Childhood Trauma and Personality Disorder: Positive Correlation With Adult CSF Corticotropin-Releasing Factor Concentrations
Abstract
Objective To test the hypothesis that early life trauma results in adult stress hormone alterations in individuals with personality disorders, the authors examined the relationship between history of childhood adversity and lumbar CSF corticotropin-releasing factor (CRF). Method Participants were 20 otherwise healthy men who met DSM-IV criteria for personality disorders. CSF CRF was obtained by lumbar puncture, and childhood adversity was measured by the Childhood Trauma Questionnaire. Correlations were obtained between CSF CRF and the total score on the Childhood Trauma Questionnaire as well as scores on its four subscales. Results CSF CRF concentrations were positively correlated with the total score on the Childhood Trauma Questionnaire. Analysis of the subscales revealed that CSF CRF was correlated with emotional neglect. Correlations between CSF CRF level and physical and emotional abuse and with physical neglect were not statistically significant. Conclusions Consistent with the hypothesis that the severity of early life stress is correlated with stress hormone abnormalities in adulthood, Childhood Trauma Questionnaire total scores and emotional neglect scores were significantly correlated with CSF CRF levels in individuals with personality disorders.
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Elevated CSF levels of CRF in adults associate with a history of childhood maltreatment, poor quality of parental care, and childhood stressful experience.
“Elevated CSF levels of CRF in adults associate with a history of childhood maltreatment,58,59 a poor quality of parental care,60 and childhood stressful experience.61”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [59]
Cites
Endicott, J. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770310043002 · Cited by 5,686 · see citing works
A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal
Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678 · see citing works
Initial reliability and validity of a new retrospective measure of child abuse and neglect
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.8.1132 · Cited by 3,577 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Validity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population
BERNSTEIN, D. P., AHLUVALIA, T., POGGE, D., & HANDELSMAN, L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199703000-00012 · Cited by 1,574 · see citing works
Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746 · see citing works
Coplan, J. D., Andrews, M. W., Rosenblum, L. A., Owens, M. J., Friedman, S., Gorman, J. M., & Nemeroff, C. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.4.1619 · Cited by 649 · see citing works
Cerebrospinal Fluid Vasopressin Levels
Coccaro, E. F., Kavoussi, R. J., Hauger, R. L., Cooper, T. B., & Ferris, C. F. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.8.708 · Cited by 392 · see citing works
Self-citationCarpenter, L. L., Tyrka, A. R., McDougle, C. J., Malison, R. T., Owens, M. J., Nemeroff, C. B., & Price, L. H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300375 · Cited by 209 · see citing works
Meaney, M. J., Diorio, J. C., Francis, D. D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2007) · Developmental Neuroscience · doi:10.1159/000111396 · Cited by 43 · see citing works
The effect of feeding on cerebrospinal fluid corticotropin-releasing hormone levels in humans
Kasckow, J. W., Hagan, M., Mulchahey, J. J., Baker, D. G., Ekhator, N. N., Strawn, J. R., Nicholson, W. E., Orth, D. N., Loosen, P. T., & Geracioti, T. D. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02461-1 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works
Fonagy, P., & Luyten, P. (2009) · Development and Psychopathology · doi:10.1017/s0954579409990198 · Cited by 1,146 · see citing works
Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796 · see citing works
The evidence for a neurobiological model of childhood antisocial behavior
van Goozen, S. H. M., Fairchild, G., Snoek, H., & Harold, G. T. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.149 · Cited by 475 · see citing works
Childhood maltreatment and inflammatory markers: a systematic review.
Coelho, R., Viola, T. W., Walss‐Bass, C., Brietzke, E., & Grassi‐Oliveira, R. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12217 · Cited by 426 · see citing works
The CRF system, stress, depression and anxiety—insights from human genetic studies
Binder, E. B., & Nemeroff, C. B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.141 · Cited by 379 · see citing works
Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.149 · Cited by 347 · see citing works
The neurobiology of mentalizing.
