Cited by 3,543Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

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Hotamisligil, G S, Arner, P, Caro, J F, Atkinson, R L, Spiegelman, B M·1995·Journal of Clinical Investigation

DOI 10.1172/jci117936PMC PMC295872

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Abstract

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis. Recent studies in animal models have indicated that TNF-alpha plays an important role in mediating the insulin resistance of obesity through its overexpression in fat tissue. However, the mechanisms linking obesity to insulin resistance and diabetes in humans remain largely unknown. In this study we examined the expression pattern of TNF-alpha mRNA in adipose tissues from 18 control and 19 obese premenopausal women by Northern blot analysis. TNF-alpha protein concentrations in plasma and in conditioned medium of explanted adipose tissue were measured by ELISA. Furthermore, the effects of weight reduction by dietary treatment of obesity on the adipose expression of TNF-alpha mRNA were also analyzed in nine premenopausal obese women, before and after a controlled weight-reduction program. These studies demonstrated that obese individuals express 2.5-fold more TNF-alpha mRNA in fat tissue relative to the lean controls (P < 0.001). Similar increases were also observed in adipose production of TNF-alpha protein but circulating TNF-alpha levels were extremely low or undetectable. A strong positive correlation was observed between TNF-alpha mRNA expression levels in fat tissue and the level of hyperinsulinemia (P < 0.001), an indirect measure of insulin resistance. Finally, body weight reduction in obese subjects which resulted in improved insulin sensitivity was also associated with a decrease in TNF-alpha mRNA expression (45%, P < 0.001) in fat tissue. These results suggest a role for the abnormal regulation of this cytokine in the pathogenesis of obesity-related insulin resistance.

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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
Chirgwin, J. M., Przybyla, A., MacDonald, R. J., & Rutter, W. J. (1979) · Biochemistry · doi:10.1021/bi00591a005 · Cited by 21,460
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Self-citation
Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,463
Tumor Necrosis Factor (TNF)
Old, L. J. (1985) · Science · doi:10.1126/science.2413547 · Cited by 1,885
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,732
The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response
Beutler, B., & Cerami, A. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.003205 · Cited by 1,690
Tumor Necrosis Factor α: A Key Component of the Obesity-Diabetes Link
Hotamışlıgil, G. S., & Spiegelman, B. M. (1994) · Diabetes · doi:10.2337/diab.43.11.1271 · Cited by 1,353
Self-citation
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Self-citation
Improvement in Glucose Tolerance and Insulin Resistance in Obese Subjects Treated with Troglitazone
Nolan, J. J., Ludvik, B. H., Beerdsen, P., Joyce, M., & Olefsky, J. M. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411033311803 · Cited by 914
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha.
Hotamisligil, G. S., Budavari, A., Murray, D., & Spiegelman, B. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117495 · Cited by 819
Self-citation

Show all 28 references

Research works printed but not linked: 2

Hotamisligil, G. S., D. L. Murray, L. N. Choy, and B. M. Spiegelman. 1994. TNF-a inhibits signaling from insulin receptor. Proc. Natl. Acado Sci. USA. 91:4854-4858.
Bjorntorp, P. 1992. Regional Obesity. In Obesity. P. Bjorntorp and B. D. Brodoff, editors. J. B. Lippincott. Philadelphia. 579-586.

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Genetics of the metabolic syndrome
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Gao, Z., Zuberi, A. R., Quon, M. J., Dong, Z., & Ye, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300423200 · Cited by 262
Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training
Nicklas, B. J. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.1040769 · Cited by 259
Inflammation and Endometrial Cancer: A Hypothesis
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Association Between Elevated Liver Enzymes and C-Reactive Protein
Kerner, A., Avizohar, O., Sella, R., Bartha, P., Zinder, O., Markiewicz, W., Levy, Y., Brook, G. J., & Aronson, D. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000148324.63685.6a · Cited by 257
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Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects
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Obesity and Insulin Resistance
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Role of oxidative stress and antioxidants in daily nutrition and human health
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Frost, G. S., Leeds, A., Trew, G. H., Margara, R. A., & Dornhorst, A. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90331-6 · Cited by 241
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c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor- 1 and Negatively Regulates Its Transcriptional Activity
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Authors: Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M.
Affiliations: Dana-Farber Cancer Institute (US)
Corresponding author: Spiegelman, B M
ORCID: Arner, P
Atkinson, R L
Spiegelman, B M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1995-05-01
Volume: 95
Issue: 5
Pages: 2409-2415
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117936
PMC: PMC295872
OpenAlex: W1974033843
Cited by: 3,543
References: 28
Citations by year: 2026: 46 · 2025: 67 · 2024: 73 · 2023: 91 · 2022: 100 · 2021: 110 · 2020: 91 · 2019: 130 · 2018: 141 · 2017: 127 · 2016: 123 · 2015: 149 · 2014: 178 · 2013: 183 · 2012: 172
FWCI: 41.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Diabetes Association
National Institutes of Health (5r01dk042539-08, 5r01dk045592-05)
Medical Research Council
National Institute of Diabetes and Digestive and Kidney Diseases (DK 45592, DK42539)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: TNF-α, obesity, insulin resistance, adipose tissue, TNF-alpha mRNA expression, hyperinsulinemia, weight loss, premenopausal women, adipokines
MeSH terms: Adipose Tissue, Adult, Blood Glucose, Cholesterol, Female, Humans, Insulin, Insulin Resistance, Middle Aged, Obesity, Reference Values, Regression Analysis, RNA, Messenger, Thinness, Triglycerides, Tumor Necrosis Factor-alpha, Blotting, Northern, Gene Expression, Body Mass Index, Premenopause

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Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

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