Abandoning M1/M2 for a Network Model of Macrophage Function

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

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Macrophage activation and polarization: nomenclature and experimental guidelines

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Macrophages in Tissue Repair, Regeneration, and Fibrosis

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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Complement and microglia mediate early synapse loss in Alzheimer mouse models

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M-1/M-2 Macrophages and the Th1/Th2 Paradigm

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Development of Monocytes, Macrophages, and Dendritic Cells

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The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions

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Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

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Beyond Hunger: The Structure, Signaling, and Systemic Roles of Ghrelin

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Reversal of aging-associated increase in myelopoiesis and expression of alarmins by angiotensin-(1–7)

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Mycobacterium tuberculosis Mce2D protein blocks M1 polarization in macrophages by inhibiting the ERK signaling pathway

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Effect of stretching on inflammation in a subcutaneous carrageenan mouse model analyzed at single‐cell resolution

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Divergence of acetate uptake in proinflammatory and inflammation-resolving macrophages: implications for imaging atherosclerosis

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Ultrasound-enhanced gene transfection: vectors, methods, and biomedical applications

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Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

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Decoding the CAF–TAM axis: multi-omics dissection and therapeutic targeting of stromal–immune crosstalk in the tumor microenvironment

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Research progress on mitochondria regulating tumor immunity

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Calcium phosphate with submicron topography influences primary human macrophage response, enhancing downstream angiogenesis and osteogenesis in vitro

van Dijk, L. A., Utomo, L., Yuan, H., Groot, F. B., Gawlitta, D., Rosenberg, A. J. W. P., & de Bruijn, J. D. (2023) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2023.100070 · Cited by 11

Single-cell RNA-Seq reveals CVI-mAb-induced Lyve1+ M2-like macrophages reduce atherosclerotic plaque area in Apoe-/- mice

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Signaling pathways that control mRNA translation initiation in macrophages

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Appearance of Heterogeneous Macrophages During Development of Isoproterenol-Induced Rat Myocardial Fibrosis

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Macrophage: Hidden Criminal in Therapy Resistance

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Differential effects of macrophage subtype‐specific cytokines on fibroblast proliferation and endothelial cell function in co‐culture system

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Effects of polarized macrophages on the in vitro gene expression after Co-Culture of human pluripotent stem cell-derived cardiomyocytes

Wrona, E. A., Sun, B. Q., Romero‐Torres, S., & Freytes, D. O. (2019) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2019.100018 · Cited by 9

Macrophage origin, phenotypic diversity, and modulatory signaling pathways in the atherosclerotic plaque microenvironment

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The Interface of Cancer, Their Microenvironment and Nanotechnology

Roque, N. R., Matias, D., Bal鏰-Silva, J., Ferrer, V. P., Pessoa, L. S., & Spohr, T. C. L. D. S. E. (2022) · ONCOLOGIE · doi:10.32604/oncologie.2022.024035 · Cited by 9

Behind the monocyte’s mystique: uncovering their developmental trajectories and fates

Teh, Y. C., Chooi, M. Y., & Chong, S. Z. (2023) · Discovery Immunology · doi:10.1093/discim/kyad008 · Cited by 12

Slc7a7 licenses macrophage glutaminolysis for restorative functions in atherosclerosis

Benhmammouch, S. C., Borowczyk, C., Pierrot-Blanchet, C., Barouillet, T., Murcy, F., Dussaud, S., Blanc, M., Blériot, C., Örd, T., Habbouche, L., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01354-2 · Cited by 9

A high-calorie diet exacerbates lipopolysaccharide-induced pneumonia by promoting acetate-mediated macrophage polarization via the HDAC9/10–HIF-1α–glycolysis axis

Li, Q., Liu, H., Bai, C., Jiang, L., Chen, S., Qin, X., Liu, T., & Gu, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1614768 · Cited by 9

Inhibition of angiogenetic macrophages reduces disc degeneration-associated pain

Hou, Y., Shi, J., Guo, Y., & Shi, G. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.962155 · Cited by 8

Mechanisms and strategies for a therapeutic cardiac immune response

Ferrari, I., & Vagnozzi, R. J. (2021) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2021.05.013 · Cited by 9

