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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
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Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. However, the mechanisms linking obesity to insulin resistance and diabetes in humans remain largely unknown. In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese premenopausal women by Northern blot analysis. TNF-alpha protein concentrations in plasma and in conditioned medium of explanted adipose tissue were measured by ELISA. Furthermore, the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA were also analyzed in nine premenopausal obese women, before and after a controlled weight-reduction program. These studies demonstrated that obese individuals express 2.5-fold more TNF-alpha mRNA in fat tissue relative to the lean controls (P < 0.001). Similar increases were also observed in adipose production of TNF-alpha protein but circulating TNF-alpha levels were extremely low or undetectable. A strong positive correlation was observed between TNF-alpha mRNA expression levels in fat tissue and the level of hyperinsulinemia (P < 0.001), an indirect measure of insulin resistance. Finally, body weight reduction in obese subjects which resulted in improved insulin sensitivity was also associated with a decrease in TNF-alpha mRNA expression (45%, P < 0.001) in fat tissue. These results suggest a role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance.
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“Elevated TNF␣ mRNA and protein levels have also been detected in human obesity (51,52).”
From Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle (2005) · cites this paper as [51]
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Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Self-citationElective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,463
Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,732
The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response
Beutler, B., & Cerami, A. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.003205 · Cited by 1,690
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,353
Self-citationTumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Self-citationImprovement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone
Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 914
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
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Research works printed but not linked: 2
- Hotamisligil, G. S., D. L. Murray, L. N. Choy, and B. M. Spiegelman. 1994. TNF-a inhibits signaling from insulin receptor. Proc. Natl. Acado Sci. USA. 91:4854-4858.
- Bjorntorp, P. 1992. Regional Obesity. In Obesity. P. Bjorntorp and B. D. Brodoff, editors. J. B. Lippincott. Philadelphia. 579-586.
Cited by
Sorted by citations
Items 101–200 of 1,020
Lazar, H. L., Chipkin, S. R., Fitzgerald, C. A., Bao, Y., Cabral, H., & Apstein, C. S. (2004) · Circulation · doi:10.1161/01.cir.0000121747.71054.79 · Cited by 713
Crespo, J., Cayón, A., Fernández-Gil, P. L., Hernández‐Guerra, M., Mayorga, M., Domínguez‐Díez, A., Fernández-Escalante, J. C., & Pons‐Romero, F. (2001) · Hepatology · doi:10.1053/jhep.2001.29628 · Cited by 708
Hara, K., Boutin, P., Mori, Y., Tobe, K., Dina, C., Yasuda, K., Yamauchi, T., Otabe, S., Okada, T., Eto, K., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.2.536 · Cited by 703
Fain, J. N. (2006) · Vitamins and hormones · doi:10.1016/s0083-6729(06)74018-3 · Cited by 702
Arita, Y., Kihara, S., Ouchi, N., Maeda, K., Kuriyama, H., Okamoto, Y., Kumada, M., Hotta, K., Nishida, M., Takahashi, M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000018622.84402.ff · Cited by 698
Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment
Musselman, D. L., Betan, E. J., Larsen, H., & Phillips, L. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00569-9 · Cited by 687
The gut microbiome and metabolic syndrome
Dabke, K., Hendrick, G., & Devkota, S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129194 · Cited by 684
Oxidative Stress in the Pathogenesis of Preeclampsia
Hubel, C. A. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-139.x · Cited by 681
Adipose Tissue Dysfunction in Obesity
Blüher, M. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1192044 · Cited by 679
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans
Adams, J. M., Pratipanawatr, T., Berria, R., Wang, E. L., DeFronzo, R. A., Sullards, M. C., & Mandarino, L. J. (2004) · Diabetes · doi:10.2337/diabetes.53.1.25 · Cited by 677
Felice, F. G. D., & Ferreira, S. T. (2014) · Diabetes · doi:10.2337/db13-1954 · Cited by 676
Tripathy, D., Mohanty, P., Dhindsa, S., Syed, T., Ghanim, H., Aljada, A., & Dandona, P. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2882 · Cited by 667
The IRS-signalling system: A network of docking proteins that mediate insulin action
White, M. F. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5647-3_1 · Cited by 666
