Humans, United States, Dyslipidemias

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2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

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