Impairment of speech production predicted by lesion load of the left arcuate fasciculus
Open accessAbstract
BACKGROUND AND PURPOSE: Previous studies have suggested that patients' potential for poststroke language recovery is related to lesion size; however, lesion location may also be of importance, particularly when fiber tracts that are critical to the sensorimotor mapping of sounds for articulation (eg, the arcuate fasciculus) have been damaged. In this study, we tested the hypothesis that lesion loads of the arcuate fasciculus (ie, volume of arcuate fasciculus that is affected by a patient's lesion) and of 2 other tracts involved in language processing (the extreme capsule and the uncinate fasciculus) are inversely related to the severity of speech production impairments in patients with stroke with aphasia. METHODS: Thirty patients with chronic stroke with residual impairments in speech production underwent high-resolution anatomic MRI and a battery of cognitive and language tests. Impairment was assessed using 3 functional measures of spontaneous speech (eg, rate, informativeness, and overall efficiency) as well as naming ability. To quantitatively analyze the relationship between impairment scores and lesion load along the 3 fiber tracts, we calculated tract-lesion overlap volumes for each patient using probabilistic maps of the tracts derived from diffusion tensor images of 10 age-matched healthy subjects. RESULTS: Regression analyses showed that arcuate fasciculus lesion load, but not extreme capsule or uncinate fasciculus lesion load or overall lesion size, significantly predicted rate, informativeness, and overall efficiency of speech as well as naming ability. CONCLUSIONS: A new variable, arcuate fasciculus lesion load, complements established voxel-based lesion mapping techniques and, in the future, may potentially be used to estimate impairment and recovery potential after stroke and refine inclusion criteria for experimental rehabilitation programs.
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Persistent speech production impairments as a consequence of stroke damage to aAF have been reported in prior studies that did and did not collect DTI data.
“persistent speech production impairments as a consequence of stroke damage to aAF have been reported in prior studies that did (Marchina et al., 2011) and did not collect (Fridriksson et al., 2013) DTI data to quantify structural abnormality in white matter pathways.”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Marchina et al., 2011
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- Authors
- Marchina, S., Zhu, L. L., Norton, A., Zipse, L., Wan, C. Y., & Schlaug, G.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- From the Department of Neurology, Stroke Recovery and Neuroimaging Laboratory, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
- Venue
- Stroke
- Published
- 2011-08
- Volume
- 42
- Issue
- 8
- Pages
- 2251-2256
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC3167233
- OpenAlex
- W2142817975
- Cited by
- 230
- References
- 40
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 20 · 2020: 21 · 2019: 20 · 2018: 17 · 2017: 18 · 2016: 13 · 2015: 20 · 2014: 18 · 2013: 14 · 2012: 8
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (R01DC008796)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- arcuate fasciculus, lesion load, aphasia, extreme capsule, uncinate fasciculus, speech rate, naming ability, diffusion tensor imaging
- MeSH terms
- Aged, Aphasia, Brain, Brain Mapping, Female, Humans, Language Tests, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Speech Production Measurement, Recovery of Function, Stroke
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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