Plasma Interleukin-8 Concentrations Are Increased in Obese Subjects and Related to Fat Mass and Tumor Necrosis Factor-α System
Abstract
Obesity is associated with the increased risk of cardiovascular disease; however, mechanisms responsible for such an increase are not fully understood. IL-8 is a cytokine that might have atherogenic properties. Recent in vitro studies revealed that IL-8 is produced and secreted by human adipocytes. The aim of the present study was to evaluate plasma IL-8 concentrations in obese subjects and the relationships between circulating IL-8 and anthropometric and biochemical parameters and TNF-alpha system. A total of 75 subjects with normal glucose tolerance, 35 lean and 40 obese, were recruited for this study. Plasma IL-8 levels were measured in fasting state, after an oral glucose tolerance test and after the euglycemic hyperinsulinemic clamp. A significant increase in plasma IL-8 was observed in the obese group. In simple regression analysis, performed for the initial evaluation of relationships, plasma IL-8 was related to body mass index, percentage of body fat, fat mass (FM), and soluble TNF-alpha receptor 2 (sTNFR2) in both groups and with waist-to-hip ratio and sTNFR1 in the obese. In multiple regression analysis, FM, waist-to-hip ratio, gender, sTNFR2, and low density lipoprotein cholesterol were responsible for 44% of IL-8 variability. During oral glucose tolerance testing, mean plasma IL-8 concentrations increased in both groups, whereas clamp resulted in a significant increase in plasma IL-8 only in the obese. We conclude that plasma IL-8 levels are increased in obese subjects, and are related to FM and TNF-alpha system. Increase in circulating IL-8 might be one of the factors linking obesity with greater cardiovascular risk.
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Dietary intake of linoleic acid is not associated with CRP, IL-6, sTNFR1 or sTNFR2 concentrations in subgroups of the Physicians' Health Study and Nurses' Health Study.
“Dietary intakes of linoleic acid were not associated with CRP, IL-6, sTNFR1 or sTNFR2 concentrations in subgroups of the Physicians' Health Study and the Nurses' Health Study (583)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [583]
Dietary alpha-linolenic acid intake is not associated with CRP, IL-6, sTNFR1 or sTNFR2 concentrations in one study on subgroups of the Physicians' Health Study and Nurses' Health Study.
“Dietary a-linolenic acid intakes were not associated with CRP, IL-6, sTNFR1 or sTNFR2 concentrations in one study on subgroups of the Physicians' Health Study and the Nurses' Health Study (583)”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [583]
Dietary intake of EPA+DHA is inversely associated with CRP, sTNFR1 and sTNFR2 concentrations in subgroups of the Physicians' Health Study and Nurses' Health Study.
“Data from subgroups of the Physicians' Health Study and the Nurses' Health Study showed inverse associations between the dietary intake of EPA þ DHA and concentrations of CRP, sTNFR1 and sTNFR2 (583) , and CRP, sICAM-1, sVCAM-1 and sE-selectin (373) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [583]
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- Authors
- Straczkowski, M., Dzienis-Straczkowska, S., Stêpieñ, A., Kowalska, I., Szelachowska, M., & Kinalska, I.
- Affiliations
- Medical University of Białystok (PL)
- ORCID
- Kowalska, Irina
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2002-10
- Volume
- 87
- Issue
- 10
- Pages
- 4602-4606
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1979454503
- Cited by
- 280
- References
- 27
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 17 · 2023: 13 · 2022: 21 · 2021: 16 · 2020: 11 · 2019: 10 · 2018: 9 · 2017: 10 · 2016: 5 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 20
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- interleukin-8, obesity, adipose tissue, TNF-α, soluble TNF receptor 2, soluble TNF receptor 1, fat mass, waist-to-hip ratio, cardiovascular risk, adipocytes, insulin resistance, LDL cholesterol
- MeSH terms
- Adipose Tissue, Adult, Body Composition, Body Constitution, Cardiovascular Diseases, Female, Glucose Tolerance Test, Humans, Insulin, Cholesterol, LDL, Male, Middle Aged, Obesity, Regression Analysis, Risk Factors, Sex Characteristics, Tumor Necrosis Factor-alpha, Glucose Clamp Technique, Antigens, CD, Body Mass Index, Interleukin-8, Receptors, Tumor Necrosis Factor, Receptors, Tumor Necrosis Factor, Type I, Receptors, Tumor Necrosis Factor, Type II
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