Bays, H., Mandarino, L., & DeFronzo, R. A. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030723 · Cited by 664
Molecular pathways of nonalcoholic fatty liver disease development and progression
Bessone, F., Razori, M. V., & Roma, M. G. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2947-0 · Cited by 664
The Origins and Drivers of Insulin Resistance
Johnson, A. M. F., & Olefsky, J. M. (2013) · Cell · doi:10.1016/j.cell.2013.01.041 · Cited by 661
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans
Kullmann, S., Heni, M., Hallschmid, M., Fritsche, A., Preissl, H. T., & Häring, H. (2016) · Physiological Reviews · doi:10.1152/physrev.00032.2015 · Cited by 654
Lee, D., Lee, I., Song, K., Steffes, M. W., Toscano, W. A., Baker, B. A., & Jacobs, D. R. (2006) · Diabetes Care · doi:10.2337/dc06-0543 · Cited by 645
Kilroy, G. E., Foster, S. J., Wu, X., Ruiz, J., Sherwood, S., Heifetz, A., Ludlow, J. W., Stricker, D. M., Potiny, S., Green, P., et al. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21068 · Cited by 642
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 636
Signalling role of adipose tissue: adipokines and inflammation in obesity
Trayhurn, P., & Wood, I. S. (2005) · Biochemical Society Transactions · doi:10.1042/bst0331078 · Cited by 634
Plomgaard, P., Bouzakri, K., Krogh-Madsen, R., Mittendorfer, B., Zierath, J. R., & Pedersen, B. K. (2005) · Diabetes · doi:10.2337/diabetes.54.10.2939 · Cited by 627
Yamagishi, S., Edelstein, D., Du, X.-L., Kaneda, Y., Guzmán, M., & Brownlee, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007383200 · Cited by 622
Rui, L., Aguirre, V., Kim, J. K., Shulman, G. I., Lee, A., Corbould, A. M., Dunaif, A. E., & White, M. F. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10934 · Cited by 611
Adipokine dysregulation and adipose tissue inflammation in human obesity
Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610
Guerre-Millo, M., Gervois, P., Raspé, E., Madsen, L., Poulain, P., Derudas, B., Herbert, J.-M., Winegar, D. A., Willson, T. M., Fruchart, J.-C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.22.16638 · Cited by 605
Inflammation in maternal obesity and gestational diabetes mellitus
Pantham, P., Aye, I. L. M. H., & Powell, T. L. (2015) · Placenta · doi:10.1016/j.placenta.2015.04.006 · Cited by 599
Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 597
Sarcopenic obesity and inflammation in the InCHIANTI study
Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00627.2006 · Cited by 594
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591
Egert, S., Bosy‐Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta‐Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G. H., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509359127 · Cited by 587
The insulin signalling system and the IRS proteins
White, M. F. (1997) · Diabetologia · doi:10.1007/s001250051387 · Cited by 586
Obesity as a cardiovascular risk factor
Sowers, J. R. (2003) · The American Journal of Medicine · doi:10.1016/j.amjmed.2003.08.012 · Cited by 584
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 572
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
Holm, C., Østerlund, T., Laurell, H., & Contreras, J. A. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.365 · Cited by 572
Physiology and diseases of tissue-resident macrophages
Lazarov, T., Juarez-Carreño, S., Cox, N., & Geissmann, F. (2023) · Nature · doi:10.1038/s41586-023-06002-x · Cited by 571
Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging
Gabriely, I., Ma, X. H., Yang, X. M., Atzmon, G., Rajala, M. W., Berg, A. H., Scherer, P., Rossetti, L., & Barzilai, N. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2951 · Cited by 563
Bruun, J. M., Lihn, A. S., Pedersen, S. B., & Richelsen, B. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1696 · Cited by 555
Stephens, J. M., Lee, J., & Pilch, P. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.971 · Cited by 553
McArdle, M. A., Finucane, O. M., Connaughton, R. M., McMorrow, A. M., & Roche, H. M. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00052 · Cited by 552
Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease
Malhi, H., & Gores, G. J. (2008) · Seminars in Liver Disease · doi:10.1055/s-0028-1091980 · Cited by 552
Perreault, M., & Marette, A. (2001) · Nature Medicine · doi:10.1038/nm1001-1138 · Cited by 550
The ‘psoriatic march’: a concept of how severe psoriasis may drive cardiovascular comorbidity
Boehncke, W., Boehncke, S., Tobin, A., & Kirby, B. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01261.x · Cited by 545
The Relation of Markers of Inflammation to the Development of Glucose Disorders in the Elderly
Barzilay, J. I., Abraham, L., Heckbert, S. R., Cushman, M., Kuller, L. H., Resnick, H. E., & Tracy, R. P. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2384 · Cited by 544
Ruan, H., Hacohen, N., Golub, T. R., Parijs, L. V., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1319 · Cited by 543
