The DOI matches its Crossref record; 98 of the 99 references it cites were found in a registry or an index.
Bioengineering Human Myocardium on Native Extracellular Matrix
Open accessAbstract
Rationale: More than 25 million individuals have heart failure worldwide, with ≈4000 patients currently awaiting heart transplantation in the United States. Donor organ shortage and allograft rejection remain major limitations with only ≈2500 hearts transplanted each year. As a theoretical alternative to allotransplantation, patient-derived bioartificial myocardium could provide functional support and ultimately impact the treatment of heart failure. Objective: The objective of this study is to translate previous work to human scale and clinically relevant cells for the bioengineering of functional myocardial tissue based on the combination of human cardiac matrix and human induced pluripotent stem cell–derived cardiomyocytes. Methods and Results: To provide a clinically relevant tissue scaffold, we translated perfusion-decellularization to human scale and obtained biocompatible human acellular cardiac scaffolds with preserved extracellular matrix composition, architecture, and perfusable coronary vasculature. We then repopulated this native human cardiac matrix with cardiomyocytes derived from nontransgenic human induced pluripotent stem cells and generated tissues of increasing 3-dimensional complexity. We maintained such cardiac tissue constructs in culture for 120 days to demonstrate definitive sarcomeric structure, cell and matrix deformation, contractile force, and electrical conduction. To show that functional myocardial tissue of human scale can be built on this platform, we then partially recellularized human whole-heart scaffolds with human induced pluripotent stem cell–derived cardiomyocytes. Under biomimetic culture, the seeded constructs developed force-generating human myocardial tissue and showed electrical conductivity, left ventricular pressure development, and metabolic function. Conclusions: Native cardiac extracellular matrix scaffolds maintain matrix components and structure to support the seeding and engraftment of human induced pluripotent stem cell–derived cardiomyocytes and enable the bioengineering of functional human myocardial-like tissue of multiple complexities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“A number of groups have reported engineered tissues with contractile forces and conduction properties approaching physiologic levels observed in native myocardium [8,13,31,32].”
From Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells (2018) · cites this paper as [31]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
Matplotlib: a 2D graphics environment
Hunter, J. D. (2007) · Computing in Science & Engineering · doi:10.1109/mcse.2007.55 · Cited by 39,249
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Heart Disease and Stroke Statistics—2014 Update
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · Circulation · doi:10.1161/01.cir.0000441139.02102.80 · Cited by 5,264
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Carpenter, A. E., Jones, T. R., Lamprecht, M. R., Clarke, C., Kang, I. H., Friman, O., Guertin, D. A., Chang, J. H., Lindquist, R. A., Moffat, J., et al. (2006) · Genome biology · doi:10.1186/gb-2006-7-10-r100 · Cited by 5,212
An overview of tissue and whole organ decellularization processes
Crapo, P. M., Gilbert, T. W., & Badylak, S. F. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.01.057 · Cited by 3,591
Python for scientific computing
Oliphant, T. E. (2007) · Computing in Science & Engineering · doi:10.1109/mcse.2007.58 · Cited by 3,303 · cited 2×
“Hearts were perfusion-decellularized with 1% SDS (168 hours), deionized H 2 O (24 hours), 1% Triton-X100 (24 hours), and PBS washes (168 hours) following a standardized protocol (Figure 1A).(16) Decellularized hearts contained 346.”
Warren, L., Manos, P. D., Ahfeldt, T., Loh, Y.-H., Li, H., Lau, F., Ebina, W., Mandal, P. K., Smith, Z. D., Meissner, A., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.012 · Cited by 2,662
Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
Ott, H. C., Matthiesen, T. S., Goh, S.-K., Black, L. D., Kren, S. M., Netoff, T. I., & Taylor, D. A. (2008) · Nature Medicine · doi:10.1038/nm1684 · Cited by 2,650
Self-citationMyotubes differentiate optimally on substrates with tissue-like stiffness
Engler, A. J., Griffin, M. A., Sen, S., Bönnemann, C. G., Sweeney, H. L., & Discher, D. E. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405004 · Cited by 1,743
Research works printed but not linked: 1
- Rodriguez ML Murry CE Sniadecki NJ. Assessment of induced pluripotent stem cell-derived cardiac myocyte contractility using micropost arrays ASME 2013 Summer Bioengineering Conference; SBC2013-14640 The American Society of Mechanical Engineers pp. V01AT15A005 2013.
