Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.

Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,463

Tumor Necrosis Factor (TNF)

Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,732

The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response

Beutler, B., & Cerami, A. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.003205 · Cited by 1,690

Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link

Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,353

Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220

Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone

Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 914

Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.

Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819

Inflammatory status and insulin resistance

Grimble, R. F. (2002) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200209000-00015 · Cited by 411

Plasticity and cross-talk of Interleukin 6-type cytokines

Garbers, C., Hermanns, H. M., Schaper, F., Müller‐Newen, G., Grötzinger, J., Rose‐John, S., & Scheller, J. (2012) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2012.04.001 · Cited by 409

Transcriptional Regulation of Adipogenesis

de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160022 · Cited by 406

Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease.

Mendall, M. A., Patel, P., Asante, M. A., Ballam, L., Morris, J., Strachan, D. P., Camm, A. J., & Northfield, T. C. (1997) · Heart · doi:10.1136/hrt.78.3.273 · Cited by 402

Comparison of Risk Factors for Preeclampsia and Gestational Hypertension in a Population-based Cohort Study

Ros, H. S., Cnattingius, S., & Lipworth, L. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009400 · Cited by 401

Monocytes from type 2 diabetic patients have a pro-inflammatory profile

Giulietti, A., van Etten, E., Overbergh, L., Stoffels, K., Bouillon, R., & Mathieu, C. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2006.10.007 · Cited by 400

Cidea is associated with lipid droplets and insulin sensitivity in humans

Puri, V., Ranjit, S., Konda, S., Nicoloro, S. M. C., Straubhaar, J., Chawla, A., Chouinard, M., Lin, C.-Y., Burkart, A., Corvera, S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802063105 · Cited by 397

Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo

Mohamed‐Ali, V., Goodrick, S., Bulmer, K., Holly, J. M. P., Yudkin, J. S., & Coppack, S. W. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e971 · Cited by 396

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

Apovian, C. M., Bigornia, S., Mott, M. M., Meyers, M. R., Ulloor, J., Gagua, M., McDonnell, M. E., Hess, D. T., Joseph, L., & Gokce, N. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.170316 · Cited by 392

Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats

Rivera, L., Morón, R., Zarzuelo, A., & Galisteo, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.11.027 · Cited by 391

Secretory factors from human adipose tissue and their functional role

Hauner, H. (2005) · Proceedings of the Nutrition Society · doi:10.1079/pns2005428 · Cited by 391

Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications.

Nishikawa, T., & Araki, E. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.1458 · Cited by 391

Gestational Diabetes Induces Placental Genes for Chronic Stress and Inflammatory Pathways

Radaelli, T., Varastehpour, A., Catalano, P., & Hauguel-de Mouzon, S. (2003) · Diabetes · doi:10.2337/diabetes.52.12.2951 · Cited by 390

Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity

Alam, M. A., Subhan, N., Hossain, H., Hossain, M., Reza, H. M., Rahman, M., & Ullah, M. O. (2016) · Nutrition & Metabolism · doi:10.1186/s12986-016-0080-3 · Cited by 389

Tumour necrosis factor signalling in health and disease

Holbrook, J. A., Reyna, S. J. L., Jarosz-Griffiths, H., & McDermott, M. (2019) · F1000Research · doi:10.12688/f1000research.17023.1 · Cited by 389

Association of Adiponectin Mutation With Type 2 Diabetes

Kondo, H., Shimomura, I., Matsukawa, Y., Kumada, M., Takahashi, M., Matsuda, M., Ouchi, N., Kihara, S., Kawamoto, T., Sumitsuji, S., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.7.2325 · Cited by 386

Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone

Lagathu, C., Bastard, J.-P., Auclair, M., Maachi, M., Capeau, J., & Caron, M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.013 · Cited by 385

Genomic structure and mutations in adipose-specific gene, adiponectin

Takahashi, M., Arita, Y., Yamagata, K., Matsukawa, Y., Okutomi, K., Horie, M., Shimomura, I., Hotta, K., Kuriyama, H., Kihara, S., et al. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801244 · Cited by 381

