Molecular mediators of hepatic steatosis and liver injury

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Nonalcoholic Fatty Liver Disease

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Comparative Nontargeted Profiling of Metabolic Changes in Tissues and Biofluids in High-Fat Diet-Fed Ossabaw Pig

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Resistance to Diet-Induced Obesity in Mice with Synthetic Glyoxylate Shunt

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Dual-Emissive Detection of ATP and Hypochlorite Ions for Monitoring Inflammation-Driven Liver Injury In Vitro and In Vivo

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Is the control of dietary cholesterol intake sufficiently effective to ameliorate nonalcoholic fatty liver disease?

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Update on Ppar and Nonalcoholic Fatty Liver Disease

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Polydatin alleviates non-alcoholic fatty liver disease in rats by inhibiting the expression of TNF-α and SREBP-1c

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Treatment of Atherogenic Liver Based on the Pathogenesis of Nonalcoholic Fatty Liver Disease: A Novel Approach to Reduce Cardiovascular Risk?

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Regulation of synthesis and oxidation of fatty acids by adiponectin receptors (AdipoR1/R2) and insulin receptor substrate isoforms (IRS-1/-2) of the liver in a nonalcoholic steatohepatitis animal model

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Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice

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Response of fibroblast growth factor 19 and bile acid synthesis after a body weight-adjusted oral fat tolerance test in overweight and obese NAFLD patients: a non-randomized controlled pilot trial

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Studying non-alcoholic fatty liver disease: the ins and outs of in vivo, ex vivo and in vitro human models

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MicroRNAs as a Novel Tool in the Diagnosis of Liver Lipid Dysregulation and Fatty Liver Disease

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Relationship between Changes in Microbiota and Liver Steatosis Induced by High-Fat Feeding—A Review of Rodent Models

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Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC–ERK1/2–AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet

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Role of the Sterol Regulatory Element Binding Protein Pathway in Tumorigenesis

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A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae

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Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

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RNA helicase DEAD‐box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling

Zhang, Y., Ye, S., Lu, W.-J., Zhong, J., Leng, Y., Yang, T., Luo, J., Xu, W., Zhang, H., & Kong, L. (2022) · Hepatology · doi:10.1002/hep.32651 · Cited by 40

Toxic effects of polystyrene microplastics on the intestine of Amphioctopus fangsiao (Mollusca: Cephalopoda): From physiological responses to underlying molecular mechanisms

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Chromium attenuates high-fat diet-induced nonalcoholic fatty liver disease in KK/HlJ mice

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Clusterin Decreases Hepatic SREBP-1c Expression and Lipid Accumulation

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Lecithin/cholesterol acyltransferase modulates diet-induced hepatic deposition of triglycerides in mice

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Overweight induced by chronic risperidone exposure is correlated with overexpression of the SREBP-1c and FAS genes in mouse liver

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GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway

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Perfluorohexanesulfonic Acid (PFHxS) Induces Hepatotoxicity through the PPAR Signaling Pathway in Larval Zebrafish ( Danio rerio )

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A Combination of (ω–3) Polyunsaturated Fatty Acids, Polyphenols and L-Carnitine Reduces the Plasma Lipid Levels and Increases the Expression of Genes Involved in Fatty Acid Oxidation in Human Peripheral Blood Mononuclear Cells and HepG2 Cells

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Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity

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Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats

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New understanding of Angelica sinensis polysaccharide improving fatty liver: The dual inhibition of lipid synthesis and CD36-mediated lipid uptake and the regulation of alcohol metabolism

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Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights

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Overindulgence and metabolic syndrome: is FoxO1 a missing link?

