Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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A new mechanism of thyroid hormone receptor β agonists ameliorating nonalcoholic steatohepatitis by inhibiting intestinal lipid absorption via remodeling bile acid profiles

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Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis

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Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice

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Activation of Constitutive Androstane Receptor (CAR) in mice results in maintained biliary excretion of bile acids despite a marked decrease of bile acids in liver

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Plasma bile acid changes in type 2 diabetes correlated with insulin secretion in two‐step hyperglycemic clamp

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Bile acid composition regulates the manganese transporter Slc30a10 in intestine

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Increased whole body energy expenditure and protection against diet-induced obesity in Cyp8b1-deficient mice is accompanied by altered adipose tissue features

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Airborne PM2.5 pollution: A double-edged sword modulating hepatic lipid metabolism in middle-aged male mice

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Total Sn-2 Palmitic Triacylglycerols and the Ratio of OPL to OPO in Human Milk Fat Substitute Modulated Bile Acid Metabolism and Intestinal Microbiota Composition in Rats

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Gut Microbiota and Heart, Vascular Injury

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Induction of blood-circulating bile acids supports recovery from myelosuppressive chemotherapy

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Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1−/−mice fed low levels of cholic acid

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Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice

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Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD) on bile acid homeostasis in mice

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Human sterol 12α-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern

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Cyp7a1 is continuously increased with disrupted Fxr-mediated feedback inhibition in hypercholesterolemic TALLYHO/Jng mice

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Taurocholic acid lowers the inflammatory response of gingival fibroblasts, epithelial cells, and macrophages

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Improving glucose and lipids metabolism: drug development based on bile acid related targets

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Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice

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Glycine-β-Muricholic Acid Improves Liver Fibrosis and Gut Barrier Function by Reducing Bile Acid Pool Size and Hydrophobicity in Male Cyp2c70 Knockout Mice

Hasan, M. N., Chen, J., Wang, H., Du, Y., Clayton, Y. D., Gu, L., & Li, T. (2023) · Cells · doi:10.3390/cells12101371 · Cited by 16

CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats

Qin, X., Zhang, Y., Lu, J., Huang, S., Liu, Z., & Wang, X. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115703 · Cited by 16

Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis elegans Strongly Resembling That of Bile Acid Biosynthesis and Secretion in Vertebrates

Liu, J., Desjardins, D., Branicky, R. S., Agellon, L. B., & Hekimi, S. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002553 · Cited by 17

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis

Kim, K. H., Choi, J. M., Li, F., Arizpe, A., Wooton‐Kee, C. R., Anakk, S., Jung, S. Y., Finegold, M. J., & Moore, D. D. (2018) · Endocrinology · doi:10.1210/en.2018-00110 · Cited by 16

Essential roles of bile acid receptors FXR and TGR5 as metabolic regulators

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Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice

Gaillard, D., Masson, D., Garo, E., Souidi, M., de Barros, J.-P. P., Schoonjans, K., Grober, J., Besnard, P., & Thomas, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137163 · Cited by 15

CYP8B1 Catalyzes 12alpha-Hydroxylation of C27 Bile Acid: In Vitro Conversion of Dihydroxycoprostanic Acid into Trihydroxycoprostanic Acid

Wang, Y., Wang, Y., Hu, Y., Wu, Q., Gui, L., Zeng, W., Chen, Q., Yu, T., Zhang, X., & Lan, K. (2024) · Drug Metabolism and Disposition · doi:10.1124/dmd.124.001694 · Cited by 14

Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor

Gardès, C., Blum, D., Bleicher, K., Chaput, E., Ebeling, M., HARTMAN, P. G., Handschin, C., Richter, H. G., & Benson, G. M. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m012542 · Cited by 14

NPC1L1 Deficiency Suppresses Ileal Fibroblast Growth Factor 15 Expression and Increases Bile Acid Pool Size in High-Fat-Diet-Fed Mice

Jia, L., Ma, Y., Haywood, J., Jiang, L., Xue, B., Shi, H., Dawson, P. A., & Yu, L. (2021) · Cells · doi:10.3390/cells10123468 · Cited by 14

Increased cholesterol 7α-hydroxylase expression and size of the bile acid pool in the lactating rat

Wooton‐Kee, C. R., Cohen, D. E., & Vore, M. E. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00017.2008 · Cited by 14

Circadian PER1 controls daily fat absorption with the regulation of PER1-PKA on phosphorylation of bile acid synthetase

Ge, W., Sun, Q., Yang, Y., Ding, Z., Liu, J., & Zhang, J. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100390 · Cited by 13

Biliary System Architecture: Experimental Models and Visualization Techniques

Sarnová, L., & Gregor, M. (2017) · Physiological Research · doi:10.33549/physiolres.933499 · Cited by 11

The Physiological Importance of Bile Acid Structure and Composition on Glucose Homeostasis

Higuchi, S. (2020) · Current Diabetes Reports · doi:10.1007/s11892-020-01329-5 · Cited by 12

A metabolomic-based study on disturbance of bile acids metabolism induced by intratracheal instillation of nickel oxide nanoparticles in rats

Zhang, Q., Chang, X., Wang, X., Zhan, H., Gao, Q., Yang, M., Liu, H., Li, S., & Sun, Y. (2021) · Toxicology Research · doi:10.1093/toxres/tfab039 · Cited by 14

Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice

Fu, K., Chen, P., Zhou, Y., Jiang, Y., Gao, Y., Zhang, H., Guan, L., Wang, C., Liu, J., Huang, M., et al. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00723-3 · Cited by 13

Multi-omics analysis revealed the dysfunction of ovary and testis induced by chronic hypoxia in Pelteobagrus fulvidraco

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Small intestine-residing probiotics suppress neurotoxic bile acid production via extracellular vesicle-mediated inhibition of Clostridium scindens

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Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids

Selkälä, E. M., Kuusisto, S. M., Salonurmi, T., Savolainen, M. J., Jauhiainen, M., Pirilä, P., Kvist, A.-P., Conzelmann, E., Schmitz, W., Alexson, S. E. H., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.05.002 · Cited by 12

Bile Acid Receptor Farnesoid X Receptor: A Novel Therapeutic Target for Metabolic Diseases

Fang, S. (2017) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2017.6.1.1 · Cited by 12

Review article: insights into the bile acid‐gut microbiota axis in intestinal failure‐associated liver disease—redefining the treatment approach

Wang, Y., Zheng, L., Zhou, Z., Yao, D., Huang, Y., Liu, B., Duan, Y., & Li, Y. (2021) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16676 · Cited by 12

NUDT7 regulates total hepatic CoA levels and the composition of the intestinal bile acid pool in male mice fed a Western diet

Vickers, S. D., Shumar, S. A., Saporito, D. C., Kunovac, A., Hathaway, Q. A., Mintmier, B., KING, J. A. C., King, R. D., Rajendran, V. M., Infante, A. M., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102745 · Cited by 11

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice

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The Biliary System, Second Edition

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