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α
Ruan, H., & Lodish, H. F. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00052-2 · Cited by 541
The IRS-signalling system: A network of docking proteins that mediate insulin action
White, M. F. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006806722619 · Cited by 539
Circulating inflammatory markers in polycystic ovary syndrome: a systematic review and metaanalysis
Escobar-Morreale, H. F., Luque‐Ramírez, M., & González, F. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.11.036 · Cited by 538
Foundations of Immunometabolism and Implications for Metabolic Health and Disease
Hotamışlıgil, G. S. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.009 · Cited by 534
Changes in Nutritional Status Impact Immune Cell Metabolism and Function
Alwarawrah, Y., Kiernan, K., & MacIver, N. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01055 · Cited by 534
Hak, A. E., Stehouwer, C. D. A., Bots, M. L., Polderman, K. H., Schalkwijk, C. G., Westendorp, I. C. D., Hofman, A., & Witteman, J. C. M. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.8.1986 · Cited by 525
Pitteloud, N., Hardin, M., Dwyer, A. A., Valassi, E., Yialamas, M., Elahi, D., & Hayes, F. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-2190 · Cited by 525
Insulin Resistance, Obesity and Lipotoxicity
Yazıcı, D., & Sezer, H. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_12 · Cited by 525
Obesity and Obesity-Initiated Metabolic Syndrome
Wahba, I. M., & MAK, R. H. K. (2007) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04071206 · Cited by 524
Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients
Videla, L. A., Rodrigo, R., Myriam Orellana, B., Fernández, V., Tapia, G., Quiñones, L. A., Varela, N., CONTRERAS, J., Lazarte, R. A., Csendes, A., et al. (2004) · Clinical Science · doi:10.1042/cs20030285 · Cited by 522
Immune Regulation of Metabolic Homeostasis in Health and Disease
Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 510
Obesity and Inflammation: Epidemiology, Risk Factors, and Markers of Inflammation
Rodríguez-Hernández, H., Simental‐Mendía, L. E., Ramírez, G. R., & Reyes-Romero, M. A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/678159 · Cited by 509
Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?
Parisi, L., Gini, E., Baci, D., Tremolati, M., Fanuli, M., Bassani, B., Farronato, G., Bruno, A., & Mortara, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/8917804 · Cited by 508
Conjugated linoleic acids: are they beneficial or detrimental to health?
Wahle, K. W. J., Heys, S. D., & Rotondo, D. (2004) · Progress in Lipid Research · doi:10.1016/j.plipres.2004.08.002 · Cited by 505
Black, P. H. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00048-5 · Cited by 502
Lipid accumulation in non-adipose tissue and lipotoxicity
van Herpen, N. A., & Schrauwen-Hinderling, V. B. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.049 · Cited by 500
The impact of obesity on skeletal muscle strength and structure through adolescence to old age
Tomlinson, D. J., Erskine, R. M., Morse, C. I., Winwood, K., & Onambélé-Pearson, G. (2016) · Biogerontology · doi:10.1007/s10522-015-9626-4 · Cited by 496
Vasseur, F. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2607 · Cited by 495
Insulin resistance associated to obesity: the link TNF-alpha
Nieto-Vázquez, I., Fernández‐Veledo, S., Kramer, D., Vila‐Bedmar, R., García‐Guerra, L., & Lorenzo, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802181047 · Cited by 493
Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
Klover, P. J., Zimmers, T. A., Koniaris, L. G., & Mooney, R. A. (2003) · Diabetes · doi:10.2337/diabetes.52.11.2784 · Cited by 488
Integrative physiology of human adipose tissue
Frayn, K. N., Karpe, F., Fielding, B. A., Macdonald, I. A., & Coppack, S. W. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802326 · Cited by 480
Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
Rivera, L., Morón, R., Sánchez, M., Zarzuelo, A., & Galisteo, M. (2008) · Obesity · doi:10.1038/oby.2008.315 · Cited by 473
Adipose Tissue, Inflammation and Atherosclerosis
Gustafson, B. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.3939 · Cited by 473
Nonogaki, K., Strack, A. M., Dallman, M. F., & Tecott, L. H. (1998) · Nature Medicine · doi:10.1038/2647 · Cited by 470
Hepatic insulin resistance, metabolic syndrome and cardiovascular disease
Meshkani, R., & Adeli, K. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.05.018 · Cited by 470
Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro
Kaser, S., Kaser, A., Sandhofer, A., Ebenbichler, C. F., Tilg, H., & Patsch, J. R. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.07.003 · Cited by 465
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461
Obesity, adipocytokines, and insulin resistance in breast cancer
Rose, D. P., Komninou, D., & Stephenson, G. D. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00142.x · Cited by 460
Visceral fat and insulin resistance — causative or correlative?