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Fat and carbohydrate in western diet contribute differently to hepatic lipid accumulation

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Group IVA phospholipase A 2 participates in the progression of hepatic fibrosis

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Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases

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Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance

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Melatonin prevents chronic intermittent hypoxia-induced injury by inducing sirtuin 1-mediated autophagy in steatotic liver of mice

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Anthocyanins from Cornus kousa ethanolic extract attenuate obesity in association with anti-angiogenic activities in 3T3-L1 cells by down-regulating adipogeneses and lipogenesis

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Implantable Vascularized Liver Chip for Cross‐Validation of Disease Treatment with Animal Model

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The Associations between Liver Enzymes and Cardiovascular Risk Factors in Adults with Mild Dyslipidemia

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α-Linolenic Acid-Enriched Cold-Pressed Perilla Oil Suppress High-Fat Diet-Induced Hepatic Steatosis through Amelioration of the ER Stress-Mediated Autophagy

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Selenoprotein F knockout leads to glucose and lipid metabolism disorders in mice

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Cannabinoid receptor 1 signaling in hepatocytes and stellate cells does not contribute to NAFLD

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CD38 Deficiency Protects Mice from High Fat Diet-Induced Nonalcoholic Fatty Liver Disease through Activating NAD+/Sirtuins Signaling Pathways-Mediated Inhibition of Lipid Accumulation and Oxidative Stress in Hepatocytes

Xie, L. Y., Wen, K., Li, Q., Huang, C., Zhao, J.-L., Zhao, Q., Xiao, Y., Guan, X., Qian, Y., Gan, L., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.65588 · Cited by 38

Amelioration of nonalcoholic fatty liver disease by hepatic stimulator substance via preservation of carnitine palmitoyl transferase-1 activity

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The Use of Fish Oil Lipid Emulsion in the Treatment of Intestinal Failure Associated Liver Disease (IFALD)

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Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein KinaseIn VivoandIn Vitro

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Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy

Eguchi, A., & Feldstein, A. E. (2013) · Adipocyte · doi:10.4161/adip.24144 · Cited by 38

Atherogenic dyslipidemia and cardiovascular risk in children with nonalcoholic fatty liver disease

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Açai (Euterpe oleracea Mart.) Upregulates Paraoxonase 1 Gene Expression and Activity with Concomitant Reduction of Hepatic Steatosis in High‐Fat Diet‐Fed Rats

Pereira, R. R., de Abreu, I. C. M. E., Guerra, J. F. D. C., Lage, N. N., Lopes, J. M. M., Silva, M. A., de Lima, W. G., Silva, M. E., & Pedrosa, M. L. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8379105 · Cited by 38

Oat β-glucan inhibits adipogenesis and hepatic steatosis in high fat diet-induced hyperlipidemic mice via AMPK signaling

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Short-term inhibition of peroxisome proliferator-activated receptor-γ coactivator-1α expression reverses diet-induced diabetes mellitus and hepatic steatosis in mice

de Souza, C. T., ARAUJO, E. P. D., Prada, P. O., Saad, M. J. A., Boschero, A. C., & Velloso, L. A. (2005) · Diabetologia · doi:10.1007/s00125-005-1866-4 · Cited by 38

A Protective Role for CD154 in Hepatic Steatosis in Mice

Villeneuve, J., Lepreux, S., Mulot, A., Bérard, A. M., Higa-Nishiyama, A., Costet, P., de Lédinghen, V., Bioulac‐Sage, P., Balabaud, C. P., Nurden, A. T., et al. (2010) · Hepatology · doi:10.1002/hep.23935 · Cited by 38

UVA photoirradiation of benzo[ a ]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation

Xia, Q., Chiang, H., Yin, J., Chen, S., Cai, L., Yu, H., & Fu, P. P. (2013) · Toxicology and Industrial Health · doi:10.1177/0748233713484648 · Cited by 37

Síndrome metabólica em crianças e adolescentes: dúvidas na terminologia, mas não nos riscos cardiometabólicos

Damiani, D., Kuba, V. M., Cominato, L., Damiani, D., Dichtchekenian, V., & Filho, H. C. D. M. (2011) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302011000800011 · Cited by 37

Tacrine, an Oral Acetylcholinesterase Inhibitor, Induced Hepatic Oxidative Damage, Which Was Blocked by Liquiritigenin through GSK3-beta Inhibition

Park, S. M., Ki, S. H., Han, N. R., Cho, I. J., Ku, S., Kim, S. C., Zhao, R., & Kim, Y. W. (2015) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b14-00430 · Cited by 38

Multidisciplinary Pharmacotherapeutic Options for Nonalcoholic Fatty Liver Disease

Nakajima, K. (2012) · International Journal of Hepatology · doi:10.1155/2012/950693 · Cited by 37