Cited by
Sorted by citations
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications
Naahidi, S., Jafari, M., Logan, M., Wang, Y., Yuan, Y., Bae, H., Dixon, B., & Chen, P. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2017.05.006 · Cited by 933
Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications
Gilpin, A., & Yang, Y. (2017) · BioMed Research International · doi:10.1155/2017/9831534 · Cited by 742
Zhang, X., Chen, X., Hong, H., Hu, R., Liu, J., & Liu, C. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.09.014 · Cited by 680
The extracellular matrix in myocardial injury, repair, and remodeling
Frangogiannis, N. G. (2017) · Journal of Clinical Investigation · doi:10.1172/jci87491 · Cited by 554
The Extracellular Matrix in Ischemic and Nonischemic Heart Failure
Frangogiannis, N. G. (2019) · Circulation Research · doi:10.1161/circresaha.119.311148 · Cited by 533
Shadrin, I. Y., Allen, B. W., Qian, Y., Jackman, C. P., Carlson, A. L., Juhas, M. E., & Bursac, N. (2017) · Nature Communications · doi:10.1038/s41467-017-01946-x · Cited by 420
Crossing kingdoms: Using decellularized plants as perfusable tissue engineering scaffolds
Gershlak, J. R., Hernandez, S., Fontana, G., Perreault, L. R., Hansen, K. J., Larson, S. A., Binder, B. Y. K., Dolivo, D. M., Yang, T., Dominko, T., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.011 · Cited by 375
Self-citationDecellularized matrices in regenerative medicine
Taylor, D. A., Sampaio, L. C., Ferdous, Z., Gobin, A. S., & Taite, L. J. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.04.044 · Cited by 344
Porzionato, A., Stocco, E., Barbon, S., Grandi, F., Macchi, V., & De Caro, R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19124117 · Cited by 319
Mendibil, U., Ruiz-Hernández, R., Retegi-Carrión, S., García‐Urkía, N., Olalde, B., & Abarrategi, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155447 · Cited by 323
Biocompatibility of Subcutaneously Implanted Plant-Derived Cellulose Biomaterials
Modulevsky, D. J., Cuerrier, C. M., & Pelling, A. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157894 · Cited by 254
A tissue-engineered scale model of the heart ventricle
MacQueen, L. A., Sheehy, S. P., Chantre, C. O., Zimmerman, J. F., Pasqualini, F. S., Liu, X., Goss, J. A., Campbell, P. H., Gonzalez, G. M., Park, S.-J., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0271-5 · Cited by 227
Self-citationEngineering Cardiac Muscle Tissue
Weinberger, F., Mannhardt, I., & Eschenhagen, T. (2017) · Circulation Research · doi:10.1161/circresaha.117.310738 · Cited by 234
Goldfracht, I., Efraim, Y., Shinnawi, R., Kovalev, E., Huber, I., Gepstein, A., Arbel, G., Shaheen, N., Tiburcy, M., Zimmermann, W. H., et al. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.016 · Cited by 222
Decellularized Extracellular Matrix Materials for Cardiac Repair and Regeneration
Bejleri, D., & Davis, M. E. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801217 · Cited by 219
Naturally Engineered Maturation of Cardiomyocytes
Scuderi, G. J., & Butcher, J. T. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00050 · Cited by 208
Dynamic culture yields engineered myocardium with near-adult functional output
Jackman, C. P., Carlson, A. L., & Bursac, N. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.024 · Cited by 193
The host response to naturally-derived extracellular matrix biomaterials
Morris, A. H., Stamer, D. K., & Kyriakides, T. R. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.01.002 · Cited by 180
