Abandoning M1/M2 for a Network Model of Macrophage Function

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

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Macrophage activation and polarization: nomenclature and experimental guidelines

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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M-1/M-2 Macrophages and the Th1/Th2 Paradigm

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

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Macrophage-targeting Antisenescence nanomedicine enables in-Situ NO induction for Gaseous and antioxidative atherosclerosis intervention

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Targeting Myeloid-Derived Cells: New Frontiers in the Treatment of Non-alcoholic and Alcoholic Liver Disease

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Regenerative cross talk between cardiac cells and macrophages

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Macrophage Activation in Synovitis and Osteoarthritis of Temporomandibular Joint and Its Relationship with the Progression of Synovitis and Bone Remodeling

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Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression

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The double-edged role and therapeutic potential of TREM2 in atherosclerosis

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Alveolar macrophages: guardians of the alveolar lipid galaxy

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Recent advances in adoptive cell therapy for cancer immunotherapy

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Oleoylethanolamide stabilizes atherosclerotic plaque through regulating macrophage polarization via AMPK-PPARα pathway

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Role of macrophage in nanomedicine-based disease treatment

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Putting ATM to BED: How Adipose Tissue Macrophages Are Affected by Bariatric Surgery, Exercise, and Dietary Fatty Acids

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Myeloid cells in retinal and brain degeneration

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Tongue immune compartment analysis reveals spatial macrophage heterogeneity

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Tumor-Infiltrating Immune Cells in Colorectal Cancer

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Intracellular survival of Staphylococcus aureus in macrophages during osteomyelitis

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Overexpression of myeloid angiotensin-converting enzyme (ACE) reduces atherosclerosis

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Immune Dysregulation in HFpEF: A Target for Mesenchymal Stem/Stromal Cell Therapy

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DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways

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Single-cell sequencing reveals the cell map and transcriptional network of sporadic vestibular schwannoma

Chu, Y.-D., Chen, L., Deng, H.-X., Li, Y.-G., & Shen, Z.-S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.984529 · Cited by 20

Roles of circRNAs in regulating the tumor microenvironment

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Recycled melanoma-secreted melanosomes regulate tumor-associated macrophage diversification

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Metformin Alleviates Steatohepatitis in Diet-Induced Obese Mice in a SIRT1-Dependent Way

Guo, W., Liu, J., Cheng, L., Liu, Z., Zheng, X., Liang, H., & Xu, F. L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.704112 · Cited by 22

Harmine Inhibits Multiple TLR-Induced Inflammatory Expression through Modulation of NF-κB p65, JNK, and STAT1

Jin, S.-J., Song, Y., Park, H. S., Park, K. W., Lee, S., & Kang, H. G. (2022) · Life · doi:10.3390/life12122022 · Cited by 21

The Protective Role of TREM2 in the Heterogenous Population of Macrophages during Post-Myocardial Infarction Inflammation

Kim, S. H., Lee, K. Y., & Chang, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065556 · Cited by 21

Predominantly Pro-Inflammatory Phenotype with Mixed M1/M2 Polarization of Peripheral Blood Classical Monocytes and Monocyte-Derived Macrophages among Patients with Excessive Ethanol Intake

Fernández-Regueras, M., Carbonell, C., Salete-Granado, D., Garcı́a, J. L., Gragera, M., Pérez-Nieto, M.-Á., Morán‐Plata, F. J., Mayado, A., Torres, J. L., Corchete, L. A., et al. (2023) · Antioxidants · doi:10.3390/antiox12091708 · Cited by 21

Cell atlas of the Atlantic salmon spleen reveals immune cell heterogeneity and cell-specific responses to bacterial infection

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Caffeinated beverages contribute to a more efficient inflammatory response: Evidence from human and earthworm immune cells

Alves, A. D. O., Weis, G. C. C., Unfer, T. C., Assmann, C. E., Barbisan, F., Azzolin, V. F., Chitolina, B., Duarte, T., Filho, E. E. R., Duarte, M. M. M. F., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110809 · Cited by 21

Macrophage heterogeneity in myocardial infarction: Evolution and implications for diverse therapeutic approaches

Kanuri, B., Sreejit, G., Biswas, P., Murphy, A. J., & Nagareddy, P. R. (2024) · iScience · doi:10.1016/j.isci.2024.110274 · Cited by 19

