Recent endemic coronavirus infection is associated with less severe COVID-19
Open accessAbstract
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.
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Epidemiological evidence from a large cohort supports the possibility of some degree of pre-existing immunity.
“Epidemiological evidence from a large cohort now supports the possibility of some degree of pre-existing immunity (Sagar et al., 2021).”
From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Sagar et al., 2021
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Mechanistic Insights Into the Immune Pathophysiology of COVID-19; An In-Depth Review
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The Integrated Pulmonary Immune Response to Pneumonia
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- Authors
- Sagar, M., Reifler, K., Rossi, M., Miller, N. S., Sinha, P., White, L. F., & Mizgerd, J. P.
- Affiliations
- Boston University (US)
- Corresponding author
- Sagar, Manish
- Mizgerd, Joseph P.
- Venue
- Journal of Clinical Investigation
- Published
- 2021-01-04
- Volume
- 131
- Issue
- 1
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7773342
- OpenAlex
- W3090049663
- Cited by
- 324
- References
- 20
- Citations by year
- 2026: 13 · 2025: 28 · 2024: 32 · 2023: 59 · 2022: 77 · 2021: 109 · 2020: 6
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (HL-135756, AI-145661, AI-052074, GM-122876)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- endemic coronaviruses, SARS-CoV-2, COVID-19 severity, pre-existing immunity, cross-protection, common cold, immune response
- MeSH terms
- COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Female, Humans, Male, Middle Aged, Severity of Illness Index
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