Li, R. A., Keung, W., Cashman, T. J., Backeris, P. C., Johnson, B. V., Bardot, E. S., Wong, A. O. T., Chan, P. K. W., Chan, C. W. Y., & Costa, K. D. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.024 · Cited by 175
Research progress in decellularized extracellular matrix-derived hydrogels
Zhang, W., Du, A., Liu, S., Lv, M., & Chen, S. (2021) · Regenerative Therapy · doi:10.1016/j.reth.2021.04.002 · Cited by 176
Global position paper on cardiovascular regenerative medicine
Fernández‐Avilés, F., y, R. S.-R., Climent, A. M., Badimón, L., Bolli, R., Charron, D. J., Fuster, V., Janssens, S. P., Kastrup, J., Kim, H.-S., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehx248 · Cited by 162
The interstitium in cardiac repair: role of the immune–stromal cell interplay
Forte, E., Furtado, M. B., & Rosenthal, N. A. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0077-x · Cited by 148
Next generation of heart regenerative therapies: progress and promise of cardiac tissue engineering
Tenreiro, M. F., Louro, A. F., Alves, P. M., & Serra, M. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00140-4 · Cited by 153
Fibrous scaffolds for building hearts and heart parts
Capulli, A. K., MacQueen, L. A., Sheehy, S. P., & Parker, K. K. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.11.020 · Cited by 130
Passive myocardial mechanical properties: meaning, measurement, models
Emig, R., Zgierski-Johnston, C. M., Timmermann, V., Taberner, A. J., Nash, M. P., Kohl, P. K., & Peyronnet, R. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00838-1 · Cited by 139
Wang, Q., Yang, H., Bai, A., Jiang, W., Li, X., Wang, X., Mao, Y., Lü, C., Qian, R., Guo, F., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.035 · Cited by 126
Decellularized spinach: An edible scaffold for laboratory-grown meat
Jones, J. D., Rebello, A. S., & Gaudette, G. R. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.100986 · Cited by 123
Self-citationMajka, M., Sułkowski, M., Badyra, B., & Musiałek, P. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0484 · Cited by 118
Solid organ fabrication: comparison of decellularization to 3D bioprinting
Jung, J. P., Bhuiyan, D. B., & Ogle, B. M. (2016) · Biomaterials Research · doi:10.1186/s40824-016-0074-2 · Cited by 106
Biomaterializing the promise of cardiac tissue engineering
Pomeroy, J. E., Helfer, A., & Bursac, N. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.02.009 · Cited by 108
Kc, P., Hong, Y., & Zhang, G. (2019) · Regenerative Biomaterials · doi:10.1093/rb/rbz017 · Cited by 107
Polymer Hydrogels to Guide Organotypic and Organoid Cultures
Magno, V., Meinhardt, A., & Werner, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000097 · Cited by 110
Qasim, M., Haq, F. U., Kang, M.-H., & Kim, J. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s189587 · Cited by 109
Min, S., Kim, S., Sim, W., Choi, Y. S., Joo, H., Park, J.-H., Lee, S.-J., Kim, H., Lee, M. J., Jeong, I., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46928-y · Cited by 107
Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes
Wu, P., Deng, G., Sai, X., Guo, H., Huang, H., & Zhu, P. (2020) · Bioscience Reports · doi:10.1042/bsr20200833 · Cited by 113
Anisotropic engineered heart tissue made from laser-cut decellularized myocardium
Schwan, J., Kwaczala, A. T., Ryan, T. J., Bártulos, Ó., Ren, Y., Sewanan, L. R., Morris, A. H., Jacoby, D. L., Qyang, Y., & Campbell, S. G. (2016) · Scientific Reports · doi:10.1038/srep32068 · Cited by 95
Engineering anisotropic human stem cell-derived three-dimensional cardiac tissue on-a-chip
Veldhuizen, J., Cutts, J., Brafman, D. A., Migrino, R. Q., & Nikkhah, M. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120195 · Cited by 95
