Cited by 232Cholesterol and Lipid MetabolismDrug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

Li-Hawkins, Jia, Gåfvels, Mats, Olin, Maria, Lund, Erik G., Andersson, Ulla, Schuster, Gertrud, Björkhem, Ingemar, Russell, David W., Eggertsen, Gosta·2002·Journal of Clinical Investigation

DOI 10.1172/jci0216309

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Abstract

Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12α-hydroxylase gene (Cyp8b1) in mice prevents the synthesis of cholate, a primary bile acid, and its metabolites. Feedback regulation of the rate-limiting biosynthetic enzyme cholesterol 7α-hydroxylase (CYP7A1) is lost in Cyp8b1–/– mice, causing expansion of the bile acid pool and alterations in cholesterol metabolism. Expression of other FXR target genes is unaltered in these mice. Cholate restores CYP7A1 regulation in vivo and in vitro. The results implicate cholate as an important negative regulator of bile acid synthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor.

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Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Identification of a nuclear receptor for bile acids
Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., & Shan, B. (1999) · Science · doi:10.1126/science.284.5418.1362 · Cited by 2,714
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science · doi:10.1126/science.284.5418.1365 · Cited by 2,274
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00051-4 · Cited by 1,940
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., & Gonzalez, F. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00062-3 · Cited by 1,819
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR
Wang, H., Chen, J., Hollister, K., Sowers, L. C., & Forman, B. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80348-2 · Cited by 1,636
An oxysterol signalling pathway mediated by the nuclear receptor LXRα
Janowski, B. A., Willy, P. J., Devi, T. R., Falck, J. R., & Mangelsdorf, D. J. (1996) · Nature · doi:10.1038/383728a0 · Cited by 1,591
An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway
Kliewer, S. A., Moore, J. T., Wade, L., Staudinger, J. L., Watson, M. A., Jones, S. A., McKee, D. D., Oliver, B. B., Willson, T. M., Zetterström, R. H., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)80900-9 · Cited by 1,534

Show all 45 references

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Rao, Y., Wen, Q., Liu, R., He, M., Jiang, Z., Qian, K., Zhou, C., Li, J., Du, H., Ouyang, H., et al. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.029 · Cited by 60
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Khambu, B., Li, T., Yan, S., Yu, C., Chen, X., Goheen, M. P., Li, Y., Lin, J., Cummings, O. W., Lee, Y. A., et al. (2018) · Hepatology · doi:10.1002/hep.30407 · Cited by 58
Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice
Slätis, K., Gåfvels, M. E., Kannisto, K., Овчинникова, О. А., Paulsson‐Berne, G., Parini, P., Jiang, Z., & Eggertsen, G. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m009308 · Cited by 57
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Emerging Roles of Gut Microbial Modulation of Bile Acid Composition in the Etiology of Cardiovascular Diseases
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Sisk-Hackworth, L., Kelley, S. T., & Thackray, V. G. (2022) · Reproduction · doi:10.1530/rep-22-0303 · Cited by 53
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Yu, H., Nie, R., & Shen, C. (2023) · Endocrine Journal · doi:10.1507/endocrj.ej22-0544 · Cited by 50
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Gardès, C., Chaput, E., Staempfli, A. A., Blum, D., Richter, H. G., & Benson, G. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033423 · Cited by 42
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Xu, G., Pan, L., Li, H., Shang, Q., Honda, A., Shefer, S., Bollineni, J. S., Matsuzaki, Y., Tint, G. S., & Salen, G. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00397.2003 · Cited by 41
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Dawson, P. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00053-1 · Cited by 39
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Jiang, K., Bai, Y., Hou, R., Chen, G., Liu, L., Ciftci, O. N., Farag, M. A., & Liu, L. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.142932 · Cited by 37
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Sigurðsson, V., & Miharada, K. (2018) · International Journal of Hematology · doi:10.1007/s12185-018-2458-7 · Cited by 38

Authors: Li-Hawkins, J., Gåfvels, M., Olin, M., Lund, E. G., Andersson, U., Schuster, G., Björkhem, I., Russell, D. W., & Eggertsen, G.
Affiliations: The University of Texas Southwestern Medical Center (US)
Karolinska Institutet (SE)
Corresponding author: Russell, David W.
ORCID: Lund, Erik G.
Björkhem, Ingemar
Russell, David W.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2002-10-15
Volume: 110
Issue: 8
Pages: 1191-1200
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci0216309
OpenAlex: W4239553605
Cited by: 227
References: 45
Citations by year: 2026: 5 · 2025: 10 · 2024: 13 · 2023: 13 · 2022: 11 · 2021: 16 · 2020: 21 · 2019: 12 · 2018: 16 · 2017: 7 · 2016: 12 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 9
FWCI: 8.27
Type: journal article
Language: en
Open access: closed
Locations: Journal of Clinical Investigation (publishedVersion)
Funders: W. M. Keck Foundation
National Institutes of Health (HL20948)
Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: cholic acid, cholate, bile acid synthesis, negative feedback regulation, farnesoid X receptor, CYP8B1, sterol 12alpha-hydroxylase, CYP7A1, cholesterol metabolism

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Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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