Abandoning M1/M2 for a Network Model of Macrophage Function

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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M-1/M-2 Macrophages and the Th1/Th2 Paradigm

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

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Macrophages and microglia in inflammation and neuroinflammation underlying different pain states

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Redox-signals and macrophage biology

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Macrophage lineages in heart valve development and disease

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Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

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Fibroblasts orchestrate cellular crosstalk in the heart through the ECM

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Applying nanomedicine in maladaptive inflammation and angiogenesis

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Exogenous IL-4 shuts off pro-inflammation in neutrophils while stimulating anti-inflammation in macrophages to induce neutrophil phagocytosis following myocardial infarction

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Cellular Stress and General Pathological Processes

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SEPTIN2 suppresses an IFN-γ-independent, proinflammatory macrophage activation pathway

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Macrophage-related therapeutic strategies: Regulation of phenotypic switching and construction of drug delivery systems

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Mitochondria orchestrate macrophage effector functions in atherosclerosis

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Macrophage Subsets in Obesity, Aligning the Liver and Adipose Tissue

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Immunomodulation by systemic administration of human-induced pluripotent stem cell-derived mesenchymal stromal cells to enhance the therapeutic efficacy of cell-based therapy for treatment of myocardial infarction

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Immunophenotypical Characterization of M1/M2 Macrophages and Lymphocytes in Cisplatin-Induced Rat Progressive Renal Fibrosis

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Single-Cell RNA-Seq Analysis Reveals Macrophages Are Involved in the Pathogenesis of Human Sporadic Acute Type A Aortic Dissection

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IFN-γ Drives Human Monocyte Differentiation into Highly Proinflammatory Macrophages That Resemble a Phenotype Relevant to Psoriasis

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The tumour microenvironment of pituitary neuroendocrine tumours

Marques, P., Grossman, A. B., & Korbonits, M. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100852 · Cited by 52

Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation

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Artemisinin ameliorates intestinal inflammation by skewing macrophages to the M2 phenotype and inhibiting epithelial–mesenchymal transition

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The Immunomodulatory Effects of Statins on Macrophages

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Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis

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Understanding the complex macrophage landscape in MASLD

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Biomaterial-based physical regulation of macrophage behaviour

Zhou, H., Xue, Y., Dong, L., & Wang, C. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb00107h · Cited by 47

DAT and TH expression marks human Parkinson’s disease in peripheral immune cells

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Molecular Crosstalk Between Macrophages and Mesenchymal Stromal Cells

Stevens, H. Y., Bowles, A. C., Yeago, C., & Roy, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.600160 · Cited by 47

New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity

Rhee, A. J., & Lavine, K. J. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034412 · Cited by 46

Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium

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Immunopathogenesis and immunomodulatory therapy for myocarditis

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Immune defenses in the urinary tract

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Tumor associated macrophages in breast cancer progression: implications and clinical relevance

Stavrou, M., & Constantinidou, A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1441820 · Cited by 46

Azithromycin therapy reduces cardiac inflammation and mitigates adverse cardiac remodeling after myocardial infarction: Potential therapeutic targets in ischemic heart disease

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Immunosuppression in Sepsis: Biomarkers and Specialized Pro-Resolving Mediators

Padovani, C. M., & Yin, K. (2024) · Biomedicines · doi:10.3390/biomedicines12010175 · Cited by 48

scRank infers drug-responsive cell types from untreated scRNA-seq data using a target-perturbed gene regulatory network

Li, C., Shao, X., Zhang, S., Wang, Y., Jin, K., Yang, P., Lu, X., Fan, X., & Wang, Y. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101568 · Cited by 47

Harnessing Single-Cell RNA Sequencing to Better Understand How Diseased Cells Behave the Way They Do in Cardiovascular Disease

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The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis

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Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

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Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model

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Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues

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Understanding and improving cellular immunotherapies against cancer: From cell-manufacturing to tumor-immune models

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Unified nexus of macrophages and maresins in cardiac reparative mechanisms

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CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages

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Noncoding RNAs in Critical Limb Ischemia