Striated muscle function, regeneration, and repair
Shadrin, I. Y., Khodabukus, A., & Bursac, N. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2285-z · Cited by 106
Tissue and organ decellularization in regenerative medicine
Damodaran, R. G., & Vermette, P. (2018) · Biotechnology Progress · doi:10.1002/btpr.2699 · Cited by 91
Oikonomopoulos, A., Kitani, T., & Wu, J. C. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.02.026 · Cited by 89
Matsumura, Y., Zhu, Y., Jiang, H., D’Amore, A., Luketich, S. K., Charwat, V., Yoshizumi, T., Sato, H., Yang, B., Uchibori, T., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119289 · Cited by 88
Bioengineering approaches to treat the failing heart: from cell biology to 3D printing
Yadid, M., Oved, H., Silberman, E., & Dvir, T. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00603-7 · Cited by 83
Barbulescu, G. I., Bojin, F. M., Ordodi, V. L., Goje, I.-D., Barbulescu, A. S., & Păunescu, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113040 · Cited by 89
Decellularized scaffolds for tissue engineering: Current status and future perspective
Rajab, T. K., O’Malley, T. J., & Tchantchaleishvili, V. (2020) · Artificial Organs · doi:10.1111/aor.13701 · Cited by 87
Borrelli, C., & Buckley, C. T. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.10.002 · Cited by 76
Devalla, H. D., & Passier, R. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aah5457 · Cited by 75
The Emerging Role of Decellularized Plant-Based Scaffolds as a New Biomaterial
Harris, A. F., Lacombe, J., & Zenhausern, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212347 · Cited by 79
An Edible, Decellularized Plant Derived Cell Carrier for Lab Grown Meat
Thyden, R., Perreault, L. R., Jones, J. D., Notman, H., Varieur, B. M., Patmanidis, A. A., Dominko, T., & Gaudette, G. R. (2022) · Applied Sciences · doi:10.3390/app12105155 · Cited by 78
Self-citationZhou, X., Wang, J., Huang, X., Fang, W., Tao, Y., Zhao, T., Liang, C., Hua, J., Chen, Q., & Li, F. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.09.044 · Cited by 74
Matters of the heart: Cellular sex differences
Walker, C. J., Schroeder, M. E., Aguado, B. A., Anseth, K. S., & Leinwand, L. A. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.04.010 · Cited by 74
Gerli, M., Guyette, J. P., Evangelista-Leite, D., Ghoshhajra, B. B., & Ott, H. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191497 · Cited by 76
Self-citationTwo Methods for Decellularization of Plant Tissues for Tissue Engineering Applications
Adamski, M., Fontana, G., Gershlak, J. R., Gaudette, G. R., Le, H. D., & Murphy, W. L. (2018) · Journal of Visualized Experiments · doi:10.3791/57586 · Cited by 70
Self-citationEngineering hydrogels for personalized disease modeling and regenerative medicine
Tayler, I. M., & Stowers, R. S. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.04.020 · Cited by 70
Bioreactors for Cardiac Tissue Engineering
Paez‐Mayorga, J., Hernández‐Vargas, G., Ruiz‐Esparza, G. U., Iqbal, H. M. N., Wang, X., Zhang, Y. S., Parra‐Saldívar, R., & Khademhosseini, A. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201701504 · Cited by 68
Regenerative immunology: the immunological reaction to biomaterials
Cravedi, P., Farouk, S. S., Angeletti, A., Edgar, L., Tamburrini, R., Duisit, J., Perin, L., & Orlando, G. (2017) · Transplant International · doi:10.1111/tri.13068 · Cited by 64
Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective
Razavi, Z.-S., Soltani, M., Mahmoudvand, G., Farokhi, S., Karimi-Rouzbahani, A., Farasati-Far, B., Tahmasebi-Ghorabi, S., Pazoki-Toroudi, H., & Afkhami, H. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1385124 · Cited by 64