Obesity and osteoarthritis, more than just wear and tear: pivotal roles for inflamed adipose tissue and dyslipidaemia in obesity-induced osteoarthritis

Thijssen, E., van Caam, A., & van der Kraan, P. M. (2014) · Rheumatology · doi:10.1093/rheumatology/keu464 · Cited by 379

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

Lehr, S., Hartwig, S., & Sell, H. (2011) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201100052 · Cited by 376

Pathophysiology and Pharmacological Treatment of Insulin Resistance

Matthaei, S., Stümvoll, M., Kellerer, M., & Häring, H. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.6.0413 · Cited by 375

The Role of TNF-α in Insulin Resistance

Borst, S. E. (2004) · Endocrine · doi:10.1385/endo:23:2-3:177 · Cited by 375

C-Reactive Protein as a Predictor for Incident Diabetes Mellitus Among Middle-aged Men

Thorand, B., Löwel, H., Schneider, A. L. C., Kolb, H., Meisinger, C., Fröhlich, M., & Köenig, W. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.1.93 · Cited by 374

Expression of Mfn2, the Charcot-Marie-Tooth Neuropathy Type 2A Gene, in Human Skeletal Muscle

Bach, D., Naon, D., Pich, S., Soriano, F. X., Vega, N., Rieusset, J., Laville, M., Guillet, C., Boirie, Y., Wallberg-Henriksson, H., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2685 · Cited by 369

The complex role of adipokines in obesity, inflammation, and autoimmunity

Taylor, E. B. (2021) · Clinical Science · doi:10.1042/cs20200895 · Cited by 369

Endothelial permeability, LDL deposition, and cardiovascular risk factors—a review

Mundi, S., Massaro, M., Scoditti, E., Carluccio, M. A., van Hinsbergh, V. W. M., Iruela-Arispe, M. L., & De Caterina, R. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvx226 · Cited by 367

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 363

Expression of CD68 and Macrophage Chemoattractant Protein-1 Genes in Human Adipose and Muscle Tissues

Di Gregorio, G. B., Yao-Borengasser, A., Rasouli, N., Varma, V., Lu, T., Miles, L. M., Ranganathan, G., Peterson, C. A., McGehee, R. E., & Kern, P. A. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2305 · Cited by 362

The IRS-Signaling System: A Network of Docking Proteins That Mediate Insulin and Cytokine Action

White, M. F., & Yenush, L. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80481-6_8 · Cited by 362

Dysbiosis of Gut Microbiota [DOGMA]—A novel theory for the development of Polycystic Ovarian Syndrome

Tremellen, K., & Pearce, K. (2012) · Medical Hypotheses · doi:10.1016/j.mehy.2012.04.016 · Cited by 359

Endothelial dysfunction and diabetes: roles of hyperglycemia, impaired insulin signaling and obesity

Bakker, W., Eringa, E. C., Sipkema, P., & van Hinsbergh, V. W. M. (2008) · Cell and Tissue Research · doi:10.1007/s00441-008-0685-6 · Cited by 359

Role of cytokines and chemokines in non-alcoholic fatty liver disease

Braunersreuther, V. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i8.727 · Cited by 359

Blood flow and muscle metabolism: a focus on insulin action

Clark, M. G., Wallis, M. G., Barrett, E. J., Keske, M. A., Richards, S. M., Clerk, L. H., & Rattigan, S. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00408.2002 · Cited by 359

Type 2-diabetes is associated with elevated levels of TNF-alpha, IL-6 and adiponectin and low levels of leptin in a population of Mexican Americans: A cross-sectional study

Mirza, S., Hossain, M., Mathews, C., Martinez, P., Pino, P., Gay, J. L., Rentfro, A., McCormick, J. B., & Fisher-Hoch, S. P. (2012) · Cytokine · doi:10.1016/j.cyto.2011.09.029 · Cited by 358