The Macrophage–Fibroblast Dipole in the Context of Cardiac Repair and Fibrosis

Psarras, S. (2024) · Biomolecules · doi:10.3390/biom14111403 · Cited by 8

ITE-mediated AhR activation attenuates atherosclerosis by promoting macrophage M2-like polarization through NF-κB/LCN2 pathway suppression

Zheng, Q., Lin, Y., Zeng, L., Chen, S., Chen, L., Lin, X., Zhu, J., Lin, J., Weng, X., & Chai, D. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123715 · Cited by 7

The Immunopathogenesis of uveitis

Han, J., Harper, J., Copland, D. A., & Maghsoudlou, P. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1717056 · Cited by 7

Sex-specific transcriptomic effects of low-dose inorganic arsenic exposure on bone marrow-derived macrophages

Illingworth, E. J., Rychlik, K. A., Maertens, A., & Sillé, F. C. M. (2023) · Toxicology · doi:10.1016/j.tox.2024.153988 · Cited by 6

The promising roles of macrophages in geriatric hip fracture

Lu, Y.-N., Wang, L., & Zhang, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.962990 · Cited by 8

Role of Macrophages in Status Epilepticus Predisposing to Alzheimer’s Disease

Song, S., Chen, J., Pinpin, X., Duan, H., Zhou, Y., Wang, F., Wang, H., Zhao, Y., & Geng, Z. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190994 · Cited by 7

Chess Not Checkers: Complexities Within the Myeloid Response to the Acute Kidney Injury Syndrome

Nash, W., & Okusa, M. D. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.676688 · Cited by 7

Nanoparticles decorated with granulocyte-colony stimulating factor for targeting myeloid cells

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Modulation of inflammatory M1-macrophages phenotype by valvular interstitial cells

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Inhibition of pro-inflammatory signaling in human primary macrophages by enhancing arginase-2 via target site blockers

Fitzsimons, S., Martín, M. M., Nally, F. K., Dillon, E., Fashina, I. A., Strowitzki, M. J., Ramió‐Torrentà, L., Dowling, J. K., Santi, C. D., & McCoy, C. E. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.08.023 · Cited by 6

Glial cells in neuropathic pain

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Experimental procedures for flow cytometry of wild-type mouse brain: a systematic review

Sharp, R. C., Guenther, D. T., & Farrer, M. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1281705 · Cited by 7

Syndecan-3 positively regulates the pro-inflammatory function of macrophages

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Inactivation of Interleukin‐4 Receptor α Signaling in Myeloid Cells Protects Mice From Angiotensin II/High Salt–Induced Cardiovascular Dysfunction Through Suppression of Fibrotic Remodeling

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Sensor Array-Enabled Identification of Drugs for Repolarization of Macrophages to Anti-Inflammatory Phenotypes

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The role of salivary gland macrophages in infection, disease and repair

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Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase

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Peripheral macrophages in the development and progression of structural cerebrovascular pathologies

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Characterizing macrophage diversity in colorectal malignancies through single-cell genomics

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The new perspective of cardiac exercise rehabilitation: based on integrative physiology

You, G., Xie, J., Tong, W., & Zhao, S. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1651589 · Cited by 6

Exosome-delivered bioactive molecules regulate macrophage polarization in atherosclerosis and myocardial infarction: mechanisms and therapeutic potential

Zhou, Y., Ran, G., & Guo, H. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1739907 · Cited by 5

Plant-Based Biomaterials as Bio-Instructive Immunomodulators: Design Principles, Mechanisms, and Translational Challenges

Lamponi, S. (2026) · Life · doi:10.3390/life16040538 · Cited by 6

Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS‐CoV‐2 Infection

Mezouar, S., & Mège, J. (2025) · Reviews in Medical Virology · doi:10.1002/rmv.70034 · Cited by 5

Understanding rheumatic disease through continuous cell state analysis

Marshall, L. M., Raychaudhuri, S., & Viatte, S. (2025) · Nature Reviews Rheumatology · doi:10.1038/s41584-025-01253-6 · Cited by 5

PTPN2 Negatively Regulates Macrophage Immune Responses and Cellular Bioenergetics

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Diabetic Foot - Recent Advances