Myocardial commitment from human pluripotent stem cells: Rapid production of human heart grafts
Garreta, E., de Oñate, L., Fernández‐Santos, M. E., Oria, R., Tarantino, C., Climent, A. M., Marco, A., Samitier, M., Martínez, E., Valls-Margarit, M., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.003 · Cited by 64
Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis
Garreta, E., Moya‐Rull, D., Marco, A., Amato, G., Ullate‐Agote, A., Tarantino, C., Gallo, M., Esporrín‐Ubieto, D., Centeno, A., Vilas‐Zornoza, A., et al. (2024) · Advanced Materials · doi:10.1002/adma.202400306 · Cited by 63
Multidimensional Scientometric indicators for the detection of emerging research topics
Xu, H., Winnink, J., Yue, Z., Zhang, H., & Pang, H. (2020) · Technological Forecasting and Social Change · doi:10.1016/j.techfore.2020.120490 · Cited by 66
Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone
Leong, Y. Y., Ng, W. H., Ellison, G. M., & Tan, J. J. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00047 · Cited by 62
Dwyer, K. D., & Coulombe, K. L. K. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.015 · Cited by 61
Zheng, C., Sui, B., Hu, C., Qiu, X., Zhao, P., & Jin, Y. J. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2676 · Cited by 62
Yap, L., Wang, J., Moreno‐Moral, A., Chong, L. Y., Sun, Y., Harmston, N., Wang, X., Chong, S. Y., Vanezis, K., Öhman, M. K., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.083 · Cited by 61
Sharma, D., Ferguson, M., Kamp, T. J., & Zhao, F. (2019) · Emergent Materials · doi:10.1007/s42247-019-00046-4 · Cited by 60
Current Advances in 3D Tissue and Organ Reconstruction
Pennarossa, G., Arcuri, S., Iorio, T. D., Gandolfi, F., & Brevini, T. A. L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020830 · Cited by 59
Perea‐Gil, I., Gálvez‐Montón, C., Prat‐Vidal, C., Jorba, I., Segú-Vergés, C., Roura, S., Soler‐Botija, C., Egea, O. I., Revuelta‐López, E., Fernández, M. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25115-2 · Cited by 57
Human-scale lung regeneration based on decellularized matrix scaffolds as a biologic platform
Ohata, K., & Ott, H. C. (2020) · Surgery Today · doi:10.1007/s00595-020-02000-y · Cited by 61
Self-citationFinklea, F. B., Tian, Y., Kerscher, P., Seeto, W. J., Ellis, M. E., & Lipke, E. A. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120818 · Cited by 55
Whole Organ Engineering: Approaches, Challenges, and Future Directions
Sohn, S., Buskirk, M. V., Buckenmeyer, M. J., Londoño, R., & Faulk, D. M. (2020) · Applied Sciences · doi:10.3390/app10124277 · Cited by 57
Update on the main use of biomaterials and techniques associated with tissue engineering
Steffens, D., Braghirolli, D. I., Maurmann, N., & Pranke, P. H. L. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.03.013 · Cited by 55
CSI position statement on management of heart failure in India
Guha, S., Harikrishnan, S., Ray, S., Sethi, R., Ramakrishnan, S., Banerjee, S., Bahl, V. K., Goswami, K. C., Banerjee, A. K., Shanmugasundaram, S., et al. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.05.003 · Cited by 59
Tan, J. J., Guyette, J. P., Miki, K., Xiao, L., Kaur, G., Wu, T., Zhu, L., Hansen, K. J., Ling, K., Milan, D. J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24921-z · Cited by 53
Self-citationThe Role of Biomaterials in Stem Cell-Based Regenerative Medicine
Zhao, X., Cui, K., & Li, Z. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0347 · Cited by 54
Bioengineering Hearts: Simple yet Complex
Taylor, D. A., Parikh, R. B., & Sampaio, L. C. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0075-7 · Cited by 51
