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Molecular mediators of hepatic steatosis and liver injury
Open accessAbstract
Nonstandard abbreviations used: acetyl-CoA carboxylase (ACC); AMP-activated protein kinase (AMPK); basic helix-loop-helix-leucine zipper (bHLH-Zip); carbohydrate response element binding protein (ChREBP); carnitine palmitoyl transferase-1 (CPT-1); diethylaminoethoxyhexestrol (DEAEH); liver function test (LFT); liver-type pyruvate kinase (L-PK); malondialdehyde (MDA); mitochondrial respiratory chain (MRC); nonalcoholic fatty-liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); polyunsaturated fatty acid (PUFA); reactive oxygen species (ROS); stearoyl-CoA desaturase (SCD); trans-4-hydroxy-2-nonenal (HNE). Conflict of interest:The authors have declared that no conflict of interest exists.
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“Ectopic triglycerides usually signify the presence of long-chain free fatty acids, which are cytotoxic (15,16) and believed to interfere with normal insulin signaling leading to insulin resistance.”
From Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy (2005) · cites this paper as [16]
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Metadata
- Authors
- Browning, J. D., & Horton, J. D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Horton, Jay D.
- ORCID
- Horton, Jay D.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-07-15
- Volume
- 114
- Issue
- 2
- Pages
- 147-152
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC449757
- OpenAlex
- W4230280576
- Cited by
- 1,772
- References
- 82
- Citations by year
- 2026: 18 · 2025: 32 · 2024: 45 · 2023: 50 · 2022: 73 · 2021: 72 · 2020: 75 · 2019: 100 · 2018: 104 · 2017: 89 · 2016: 102 · 2015: 109 · 2014: 90 · 2013: 104 · 2012: 103
- FWCI
- 48.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- Funders
- American Liver Foundation
- National Institutes of Health (HL20948)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Keywords
- hepatic steatosis, liver injury, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, molecular mediators, lipid metabolism, reactive oxygen species, oxidative stress, mitochondrial dysfunction, lipid peroxidation, acetyl-CoA carboxylase, AMPK, ChREBP, stearoyl-CoA desaturase, polyunsaturated fatty acids, malondialdehyde
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