Cited by 6,746Respiratory Support and MechanismsNeonatal Respiratory Health ResearchSepsis Diagnosis and Treatment

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The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination

Bernard, G R, Artigas, A, Brigham, K L, Carlet, J, Falke, K, Hudson, L, Lamy, M, Legall, J R, Morris, A, Spragg, R·1994·American journal of respiratory and critical care medicine

DOI 10.1164/ajrccm.149.3.7509706

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Abstract

The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. The reported annual incidence in the United States is 150,000 cases, but this figure has been challenged, and it may be different in Europe. Part of the reason for these uncertainties are the heterogeneity of diseases underlying ARDS and the lack of uniform definitions for ARDS. Thus, those who wish to know the true incidence and outcome of this clinical syndrome are stymied. The American-European Consensus Committee on ARDS was formed to focus on these issues and on the pathophysiologic mechanisms of the process. It was felt that international coordination between North America and Europe in clinical studies of ARDS was becoming increasingly important in order to address the recent plethora of potential therapeutic agents for the prevention and treatment of ARDS.

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How Is Mechanical Ventilation Employed in the Intensive Care Unit?: An International Utilization Review
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Recombinant Factor VIIa as Adjunctive Therapy for Bleeding Control in Severely Injured Trauma Patients: Two Parallel Randomized, Placebo-Controlled, Double-Blind Clinical Trials
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Guidelines for the Use of Parenteral and Enteral Nutrition in Adult and Pediatric Patients
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Inflammatory Cytokines in the BAL of Patients With ARDS
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“Out of 206 patients, 91 (59.3% males; 18.7% aged ≤ 5 years, 58.2% aged 6-64 years) were SARI cases who required admission to ICU and extracorporeal membrane oxygenation (ECMO) therapy, and 115 (62.6% males; 16.5% aged ≤ 5 years, 60% aged 6-64 years) were ARDS cases, as defined by the European Consensus Conference [8] .”
MethodInfluential
Acute Lung Injury and the Acute Respiratory Distress Syndrome
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Long-Term Effects of Spontaneous Breathing During Ventilatory Support in Patients with Acute Lung Injury
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Physical Complications in Acute Lung Injury Survivors: A Two-Year Longitudinal Prospective Study
Fan, E., Dowdy, D. W., Colantuoni, E., Mendez-Tellez, P. A., Sevransky, J. E., Shanholtz, C., Dennison Himmelfarb, C. R., Desai, S. V., Ciesla, N., Herridge, M. S., et al. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000040 · Cited by 615
“Study Design Mechanically ventilated patients with ALI (14) were consecutively enrolled in the prospective Improving Care of ALI Patients (ICAP) cohort study between October 2004 and October 2007 from 13 ICUs at four hospitals in Baltimore, MD (13, 15).”
Method
The Adult Respiratory Distress Syndrome Cognitive Outcomes Study: Long-Term Neuropsychological Function in Survivors of Acute Lung Injury
Mikkelsen, M. E., Christie, J. D., Lanken, P. N., Biester, R. C., Thompson, B. T., Bellamy, S. L., Localio, A. R., Demissie, E., Hopkins, R. O., & Angus, D. C. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2025oc · Cited by 615
Prognosis for long-term survival and renal recovery in critically ill patients with severe acute renal failure: a population-based study
Bagshaw, S. M., Laupland, K. B., Doig, C. J., Mortis, G., Fick, G. H., Mucenski, M., Godinez-Luna, T., Svenson, L. W., & Rosenal, T. (2005) · Critical Care · doi:10.1186/cc3879 · Cited by 612
Infusion Nursing Standards of Practice
Gorski, L. A. (2007) · Journal of Infusion Nursing · doi:10.1097/01.nan.0000270673.13439.95 · Cited by 600
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Khan, A., Benthin, C., Zeno, B. R., Albertson, T. E., Boyd, J. H., Christie, J. D., Hall, R., Poirier, G., Ronco, J. J., Tidswell, M., et al. (2017) · Critical Care · doi:10.1186/s13054-017-1823-x · Cited by 605
“Eligible patients included male or female subjects 18–80 years of age who were diagnosed with ARDS within 48 h of randomization that was associated with infection, sepsis, pneumonia, aspiration, or similar disease, based on the American-European Consensus Criteria [27].”
Method
Health-related quality of life and posttraumatic stress disorder in survivors of the acute respiratory distress syndrome
Schelling, G., Stoll, C., Haller, M., Briegel, J., Manert, W., Hummel, T., Lenhart, A., Heyduck, M., Polasek, J., Meier, M., et al. (1998) · Critical Care Medicine · doi:10.1097/00003246-199804000-00011 · Cited by 606
Incidence and Mortality after Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Sweden, Denmark, and Iceland
LUHR, O. R., Antonsen, K., Karlsson, M. K., Aardal, S., Thorsteinsson, A., FROSTELL, C. G., & Bonde, J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.6.9808136 · Cited by 595

Authors: Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R.
Affiliations: Vanderbilt University (US)
Vanderbilt University, Nashville, Tennessee
ORCID: Bernard, G R
Artigas, A
Carlet, J
Lamy, M
Morris, A
Venue: American journal of respiratory and critical care medicine
Publisher: Oxford University Press (OUP)
Published: 1994-03-01
Volume: 149
Issue: 3
Pages: 818-824
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/ajrccm.149.3.7509706
OpenAlex: W2161328469
Cited by: 6,746
References: 20
Citations by year: 2026: 54 · 2025: 112 · 2024: 107 · 2023: 119 · 2022: 126 · 2021: 164 · 2020: 158 · 2019: 184 · 2018: 156 · 2017: 192 · 2016: 238 · 2015: 241 · 2014: 289 · 2013: 341 · 2012: 364
FWCI: 80.47
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
D-Scholarship@Pitt (University of Pittsburgh) (acceptedVersion)
Funders: National Institutes of Health (5r01hl043167-05, 5p50hl019153-22)
National Heart, Lung, and Blood Institute (NHLBI HL19153, NHLBI HL43167)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords: acute respiratory distress syndrome, ARDS definition, ARDS pathophysiology, ARDS incidence, ARDS mortality, clinical trial coordination
MeSH terms: Americas, Clinical Protocols, Clinical Trials as Topic, Europe, Humans, Oxygen Inhalation Therapy, Prognosis, Radiography, Respiratory Distress Syndrome, Risk Factors, Incidence, Prevalence

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The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination

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