Luyten, P., & Fonagy, P. (2015) · Personality disorders · doi:10.1037/per0000117 · Cited by 307 · see citing works
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker, C., O'Donnell, K. J., & Meaney, M. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/canacker · Cited by 237 · see citing works
Epigenetics and the Biological Basis of Gene × Environment Interactions
Bagot, R. C., & Meaney, M. J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.06.001 · Cited by 177 · see citing works
Epigenetics and parental effects
Kappeler, L., & Meaney, M. J. (2010) · BioEssays · doi:10.1002/bies.201000015 · Cited by 150 · see citing works
Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T. C., Smith, A. K., Gillespie, C. F., Nemeroff, C. B., Cubells, J. F., & Binder, E. B. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31052 · Cited by 140 · see citing works
A Multilevel Perspective on the Development of Borderline Personality Disorder
Fonagy, P., & Luyten, P. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy317 · Cited by 131 · see citing works
Microbiota, immunoregulatory old friends and psychiatric disorders
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117 · see citing works
The Interface of Pain and Mood Disturbances in the Rheumatic Diseases
Goldenberg, D. L. (2009) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.11.005 · Cited by 112 · see citing works
van Goozen, S. H. M., & Fairchild, G. F. (2008) · Development and Psychopathology · doi:10.1017/s095457940800045x · Cited by 94 · see citing works
Corticotropin-releasing hormone and the hypothalamic–pituitary–adrenal axis in psychiatric disease
Naughton, M., Dinan, T. G., & Scott, L. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00005-8 · Cited by 90 · see citing works
Wilkinson, P. O., & Goodyer, I. M. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000472 · Cited by 86 · see citing works
Role of childhood traumatic experience in personality disorders in China
Zhang, T., Chow, A., Wang, L., Dai, Y., & Xiao, Z. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.10.004 · Cited by 83 · see citing works
Environmental regulation of the neural epigenome
Caldji, C., Hellstrom, I. C., Zhang, T.-Y., Diorio, J., & Meaney, M. J. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.032 · Cited by 82 · see citing works
Link, C. L., Lutfey, K., Steers, W. D., & McKinlay, J. B. (2007) · European Urology · doi:10.1016/j.eururo.2007.03.024 · Cited by 76 · see citing works
Taché, Y., & Brunnhuber, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.007 · Cited by 76 · see citing works
Developmental psychopathology and neurobiology of aggression
Gollan, J. K., Lee, R., & Coccaro, E. F. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050546 · Cited by 63 · see citing works
Self-citationLee, R. S. (2018) · Alcohol research · doi:10.35946/arcr.v39.2.05 · Cited by 59 · see citing works
Self-citationEarly-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study
Coplan, J. D., Abdallah, C. G., Kaufman, J., Gelernter, J. E., Smith, E. L., Perera, T. D., Dwork, A. J., Kaffman, A., Gorman, J. M., Rosenblum, L. A., et al. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.011 · Cited by 55 · see citing works
Zhang, H., Wang, F., Kranzler, H. R., Zhao, H., & Gelernter, J. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065648 · Cited by 48 · see citing works
Lee, R. J., Gollan, J., Kasckow, J., Geracioti, T., & Coccaro, E. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301104 · Cited by 44 · see citing works
Self-citationHistory of childhood maltreatment in Intermittent Explosive Disorder and suicidal behavior
Fanning, J. R., Meyerhoff, J., Lee, R., & Coccaro, E. F. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.04.012 · Cited by 44 · see citing works
Self-citationPeng, H., Long, Y., Li, J., Guo, Y., Wu, H., Yang, Y., Ding, Y., He, J., & Ning, Y. (2014) · BMC Psychiatry · doi:10.1186/1471-244x-14-45 · Cited by 44 · see citing works
Watson, S., Owen, B. M., Gallagher, P., Hearn, A. J., Young, A. H., & Ferrier, I. N. (2007) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a939 · Cited by 42 · see citing works
Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood
Tóth, M., Flandreau, E. I., Deslauriers, J., Geyer, M. A., Mansuy, I. M., Pich, E. M., & Risbrough, V. B. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.338 · Cited by 40 · see citing works