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The secretome of Staphylococcus aureus strains with opposite within-herd epidemiological behavior affects bovine mononuclear cell response

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Spotlight on liver macrophages for halting liver disease progression and injury

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Leptin enhances the efficacy of glucantime to modulate macrophage polarization toward the M1 phenotype in Leishmania tropica-infected macrophages

Keyhani, A., Jafarzadeh, A., Sharifi, I., & Salarkia, E. (2025) · Parasites & Vectors · doi:10.1186/s13071-025-07004-6 · Cited by 4

Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progression

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The application of nanomedicines in repairing damage in myocardial infarction

Zheng, S., Chen, D., Zhao, M., & Hu, H. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114388 · Cited by 4

Pareto optimality reveals an atlas of cellular archetypes

Crowley, G., Alon, U., & Quake, S. R. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2530194123 · Cited by 4

Branched-chain amino acids and innate immunity in metabolic disease: Mechanisms, paradox, and therapeutic opportunities

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A comprehensive evaluation of murine and humanex vivocultured alveolar macrophages

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Eutopic macrophages facilitate endometriosis progression via ferroptosis-mediated release of S100A9

Ye, C., Ma, P., Li, N., Zhang, R., Wang, J., Zhou, Z., Wu, J., Liu, D., Sun, J., Pan, W., et al. (2025) · Molecular Human Reproduction · doi:10.1093/molehr/gaaf027 · Cited by 4

Estrogen and Estrogen Receptors in Cardioimmunology: Implications in Physiology, Pathophysiology, and Therapeutic Strategies

Hou, H., & Adzika, G. K. (2025) · Acta Physiologica · doi:10.1111/apha.70124 · Cited by 4

Tissue-plasminogen activator effects on the phenotype of splenic myeloid cells in acute inflammation

Seillier, C., Lesec, L., Hélie, P., Marie, C., Vivien, D., Docagne, F., Mauff, B. L., & Toutirais, O. (2024) · Journal of Inflammation · doi:10.1186/s12950-024-00375-0 · Cited by 4

Single-cell analysis identified key macrophage subpopulations associated with atherosclerosis

Zhao, Z., Qin, Y., Wu, R., Li, W., & Dong, Y. (2024) · Open Medicine · doi:10.1515/med-2024-1088 · Cited by 6

Novel histone modifications in microglia derived from a mouse model of chronic pain

Zhang, P., Guergues, J., Alleyne, A. R., Cirino, T. J., Nadeau, O. W., Figueroa, A. M., Stacy, H. M., Suzuki, T., McLaughlin, J. P., Stevens, S. M., et al. (2022) · PROTEOMICS · doi:10.1002/pmic.202100137 · Cited by 4

[Roles of macrophages in formation and progression of intracranial aneurysms].

Wang, Y., & Jin, J. (2019) · PubMed Central · doi:10.3785/j.issn.1008-9292.2019.04.13 · Cited by 4

Exosome-loaded conductive hydrogel with immune-modulating and neurogenesis-enhancing properties for synergistic spinal cord injury repairPreprint

Fan, L., Liu, C., Chen, X., Zou, Y., Wen, H., Lu, F., Luo, Y., Tan, G., Yu, P., Chen, D., et al. (2020) · doi:10.21203/rs.3.rs-69851/v1 · Cited by 4

Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients

Wang, T., Zhang, L., Chen, W., Long, Y., Zhang, Y., Wang, L., & Hou, Z. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s496650 · Cited by 4

Induction of M2 Macrophages by Fibrin Hydrogels Enhances Bone Regeneration

Aihara, R., Murata, K., Unzai, T., Kitamura, C., & Tabata, Y. (2025) · Tissue Engineering. Part A · doi:10.1177/19373341251364271 · Cited by 3

Single-cell analysis reveals an important role of CD137L+ macrophages in the host response to uropathogenic Escherichia coli infection in the bladder

Liu, Y., Yang, Z., Xiang, Y., Cheng, G., Chen, L., Wang, S., Zang, M., Zhou, N., Zhang, X., Chen, R., et al. (2025) · PLoS Pathogens · doi:10.1371/journal.ppat.1013543 · Cited by 3

