Cited by 178Smoking Behavior and CessationNicotinic Acetylcholine Receptors StudyTreatment of Major Depression

Biological Aspects of the Link between Smoking and Depression

Quattrocki, Elizabeth, Baird, Abigail, Yurgelun-Todd, Deborah·2000·Harvard Review of Psychiatry

Abstract

A link between smoking and depressive symptoms has been described in the literature for over a decade. The neurotransmitter systems affected by cigarette smoke mirror the neurotransmitter pathways thought to be involved in the biological mechanisms of depression. Cigarette smoke contains several psychoactive chemicals; nicotine is the best studied among these and is widely accepted to be the addictive substance in tobacco. Nicotine binds to nicotinic receptors in the brain, augmenting the release of numerous neurotransmitters, including dopamine, serotonin, norepinephrine, acetylcholine, gamma-aminobutyric acid, and glutamate. Cigarette smoke has other psychoactive properties apart from nicotinic receptor stimulation. For example, it inhibits monoamine oxidase (the enzyme responsible for breaking down the biogenic amine neurotransmitters norepinephrine, serotonin, and dopamine) in the brain. Various antidepressants act through modulation of the biogenic amine neurotransmitter pathways. That the neural substrates modified by both smoking and antidepressant drugs overlap has relevance to smoking cessation. The use of antidepressants as adjuvants to smoking-cessation treatment can enhance cessation success rates. Understanding the neurobiological mechanisms underlying the association between smoking and depression may improve physicians' ability to assist smokers in their efforts to quit and will contribute to a more thorough comprehension of both the biology of addiction and th…

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Crossref · 10.1080/hrp_8.3.99

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Authors
Quattrocki, E., Baird, A., & Yurgelun-Todd, D.
Affiliations
Harvard University (US)
Venue
Harvard Review of Psychiatry
Published
2000-09
Volume
8
Issue
3
Pages
99-110
ISSN
1067-3229 (ISSN-L)
OpenAlex
W2022451998
Cited by
176
References
101
Citations by year
2026: 4 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 6 · 2020: 1 · 2018: 6 · 2017: 1 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 11 · 2012: 3
FWCI
4.28
Type
journal article
Language
en
Open access
closed
Locations
  • Harvard Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
smoking, depression, nicotine, nicotinic acetylcholine receptors, neurotransmitters, monoamine oxidase inhibition, antidepressants, smoking cessation, nicotine dependence, dopamine, serotonin, norepinephrine
MeSH terms
Smoking Prevention, Affect, Brain, Cognition, Depression, Humans, Monoamine Oxidase, Nicotine, Receptors, Nicotinic, Reinforcement, Psychology, Smoking, Smoking Cessation, Neurotransmitter Agents

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