The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Regional Brain Activity in Women Grieving a Romantic Relationship Breakup
Abstract
OBJECTIVE: Separation from loved ones commonly leads to grief reactions. In some individuals, grief can evolve into a major depressive episode. The brain regions involved in grief have not been specifically studied. The authors studied brain activity in women actively grieving a recent romantic relationship breakup. It was hypothesized that while remembering their ex-partner, subjects would have altered brain activity in regions identified in sadness imaging studies: the cerebellum, anterior temporal cortex, insula, anterior cingulate, and prefrontal cortex. METHOD: Nine right-handed women whose romantic relationship ended within the preceding 4 months were studied. Subjects were scanned using blood-oxygen-level-dependent functional magnetic resonance imaging while they alternated between recalling a sad, ruminative thought about their loved one (grief state) and a neutral thought about a different person they knew an equally long time. RESULTS: Acute grief (grief minus neutral state) was associated with increased group activity in posterior brain regions, including the cerebellum, posterior brainstem, and posterior temporoparietal and occipital brain regions. Decreased activity was more prominent anteriorly and on the left and included the anterior brainstem, thalamus, striatum, temporal cortex, insula, and dorsal and ventral anterior cingulate/prefrontal cortex. When a more lenient statistical threshold for regions of interest was used, additional increases were found in the lateral temporal cortex, supragenual anterior cingulate/medial prefrontal cortex, and right inferomedial dorsolateral prefrontal cortex, all of which were adjacent to spatially more prominent decreases. In nearly all brain regions showing brain activity decreases with acute grief, activity decreases were greater in women reporting higher grief levels over the past 2 weeks. CONCLUSIONS: During acute grief, subjects showed brain activity changes in the cerebellum, anterior temporal cortex, insula, anterior cingulate, and prefrontal cortex, consistent with the hypothesis. Subjects with greater baseline grief showed greater decreases in all these regions except for the cerebellum. Further imaging studies are needed to understand the relationship between normal sadness, grief, and depression.
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“In fact, acute grief after a relationship breakup (128,129) or the loss of an unborn child (130) is related to intense responses of the physical pain network encompassing the ACC and insula.”
From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [128]
In the citing paper
“Finally, they found that activity in the anterior cingulate, insula, and amygdala was inversely related to the level of a subject’s grief.”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Najib et al., 2004
In the citing paper
“In contrast to the romance-studies which found activations in the anterior cingulate, they also found that romantic grief was consistently associated with deactivations in this region.”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Najib et al., 2004
In the citing paper
“They found that acute grief related to the loss of a romantic attachment figure modulated activity in some of the same areas implicated in social attachment and parenting when they recalled sad thoughts about their loved one (Najib et al., 2004).”
From The human parental brain: In vivo neuroimaging (2011) · cites this paper as Najib et al., 2004
Citations
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Puzzlingly High Correlations in fMRI Studies of Emotion, Personality, and Social Cognition
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A meta-analysis of cerebellar contributions to higher cognition from PET and fMRI studies
E, K., Chen, S. A., Ho, M. R., & Desmond, J. E. (2014) · Human Brain Mapping · doi:10.1002/hbm.22194 · Cited by 516
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Metadata
- Authors
- Najib, A., Lorberbaum, J. P., Kose, S., Bohning, D. E., & George, M. S.
- Affiliations
- Medical University of South Carolina (US)
- ORCID
- George, Mark S.
- Venue
- American Journal of Psychiatry
- Published
- 2004-12-01
- Volume
- 161
- Issue
- 12
- Pages
- 2245-2256
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2116869263
- Cited by
- 161
- References
- 51
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 25 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 4 · 2015: 12 · 2014: 6 · 2013: 6 · 2012: 9
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Grief, Bereavement, and Mental Health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
- Keywords
- acute grief, romantic breakup, brain activity, women, cerebellum, anterior cingulate cortex, prefrontal cortex, insula, anterior temporal cortex, sadness, major depressive episode, ruminative thoughts
- MeSH terms
- Brain, Courtship, Depression, Depressive Disorder, Emotions, Female, Grief, Humans, Interpersonal Relations, Functional Laterality, Love, Magnetic Resonance Imaging, Oxygen, Psychiatric Status Rating Scales, Sex Factors, Temporal Lobe, Prefrontal Cortex
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