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Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma

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Mycobacterium tuberculosis Rv1987 protein induces M2 polarization of macrophages through activating the PI3K/Akt1/mTOR signaling pathway

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Low Intensity Shockwave Treatment Modulates Macrophage Functions Beneficial to Healing Chronic Wounds

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Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism

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Diamonds in the Rough: Harnessing Tumor-Associated Myeloid Cells for Cancer Therapy

Clappaert, E. J., Murgaski, A., Damme, H. V., Kiss, M., & Laoui, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02250 · Cited by 37

Human nasal wash RNA-Seq reveals distinct cell-specific innate immune responses in influenza versus SARS-CoV-2

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Regulation of Magnesium Matrix Composites Materials on Bone Immune Microenvironment and Osteogenic Mechanism

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Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

Vlachou, F. J., Varela, A., Σταθοπούλου, Κ., Ntatsoulis, K., Synolaki, E., Pratsinis, H., Kletsas, D., Sideras, P., Davos, C. H., Capetanaki, Y., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04266-6 · Cited by 39

Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease

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Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke

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Inorganic material based macrophage regulation for cancer therapy: basic concepts and recent advances

Zhao, R., Cao, J., Yang, X., Zhang, Q., Iqbal, M. Z., Lü, J., & Kong, X. (2021) · Biomaterials Science · doi:10.1039/d1bm00508a · Cited by 35

The role of the mineralocorticoid receptor in immune cells in cardiovascular disease

van der Heijden, C. D. C. C., Bode, M., Riksen, N. P., & Wenzel, U. O. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15782 · Cited by 36

Emerging role of macrophages in non-infectious diseases: An update

Yousaf, H., Khan, M. I. U., Ali, I., Munir, M. U., & Lee, K. Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114426 · Cited by 38

Host Immune Regulation in Implant-Associated Infection (IAI): What Does the Current Evidence Provide Us to Prevent or Treat IAI?

Maimaiti, Z., Li, Z. Y., Xu, C., Fu, J., Hao, L., Chen, J., & Chai, W. (2023) · Bioengineering · doi:10.3390/bioengineering10030356 · Cited by 34

Targeting Macrophage Polarization in Infectious Diseases: M1/M2 Functional Profiles, Immune Signaling and Microbial Virulence Factors

Cerdeira, C. D., & Brigagão, M. R. P. L. (2024) · Immunological Investigations · doi:10.1080/08820139.2024.2367682 · Cited by 36

The Immune Mechanisms of Severe Equine Asthma—Current Understanding and What Is Missing

Simões, J., Batista, M., & Tilley, P. (2022) · Animals · doi:10.3390/ani12060744 · Cited by 34

Mechanisms of exercise in the treatment of lung cancer – a mini-review

Luo, Z., Wan, R., Liu, S., Feng, X., Peng, Z., Wang, Q., Chen, S., & Shang, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1244764 · Cited by 35

Impact of Immunity on Coronary Artery Disease: An Updated Pathogenic Interplay and Potential Therapeutic Strategies

Laera, N., Malerba, P., Vacanti, G., Nardin, S., Pagnesi, M., & Nardin, M. (2023) · Life · doi:10.3390/life13112128 · Cited by 34

Heterogeneity of glioblastoma stem cells in the context of the immune microenvironment and geospatial organization

Silver, A., Feier, D., Ghosh, T., Rahman, M., Huang, J., Sarkisian, M. R., & Deleyrolle, L. P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1022716 · Cited by 36

Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction

Ghosh, M., Thangada, S., Dasgupta, O., Khanna, K. M., Yamase, H., Kashgarian, M. J., Hla, T., Shapiro, L. H., & Ferrer, F. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194053 · Cited by 33

Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages

Han, Z., Ma, J., Han, Y., Yuan, G., Jiao, R., & Meng, A. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5235 · Cited by 35

Nanodrug delivery: Strategies to circumvent nanoparticle trafficking by Kupffer cells in the liver

Ezhilarasan, D., & Harini, K. S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104731 · Cited by 38