A review on macrophage biology and its potential role in spontaneous abortion

Zhao, X., Ding, X., Fan, Q., Yao, X., Jin, L., Sun, C., Ke, H., Yang, Q., Chen, X., Ye, S., et al. (2025) · Molecular Human Reproduction · doi:10.1093/molehr/gaaf048 · Cited by 3

Unraveling atherosclerosis through single-cell RNA sequencing: insights into cellular heterogeneity and disease mechanisms

Junior, C. V. S., Ribeiro, M. D. O. L., Bichuette, L. D., Scarpa, B. R., Severino, P., Gollob, K. J., Lima, J. A. C., & Libby, P. (2025) · Einstein (São Paulo) · doi:10.31744/einstein_journal/2025rw1780 · Cited by 3

Nanomedicine meets transplantation: Unlocking precision therapeutics for organ rejection

Quan, Y., Ding, M., Hu, X., Xu, G., Cui, N., He, F., Wang, W., Zhou, W., Gao, T., Xie, M., et al. (2025) · EngMedicine · doi:10.1016/j.engmed.2025.100114 · Cited by 4

The Transcription Factor DDIT3 Regulates Macrophage Function by Inhibiting KLF10 to Attenuate ALI/ARDS Inflammation

Sun, M., Yang, Q., Tan, Y., Hu, C., Zhao, S., Lu, X., Gao, J., & Xing, L. (2026) · Inflammation · doi:10.1007/s10753-026-02451-4 · Cited by 3

Breaking the immunosuppressive barrier: an armored CAR-M biotechnology with the original M1 phenotype dominance rescues antitumor immunity

Du, F., Xu, Y., Chu, W., Qiu, J., Jiang, M., Wang, X., Guan, D., Su, M., He, A., Ye, Z., et al. (2026) · Trends in biotechnology · doi:10.1016/j.tibtech.2026.02.011 · Cited by 4

MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-like colitis in male mice

Vámos, E., Vántus, V. B., Deák, P., Kálmán, N., Sturm, E. M., Nayak, B. B., Makszin, L., Lóránd, T., Gallyas, F., & Radnai, B. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1558079 · Cited by 3

Itaconate: A Potential Therapeutic Strategy for Autoimmune Disease

Xie, Y., Cheng, Q., Xu, M. M., Xue, J., Wu, H., & Du, Y. (2025) · Scandinavian Journal of Immunology · doi:10.1111/sji.70026 · Cited by 3

Skin Immune Responses and Oncogenesis: A Delicate Balance

Wang, Z., Dai, X., Shu, H., & Yu, S. (2025) · Immunological Investigations · doi:10.1080/08820139.2025.2576577 · Cited by 3

Modulating hepatic macrophages with annexin A1 in non-alcoholic steatohepatitis

Ponti, F. F. D., & Scott, C. L. (2022) · Clinical Science · doi:10.1042/cs20220258 · Cited by 3

Repetitive Low-Level Blast Exposure via Akt/NF-κB Signaling Pathway Mediates the M1 Polarization of Mouse Alveolar Macrophage MH-S Cells

Geng, C., Wang, X., Chen, J., Sun, N., Wang, Y., Li, Z., Han, L., Hou, S., Fan, H., Li, N., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310596 · Cited by 3

Unveiling the Hidden Landscape of Arterial Diseases at Single-Cell Resolution

Scipione, C. A., Hyduk, S. J., Polenz, C. K., & Cybulsky, M. I. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.09.009 · Cited by 4

Correlation Analysis of Macrophage Distribution and Pathological Features of Carotid Atherosclerotic Plaque

Wei, J., Shen, S., Tian, Y., Kang, P., & Sun, G. (2023) · Annals of Vascular Surgery · doi:10.1016/j.avsg.2023.08.030 · Cited by 3

From dichotomy to diversity: deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

Wang, X., Chen, J., & Jia, G. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0370 · Cited by 4

Single-Cell Multi-Omics Profiling of Immune Cells Isolated from Atherosclerotic Plaques in Male ApoE Knockout Mice Exposed to Arsenic

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Mycobacterium tuberculosis curli pili reduces oxygen consumption rate of THP-1 macrophages during early infection

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