Adiponectin inhibits LPS-induced NF-κB activation and IL-6 production and increases PPARγ2 expression in adipocytes

Ajuwon, K. M., & Spurlock, M. E. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00397.2004 · Cited by 358

Effects ofLactobacillus acidophilusNCFM on insulin sensitivity and the systemic inflammatory response in human subjects

Andreasen, A. S., Larsen, N., Pedersen-Skovsgaard, T., Berg, R. M. G., Møller, K., Svendsen, K. D., Jakobsen, M., & Pedersen, B. K. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510002874 · Cited by 357

Ganglioside GM3 Participates in the Pathological Conditions of Insulin Resistance

Tagami, S., Inokuchi, J.-I., Kabayama, K., Yoshimura, H., Kitamura, F., Uemura, S., Ogawa, C., Ishii, A., Saito, M., Ohtsuka, Y., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103705200 · Cited by 355

Body Mass and Glucocorticoid Response in Asthma

Sutherland, E. R., Goleva, E., Strand, M. J., Beuther, D. A., & Leung, D. Y. M. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-076oc · Cited by 355

Inflammatory alterations in mesenteric adipose tissue in Crohn's disease

Desreumaux, P., Ernst, O., Geboes, K., Gambiez, L. P., Berrebi, D. D., Müller‐Alouf, H., Hafraoui, S., Émilie, D., Ectors, N., Peuchmaur, M. M., et al. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70552-4 · Cited by 354

Decreased Serum Levels of Adiponectin Are a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population

Daimon, M., Oizumi, T., Saitoh, T., Kameda, W., Hirata, A., Yamaguchi, H., Ohnuma, H., Igarashi, M., Tominaga, M., & Kato, T. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2015 · Cited by 354

Adipose tissue: a regulator of inflammation

Juge-Aubry, C. E., Henrichot, E., & Meier, C. A. (2005) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2005.07.009 · Cited by 353

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

Ma, Y.-Y. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6911 · Cited by 352

Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes

Hotamisligil, G. S. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s73 · Cited by 352

von Willebrand factor, endothelial dysfunction, and cardiovascular disease

Vischer, U. M. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01949.x · Cited by 351

Nonalcoholic Fatty Liver Disease: A Review and Update

Lewis, J. R., & Mohanty, S. R. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1081-0 · Cited by 350

Endocrine Functions of Adipose Tissue

Waki, H., & Tontonoz, P. (2006) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.091859 · Cited by 348

Recent Advances in Our Understanding of Insulin Action and Insulin Resistance

Roith, D. L., & Zick, Y. (2001) · Diabetes Care · doi:10.2337/diacare.24.3.588 · Cited by 347

Metabolic syndrome: from epidemiology to systems biology

Lusis, A. J., Attie, A., & Reue, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2468 · Cited by 345

Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity.

Alessi, M. C., Bastelica, D., Morange, P., Berthet, B., Leduc, I., Verdier, M., Geel, O., & Juhan-Vague, I. (2000) · Diabetes · doi:10.2337/diabetes.49.8.1374 · Cited by 344

Broad spectrum of cytokine abnormalities in panic disorder and posttraumatic stress disorder

Hoge, E. A., Brandstetter, K., Moshier, S., Pollack, M. H., Wong, K. K., & Simon, N. M. (2009) · Depression and Anxiety · doi:10.1002/da.20564 · Cited by 343

The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study

PANAGIOTAKOS, D., PITSAVOS, C., YANNAKOULIA, M., CHRYSOHOOU, C., & STEFANADIS, C. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.010 · Cited by 340

From excess adiposity to insulin resistance: The role of free fatty acids

Capurso, C., & Capurso, A. (2012) · Vascular Pharmacology · doi:10.1016/j.vph.2012.05.003 · Cited by 337

