Cited by 324SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesRespiratory viral infections research

Recent endemic coronavirus infection is associated with less severe COVID-19

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Sagar, Manish, Reifler, Katherine, Rossi, Michael, Miller, Nancy S., Sinha, Pranay, White, Laura F., Mizgerd, Joseph P.·2021·Journal of Clinical Investigation

Abstract

Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.

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  • Epidemiological evidence from a large cohort supports the possibility of some degree of pre-existing immunity.

    “Epidemiological evidence from a large cohort now supports the possibility of some degree of pre-existing immunity (Sagar et al., 2021).”

    From Adaptive immunity to SARS-CoV-2 and COVID-19 (2021) · cites this paper as Sagar et al., 2021

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Authors
Sagar, M., Reifler, K., Rossi, M., Miller, N. S., Sinha, P., White, L. F., & Mizgerd, J. P.
Affiliations
Boston University (US)
Corresponding author
  • Sagar, Manish
  • Mizgerd, Joseph P.
Venue
Journal of Clinical Investigation
Published
2021-01-04
Volume
131
Issue
1
ISSN
  • 0021-9738 (ISSN-L)
  • 1558-8238
OpenAlex
W3090049663
Cited by
324
References
20
Citations by year
2026: 13 · 2025: 28 · 2024: 32 · 2023: 59 · 2022: 77 · 2021: 109 · 2020: 6
FWCI
8.19
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (HL-135756, AI-145661, AI-052074, GM-122876)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
endemic coronaviruses, SARS-CoV-2, COVID-19 severity, pre-existing immunity, cross-protection, common cold, immune response
MeSH terms
COVID-19, SARS-CoV-2, Adult, Aged, Antibodies, Viral, Female, Humans, Male, Middle Aged, Severity of Illness Index

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