Cited by 1,772Liver Disease Diagnosis and TreatmentLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Molecular mediators of hepatic steatosis and liver injury

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Browning, Jeffrey D., Horton, Jay D.·2004·Journal of Clinical Investigation

DOI 10.1172/jci200422422PMC PMC449757

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Abstract

Nonstandard abbreviations used: acetyl-CoA carboxylase (ACC); AMP-activated protein kinase (AMPK); basic helix-loop-helix-leucine zipper (bHLH-Zip); carbohydrate response element binding protein (ChREBP); carnitine palmitoyl transferase-1 (CPT-1); diethylaminoethoxyhexestrol (DEAEH); liver function test (LFT); liver-type pyruvate kinase (L-PK); malondialdehyde (MDA); mitochondrial respiratory chain (MRC); nonalcoholic fatty-liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); polyunsaturated fatty acid (PUFA); reactive oxygen species (ROS); stearoyl-CoA desaturase (SCD); trans-4-hydroxy-2-nonenal (HNE). Conflict of interest:The authors have declared that no conflict of interest exists.

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Authors: Browning, J. D., & Horton, J. D.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Horton, Jay D.
ORCID: Horton, Jay D.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-07-15
Volume: 114
Issue: 2
Pages: 147-152
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200422422
PMC: PMC449757
OpenAlex: W4230280576
Cited by: 1,772
References: 82
Citations by year: 2026: 18 · 2025: 32 · 2024: 45 · 2023: 50 · 2022: 73 · 2021: 72 · 2020: 75 · 2019: 100 · 2018: 104 · 2017: 89 · 2016: 102 · 2015: 109 · 2014: 90 · 2013: 104 · 2012: 103
FWCI: 48.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
Funders: American Liver Foundation
National Institutes of Health (HL20948)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: hepatic steatosis, liver injury, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, molecular mediators, lipid metabolism, reactive oxygen species, oxidative stress, mitochondrial dysfunction, lipid peroxidation, acetyl-CoA carboxylase, AMPK, ChREBP, stearoyl-CoA desaturase, polyunsaturated fatty acids, malondialdehyde

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Molecular mediators of hepatic steatosis and liver injury

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