Cardiometabolic Aspects of the Polycystic Ovary Syndrome

Randeva, H. S., Tan, B. K., Weickert, M. O., Lois, K. B., Nestler, J. E., Sattar, N. A., & Lehnert, H. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1003 · Cited by 336

TNF-α and Obesity

Tzanavari, T., Giannogonas, P., & Karalis, K. P. (2010) · Current directions in autoimmunity · doi:10.1159/000289203 · Cited by 333

Reduced physical activity increases intermuscular adipose tissue in healthy young adults

Manini, T. M., Clark, B. C., Nalls, M. A., Goodpaster, B. H., Ploutz-Snyder, L. L., & Harris, T. B. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.377 · Cited by 332

Epicardial and perivascular adipose tissues and their influence on cardiovascular disease: Basic mechanisms and clinical associations

Fitzgibbons, T. P., & Czech, M. P. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000582 · Cited by 331

Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian

Krakoff, J. A., Funahashi, T., Stehouwer, C. D. A., Schalkwijk, C. G., Tanaka, S., Matsuzawa, Y., Kobes, S., Tataranni, P. A., Hanson, R. L., Knowler, W. C., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1745 · Cited by 330

Chronic adipose tissue inflammation: all immune cells on the stage

Cildir, G., Akıncılar, S. C., & Tergaonkar, V. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.001 · Cited by 329

Long-term treatment with interleukin-1β induces insulin resistance in murine and human adipocytes

Lagathu, C., Yvan‐Charvet, L., Bastard, J., Maachi, M., Quignard‐Boulangé, A., Capeau, J., & Caron, M. (2006) · Diabetologia · doi:10.1007/s00125-006-0335-z · Cited by 328

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

Stanley, T. L., Zanni, M. V., Johnsen, S., Rasheed, S., Makimura, H., Lee, H., Khor, V. K., Ahima, R. S., & Grinspoon, S. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1170 · Cited by 328

TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents

Valerio, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28570 · Cited by 327

Adiposity Elevates Plasma MCP-1 Levels Leading to the Increased CD11b-positive Monocytes in Mice

Takahashi, K., Mizuarai, S., Araki, H., Mashiko, S., Ishihara, A., Kanatani, A., Itadani, H., & Kotani, H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m309895200 · Cited by 327

Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues

Dusserre, E., Moulin, P., & Vidal, H. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(99)00091-5 · Cited by 326

Central Obesity and the Aging Brain

Jagust, W. J., Harvey, D. J., Mungas, D., & Haan, M. N. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1545 · Cited by 326

TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation

Velloso, L. A., Folli, F. B., & Saad, M. J. A. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1100 · Cited by 323

Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in diet-induced obese mice

Bradley, R. L., Jeon, J. Y., Liu, F.-F., & Maratos–Flier, E. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00309.2007 · Cited by 323

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

Sun, S., Ji, Y., Kersten, S., & Qi, L. (2012) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 322

Developmental Programming in Response to Maternal Overnutrition

Alfaradhi, M. Z., & Ozanne, S. E. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00027 · Cited by 321

Serum Levels of Tumor Necrosis Factor- Are Increased in Obese Patients with Noninsulin-Dependent Diabetes Mellitus

Katsuki, A., Sumida, Y., Murashima, S., Murata, K., Takarada, Y., Ito, K., Fujii, M., Tsuchihashi, K., Goto, H., Nakatani, K., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4618 · Cited by 321

Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome

Aronson, D., Bartha, P., Zinder, O., Kerner, A., Markiewicz, W., Avizohar, O., Brook, G. J., & Levy, Y. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802609 · Cited by 320

Dietary Combination of Fucoxanthin and Fish Oil Attenuates the Weight Gain of White Adipose Tissue and Decreases Blood Glucose in Obese/Diabetic KK-Ay Mice

Maeda, H., Hosokawa, M., Sashima, T., & Miyashita, K. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071569n · Cited by 319

