The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
The Nature of Traumatic Memories: A 4-T fMRI Functional Connectivity Analysis
Abstract
OBJECTIVE: This study used functional connectivity analyses to assess interregional brain activity correlations during the recall of traumatic memories in traumatized subjects with and without posttraumatic stress disorder (PTSD). METHOD: Both 4-T functional magnetic resonance imaging (fMRI) and functional connectivity analyses were used to assess interregional brain activity correlations during script-driven symptom provocation in traumatized subjects with (N=11) and without (N=13) PTSD. Functional connectivity analyses were carried out by using data for brain regions activated in both the PTSD group and the comparison group. The use of functional connectivity analyses in addition to subtraction analyses allowed assessment of specific brain regions involved in the recall of traumatic events and of the neuronal networks underlying the recall of such events. RESULTS: Significant between-group differences in functional connectivity were found. Comparison of connectivity maps at coordinates x=2, y=20, z=36 (right anterior cingulate gyrus) for the two groups showed that the subjects without PTSD had greater correlation than the PTSD subjects in the left superior frontal gyrus (Brodmann's area 9), left anterior cingulate gyrus (Brodmann's area 32), left striatum (caudate), left parietal lobe (Brodmann's areas 40 and 43), and left insula (Brodmann's area 13). In contrast, the PTSD subjects showed greater correlation than the subjects without PTSD in the right posterior cingulate gyrus (Brodmann's area 29), right caudate, right parietal lobe (Brodmann's areas 7 and 40), and right occipital lobe (Brodmann's area 19). CONCLUSIONS: The differences in brain connectivity between PTSD and comparison subjects may account for the nonverbal nature of traumatic memory recall in PTSD subjects, compared to a more verbal pattern of traumatic memory recall in comparison subjects.
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“The insula is related to body awareness and associated with both mindfulness training [58–60], and traumatic re-experiencing [61–63].”
From Childhood trauma and subclinical PTSD symptoms predict adverse effects and worse outcomes across two mindfulness-based programs for active depression (2025) · cites this paper as [61]
Citations
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Research works printed but not linked: 1
- Shaw ME, Strother SC, McFarlane AC, Morris P, Anderson J, Clark CR, Egan GF: Abnormal functional connectivity in posttraumatic stress disorder. Neuroimage 2002; 15:661–674 · DOI
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Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
SHIN, L. M., RAUCH, S. L., & PITMAN, R. K. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.007 · Cited by 1,203
Amygdala–frontal connectivity during emotion regulation
Banks, S. J., Eddy, K. T., Angstadt, M., Nathan, P. J., & Phan, K. L. (2007) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsm029 · Cited by 1,187
“…be dysfunctional during cognitive-emotional tasks in patients with depression (Mayberg, 1997; Beauregard et al., 2006), anxiety (Shin et al., 2001; Lanius et al., 2004), impulsive aggression (Coccaro et al., in press) and personality disorders (McCloskey et al., 2005; New et al., 2007);…”
BackgroundThe functional neuroanatomy of PTSD: a critical review
Liberzon, I., & Sripada, C. S. (2007) · Progress in Brain Research · doi:10.1016/s0079-6123(07)67011-3 · Cited by 594
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546
Impaired safety signal learning may be a biomarker of PTSD
Jovanovic, T., Kazama, A., Bachevalier, J., & Davis, M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.023 · Cited by 473
Metadata
- Authors
- Lanius, R. A., Williamson, P. C., Densmore, M., Boksman, K., Neufeld, R. W., Gati, J. S., & Menon, R. S.
- Affiliations
- Western University (CA)
- Venue
- American Journal of Psychiatry
- Published
- 2004-01-01
- Volume
- 161
- Issue
- 1
- Pages
- 36-44
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2133664593
- Cited by
- 262
- References
- 46
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 13 · 2016: 5 · 2015: 21 · 2014: 13 · 2013: 11 · 2012: 9
- FWCI
- 13.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- post-traumatic stress disorder, functional connectivity, anterior cingulate cortex, posterior cingulate cortex, caudate nucleus, insula, parietal lobe, occipital lobe, traumatic brain injury
- MeSH terms
- Brain, Humans, Image Interpretation, Computer-Assisted, Imagination, Magnetic Resonance Imaging, Nerve Net, Mental Recall, Severity of Illness Index, Stress Disorders, Post-Traumatic, Subtraction Technique
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