Precision cardiovascular medicine: shifting the innovation paradigm

Aikawa, M., Sonawane, A. R., Chelvanambi, S., Asano, T., Halu, A., Matamalas, J. T., Singh, S. A., Uchida, S., Aïkawa, E., Arenas, À., et al. (2025) · Frontiers in Science · doi:10.3389/fsci.2025.1474469 · Cited by 24

A Pathogenic Th17/CD38+ Macrophage Feedback Loop Drives Inflammatory Arthritis through TNF-α

Muench, D. E., Sun, Z., Sharma, A., Tang, C., Crampton, J. C., Lao, C. R., Kersjes, K., Chang, W. Y., & Na, S. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2101025 · Cited by 19

Single-cell RNA-seq reveals cellular heterogeneity from deep fascia in patients with acute compartment syndrome

Wang, T., Long, Y., Ma, L., Dong, Q., Li, Y., Guo, J., Jin, L., Di, L., Zhang, Y., Wang, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1062479 · Cited by 20

Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence

Pappert, M., Khosla, S., & Doolittle, M. L. (2023) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00820-8 · Cited by 22

Macrophage heterogeneity in atherosclerosis: A matter of context

Wieland, E. B., Kempen, L. J., Donners, M. M. P. C., Biessen, E. A. L., & Goossens, P. (2023) · European Journal of Immunology · doi:10.1002/eji.202350464 · Cited by 26

Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease

Zhang, C., Shi, Y., Liu, C., Sudesh, S. M., Zhao, H., Li, P., Liu, Q., Ma, Y., Shi, A., & Cai, H. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02273-4 · Cited by 24

Innate immunity champions: The diverse functions of macrophages

Biscu, F., Zouzaf, A., Cicia, D., Pridans, C., & Matteoli, G. (2024) · European Journal of Immunology · doi:10.1002/eji.202451139 · Cited by 25

Heme oxygenase-1—Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice

El‐Achkar, G. A., Mrad, M. F., Mouawad, C. A., Badran, B. M., Jaffa, A. A., Motterlini, R., Hamade, E., & Habib, A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0216405 · Cited by 20

HIIT Promotes M2 Macrophage Polarization and Sympathetic Nerve Density to Induce Adipose Tissue Browning in T2DM Mice

Guo, Y., Zhang, Q., Yang, D., Chen, P., & Xiao, W. (2024) · Biomolecules · doi:10.3390/biom14030246 · Cited by 19

Application of an Injectable Thermosensitive Hydrogel Drug Delivery System for Degenerated Intervertebral Disc Regeneration

Liu, Y., Guo, C. F., Wang, Y., & Kong, Q. (2024) · Biomacromolecules · doi:10.1021/acs.biomac.4c00965 · Cited by 19

Trafficking of Mononuclear Phagocytes in Healthy Arteries and Atherosclerosis

Tomas, L., Prica, F., & Schulz, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.718432 · Cited by 22

Dual RNA Sequencing of Mycobacterium tuberculosis-Infected Human Splenic Macrophages Reveals a Strain-Dependent Host–Pathogen Response to Infection

López-Agudelo, V. A., Baena, A., Enriquez, V. P. B., Cabarcas, F., Álzate, J. F., Beste, D. J. V., Ríos‐Estepa, R., & Barrera, L. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031803 · Cited by 20

Peripheral Ischemia Imprints Epigenetic Changes in Hematopoietic Stem Cells to Propagate Inflammation and Atherosclerosis

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Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction

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Subverted macrophages in the triple-negative breast cancer ecosystem

Shang, L., Zhong, Y., Yao, Y., Liu, C., Wang, L., Zhang, W., Liu, J., Wang, X., & Sun, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115414 · Cited by 21

iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction

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Salt-sensitive blood pressure rise in type 1 diabetes patients is accompanied by disturbed skin macrophage influx and lymphatic dilation—a proof-of-concept study

Wenstedt, E. F. E., Engberink, R. O., Rorije, N. M. G., van den Born, B. H., Claessen, N., Aten, J., & Vogt, L. (2019) · Translational research · doi:10.1016/j.trsl.2019.12.001 · Cited by 19

Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs

Nogieć, A., Bzowska, M., Demczuk, A., Varol, C., & Guzik, K. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01592 · Cited by 21

The Cardiac Injury Immune Response as a Target for Regenerative and Cellular Therapies