Abiri, D., Douglas, C. E., Calakos, K. C., Barbayannis, G., Roberts, A. G., & Bauer, E. P. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.06.021 · Cited by 36 · see citing works
Bijlsma, E. Y., van Leeuwen, M. L. F., Westphal, K. G. C., Olivier, B., & Groenink, L. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.026 · Cited by 38 · see citing works
Ohmura, Y., Yamaguchi, T., Futami, Y., Togashi, H., Izumi, T., Matsumoto, M., Yoshida, T., & Yoshioka, M. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.11.025 · Cited by 37 · see citing works
Neural effects of social environmental stress – an activation likelihood estimation meta-analysis
Mothersill, O., & Donohoe, G. J. (2016) · Psychological Medicine · doi:10.1017/s0033291716000477 · Cited by 36 · see citing works
Alcántara‐Alonso, V., Panetta, P., de Gortari, P., & Grammatopoulos, D. K. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00161 · Cited by 35 · see citing works
Early Life Stress Exacerbates Outcome after Traumatic Brain Injury
Sanchez, C. M., Titus, D. J., Wilson, N. M., Freund, J. E., & Atkins, C. M. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2020.7267 · Cited by 34 · see citing works
Bardo, M. T., Hammerslag, L. R., & Malone, S. G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108567 · Cited by 32 · see citing works
Mazer, A. K., Cleare, A. J., Young, A. H., & Juruena, M. F. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.015 · Cited by 32 · see citing works
Molecular impacts of childhood abuse on the human brain
Ibrahim, P., Almeida, D. M., Nagy, C., & Turecki, G. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100343 · Cited by 33 · see citing works
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 28 · see citing works
Tóth, M., Gresack, J. E., Bangasser, D. A., Plona, Z., Valentino, R. J., Flandreau, E. I., Mansuy, I. M., Merlo‐Pich, E., Geyer, M. A., & Risbrough, V. B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.336 · Cited by 28 · see citing works
The Neuroendocrinology of Childhood Trauma in Personality Disorder
Lee, R. J., Hempel, J., Tenharmsel, A., Liu, T., Mathé, A., & Klock, A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.006 · Cited by 25 · see citing works
Self-citationMaria, M. M. M., McRae‐Clark, A. L., Back, S. E., DeSantis, S. M., Baker, N. L., Spratt, E. G., Simpson, A. N., & Brady, K. T. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.001 · Cited by 24 · see citing works
Almeida, M., Lee, R., & Coccaro, E. F. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.02.012 · Cited by 23 · see citing works
Self-citationRomero-Pimentel, A. L., Almeida, D. M., Muñoz-Montero, S. A., Rangel‐Escareño, C., Mendoza-Morales, R., González-Sáenz, E. E., Nagy, C., Chen, G., Aouabed, Z., Théroux, J., et al. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab042 · Cited by 22 · see citing works
Depue, R. A., & Fu, Y. (2011) · International Review of Psychiatry · doi:10.3109/09540261.2011.599315 · Cited by 23 · see citing works
Childhood trauma and personality disorder: Toward a biological model
Lee, R. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0080-5 · Cited by 23 · see citing works
Self-citationA polymorphism in the Crhr1 gene determines stress vulnerability in male mice.
Labermaier, C., Kohl, C., Hartmann, J., Devigny, C., Altmann, A., Weber, P., Arloth, J., Quast, C., Wagner, K., Scharf, S. H., et al. (2014) · Endocrinology · doi:10.1210/en.2013-1986 · Cited by 20 · see citing works
Ohmura, Y., Yamaguchi, T., Izumi, T., Matsumoto, M., & Yoshioka, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.023 · Cited by 18 · see citing works
Pinto, R. J., Fernandes, A. I., Mesquita, C. D. S., & Maia, Â. (2015) · Violence and Victims · doi:10.1891/0886-6708.vv-d-13-00002 · Cited by 14 · see citing works
The hygiene hypothesis and affective and anxiety disorders
Rook, G. A. W., & Lowry, C. A. (2009) · Birkhäuser Basel eBooks · doi:10.1007/978-3-7643-8903-1_11 · Cited by 13 · see citing works
Effects of social rank and pubertal delay on brain structure in female rhesus macaques
Godfrey, J. R., Howell, B., Mummert, A., Shi, Y., Styner, M. A., Wilson, M. E., & Sánchez, M. M. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105987 · Cited by 12 · see citing works
Stress and the Reproductive System
Li, X.-F., & O’Byrne, K. T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00036-3 · Cited by 13 · see citing works
Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family.
