Cited by 194Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionSchizophrenia research and treatment

Decreased presynaptic dopamine function in the left caudate of depressed patients with affective flattening and psychomotor retardation

Martinot, Marie-Laure Paillère, Bragulat, Véronique, Artiges, Eric, Dollé, Frédéric, Hinnen, Françoise, Jouvent, Roland, Martinot, Jean-Luc·2001·American Journal of Psychiatry

Abstract

OBJECTIVE: The study assessed striatal presynaptic dopamine function in patients with different subtypes of depression. METHOD: Magnetic resonance imaging and positron emission tomography with [(18)F]fluorodopa ([(18)F]DOPA) were used to compare six depressed patients with marked affective flattening and psychomotor retardation, six depressed patients with marked impulsivity and anxiety, and 10 healthy comparison subjects. Depressed patient groups were matched for severity of depression. RESULTS: [(18)F]DOPA uptake K(i) values in the left caudate were significantly lower in patients with psychomotor retardation than in patients with high impulsivity and in comparison subjects. CONCLUSIONS: These results suggest that left caudate dopamine function differs between depressed patients with psychomotor retardation and those with impulsivity and provide direct evidence of a link between dopamine hypofunction and psychomotor retardation in depression.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.158.2.314

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Depressed patients with psychomotor slowing exhibit decreased presynaptic dopamine function in the left caudate.

    “Moreover, depressed patients with psychomotor slowing (as assessed by a clinician) exhibit decreased cerebrospinal fluid levels of homovanillic acid, the primary metabolite of dopamine (van Praag and Korf, 1971), and decreased presynaptic dopamine function in the left caudate (Martinot et al., 2001).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Martinot, M.-L. P., Bragulat, V., Artiges, E., Dollé, F., Hinnen, F., Jouvent, R., & Martinot, J.-L.
Affiliations
Pitié-Salpêtrière Hospital (FR)
Venue
American Journal of Psychiatry
Published
2001-02-01
Volume
158
Issue
2
Pages
314-316
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2104260598
Cited by
194
References
13
Citations by year
2026: 8 · 2025: 8 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 12 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 8 · 2014: 9 · 2013: 11 · 2012: 10
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
depression, caudate nucleus, psychomotor retardation, affective flattening, impulsivity, anxiety, striatum, depression subtypes
MeSH terms
Adult, Caudate Nucleus, Depressive Disorder, Dihydroxyphenylalanine, Dopamine, Female, Humans, Functional Laterality, Male, Middle Aged, Psychiatric Status Rating Scales, Radionuclide Imaging, Severity of Illness Index, Presynaptic Terminals

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review