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Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter

Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O’Brien, Darren I., Shah, Reshma, Syed, Nelofer, Spender, Lindsay C., Herrera, Blanca, Thurlow, Johanna K., Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E., Buffa, Francesca M., Mann, Jelena, Chu, David C.K., West, Catharine M.L., Patridge, Max, Oien, Karin A., Cooper, Jonathan A., Frame, Margaret C., Harris, Adrian L., Hiller, Louise, Nicholson, Linda J., Gasco, Milena, Crook, Tim, Inman, Gareth J.·2010·Journal of Clinical Investigation

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Crossref · 10.1172/jci36125

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  • Dab2 loss in head and neck cancer compromises the tumor suppressor function of TGF-beta while enabling its tumor-promoting activities, and Dab2 is a molecular switch for TGF-beta from a tumor suppressor to a promoter.

    “another study found that Dab2 dose not impact the canonical TGF-beta pathway but Dab2 loss in head and neck cancer compromised the tumor suppressor function of TGF-beta, while enabling its tumor-promoting activities, and concluded that Dab2 is a molecular switch for TGF-beta from a tumor suppressor to a promoter (Hannigan et al., 2010).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Hannigan et al., 2010

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Metadata

Authors
Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O’Brien, D. I., Shah, R., Syed, N., Spender, L. C., Herrera, B., Thurlow, J. K., Lattanzio, L., Monteverde, M., Maurer, M. E., Buffa, F. M., Mann, J., Chu, D. C. K., West, C. M. L., Patridge, M., Oien, K. A., Cooper, J. A., Frame, M. C., Harris, A. L., Hiller, L., Nicholson, L. J., Gasco, M., Crook, T., & Inman, G. J.
Venue
Journal of Clinical Investigation
Published
2010-08-02
Volume
120
Issue
8
Pages
2842-2857
ISSN
0021-9738
Cited by
92
References
4
Language
en

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