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Overexpression of Endothelial Nitric Oxide Synthase Prevents Diet-Induced Obesity and Regulates Adipocyte Phenotype
Open accessAbstract
RATIONALE: Endothelial dysfunction is a characteristic feature of diabetes and obesity in animal models and humans. Deficits in nitric oxide production by endothelial nitric oxide synthase (eNOS) are associated with insulin resistance, which is exacerbated by high-fat diet. Nevertheless, the metabolic effects of increasing eNOS levels have not been studied. OBJECTIVE: The current study was designed to test whether overexpression of eNOS would prevent diet-induced obesity and insulin resistance. METHODS AND RESULTS: In db/db mice and in high-fat diet-fed wild-type C57BL/6J mice, the abundance of eNOS protein in adipose tissue was decreased without significant changes in eNOS levels in skeletal muscle or aorta. Mice overexpressing eNOS (eNOS transgenic mice) were resistant to diet-induced obesity and hyperinsulinemia, although systemic glucose intolerance remained largely unaffected. In comparison with wild-type mice, high-fat diet-fed eNOS transgenic mice displayed a higher metabolic rate and attenuated hypertrophy of white adipocytes. Overexpression of eNOS did not affect food consumption or diet-induced changes in plasma cholesterol or leptin levels, yet plasma triglycerides and fatty acids were decreased. Metabolomic analysis of adipose tissue indicated that eNOS overexpression primarily affected amino acid and lipid metabolism; subpathway analysis suggested changes in fatty acid oxidation. In agreement with these findings, adipose tissue from eNOS transgenic mice showed higher levels of PPAR-α and PPAR-γ gene expression, elevated abundance of mitochondrial proteins, and a higher rate of oxygen consumption. CONCLUSIONS: These findings demonstrate that increased eNOS activity prevents the obesogenic effects of high-fat diet without affecting systemic insulin resistance, in part, by stimulating metabolic activity in adipose tissue.
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“lower NOS3 abundance is found in both adipose tissue and skeletal muscle of obese humans and rodents [120-124].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [122]
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Cites
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
Sreekumar, A., Poisson, L., Rajendiran, T. M., Khan, A. P., Cao, Q., Yu, J., Laxman, B., Mehra, R., Lonigro, R. J., Li, Y., et al. (2009) · Nature · doi:10.1038/nature07762 · Cited by 2,269
Environmental Contributions to the Obesity Epidemic
Hill, J. O., & Peters, J. C. (1998) · Science · doi:10.1126/science.280.5368.1371 · Cited by 2,258
Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230
Hu, F. B., Li, T. Y., Colditz, G. A., Willett, W. C., & Manson, J. E. (2003) · JAMA · doi:10.1001/jama.289.14.1785 · Cited by 1,892
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
Hirschey, M. D., Shimazu, T., Goetzman, E., Jing, E., Schwer, B., Lombard, D. B., Grueter, C. A., Harris, C., Biddinger, S., Ilkayeva, O. R., et al. (2010) · Nature · doi:10.1038/nature08778 · Cited by 1,687
Developmental Origin of Fat: Tracking Obesity to Its Source
Gesta, S., Tseng, Y.-H., & Kahn, C. R. (2007) · Cell · doi:10.1016/j.cell.2007.10.004 · Cited by 1,508
Lehrke, M., & Lazar, M. A. (2005) · Cell · doi:10.1016/j.cell.2005.11.026 · Cited by 1,472
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice
Seale, P., Conroe, H. M., Estall, J. L., Kajimura, S., Frontini, A., Ishibashi, J., Cohen, P., Cinti, S., & Spiegelman, B. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci44271 · Cited by 1,273
Insulin sensitivity: Modulation by nutrients and inflammation
Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,186
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
Nisoli, E., Tonello, C., Cardile, A., Cozzi, V., Bracale, R., Tedesco, L., Falcone, S., Valerio, A., Cantoni, O., Clementi, E., et al. (2005) · Science · doi:10.1126/science.1117728 · Cited by 1,107
