Simultaneous stimulation of slow-wave sleep and growth hormone secretion by gamma-hydroxybutyrate in normal young Men.
Open accessAbstract
The aim of this study was to investigate, in normal young men, whether gamma-hydroxybutyrate (GHB), a reliable stimulant of slow-wave (SW) sleep in normal subjects, would simultaneously enhance sleep related growth hormone (GH) secretion.Eight healthy young men participated each in four experiments involving bedtime oral administration of placebo, 2.5, 3.0, and 3.5 g of GHB.Polygraphic sleep recordings were performed every night, and blood samples were obtained at 15-min intervals from 2000 to 0800.GHB effects were mainly observed during the first 2 h after sleep onset.There was a doubling of GH secretion, resulting from an increase of the amplitude and the duration of the first GH pulse after sleep onset.This stimulation of GH secretion was significantly correlated to a simultaneous increase in the amount of sleep stage IV.Abrupt but transient elevations of prolactin and cortisol were also observed, but did not appear to be associated with the concomitant stimulation of SW sleep.Thyrotropin and melatonin profiles were not altered by GHB administration.These data suggest that pharmacological agents that reliably stimulate SW sleep, such as GHB, may represent a novel class of powerful GH secretagogues.( J. Clin.Invest.1997.100:745-753.)Key words: cortisol • prolactin • delta waves • aging • growth hormone-releasing hormone (GHRH) Methods SubjectsEight healthy nonobese young men (age: 26 Ϯ 2 yr; body mass index (BMI): 23.5 Ϯ 0.7 kg/m 2 ; mean Ϯ SEM) were included in the study after
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Growth hormone levels were lower in slow-wave-sleep-deprived individuals and higher in individuals with pharmacologically induced slow-wave sleep.
“GH levels were lower in SWS-deprived individuals50 and higher in individuals with pharmacologically induced SWS.51”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [51]
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- Authors
- Van Cauter, E., Plat, L., Scharf, M. B., Leproult, R., Cespedes, S., L'Hermite-Balériaux, M., & Copinschi, G.
- Affiliations
- Université Libre de Bruxelles (BE)
- University of Chicago (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1997-08-01
- Volume
- 100
- Issue
- 3
- Pages
- 745-753
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508244
- OpenAlex
- W2094746288
- Cited by
- 234
- References
- 64
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 1 · 2022: 6 · 2021: 4 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 11 · 2014: 16 · 2013: 10 · 2012: 10
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- John D. and Catherine T. MacArthur Foundation
- University of Chicago
- National Institutes of Health
- National Institute on Aging (P01AG011412, AG-11412)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-41814, R01DK041814)
- National Center for Research Resources (RR-00055)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- gamma-hydroxybutyric acid, slow-wave sleep, growth hormone secretion, prolactin, cortisol, delta oscillations, growth hormone secretagogues, young men
- MeSH terms
- Administration, Oral, Adult, Humans, Male, Melatonin, Sleep, Sodium Oxybate, Thyrotropin, Human Growth Hormone
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