Hume, R. D., & Chong, J. J. H. (2020) · Clinical Therapeutics · doi:10.1016/j.clinthera.2020.09.006 · Cited by 19

Liposomal delivery of azithromycin enhances its immunotherapeutic efficacy and reduces toxicity in myocardial infarction

Al‐Darraji, A., Donahue, R. R., Tripathi, H., Peng, H., Levitan, B. M., Chelvarajan, L., Haydar, D., Gao, E., Henson, D. M., Gensel, J. C., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-73593-0 · Cited by 19

Myeloid interleukin-4 receptor α is essential in postmyocardial infarction healing by regulating inflammation and fibrotic remodeling

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Lung Interstitial Macrophages: Establishing Identity and Uncovering Heterogeneity

Koch, C. M., Chiu, S. F., Misharin, A. V., & Ridge, K. M. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0150ed · Cited by 19

Immune in myocardial ischemia/reperfusion injury: potential mechanisms and therapeutic strategies

Xuan, X., Fan, J., Zhang, J., Ren, M., & Feng, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558484 · Cited by 22

Immune Cell Regulation of White Adipose Progenitor Cell Fate

Altun, I., Yan, X., & Ussar, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.859044 · Cited by 17

Therapeutics That Promote Sympathetic Reinnervation Modulate the Inflammatory Response After Myocardial Infarction

Sepe, J. J., Gardner, R. T., Blake, M. R., Brooks, D. M., Staffenson, M. A., Betts, C. B., Sivagnanam, S., Larson, W., Kumar, S., Bayles, R., et al. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.04.009 · Cited by 17

Advances in Metabolic Regulation of Macrophage Polarization State

Liu, X., Xiang, R., Fang, X., Wang, G., & Zhou, Y. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2302828 · Cited by 19

ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regeneration

Sun, J., Peterson, E., Chen, X., & Wang, J. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114092 · Cited by 26

Integrated multi-omics analyses reveal the pro-inflammatory and pro-fibrotic pulmonary macrophage subcluster in silicosis

Kang, H., Gu, X., Cao, S., Tong, Z., & Song, N. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116899 · Cited by 17

STINGing Cancer: Development, Clinical Application, and Targeted Delivery of STING Agonists

Nerdinger, Y. G., Binder, A. K., Bremm, F., Feuchter, N., Schaft, N., & Dörrie, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189008 · Cited by 21

Cadherin-11 Regulates Macrophage Development and Function

To, S., Chavula, T., Pedroza, M., Smith, J., & Agarwal, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.795337 · Cited by 17

Soft tissue-mimicking hydrogel stiffness modulates polarisation of human monocyte-derived macrophages

Coser, C., Ghaemmaghami, A. M., & Yang, J. (2025) · Biomaterials Science · doi:10.1039/d5bm01187f · Cited by 17

A functional cardiac patch promotes cardiac repair by modulating the CCR2− cardiac-resident macrophage niche and their cell crosstalk

Ding, C., Tang, G., Sun, Y. K., Fu, X., Tian, Y., Zhan, J., Zhang, S., Xing, X., Liu, J., Qiu, X., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101932 · Cited by 16

Immunomodulatory microneedle patch for cardiac repair in rodent and porcine models of myocardial infarction

Huang, K., Zhu, D., Soto, J., Hu, S., Fang, J., Huang, J. Y., Zhang, X., Li, J., Li, Y., Tasoudis, P., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100152 · Cited by 22

Exploring the mechanisms of mutual influence between lactylation and macrophage polarization in the context of disease

Guo, H., Luan, N., Gao, J., Pang, X., Bi, J., & Zhu, L. (2025) · Clinical and Translational Medicine · doi:10.1002/ctm2.70499 · Cited by 20

Macrophages in ventricular remodeling and heart failure: orchestrators of inflammation and repair

Han, F., Hu, W., Liu, Y., Xu, X., Zhou, P., Qu, C., & Liu, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1682294 · Cited by 19

Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10

Huang, Y., Yan, S., Dong, X., Jiao, X., Wang, S., Li, D., & Wang, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.993788 · Cited by 16

Where Are They Now: Spatial and Molecular Diversity of Tissue-Resident Macrophages in the Kidney

Cheung, M. D., Agarwal, A., & George, J. F. (2022) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2022.10.002 · Cited by 15

