Cited by 166Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorGenetic Associations and Epidemiology

Genetics of adult attention-deficit/hyperactivity disorder

Faraone, Stephen V·2004·Psychiatric Clinics of North America

Abstract

Results of behavioral genetic investigations using family twin and adoption studies converge with those of molecular genetic studies in showing that genes influence susceptibility to'attention-deficit/hyperactivity disorder (ADHD). These finding suggest that genetic mechanisms that predispose individuals to ADHD are complex. It seems likely that the disorder is caused by the combined actions of several genes. It is equally clear that aberrant genes create a vulnerability to the disorder that is not expressed in all environments. The literature about the genetics of adult ADHD is relatively small, but it suggests not only that the persistent form of ADHD is familial, but that it is more familial than the nonpersistent form. More work from twin and molecular genetic studies is needed to determine if the increased familiality of persistent ADHD reflects the actions of genes or of familial environmental causes.

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Crossref · 10.1016/s0193-953x(03)00090-x

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Authors
Faraone, S. V.
Affiliations
Harvard University (US)
Corresponding author
Faraone, Stephen V
Venue
Psychiatric Clinics of North America
Publisher
Elsevier BV
Published
2004-06
Volume
27
Issue
2
Pages
303-321
ISSN
0193-953X (ISSN-L)
OpenAlex
W2054753933
Cited by
166
References
110
Citations by year
2026: 3 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 1 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 8 · 2012: 12
FWCI
2.57
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatric Clinics of North America (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
adult ADHD, genetic susceptibility, familiality, persistent ADHD, twin studies, adoption studies, molecular genetics, gene-environment interaction
MeSH terms
Adoption, Adult, Attention Deficit Disorder with Hyperactivity, Corpus Striatum, Humans, Membrane Glycoproteins, Nerve Tissue Proteins, Serotonin, Twins, Tomography, Emission-Computed, Single-Photon, Twin Studies as Topic, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins

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