Ervin, R. B. (2009) · PubMed · Cited by 1,000
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Fleming, I., & Busse, R. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00323.2002 · Cited by 955
Acquired and Inherited Lipodystrophies
Garg, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra025261 · Cited by 940
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals
Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.015 · Cited by 804
Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae
Shaul, P. W., Smart, E. J., Robinson, L. J., German, Z., Yuhanna, I. S., Ying, Y., Anderson, R. G. W., & Michel, T. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.11.6518 · Cited by 800
Kong, X., Wang, R., Xue, Y., Liu, X., Zhang, H., Chen, Y., Fang, F., & Chang, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011707 · Cited by 718
García‐Cardeña, G., Oh, P., Liu, J., Schnitzer, J. E., & Sessa, W. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6448 · Cited by 679
Zhang, Y., Goldman, S., Baerga, R., Zhao, Y., Komatsu, M., & Jin, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906048106 · Cited by 634
S-glutathionylation uncouples eNOS and regulates its cellular and vascular function
Chen, C.-A., Wang, T.-Y., Varadharaj, S., Reyes, L. A., Hemann, C., Talukder, M. A. H., Chen, Y.-R., Druhan, L. J., & Zweier, J. L. (2010) · Nature · doi:10.1038/nature09599 · Cited by 594
Self-citationD'Antona, G., Ragni, M., Cardile, A., Tedesco, L., Dossena, M., Bruttini, F., Caliaro, F., Corsetti, G., Bottinelli, R., Carruba, M. O., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.08.016 · Cited by 568
Cederberg, A., Grønning, L. M., Åhrén, B., Taskén, K., Carlsson, P., & Enerbäck, S. (2001) · Cell · doi:10.1016/s0092-8674(01)00474-3 · Cited by 557
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 556
Duplain, H., Burcelin, R., Sartori, C., Cook, S., Egli, M., Lepori, M., Vollenweider, P., Pedrazzini, T., Nicod, P., Thorens, B., et al. (2001) · Circulation · doi:10.1161/01.cir.104.3.342 · Cited by 533
Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration
Polak, P., Cybulski, N., Feige, J. N., Auwerx, J., Rüegg, M. A., & Hall, M. N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.09.003 · Cited by 480
Pioglitazone Induces Mitochondrial Biogenesis in Human Subcutaneous Adipose Tissue In Vivo
Bogacka, I., Xie, H., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.5.1392 · Cited by 467
Boo, Y. C., Sorescu, G. P., Boyd, N. L., Shiojima, I., Walsh, K., Du, J., & Jo, H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108789200 · Cited by 447
Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
Petersen, K. F., & Shulman, G. I. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02554-7 · Cited by 399
Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 392
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
Hallows, W. C., Yu, W., Smith, B. C., Devires, M. K., Ellinger, J. J., Someya, S., Shortreed, M. R., Prolla, T., Markley, J. L., Smith, L. M., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.002 · Cited by 389
Carlström, M., Larsen, F. J., Nyström, T., Hezel, M., Borniquel, S., Weitzberg, E., & Lundberg, J. O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008872107 · Cited by 382
Kim, F., Pham, M., Maloney, E., Rizzo, N. O., Morton, G. J., Wisse, B. E., Kirk, E. A., Chait, A., & Schwartz, M. W. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.169722 · Cited by 364
Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00284.2006 · Cited by 359
Rong, J. X., Qiu, Y., Hansen, M. K., Zhu, L., Zhang, V., Xie, M., Okamoto, Y., Mattie, M. D., Higashiyama, H., Asano, S., et al. (2007) · Diabetes · doi:10.2337/db06-1135 · Cited by 335
TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Valerio, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28570 · Cited by 327
Recreational physical activity and ten-year weight change in a US national cohort.
