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Epigenetic downregulation of human disabled homolog 2 switches TGF-β from a tumor suppressor to a tumor promoter
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Dab2 loss in head and neck cancer compromises the tumor suppressor function of TGF-beta while enabling its tumor-promoting activities, and Dab2 is a molecular switch for TGF-beta from a tumor suppressor to a promoter.
“another study found that Dab2 dose not impact the canonical TGF-beta pathway but Dab2 loss in head and neck cancer compromised the tumor suppressor function of TGF-beta, while enabling its tumor-promoting activities, and concluded that Dab2 is a molecular switch for TGF-beta from a tumor suppressor to a promoter (Hannigan et al., 2010).”
From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Hannigan et al., 2010
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Targeting the TGFβ signalling pathway in disease
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Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice
Tao, W., Moore, R., Smith, E. R., & Xu, X.-X. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00129 · Cited by 43
Metadata
- Authors
- Hannigan, A., Smith, P., Kalna, G., Lo Nigro, C., Orange, C., O’Brien, D. I., Shah, R., Syed, N., Spender, L. C., Herrera, B., Thurlow, J. K., Lattanzio, L., Monteverde, M., Maurer, M. E., Buffa, F. M., Mann, J., Chu, D. C. K., West, C. M. L., Patridge, M., Oien, K. A., Cooper, J. A., Frame, M. C., Harris, A. L., Hiller, L., Nicholson, L. J., Gasco, M., Crook, T., & Inman, G. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-08-02
- Volume
- 120
- Issue
- 8
- Pages
- 2842-2857
- ISSN
- 0021-9738
- Cited by
- 92
- References
- 4
- Language
- en
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