The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1
Open accessAbstract
Background— Aging is a major risk factor for the development of atherosclerosis and coronary artery disease. Through a microarray approach, we have identified a microRNA ( miR-217 ) that is progressively expressed in endothelial cells with aging. miR-217 regulates the expression of silent information regulator 1 (SirT1), a major regulator of longevity and metabolic disorders that is progressively reduced in multiple tissues during aging. Methods and Results— miR-217 inhibits SirT1 expression through a miR-217 –binding site within the 3′-UTR of SirT1. In young human umbilical vein endothelial cells, human aortic endothelial cells, and human coronary artery endothelial cells, miR-217 induces a premature senescence-like phenotype and leads to an impairment in angiogenesis via inhibition of SirT1 and modulation of FoxO1 (forkhead box O1) and endothelial nitric oxide synthase acetylation. Conversely, inhibition of miR-217 in old endothelial cells ultimately reduces senescence and increases angiogenic activity via an increase in SirT1. miR-217 is expressed in human atherosclerotic lesions and is negatively correlated with SirT1 expression and with FoxO1 acetylation status. Conclusions— Our data pinpoint miR-217 as an endogenous inhibitor of SirT1, which promotes endothelial senescence and is potentially amenable to therapeutic manipulation for prevention of endothelial dysfunction in metabolic disorders.
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Metadata
- Authors
- Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., Vasa-Nicotera, M., Ippoliti, A., Novelli, G., Melino, G., Lauro, R., & Federici, M.
- Venue
- Circulation
- Published
- 2009-10-13
- Volume
- 120
- Issue
- 15
- Pages
- 1524-1532
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2168774749
- Cited by
- 482
- References
- 32
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Menghini, R., Casagrande, V., Cardellini, M., Martelli, E., Terrinoni, A., Amati, F., Vasa-Nicotera, M., Ippoliti, A., Novelli, G., Melino, G., Lauro, R., & Federici, M. (2009). MicroRNA 217 Modulates Endothelial Cell Senescence via Silent Information Regulator 1. Circulation. https://doi.org/10.1161/circulationaha.109.864629
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