A step towards clinical application of acellular matrix: A clue from macrophage polarization
Petrosyan, A., Da Sacco, S., Tripuraneni, N., Kreuser, U., Lavarreda-Pearce, M., Tamburrini, R., De Filippo, R. E., Orlando, G., Cravedi, P., & Perin, L. (2017) · Matrix Biology · doi:10.1016/j.matbio.2016.08.009 · Cited by 48
Culturomics: A New Kid on the Block of OMICS to Enable Personalized Medicine
Kambouris, M. E., Pavlidis, C., Skoufas, E., Arabatzis, M., Καντζάνου, Μ., Velegraki, A., & Patrinos, G. P. (2017) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2017.0017 · Cited by 48
Li, B., Yang, H., Wang, X., Zhan, Y., Sheng, W., Cai, H., Xin, H., Liang, Q., Zhou, P., Lü, C., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0651-x · Cited by 47
Engineering approaches for cardiac organoid formation and their characterization
Joddar, B., Natividad-Diaz, S. L., Padilla, A. E., Esparza, A., Ramirez, S. P., Chambers, D. R., & Ibaroudene, H. (2022) · Translational research · doi:10.1016/j.trsl.2022.08.009 · Cited by 48
Ewoldt, J. K., DePalma, S. J., Jewett, M. E., Karakan, M. Ç., Lin, Y.-M., Hashemian, P. M., Gao, X., Lou, L., McLellan, M. A., Tabares, J., et al. (2024) · Nature Methods · doi:10.1038/s41592-024-02480-7 · Cited by 57
Creation of a Bioengineered Skin Flap Scaffold with a Perfusable Vascular Pedicle
Jank, B. J., Goverman, J. M., Guyette, J. P., Charest, J. M., Randolph, M. A., Gaudette, G. R., Gershlak, J. R., Purschke, M., Javorsky, E., Nazarian, R. M., et al. (2017) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0487 · Cited by 46
Self-citationBlazeski, A., Lowenthal, J., Zhu, R., Ewoldt, J., Boheler, K. R., & Tung, L. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.04.002 · Cited by 40
Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy
Liu, W., Zhang, X., Jiang, X., Dai, B., Zhang, L., & Zhu, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.10.015 · Cited by 47
Meglio, F. D., Nurzyńska, D., Romano, V., Miraglia, R., Belviso, I., Sacco, A. M., Barbato, V., Gennaro, M. D., Granato, G., Maiello, C., et al. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0267 · Cited by 43
Myocardial Tissue Engineering for Regenerative Applications
Fujita, B., & Zimmermann, W. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0892-4 · Cited by 43
Rajabi, S., Pahlavan, S., Ashtiani, M. K., Ansari, H., Abbasalizadeh, S., Sayahpour, F. A., Varzideh, F., Sawa Kostin, D., Aghdami, N., Braun, T. W., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.054 · Cited by 43
Robbins, E. R., Pins, G. D., Laflamme, M. A., & Gaudette, G. R. (2020) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36971 · Cited by 42
Self-citationFang, Y., Sun, W., Zhang, T., & Xiong, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121298 · Cited by 40
Generation of a Functioning and Self-Renewing Diaphragmatic Muscle Construct
Trevisan, C., Fallas, M. E. A., Maghin, E., Franzin, C., Pavan, P. G., Caccin, P., Chiavegato, A., Carraro, E., Boso, D., Boldrin, F., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0206 · Cited by 41
Cardiac Organoids: A 3D Technology for Modeling Heart Development and Disease
Zhu, L., Liu, K. Y., Feng, Q., & Liao, Y. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10385-1 · Cited by 43
Challenges to success in heart failure: Cardiac cell therapies in patients with heart diseases
Oh, H., Ito, H., & Sano, S. (2016) · Journal of Cardiology · doi:10.1016/j.jjcc.2016.04.010 · Cited by 40
Fiber Scaffold Patterning for Mending Hearts: 3D Organization Bringing the Next Step