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00522.2007 · Cited by 317

Elevated Serum C-Reactive Protein Levels and Early Arterial Changes in Healthy Children

Järvisalo, M. J., Harmoinen, A. P. T., Hakanen, M., Paakkunainen, U., Viikari, J. S. A., Hartiala, J., Lehtimäki, T. J., Simell, O., & Raitakari, O. T. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000024222.06463.21 · Cited by 317

Pathophysiological implications of insulin resistance on vascular endothelial function

Wheatcroft, S. B., Williams, I. L., Shah, A. M., & Kearney, M. T. (2003) · Diabetic Medicine · doi:10.1046/j.1464-5491.2003.00869.x · Cited by 316

Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.

Peraldi, P., Xu, M., & Spiegelman, B. M. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119715 · Cited by 315

The impact of aging on adipose function and adipokine synthesis

Mancuso, P., & Bouchard, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00137 · Cited by 314

MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice

Ying, W., Gao, H., Reis, F. C. G., Bandyopadhyay, G. K., Ofrecio, J. M., Luo, Z., Ji, Y., Jin, Z., Ly, C., & Olefsky, J. M. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.019 · Cited by 311

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

Timpson, N. J., Nordestgaard, B. G., Harbord, R. M., Zacho, J., Frayling, T. M., Tybjærg-Hansen, A., & Davey Smith, G. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.137 · Cited by 310

Plasma concentration of C-reactive protein is increased in Type I diabetic patients without clinical macroangiopathy and correlates with markers of endothelial dysfunction: evidence for chronic inflammation

Schalkwijk, C., Poland, D. C. W., van Dijk, W., Kok, A., EMEIS, J. J., Dräger, A. M., Doni, A., van Hinsbergh, V. W. M., & Stehouwer, C. D. A. (1999) · Diabetologia · doi:10.1007/s001250051162 · Cited by 310

The role of low-grade inflammation in the polycystic ovary syndrome

Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 310

Inflammatory Process in Type 2 Diabetes: The Role of Cytokines

ALEXANDRAKI, K., PIPERI, C., KALOFOUTIS, C., SINGH, J., ALAVERAS, A., & KALOFOUTIS, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1372.039 · Cited by 309

Rimonabant reduces obesity-associated hepatic steatosis and features of metabolic syndrome in obese Zucker fa/fa rats

Gary‐Bobo, M., Elachouri, G., Gallas, J., Janiak, P., Marini, P., Ravinet‐Trillou, C., Chabbert, M., Cruccioli, N., Pfersdorff, C., Roque, C., et al. (2007) · Hepatology · doi:10.1002/hep.21641 · Cited by 309

Leptin revisited: its mechanism of action and potential for treating diabetes

Coppari, R., & Bjørbæk, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3757 · Cited by 308

The Roles of Adipokines, Proinflammatory Cytokines, and Adipose Tissue Macrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction

Kang, Y. E., Kim, J. M., Joung, K. H., Lee, J. H., You, B. R., Choi, M. J., Ryu, M. J., Ko, Y. B., Lee, M. A., Lee, J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154003 · Cited by 306

Profiling Gene Transcription In Vivo Reveals Adipose Tissue as an Immediate Target of Tumor Necrosis Factor-α

Ruan, H., Miles, P. D. G., Ladd, C. M., Ross, K. N., Golub, T. R., Olefsky, J. M., & Lodish, H. F. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3176 · Cited by 305

Elevated Expression of Transforming Growth Factor-β in Adipose Tissue from Obese Mice

Samad, F., Yamamoto, K., Pandey, M., & Loskutoff, D. J. (1997) · Molecular Medicine · doi:10.1007/bf03401666 · Cited by 303

Obesity and the lung: 5 {middle dot} Obesity and COPD

Franssen, F. M. E., O'Donnell, D. E., Goossens, G. H., Blaak, E. E., & Schols, A. M. W. J. (2008) · Thorax · doi:10.1136/thx.2007.086827 · Cited by 303

