Cited by 481Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

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Butovsky, Oleg, Siddiqui, Shafiuddin, Gabriely, Galina, Lanser, Amanda J., Dake, Ben, Murugaiyan, Gopal, Doykan, Camille E., Wu, Pauline M., Gali, Reddy R., Iyer, Lakshmanan K., Lawson, Robert, Berry, James, Krichevsky, Anna M., Cudkowicz, Merit E., Weiner, Howard L.·2012·Journal of Clinical Investigation

DOI 10.1172/jci62636PMC PMC3428086

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Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes were activated and that their progressive recruitment to the spinal cord, but not brain, correlated with neuronal loss. We also found a decrease in resident microglia in the spinal cord with disease progression. Prior to disease onset, splenic Ly6Chi monocytes expressed a polarized macrophage phenotype (M1 signature), which included increased levels of chemokine receptor CCR2. As disease onset neared, microglia expressed increased CCL2 and other chemotaxis-associated molecules, which led to the recruitment of monocytes to the CNS by spinal cord-derived microglia. Treatment with anti-Ly6C mAb modulated the Ly6Chi monocyte cytokine profile, reduced monocyte recruitment to the spinal cord, diminished neuronal loss, and extended survival. In humans with ALS, the analogous monocytes (CD14+CD16-) exhibited an ALS-specific microRNA inflammatory signature similar to that observed in the ALS mouse model, linking the animal model and the human disease. Thus, the profile of monocytes in ALS patients may serve as a biomarker for disease stage or progression. Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach.

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Authors: Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., Lawson, R., Berry, J., Krichevsky, A. M., Cudkowicz, M. E., & Weiner, H. L.
Affiliations: Brigham and Women's Hospital (US)
Harvard University (US)
Tufts University (US)
Corresponding author: Weiner, Howard L.
ORCID: Butovsky, Oleg
Gabriely, Galina
Lanser, Amanda J.
Murugaiyan, Gopal
Iyer, Lakshmanan K.
Lawson, Robert
Berry, James
Krichevsky, Anna M.
Cudkowicz, Merit E.
Weiner, Howard L.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2012-09-04
Volume: 122
Issue: 9
Pages: 3063-3087
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci62636
PMC: PMC3428086
OpenAlex: W2119656827
Cited by: 481
References: 81
Citations by year: 2026: 6 · 2025: 18 · 2024: 23 · 2023: 32 · 2022: 41 · 2021: 35 · 2020: 46 · 2019: 23 · 2018: 35 · 2017: 47 · 2016: 50 · 2015: 46 · 2014: 42 · 2013: 28 · 2012: 7
FWCI: 25.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: ALS Association
Harvard NeuroDiscovery Center
Brigham and Women's Hospital
National Institutes of Health
Center for Neuroscience Research (P30 NS047243)
National Institute on Aging (AG027437, R01AG027437)
National Institute of Neurological Disorders and Stroke (P30NS047243, R01NS088137)
Topics: Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: amyotrophic lateral sclerosis, inflammatory monocytes, microRNA signature, innate immunity, microglia, monocyte recruitment, spinal cord, CCR2, MCP-1, Ly6C, macrophage polarization, neuronal loss, disease biomarkers, therapeutic target
MeSH terms: Superoxide Dismutase-1, Amyotrophic Lateral Sclerosis, Animals, Antibodies, Monoclonal, Antigens, Ly, Apyrase, Chemotaxis, Female, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Rats, Inbred Lew, Spinal Cord, Spleen, Superoxide Dismutase, Transcription Factors, Antigens, CD, Macrophages, Alveolar, Apoptosis, Microglia, Inflammation Mediators, Oligonucleotide Array Sequence Analysis, RNA Interference, MicroRNAs, Cell Proliferation, Mice, Rats, Gene Regulatory Networks, Metabolic Networks and Pathways, Immunomodulation, Transcriptome

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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

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