Kristen, M., Ainsworth, M. J., Chirico, N., van der Ven, C. F. T., Doevendans, P. A., Sluijter, J. P. G., Malda, J., van Mil, A., & Castilho, M. D. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900775 · Cited by 40
Hochman‐Mendez, C., de Campos, D. B. P., Pinto, R. S., Mendes, B. J. D. S., Rocha, G. M., Monnerat, G., Weissmüller, G., Sampaio, L. C., Carvalho, A. B., Taylor, D. A., et al. (2020) · Journal of Tissue Engineering · doi:10.1177/2041731420921482 · Cited by 40
Recellularization of Native Tissue Derived Acellular Scaffolds with Mesenchymal Stem Cells
Ahmed, E., Saleh, T., & Xu, M. (2021) · Cells · doi:10.3390/cells10071787 · Cited by 44
Corridon, P. R., Ko, I. K., Yoo, J. J., & Atala, A. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0079-3 · Cited by 40
Nguyen, D. T., O’Hara, M., Granéli, C., Hicks, R., Miliotis, T., Nyström, A., Hansson, S., Davidsson, P., Gan, L., Magnone, M. C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-25883-x · Cited by 39
Cardiomyogenesis Modeling Using Pluripotent Stem Cells: The Role of Microenvironmental Signaling
Leitolis, A., Robert, A. W., Pereira, I. T., Correa, A., & Stimamiglio, M. A. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00164 · Cited by 41
Izadifar, M., Kelly, M., & Chen, D. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0220 · Cited by 38
Hoes, M. F., Bömer, N., & van der Meer, P. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0052 · Cited by 43
Barkestani, M. N., Naserian, S., Uzan, G., & Shamdani, S. (2021) · Journal of Tissue Engineering · doi:10.1177/2041731420983562 · Cited by 39
Das, A., Nikhil, A., Shiekh, P. A., Yadav, B., Jagavelu, K., & Kumar, A. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.009 · Cited by 38
Metadata
- Authors
- Guyette, J. P., Charest, J. M., Mills, R. W., Jank, B. J., Moser, P. T., Gilpin, S. E., Gershlak, J. R., Okamoto, T., Gonzalez, G., Milan, D. J., Gaudette, G. R., & Ott, H. C.
- Affiliations
- Worcester Polytechnic Institute (US)
- From the Center for Regenerative Medicine (J.P.G., J.M.C., B.J.J., P.T.M., S.E.G., T.O., G.G., H.C.O.), Cardiovascular Research Center (R.W.M., D.J.M.), Division of Cardiology (D.J.M.), and Division of Thoracic Surgery, Department of Surgery (H.C.O.), Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA (J.P.G., B.J.J., P.T.M., S.E.G., G.G., H.C.O.); Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, MA (J.R.G., G.R.G.); and Harvard Stem Cell...
- ORCID
- Venue
- Circulation Research
- Published
- 2016-01-08
- Volume
- 118
- Issue
- 1
- Pages
- 56-72
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- PMC
- PMC4740234
- OpenAlex
- W1821166167
- Cited by
- 343
- References
- 99
- Citations by year
- 2026: 13 · 2025: 19 · 2024: 19 · 2023: 26 · 2022: 31 · 2021: 50 · 2020: 37 · 2019: 36 · 2018: 45 · 2017: 38 · 2016: 27
- FWCI
- 37.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1dp2od008749-01)
- National Heart, Lung, and Blood Institute (R01HL115282, R21HL108663, R21 HL108663-2)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK057521, P30DK043351)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR066261)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Keywords
- bioartificial heart, human myocardium, cardiac extracellular matrix, decellularization, perfusion decellularization, iPSC-derived cardiomyocytes, heart failure, heart transplantation, cardiac tissue engineering, recellularization, electrical conduction, contractile force, left ventricular pressure
- MeSH terms
- Adult, Aged, Cell Differentiation, Extracellular Matrix, Female, Humans, Male, Middle Aged, Myocardium, Pluripotent Stem Cells, Bioengineering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
