Cited by 332Autophagy in Disease and TherapyAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Autophagy and neurodegeneration

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Frake, Rebecca A., Ricketts, Thomas, Menzies, Fiona M., Rubinsztein, David C.·2015·Journal of Clinical Investigation

DOI 10.1172/jci73944PMC PMC4382230

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Abstract

Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons. Autophagy is a powerful process for removing such proteins. In this Review, we consider how certain neurodegenerative diseases may be associated with impaired autophagy and how this may affect pathology. We also discuss how autophagy induction may be a plausible therapeutic strategy for some conditions and review studies in various models that support this hypothesis. Finally, we briefly describe some of the signaling pathways that may be amenable to therapeutic targeting for these goals.

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Authors: Frake, R. A., Ricketts, T., Menzies, F. M., & Rubinsztein, D. C.
Corresponding author: Rubinsztein, David C.
ORCID: Frake, Rebecca A.
Rubinsztein, David C.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2015-01-02
Volume: 125
Issue: 1
Pages: 65-74
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci73944
PMC: PMC4382230
OpenAlex: W2029582543
Cited by: 332
References: 153
Citations by year: 2026: 17 · 2025: 14 · 2024: 19 · 2023: 28 · 2022: 18 · 2021: 36 · 2020: 38 · 2019: 30 · 2018: 40 · 2017: 37 · 2016: 36 · 2015: 19
FWCI: 5.72
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Apollo (University of Cambridge) (submittedVersion)
Funders: Wellcome Trust (100140, 095317)
National Institute for Health and Care Research
Tau Consortium
Medical Research Council
Cambridge Institute for Medical Research, University of Cambridge
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: autophagy, neurodegenerative diseases, protein aggregation, protein clearance, autophagy dysfunction, therapeutic targeting, signaling pathways, neuronal pathology
MeSH terms: Animals, Autophagy, Humans, Neurodegenerative Diseases, Protein Kinase Inhibitors, TOR Serine-Threonine Kinases

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