Granular Hydrogels for Harnessing the Immune Response

Widener, A. E., Roberts, A., & Phelps, E. A. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202303005 · Cited by 32

Tissue-Resident Macrophage Membrane-Coated Nanomedicine for Targeted Tumor Therapy

Su, X., Su, M., Guo, E., Zhou, Y., Yang, X., Li, S., & Ye, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c04463 · Cited by 34

A comprehensive approach to modeling maternal immune activation in rodents

Bucknor, M. C., Gururajan, A., Dale, R. C., & Hofer, M. J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1071976 · Cited by 37

SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics

Barrozo, E. R., Seferovic, M. D., Castro, E. C. C., Major, A. M., Moorshead, D., Jochum, M. D., Rojas, R., Shope, C. D., & Aagaard, K. M. (2023) · Med · doi:10.1016/j.medj.2023.06.003 · Cited by 34

SHIP-1 Regulates Phagocytosis and M2 Polarization Through the PI3K/Akt–STAT5–Trib1 Circuit in Pseudomonas aeruginosa Infection

Qin, S., Li, J., Zhou, C., Privratsky, B., Schettler, J., Deng, X., Xia, Z., Zeng, Y., Wu, H. M., & Wu, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00307 · Cited by 31

How Does Continuous Renal Replacement Therapy Affect Septic Acute Kidney Injury?

Zhang, J., Tian, J., Sun, H., Digvijay, K., Neri, M., Bhargava, V., Yin, Y., & Ronco, C. (2018) · Blood Purification · doi:10.1159/000492026 · Cited by 32

Uptake of Cyclodextrin Nanoparticles by Macrophages is Dependent on Particle Size and Receptor-Mediated Interactions

Soni, S. S., Kim, K. M., Sarkar, B., & Rodell, C. B. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00985 · Cited by 32

The maternal-fetal interface at single-cell resolution: uncovering the cellular anatomy of the placenta and decidua

Levenson, D., Romero, R. J., Miller, D., Galaz, J., Garcia‐Flores, V., Neshek, B., Piqué-Regi, R., & Gomez‐Lopez, N. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2024.12.032 · Cited by 34

Methods for macrophage differentiation and in vitro generation of human tumor associated-like macrophages

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Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals

Ciaglia, E., Montella, F., Lopardo, V., Scala, P., Ferrario, A., Cattaneo, M., Carrizzo, A., Malovini, A. L., Madeddu, P., Vecchione, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01034 · Cited by 33

Pharmacological inhibition of GLUT1 as a new immunotherapeutic approach after myocardial infarction

Chen, Z., Dudek, J., Maack, C., & Hofmann, U. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114597 · Cited by 31

Male and female gonadal ageing: its impact on health span and life span

Frungieri, M. B., Calandra, R. S., Bartke, A., & Matzkin, M. E. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111519 · Cited by 31

Pulmonary macrophages and SARS-Cov2 infection

Bain, C. C., Lucas, C. D., & Rossi, A. G. (2022) · International review of cytology · doi:10.1016/bs.ircmb.2022.01.001 · Cited by 31

Dissecting and Visualizing the Functional Diversity of Cardiac Macrophages

Holt, M., Lin, J., Cicka, M., Wong, A., Epelman, S., & Lavine, K. J. (2024) · Circulation Research · doi:10.1161/circresaha.124.323817 · Cited by 32

Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction

Lörchner, H., Hou, Y., Adrian-Segarra, J. M., Kulhei, J., Detzer, J., Günther, S., Gajawada, P., Warnecke, H., Niessen, H. W. M., Pöling, J., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy126 · Cited by 31

Identification of monocyte-associated genes as predictive biomarkers of heart failure after acute myocardial infarction

Chen, Q., Yin, Q., Song, J., Liu, C., Chen, H., & Li, S. (2021) · BMC Medical Genomics · doi:10.1186/s12920-021-00890-6 · Cited by 29

Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation

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Adiponectin, May Be a Potential Protective Factor for Obesity-Related Osteoarthritis

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