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CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism
Open accessAbstract
Multiligand receptorsCD36, identified more than a quarter of a century ago as a platelet integral membrane glycoprotein (glycoprotein IV), was until recently best known as a receptor for thrombospondin-1 (TSP-1).TSP-1 is found in ECMs and platelet α granules, and it participates in cell attachment, motility, and proliferation, as well as in modulation of protease activity, TGF-β activation, neurite outgrowth, and angiogenesis (1).Initially, this receptor-ligand pair was shown to mediate interactions between platelets and monocytes, tumor cells, and matrix.Since then, CD36 has been implicated in multiple biological processes that define it as a multiligand scavenger receptor (see ref.2 for review).These ligands appear remarkably diverse: In addition to TSP-1, they include long-chain fatty acids, modified LDL, retinal photoreceptor outer segments, Plasmodium falciparum malaria-parasitized erythrocytes, sickle erythrocytes, anionic phospholipids, apoptotic cells, and collagens I and IV.The biology of CD36 can be broadly divided in terms of functions that it mediates with or without TSP-1, but it is probable that it acts in concert with other proteins, such as fatty acid-binding proteins, caveola-associated proteins, integrins, cytoskeletal proteins, and signaling molecules, to effect its diverse functions.
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Metadata
- Authors
- Febbraio, M., Hajjar, D. P., & Silverstein, R. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-09-15
- Volume
- 108
- Issue
- 6
- Pages
- 785-791
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2128594838
- Cited by
- 1,193
- References
- 1
- FWCI
- 13.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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