Frayn, K. N. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500000982 · Cited by 456
Gustafson, B., Hammarstedt, A., Andersson, C. X., & Smith, U. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147835 · Cited by 447
Cook, D. G., Mendall, M. A., Whincup, P. H., Carey, I. M., Ballam, L., Morris, J. E., Miller, G. J., & Strachan, D. P. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00312-3 · Cited by 446
Metabolic Syndrome Pathophysiology and Predisposing Factors
Bovolini, A., Garcia, J., Andrade, M. A., & Duarte, J. A. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1263-0898 · Cited by 446
Leptin resistance and diet-induced obesity: central and peripheral actions of leptin
Sáinź, N., Barrenetxe, J., Moreno-Aliaga, M. J., & Martínez, J. A. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.015 · Cited by 445
Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes
Hummasti, S., & Hotamışlıgil, G. S. (2010) · Circulation Research · doi:10.1161/circresaha.110.225698 · Cited by 445
Endothelial dysfunction and pathogenesis of diabetic angiopathy
Stehouwer, C. D. A. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00272-6 · Cited by 443
Flynn, L. E. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.046 · Cited by 441
Ceramides as modulators of cellular and whole-body metabolism
Bikman, B. T., & Summers, S. A. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57144 · Cited by 440
Bruun, J. M., Helge, J. W., Richelsen, B., & Stallknecht, B. M. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00506.2005 · Cited by 437
Zhang, H., Halbleib, M., Ahmad, F., Manganiello, V. C., & Greenberg, A. S. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2929 · Cited by 436
de Álvaro, C., Teruel, T., Hernández, R., & Lorenzo, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312021200 · Cited by 435
The role of TNFα in adipocyte metabolism
Sethi, J. K., & Hotamışlıgil, G. S. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0273 · Cited by 433
Insulin resistance as the core defect in type 2 diabetes mellitus
Goldstein, B. J. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02553-5 · Cited by 432
Zhuang, G., Meng, C., Guo, X., Cheruku, P. S., Shi, L., Xu, H., Li, H., Wang, G., Evans, A. R., Safe, S., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.087817 · Cited by 428
The Molecular-Genetic Basis of Functional Hyperandrogenism and the Polycystic Ovary Syndrome
Escobar-Morreale, H. F., Luque‐Ramírez, M., & Millán, J. L. S. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0004 · Cited by 426
Tanaka, N., Yonekura, H., Yamagishi, S., Fujimori, H., Yamamoto, Y., & Yamamoto, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001235200 · Cited by 425
Upadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 425
Steinberg, G. R., Michell, B. J., van Denderen, B. J. W., Watt, M. J., Carey, A. L., Fam, B. C., Andrikopoulos, S., Proietto, J., Görgün, C. Z., Carling, D., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.005 · Cited by 424
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Sakkinen, P. A., WAHL, P. W., Cushman, M., Lewis, M. R., & Tracy, R. P. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.10.897 · Cited by 420
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Self-citation
Metadata
- Authors
- Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M.
- Affiliations
- Dana-Farber Cancer Institute (US)
- Corresponding author
- Spiegelman, B M
- Venue
- Journal of Clinical Investigation
- Published
- 1995-05-01
- Volume
- 95
- Issue
- 5
- Pages
- 2409-2415
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC295872
- OpenAlex
- W1974033843
- Cited by
- 3,543
- References
- 28
- Citations by year
- 2026: 46 · 2025: 67 · 2024: 73 · 2023: 91 · 2022: 100 · 2021: 110 · 2020: 91 · 2019: 130 · 2018: 141 · 2017: 127 · 2016: 123 · 2015: 149 · 2014: 178 · 2013: 183 · 2012: 172
- FWCI
- 41.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (5r01dk042539-08, 5r01dk045592-05)
- Medical Research Council
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 45592, DK42539)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- TNF-α, obesity, insulin resistance, adipose tissue, TNF-alpha mRNA expression, hyperinsulinemia, weight loss, premenopausal women, adipokines
- MeSH terms
- Adipose Tissue, Adult, Blood Glucose, Cholesterol, Female, Humans, Insulin, Insulin Resistance, Middle Aged, Obesity, Reference Values, Regression Analysis, RNA, Messenger, Thinness, Triglycerides, Tumor Necrosis Factor-alpha, Blotting, Northern, Gene Expression, Body Mass Index, Premenopause
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