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Multipotent Retinal Progenitors Express Developmental Markers, Differentiate into Retinal Neurons, and Preserve Light-Mediated Behavior
Abstract
PURPOSE: To use progenitor cells isolated from the neural retina for transplantation studies in mice with retinal degeneration. METHODS: Retinal progenitor cells from postnatal day 1 green fluorescent protein-transgenic mice were isolated and characterized. These cells can be expanded greatly in culture and express markers characteristic of neural progenitor cells and/or retinal development. RESULTS: After they were grafted to the degenerating retina of mature mice, a subset of the retinal progenitor cells developed into mature neurons, including presumptive photoreceptors expressing recoverin, rhodopsin, or cone opsin. In rho-/- hosts, there was rescue of cells in the outer nuclear layer (ONL), along with widespread integration of donor cells into the inner retina, and recipient mice showed improved light-mediated behavior compared with control animals. CONCLUSIONS: These findings have implications for the treatment of retinal degeneration, in which neuronal replacement and photoreceptor rescue are major therapeutic goals.
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Metadata
- Authors
- Klassen, H. J., Ng, T. F., Kurimoto, Y., Kirov, I., Shatos, M., Coffey, P., & Young, M. J.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2004-11-01
- Volume
- 45
- Issue
- 11
- Pages
- 4167
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W1999851896
- Cited by
- 324
- References
- 46
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
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