Exosomal Non-Coding RNA Mediates Macrophage Polarization: Roles in Cardiovascular Diseases

Wang, H., Ye, X., Spanos, M., Wang, H., Yang, Z., Li, G., Xiao, J., & Zhou, L. (2023) · Biology · doi:10.3390/biology12050745 · Cited by 18

New Targets in Atherosclerosis: Vascular Smooth Muscle Cell Plasticity and Macrophage Polarity

Hutton, M., Frazer, M., Lin, A., Patel, S., & Misra, A. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.08.015 · Cited by 17

12,13‐diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens

Lin, D. L., Magnaye, K. M., Porsche, C. E., Levan, S., Rackaityte, E., Özçam, M., & Lynch, S. V. (2024) · Journal of Immunology Research · doi:10.1155/2024/2506586 · Cited by 16

M2 Macrophage-Derived Exosomes Inhibit Atherosclerosis Progression by Regulating the Proliferation, Migration, and Phenotypic Transformation of Smooth Muscle Cells

Wang, S., Wang, X., Lv, Y., Zhang, Z., He, T., Hao, X., Wang, S., Wang, C., Meng, J., Zhong, K., et al. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2908288 · Cited by 16

The Role of Antigen Presentation in Tumor-Associated Macrophages

Stopforth, R. J., & Ward, E. S. (2020) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2020034910 · Cited by 17

TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling

Ma, Z., Wang, C., Bai, X., Wang, L., Wu, Q., Cai, Z., Wang, W., Ma, Z., Liu, X., Feng, J., et al. (2022) · Bioscience Reports · doi:10.1042/bsr20212064 · Cited by 16

Dysregulation of the AMPK-SREBP1-FASN axis in MASLD: driving a vicious cycle of lipotoxicity and metabolic-immune crosstalk

Zhao, Q.-Q., Lu, S.-W., Guan, Y., Sun, Z.-W., Qiu, S., & Zhang, A.-H. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02867-9 · Cited by 15

The Dual Regulatory Roles of Macrophages in Acute Allogeneic Organ Graft Rejection

Tan, L., Guo, Y., Feng, C., Hou, Y., Xie, X., & Zhao, Y. X. (2021) · Engineering · doi:10.1016/j.eng.2021.10.015 · Cited by 15

Targeted Accumulation of Macrophages Induced by Microbeam Irradiation in a Tissue-Dependent Manner

Trappetti, V., Fazzari, J., Fernández-Palomo, C., Smyth, L. M. L., Potez, M., Shintani, N., Dietler, B. D. B., Martin, O. A., & Djonov, V. (2022) · Biomedicines · doi:10.3390/biomedicines10040735 · Cited by 15

Identification of a unique intervillous cellular signature in chronic histiocytic intervillositis

Krop, J., van der Meeren, L. E., van der Hoorn, M., Ijsselsteijn, M. E., Dijkstra, K. L., Kapsenberg, H., van der Keur, C., Cornish, E. F., Nikkels, P. G. J., Koning, F., et al. (2023) · Placenta · doi:10.1016/j.placenta.2023.05.007 · Cited by 15

Ly6Chi Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation

Purvis, G. S. D., McNeill, E., Wright, B., Channon, K. M., & Greaves, D. R. (2024) · Cells · doi:10.3390/cells13110916 · Cited by 17

Efferocytosis and Bone Dynamics

Batoon, L., Hawse, J. R., McCauley, L. K., Weivoda, M. M., & Roca, H. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00878-y · Cited by 16

Black, White, and Gray: Macrophages in Skin Repair and Disease

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CpG postconditioning after reperfused myocardial infarction is associated with modulated inflammation, less apoptosis, and better left ventricular function

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Characterizing the Macrophage Population in Patients With Idiopathic Subglottic Stenosis

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Near Complete Repair After Myocardial Infarction in Adult Mice by Altering the Inflammatory Response With Intramyocardial Injection of α-Gal Nanoparticles

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A Human CD68 Promoter-Driven Inducible Cre-Recombinase Mouse Line Allows Specific Targeting of Tissue Resident Macrophages

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Update on the roles of macrophages in the degeneration and repair process of intervertebral discs

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The roles of immune cells in atherosclerotic calcification

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Macrophage EP4 Deficiency Drives Atherosclerosis Progression via CD36-Mediated Lipid Uptake and M1 Polarization

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