Fan, J., Chen, X., & Du, J.-Z. (2014) · PubMed · Cited by 11 · see citing works
Neuroregulatory Peptides of Central Nervous System Origin: From Laboratory to Clinic
Geracioti, T. D., Strawn, J. R., Ekhator, N. N., Wortman, M. D., & Kasckow, J. W. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00082-6 · Cited by 10 · see citing works
Self-citationSharma, T. R. (2015) · Journal of psychiatry · doi:10.4172/2378-5756.1000336 · Cited by 9 · see citing works
Toward a Neurobiology of Child Psychotherapy
Kay, J. (2009) · Journal of Loss and Trauma · doi:10.1080/15325020903004566 · Cited by 9 · see citing works
Childhood Trauma and Personality Disorder
Perry, C., & Lee, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-49414-8_12 · Cited by 8 · see citing works
Self-citationSzabo, S. T., & Nemeroff, C. B. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410529-4.00103-0 · Cited by 6 · see citing works
Stress and the Gastrointestinal System
Bonaz, B. (2016) · Springer eBooks · doi:10.1007/978-3-319-28609-9_7 · Cited by 6 · see citing works
Depue, R. A., & Fu, Y. (2012) · Psychodynamic Psychiatry · doi:10.1521/pdps.2012.40.1.131 · Cited by 4 · see citing works
The Psychiatric–Child Protection Interface: Research to Inform Practice
Pritchard, C. W. (2010) · Wiley eBooks · doi:10.1002/9780470684214.ch37 · Cited by 3 · see citing works
LUPIEN, S. J., Fiocco, A. J., Wan, N. R. S., Maheu, F. S., Lord, C., Schramek, T. E., & Tu, M. T. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.012 · Cited by 3 · see citing works
Bramlett, S. N., Foster, S. L., Weinshenker, D., & Hepler, J. R. (2025) · Addiction Neuroscience · doi:10.1016/j.addicn.2025.100203 · Cited by 3 · see citing works
Pharmacological and behavioral characterization of the novel CRF1 antagonist BMS-763534
Lodge, N. J., Lelas, S., Li, Y.-W., Molski, T. F. P., Grace, J. E., Sivarao, D. V., Post-Munson, D. J., Healy, F. L., Bronson, J. J., Hartz, R. A., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.025 · Cited by 2 · see citing works
The Epigenetics of Parental Effects
Zhang, T.-Y., Caldji, C., Diorio, J., Dhir, S. K., Turecki, G., & Meaney, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-391494-1.00004-5 · Cited by 1 · see citing works
Rinne, T., & Langeland, W. (2017) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-0931-3_1 · Cited by 1 · see citing works
Rinne, T., & Langeland, W. (2009) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6821-1_1 · Cited by 1 · see citing works
Towards Achieving a Home-based Brain Stimulation System
Mansouri, F. (2019) · TSpace (University of Toronto) · Cited by 1 · see citing works
Rinne, T., & Langeland, W. (2007) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6404-6_1 · Cited by 1 · see citing works
Bramlett, S. N., Foster, S. L., Weinshenker, D., & Hepler, J. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.12.612719 · Cited by 1 · see citing works
The Neurobiology of Stress Throughout the Life Cycle
Kay, J. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0748-6_3
Deslauriers, J., Tóth, M., Scadeng, M., McKenna, B. S., Bussell, R., Gresack, J. E., Rissman, R. A., Risbrough, V. B., & Brown, G. G. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111137
Current awareness in human psychopharmacology
(2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.639
Childhood trauma and personality disorder: Toward a biological model
Lee, R. (1996) · Current Psychiatry Reports · doi:10.1007/s11920-996-0061-8
Self-citationWood, E. K., Aston, S. A., O'Connell, P., Hafen, E., Skowbo, A. N., Schwandt, M. L., Lindell, S. G., Smith, E., Johnson, M., Baron, Z., et al. (2024) · Stress · doi:10.1080/10253890.2024.2377272
Chapter 14. Aggression in Personality Disorders
Lee, R. (2019) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379071.lg14
Self-citation
- Authors
- Lee, R., Geracioti, T. D., Kasckow, J. W., & Coccaro, E. F.
- Affiliations
- University of Chicago (US)
- Venue
- American Journal of Psychiatry
- Published
- 2005-05-01
- Volume
- 162
- Issue
- 5
- Pages
- 995-997
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2119333919
- Cited by
- 84
- References
- 12
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 13 · 2013: 5 · 2012: 3
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- childhood trauma, personality disorders, corticotropin-releasing factor, cerebrospinal fluid, early life stress, emotional neglect, childhood abuse, child neglect, stress hormones, Childhood Trauma Questionnaire
- MeSH terms
- Adult, Age Factors, Child, Child Abuse, Corticotropin-Releasing Hormone, Humans, Life Change Events, Male, Personality Disorders, Psychiatric Status Rating Scales, Surveys and Questionnaires, Spinal Puncture, Subarachnoid Space, Diagnostic and Statistical Manual of Mental Disorders
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