Insulin Sensitivity, Insulin Secretion, and Abdominal Fat

Wagenknecht, L. E., Langefeld, C. D., Scherzinger, A. L., Norris, J. M., Haffner, S. M., Saad, M. F., & Bergman, R. N. (2003) · Diabetes · doi:10.2337/diabetes.52.10.2490 · Cited by 302

Effect of Probiotic (VSL#3) and Omega-3 on Lipid Profile, Insulin Sensitivity, Inflammatory Markers, and Gut Colonization in Overweight Adults: A Randomized, Controlled Trial

Rajkumar, H., Mahmood, N., Kumar, M., Varikuti, S. R., Challa, H. R., & Myakala, S. P. (2014) · Mediators of Inflammation · doi:10.1155/2014/348959 · Cited by 301

Bariatric surgery for non-alcoholic steatohepatitis in obese patients

Chávez-Tapia, N. C., Téllez-Ávila, F. I., Barrientos‐Gutiérrez, T., Méndez‐Sánchez, N., Lizardi-Cervera, J., & Uribe, M. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007340.pub2 · Cited by 301

Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men

Bruun, J. M., Verdich, C., Toubro, S., Astrup, A. V., & Richelsen, B. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480535 · Cited by 301

Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide.

Samad, F., Yamamoto, K., & Loskutoff, D. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118404 · Cited by 301

Role of NF-κB in the pathogenesis of diabetes and its associated complications

Patel, S., & Santani, D. D. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70111-2 · Cited by 300

Role for TNF in atherosclerosis? Lessons from autoimmune disease

McKellar, G., McCarey, D. W., Sattar, N. A., & McInnes, I. B. (2009) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.57 · Cited by 299

Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications

Pillon, N. J., Bilan, P. J., Fink, L. N., & Klip, A. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2012 · Cited by 299

Metabolism of lipids in human white adipocyte

Large, V., Peroni, O. D., Letexier, D., Ray, H., & Beylot, M. (2004) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70121-0 · Cited by 298

Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity

Law, I. K. M., Xu, A., Lam, K. S. L., Berger, T., Mak, T. W., Vanhoutte, P. M., Liu, J. T. C., Sweeney, G., Zhou, M., Yang, B., et al. (2010) · Diabetes · doi:10.2337/db09-1541 · Cited by 297

Interactions between inflammation and lipid metabolism: Relevance for efficacy of anti-inflammatory drugs in the treatment of atherosclerosis

van Diepen, J. A., Berbée, J. F. P., Havekes, L. M., & Rensen, P. C. N. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.02.028 · Cited by 297

Activins and Inhibins: Roles in Development, Physiology, and Disease

Namwanje, M., & Brown, C. W. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021881 · Cited by 294

Analysis of an expression profile of genes in the human adipose tissue

Maeda, K., Okubo, K., Shimomura, I., Mizuno, K., Matsuzawa, Y., & Matsubara, K. (1997) · Gene · doi:10.1016/s0378-1119(96)00730-5 · Cited by 294

Differential Regulation of the p80 Tumor Necrosis Factor Receptor in Human Obesity and Insulin Resistance

Hotamışlıgil, G. S., Arner, P., Atkinson, R. L., & Spiegelman, B. M. (1997) · Diabetes · doi:10.2337/diab.46.3.451 · Cited by 209

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Expression of Tumor Necrosis Factor-α Gene in Omental Adipose Tissue of Obesity and Insulin Resistance Patients

Li, L. (2001) · Fujian Yike Daxue xuebao

The study on the mRNA expressions of adiponectin and tumor necrosis factor alphal and on their relation with insulin resistance in omental adipose tissue of obese subjects

Heng-jie, H. (2008) · Zhongguo tangniaobing zazhi

Tumor necrosis factor-α as a mediator of the insulin resistance of obesity

Rosen, E. D., & Spiegelman, B. M. (1999) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-199904000-00014 · Cited by 14