Cited by 82Sleep and Wakefulness ResearchSleep and related disordersCircadian rhythm and melatonin

Sleep and manipulations of the sleep–wake rhythm in depression

Berger, M., Van Calker, D., Riemann, D.·2003·Acta Psychiatrica Scandinavica

Abstract

Objective: Disturbed sleep is typical for most depressed patients and complaints about disordered sleep are the hallmarks of the disorder. Polysomnographic sleep research has demonstrated that besides impaired sleep continuity, sleep in depression is characterized by a reduction of slow wave sleep and a disinhibition of random eye movement (REM) sleep, with a shortening of REM latency, a prolongation of the first REM period and increased REM density. Method: Our own experimental work has focused on the reciprocal interaction hypothesis of non‐REM and REM sleep regulation as a model to explain the characteristic features of depressed sleep. Results: In agreement with the major tenet of this model, administration of cholinomimetics provoked shortened REM latency in healthy subjects and led to an even stronger REM sleep disinhibition in depressed patients. Manipulations of the sleep–wake cycle, such as sleep deprivation or a phase advance of the sleep period, alleviate depressive symptoms. Conclusion: These data indicate a strong bidirectional relationship between sleep, sleep alterations and depression.

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Crossref · 10.1034/j.1600-0447.108.s418.17.x

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  • Wake therapy directly alters sleep-wake rhythms by increasing slow-wave sleep, reducing latency to REM sleep, and reducing duration of REM sleep.

    “Wake therapy directly alters sleep-wake rhythms by increasing the amount of SWS, reducing the latency to REM sleep, and reducing the duration of REM sleep87.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [87]

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Authors
Berger, M., Van Calker, D., & Riemann, D.
Affiliations
University Medical Center Freiburg (DE)
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2003-09-04
Volume
108
Issue
s418
Pages
83-91
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W2106036773
Cited by
82
References
81
Citations by year
2025: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 5 · 2014: 4 · 2013: 6 · 2012: 7
FWCI
0.69
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
depression, sleep disorders, sleep-wake cycle, REM sleep, slow-wave sleep, REM latency, cholinergic drugs, sleep deprivation, sleep phase advance
MeSH terms
Depressive Disorder, Humans, Risk Factors, Sleep Wake Disorders, Sleep, REM, Polysomnography, Cholinergic Agents

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