Williamson, D. F., Madans, J. H., Anda, R. F., Kleinman, J. C., Kahn, H. S., & Byers, T. (1993) · PubMed · Cited by 322
Hellmann, J. L., Tang, Y., Kosuri, M., Bhatnagar, A., & Spite, M. R. (2011) · The FASEB Journal · doi:10.1096/fj.10-178657 · Cited by 316
Cellular hypoxia and adipose tissue dysfunction in obesity
Wood, I. S., de Heredia, F. P., Wang, B., & Trayhurn, P. (2009) · Proceedings of The Nutrition Society · doi:10.1017/s0029665109990206 · Cited by 302
Shankar, R. R., Yu-ling, W., Shen, H.-Q., Zhu, J. S., & Baron, A. (2000) · Diabetes · doi:10.2337/diabetes.49.5.684 · Cited by 297
Taniguchi, C. M., Kondo, T., Sajan, M. P., Luo, J., Bronson, R. T., Asano, T., Farese, R. V., Cantley, L. C., & Kahn, C. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.005 · Cited by 288
Ohashi, Y., Kawashima, S., Hirata, K., Yamashita, T., Ishida, T., Inoue, N., Sakoda, T., Kurihara, H., Yazaki, Y., & Yokoyama, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4394 · Cited by 275
Macotela, Y., Emanuelli, B., Bång, A. M., Espinoza, D., Boucher, J., Beebe, K. D., Gall, W., & Kahn, C. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021187 · Cited by 271
Cortés, V., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.002 · Cited by 231
Musicki, B., Kramer, M. F., Becker, R. E., & Burnett, A. L. “. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502488102 · Cited by 230
Endothelial nitric oxide synthase overexpression attenuates myocardial reperfusion injury
Jones, S. P., Greer, J. J. M., Kakkar, A. K., Ware, P. D., Turnage, R. H., Hicks, M., van Haperen, R., de Crom, R., Kawashima, S., Yokoyama, M., et al. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00129.2003 · Cited by 206
McGuinness, O. P., Ayala, J. E., Laughlin, M. R., & Wasserman, D. H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90996.2008 · Cited by 189
Seipin ablation in mice results in severe generalized lipodystrophy
Cui, X., Wang, Y., Tang, Y., Liu, Y., Zhao, L., Deng, J., Xu, G., Peng, X.-D., Ju, S., Liu, C., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr205 · Cited by 186
Spite, M. R., Hellmann, J. L., Tang, Y., Mathis, S., Kosuri, M., Bhatnagar, A., Jala, V. R., & Haribabu, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100196 · Cited by 182
Ahima, R. S. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58719 · Cited by 180
Li, P., Zhu, Z., Lu, Y., & Granneman, J. G. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2005 · Cited by 143
Resistance to Endotoxin Shock in Transgenic Mice Overexpressing Endothelial Nitric Oxide Synthase
Yamashita, T., Kawashima, S., Ohashi, Y., Ozaki, M., Ueyama, T., Ishida, T., Inoue, N., Hirata, K., Akita, H., & Yokoyama, M. (2000) · Circulation · doi:10.1161/01.cir.101.8.931 · Cited by 140
Endothelial Nitric Oxide Synthase (eNOS) Knockout Mice Have Defective Mitochondrial β-Oxidation
Gouill, E. L., Jimenez, M., Binnert, C., Jayet, P.-Y., Thalmann, S., Nicod, P., Scherrer, U., & Vollenweider, P. (2007) · Diabetes · doi:10.2337/db06-1228 · Cited by 130
Harats, D., Kurihara, H., Belloni, P., Oakley, H., Ziober, A. F., Ackley, D., Cain, G., Kurihara, Y., Lawn, R. M., & Sigal, E. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117784 · Cited by 129
Activation of AMP kinase α1 subunit induces aortic vasorelaxation in mice
Goirand, F., Solar, M., Athea, Y., Viollet, B., Mateo, P., Fortin, D., Leclerc, J., Hoerter, J., Ventura‐Clapier, R., & Garnier, A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.132589 · Cited by 121
Kawashima, S., Yamashita, T., Ozaki, M., Ohashi, Y., Azumi, H., Inoue, N., Hirata, K., Hayashi, Y., Itoh, H., & Yokoyama, M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.2.201 · Cited by 95
Development of obesity in diabetic mice pair-fed with lean siblings.
