An fMRI Study of Frontostriatal Circuits During the Inhibition of Eye Blinking in Persons With Tourette Syndrome
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OBJECTIVE: The authors sought to study activity in neural circuits that subserve the inhibition of a semi-involuntary motor behavior, eye blinking, in children and adults with Tourette syndrome and in healthy comparison subjects. METHOD: Functional magnetic resonance imaging was used to scan 120 participants (51 with Tourette syndrome and 69 comparison subjects) as they either blinked normally or successfully inhibited eye blinking. The authors compared the blood-oxygen-level dependent signal during these two conditions across the Tourette and comparison groups. RESULTS: Relative to comparison subjects, patients with Tourette syndrome activated more strongly the frontal cortex and striatum during eye blink inhibition. Activation increased more with age in the dorsolateral and inferolateral prefrontal cortex and caudate nucleus in the Tourette group relative to comparison subjects. In addition, the Tourette group more strongly activated the middle frontal gyrus, dorsal anterior cingulate, and temporal cortices. The severity of tic symptoms in the Tourette group correlated inversely with activation in the putamen and inferolateral prefrontal cortex. CONCLUSIONS: Frontostriatal activity is increased in persons with Tourette syndrome during the inhibition of eye blinks. Activation of frontostriatal circuits in this population may help to maintain regulatory control over semi-involuntary behaviors, whether these are tics or eye blinks.
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A recent fMRI study of tic inhibition implicated the striatum and associated dorsal frontal regions during tic suppression.
“a recent fMRI study of tic inhibition implicated the striatum and associated dorsal frontal regions during tic suppression [622]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [622]
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- Authors
- Mazzone, L., Yu, S., Blair, C., Gunter, B. C., Wang, Z., Marsh, R., & Peterson, B. S.
- Affiliations
- New York State Psychiatric Institute (US)
- Pennsylvania State University (US)
- Columbia University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2010-03-01
- Volume
- 167
- Issue
- 3
- Pages
- 341-349
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC4295823
- OpenAlex
- W2090181762
- Cited by
- 100
- References
- 36
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 12 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 9 · 2012: 8
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion, other-oa)
- Funders
- National Institutes of Health (5k02mh074677-05)
- Italian Academy for Advanced Studies in America, Columbia University
- U.S. Public Health Service (K-02-74677)
- National Institute of Mental Health (MH59139, R01MH059139, MH-01232, R01MH068318, MH 068318, K02-74677, K08MH001232, K02-MH-074677)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-39667, P01HD039667, HD-051502, R01HD051502)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Stuttering Research and Treatment
- Keywords
- Tourette syndrome, frontostriatal circuits, tic suppression, prefrontal cortex, striatum, caudate nucleus, putamen, dorsolateral prefrontal cortex, tic severity, children and adults
- MeSH terms
- Adolescent, Adult, Blinking, Caudate Nucleus, Child, Corpus Striatum, Dominance, Cerebral, Female, Frontal Lobe, Tourette Syndrome, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neuronal Plasticity, Putamen, Temporal Lobe, Prefrontal Cortex, Young Adult
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