Cited by 1,772Liver Disease Diagnosis and TreatmentLiver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

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Molecular mediators of hepatic steatosis and liver injury

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Browning, Jeffrey D., Horton, Jay D.·2004·Journal of Clinical Investigation

DOI 10.1172/jci200422422PMC PMC449757

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Abstract

Nonstandard abbreviations used: acetyl-CoA carboxylase (ACC); AMP-activated protein kinase (AMPK); basic helix-loop-helix-leucine zipper (bHLH-Zip); carbohydrate response element binding protein (ChREBP); carnitine palmitoyl transferase-1 (CPT-1); diethylaminoethoxyhexestrol (DEAEH); liver function test (LFT); liver-type pyruvate kinase (L-PK); malondialdehyde (MDA); mitochondrial respiratory chain (MRC); nonalcoholic fatty-liver disease (NAFLD); nonalcoholic steatohepatitis (NASH); polyunsaturated fatty acid (PUFA); reactive oxygen species (ROS); stearoyl-CoA desaturase (SCD); trans-4-hydroxy-2-nonenal (HNE). Conflict of interest:The authors have declared that no conflict of interest exists.

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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
Esterbauer, H., Schaur, R. J., & Zollner, H. (1991) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(91)90192-6 · Cited by 6,672
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Nonalcoholic Fatty Liver Disease
Angulo, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011775 · Cited by 5,228
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science · doi:10.1126/science.7624777 · Cited by 4,451
Steatohepatitis: A tale of two “hits”?
Day, C. P., & James, O. F. W. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70599-2 · Cited by 4,285
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Self-citation
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,564
Nonalcoholic Fatty Liver Disease
Marchesini, G., Brizi, M., Bianchi, G., Tomassetti, S., Bugianesi, E., Lenzi, M., McCullough, A. J., Natale, S., Forlani, G., & Melchionda, N. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1844 · Cited by 2,581
Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference
Neuschwander‐Tetri, B. A., & Caldwell, S. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50193 · Cited by 2,166

Show all 82 references

Research works printed but not linked: 1

Garcia-Ruiz, 1995, Mol. Pharmacol., 48, 825

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Self-citation
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Authors: Browning, J. D., & Horton, J. D.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Horton, Jay D.
ORCID: Horton, Jay D.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2004-07-15
Volume: 114
Issue: 2
Pages: 147-152
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200422422
PMC: PMC449757
OpenAlex: W4230280576
Cited by: 1,772
References: 82
Citations by year: 2026: 18 · 2025: 32 · 2024: 45 · 2023: 50 · 2022: 73 · 2021: 72 · 2020: 75 · 2019: 100 · 2018: 104 · 2017: 89 · 2016: 102 · 2015: 109 · 2014: 90 · 2013: 104 · 2012: 103
FWCI: 48.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
Funders: American Liver Foundation
National Institutes of Health (HL20948)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Keywords: hepatic steatosis, liver injury, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, molecular mediators, lipid metabolism, reactive oxygen species, oxidative stress, mitochondrial dysfunction, lipid peroxidation, acetyl-CoA carboxylase, AMPK, ChREBP, stearoyl-CoA desaturase, polyunsaturated fatty acids, malondialdehyde

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Molecular mediators of hepatic steatosis and liver injury

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