Cox, J. E., & Powley, T. L. (1977) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077322 · Cited by 95
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury
Duranski, M. R., Elrod, J. W., Calvert, J. W., Bryan, N. S., Feelisch, M., & Lefer, D. J. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01173.2005 · Cited by 89
Xue, Y., Lim, S., Bråkenhielm, E., & Cao, Y. (2010) · Nature Protocols · doi:10.1038/nprot.2010.46 · Cited by 84
Zhang, H., Wang, Y., Zhang, J., Potter, B. J., Sowers, J. R., & Zhang, C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.225870 · Cited by 76
Stimulation of oxidation of mitochondrial fatty acids and of acetate by acetylcarnitine
Siliprandi, N., SILIPRANDI, D., & Ciman, M. (1965) · Biochemical Journal · doi:10.1042/bj0960777 · Cited by 68
Regulation of Oxygen Distribution in Tissues by Endothelial Nitric Oxide
Víctor, V. M., Nuñez, C., D’Ocón, P., Taylor, C. T., Esplugues, J. V., & Moncada, S. (2009) · Circulation Research · doi:10.1161/circresaha.109.197228 · Cited by 63
Koh, Y. J., Park, B., Park, J., Han, J., Lee, I., Park, J., & Koh, G. Y. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.12.094 · Cited by 63
Georgescu, A., Popov, D., Constantin, A., Nemecz, M., Alexandru, N., Cochior, D., & Tudor, A. (2011) · Clinical Science · doi:10.1042/cs20100355 · Cited by 54
Takenaka, K., Nishimura, Y., Nishiuma, T., Sakashita, A., Yamashita, T., Kobayashi, K., Satouchi, M., Ishida, T., Kawashima, S., & Yokoyama, M. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00239.2005 · Cited by 54
Sayed‐Ahmed, M. M. (2000) · Pharmacological Research · doi:10.1006/phrs.1999.0583 · Cited by 43
Transcriptional control of human adipose tissue blood flow
Perez‐Matute, P., Neville, M. J., Tan, G. D., Frayn, K. N., & Karpe, F. (2009) · Obesity · doi:10.1038/oby.2008.606 · Cited by 32
Kelpke, S. S., Chen, B., Bradley, K. M., Teng, X., Chumley, P., Brandon, A., Yancey, B., Moore, B., Head, H., Viera, L., et al. (2012) · Kidney International · doi:10.1038/ki.2012.116 · Cited by 28
Mingorance, C., Pozo, M. G., Herrera, M. D., & de Sotomayor, M. Á. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509389230 · Cited by 26
Obesity and Inflammatory Vasculopathy
Heusch, G. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.232264 · Cited by 7
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Metadata
- Authors
- Sansbury, B. E., Cummins, T. D., Tang, Y., Hellmann, J., Holden, C. R., Harbeson, M. A., Chen, Y., Patel, R. P., Spite, M., Bhatnagar, A., & Hill, B. G.
- Affiliations
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- Circulation Research
- Published
- 2012-10-12
- Volume
- 111
- Issue
- 9
- Pages
- 1176-1189
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC3707504
- OpenAlex
- W2078821762
- Cited by
- 156
- References
- 79
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 13 · 2021: 6 · 2020: 14 · 2019: 10 · 2018: 6 · 2017: 17 · 2016: 12 · 2015: 12 · 2014: 24 · 2013: 13 · 2012: 1
- FWCI
- 11.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL-106173, HL 59378, R01HL059378, R01HL055477, HL55477, R01HL106173)
- National Institute of General Medical Sciences (P20GM103492)
- National Center for Research Resources (RR-024489, P20RR024489)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- endothelial nitric oxide synthase, diet-induced obesity, insulin resistance, adipocyte hypertrophy, adipose tissue metabolism, fatty acid oxidation, PPARα, PPARγ, mitochondrial function, hyperinsulinemia, db/db mice, transgenic mice, nitric oxide
- MeSH terms
- Amino Acids, Animals, Disease Models, Animal, Hypertrophy, Insulin Resistance, Mice, Inbred C57BL, Mice, Transgenic, Obesity, Phenotype, Adipocytes, PPAR alpha, PPAR gamma, Lipid Metabolism, Mice, Nitric Oxide Synthase Type III, Diet, High-Fat
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