Biogenesis of apolipoprotein A-V and its impact on VLDL triglyceride secretion

Blade, A. M., Fabritius, M. A., Hou, L., Weinberg, R. B., & Shelness, G. S. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m010793 · Cited by 37

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation

Li, X.-X., Lu, X.-Y., Zhang, S., Chiu, A. P., Lo, L. H., Largaespada, D. A., Chen, Q.-B., & Keng, V. W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.019 · Cited by 37

CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress

Lee, S. J., Kang, J. S., Kim, H. M., Lee, E. Y., Lee, J.-H., Chung, C. H., & Lee, E. Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222352 · Cited by 37

Dairy Foods and Dairy Fats: New Perspectives on Pathways Implicated in Cardiometabolic Health

Hirahatake, K. M., Bruno, R. S., Bolling, B. W., Blesso, C. N., Alexander, L. M., & Adams, S. H. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz105 · Cited by 37

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Wattacheril, J. J. (2019) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2019.10.002 · Cited by 37

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis

Matsumoto, M., Yashiro, H., Ogino, H., Aoyama, K., Nambu, T., Nakamura, S., Nishida, M., Wang, X., Erion, D. M., & Kaneko, M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228212 · Cited by 37

CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis

Yu, L., Li, Y., Grisé, A., & Wang, H. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-6082-8_13 · Cited by 39

Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

Barchetta, I., Ceccarelli, V., Cimini, F. A., Barone, E., Sentinelli, F., Coluzzi, M., Chiappetta, C., Bertoccini, L., Tramutola, A., Labbadia, G., et al. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01392-5 · Cited by 37

Comparative study of dietary fat: lard and sugar as a better obesity and metabolic syndrome mice model

Guimarães, V. H. D., Lelis, D. D. F., Oliveira, L. P., Borém, L. M. A., Guimarães, F. A. D., Farias, L. C., de Paula, A. M. B., Guimarães, A. L. S., & Santos, S. H. S. (2020) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2020.1835986 · Cited by 37

Artemisia capillaris Inhibits Lipid Accumulation in 3T3-L1 Adipocytes and Obesity in C57BL/6J Mice Fed a High Fat Diet

Hong, J.-H., Hwang, E.-Y., Kim, H. J., Jeong, Y., & Lee, I. S. (2009) · Journal of Medicinal Food · doi:10.1089/jmf.2008.1240 · Cited by 37

Use of three‐dimensional spheroids of hepatocyte‐derived reporter cells to study the effects of intracellular fat accumulation and subsequent cytokine exposure

Janorkar, A. V., Harris, L. M., Murphey, B., & Sowell, B. L. (2010) · Biotechnology and Bioengineering · doi:10.1002/bit.23025 · Cited by 37

Hepatic Differentiated Embryo-Chondrocyte-expressed Gene 1 (Dec1) Inhibits Sterol Regulatory Element-binding Protein-1c (Srebp-1c) Expression and Alleviates Fatty Liver Phenotype

Shen, L., Cui, A., Xue, Y., Cui, Y., Dong, X., Gao, Y., Yang, H., Fang, F., & Chang, Y. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.526343 · Cited by 37

Effect of Pancreaticoduodenectomy on the Course of Hepatic Steatosis

Yu, H., Shan, Y., & Lin, P. (2010) · World Journal of Surgery · doi:10.1007/s00268-010-0636-8 · Cited by 37

Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease

Krautbauer, S., Eisinger, K., Lupke, M., Wanninger, J., Ruemmele, P., Hader, Y., Weiß, T. S., & Buechler, C. (2013) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2013.10.003 · Cited by 37

Obesity-Associated Hepatosteatosis and Impairment of Glucose Homeostasis Are Attenuated by Haptoglobin Deficiency

Lisi, S., Gamucci, O., Vottari, T., Scabia, G., Funicello, M., Marchi, M., Galli, G., Arisi, I., Brandi, R., D’Onofrio, M., et al. (2011) · Diabetes · doi:10.2337/db10-1536 · Cited by 37

Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice

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Effects of Sex, Drinking History, and Omega‐3 and Omega‐6 Fatty Acids Dysregulation on the Onset of Liver Injury in Very Heavy Drinking Alcohol‐Dependent Patients

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