Cited by 100Obsessive-Compulsive Spectrum DisordersNeural and Behavioral Psychology StudiesStuttering Research and Treatment

An fMRI Study of Frontostriatal Circuits During the Inhibition of Eye Blinking in Persons With Tourette Syndrome

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Mazzone, Luigi, Yu, Shan, Blair, Clancy, Gunter, Benjamin C., Wang, Zhishun, Marsh, Rachel, Peterson, Bradley S.·2010·American Journal of Psychiatry

Abstract

OBJECTIVE: The authors sought to study activity in neural circuits that subserve the inhibition of a semi-involuntary motor behavior, eye blinking, in children and adults with Tourette syndrome and in healthy comparison subjects. METHOD: Functional magnetic resonance imaging was used to scan 120 participants (51 with Tourette syndrome and 69 comparison subjects) as they either blinked normally or successfully inhibited eye blinking. The authors compared the blood-oxygen-level dependent signal during these two conditions across the Tourette and comparison groups. RESULTS: Relative to comparison subjects, patients with Tourette syndrome activated more strongly the frontal cortex and striatum during eye blink inhibition. Activation increased more with age in the dorsolateral and inferolateral prefrontal cortex and caudate nucleus in the Tourette group relative to comparison subjects. In addition, the Tourette group more strongly activated the middle frontal gyrus, dorsal anterior cingulate, and temporal cortices. The severity of tic symptoms in the Tourette group correlated inversely with activation in the putamen and inferolateral prefrontal cortex. CONCLUSIONS: Frontostriatal activity is increased in persons with Tourette syndrome during the inhibition of eye blinks. Activation of frontostriatal circuits in this population may help to maintain regulatory control over semi-involuntary behaviors, whether these are tics or eye blinks.

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Crossref · 10.1176/appi.ajp.2009.08121831

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  1. [30]Shapiro AK Shapiro ES Young JG Feinberg TE Shapiro AK Shapiro ES Young JG Feinberg TE Signs, symptoms, and clinical course, in Gilles de la Tourette Syndrome 1988 New York Raven Press 127 193

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Authors
Mazzone, L., Yu, S., Blair, C., Gunter, B. C., Wang, Z., Marsh, R., & Peterson, B. S.
Affiliations
  • New York State Psychiatric Institute (US)
  • Pennsylvania State University (US)
  • Columbia University (US)
Venue
American Journal of Psychiatry
Published
2010-03-01
Volume
167
Issue
3
Pages
341-349
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
OpenAlex
W2090181762
Cited by
100
References
36
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 8
FWCI
10.16
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
Funders
  • National Institutes of Health (5k02mh074677-05)
  • Italian Academy for Advanced Studies in America, Columbia University
  • U.S. Public Health Service (K-02-74677)
  • National Institute of Mental Health (MH59139, R01MH059139, MH-01232, R01MH068318, MH 068318, K02-74677, K08MH001232, K02-MH-074677)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-39667, P01HD039667, HD-051502, R01HD051502)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Stuttering Research and Treatment
Keywords
Tourette syndrome, frontostriatal circuits, tic suppression, prefrontal cortex, striatum, caudate nucleus, putamen, dorsolateral prefrontal cortex, tic severity, children and adults
MeSH terms
Adolescent, Adult, Blinking, Caudate Nucleus, Child, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Tourette Syndrome, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuronal Plasticity, Putamen, Temporal Lobe, Prefrontal Cortex, Young Adult

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