Cited by 273Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

Open access

Tripp, Adam, Oh, Hyunjung, Guilloux, Jean-Philippe, Martinowich, Keri, Lewis, David A., Sibille, Etienne·2012·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2012.12020248PMC PMC3638149

Open this paper in CoChat — free account

Abstract

OBJECTIVE: The subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of brain-derived neurotrophic factor (BDNF) and reduced markers for GABA function, including in the amygdala, are reported in major depression, but their contribution to subgenual anterior cingulate cortex dysfunction is not known. METHOD: Using polymerase chain reaction, we first assessed the degree to which BDNF controls mRNA expression (defined as BDNF dependency) of 15 genes relating to GABA and neuropeptide functions in the cingulate cortex of mice with reduced BDNF function (BDNF-heterozygous [Bdnf(+/-)] mice and BDNF exon-IV knockout [Bdnf(KIV)] mice). Gene expression was then quantified in the subgenual anterior cingulate cortex of 51 postmortem subjects with major depressive disorder and comparison subjects (total subjects, N=102; 49% were women) and compared with previous amygdala results. RESULTS: Based on the results in Bdnf(+/-) and Bdnf(KIV) mice, genes were sorted into high, intermediate, and no BDNF dependency sets. In postmortem human subjects with major depression, BDNF receptor (TRKB) expression, but not BDNF, was reduced. Postmortem depressed subjects exhibited down-regulation in genes with high and intermediate BDNF dependency, including markers of dendritic targeting interneurons (SST, NPY, and CORT) and a GABA synthesizing enzyme (GAD2). Changes extended to BDNF-independent genes (PVALB and GAD1). Changes were greater in men (potentially because of low baseline expression in women), displayed notable differences from prior amygdala results, and were not explained by demographic or clinical factors other than sex. CONCLUSIONS: These parallel human/mouse analyses provide direct (low TRKB) and indirect (low expression of BDNF-dependent genes) evidence in support of decreased BDNF signaling in the subgenual anterior cingulate cortex in individuals with major depressive disorder, implicate dendritic targeting GABA neurons and GABA synthesis, and, together, suggest a common BDNF-/GABA-related pathology in major depression with sex- and brain region-specific features.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1176/appi.ajp.2012.12020248

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059
Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness
Mayberg, H. S., Liotti, M., Brannan, S. K., McGinnis, S., Mahurin, R. K., Jerabek, P. A., Silva, J. A., Tekell, J. L., Martin, C. C., Lancaster, J. L., et al. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.5.675 · Cited by 2,416
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654
Hippocampal volume and depression: a meta-analysis of MRI studies
Videbech, P., & Ravnkilde, B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.1957 · Cited by 1,590
Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.
Korte, M., Carroll, P., Wolf, E., Brem, G., Thoenen, H., & Bonhoeffer, T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8856 · Cited by 1,426
Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115
The GABAergic deficit hypothesis of major depressive disorder
Luscher, B., Shen, Q., & Sahir, N. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.120 · Cited by 934
Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875

Show all 40 references

Research works printed but not linked: 1

Guilloux JP, 2011, Mol Psychiatry

Sorted by citations

Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments
Duman, R. S., Sanacora, G., & Krystal, J. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.013 · Cited by 1,026
Sex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748
Astrocyte Pathology in Major Depressive Disorder: Insights from Human Postmortem Brain Tissue
Rajkowska, G., & Stockmeier, C. (2013) · Current Drug Targets · doi:10.2174/13894501113149990156 · Cited by 603
Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action
Castrén, E., & Monteggia, L. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.05.008 · Cited by 540
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 486
The Role of BDNF on Neural Plasticity in Depression
Yang, T., Nie, Z., Shu, H., Kuang, Y., Chen, X., Cheng, J., Yu, S., & Liu, H. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00082 · Cited by 435
Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions
Fogaça, M. V., & Duman, R. S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00087 · Cited by 396
Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Castrén, E., & Kojima, M. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.010 · Cited by 337
Somatostatin-Positive Gamma-Aminobutyric Acid Interneuron Deficits in Depression: Cortical Microcircuit and Therapeutic Perspectives
Fee, C., Banasr, M., & Sibille, E. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.05.024 · Cited by 329
Self-citation
Targeting TRK family proteins in cancer
Khotskaya, Y. B., Holla, V. R., Farago, A. F., Mills Shaw, K. R., Meric-Bernstam, F., & Hong, D. S. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.006 · Cited by 292
Biological Sex Differences in Depression: A Systematic Review
Labaka, A., Goñi‐Balentziaga, O., Lebeña, A., & Pérez-Tejada, J. (2018) · Biological Research For Nursing · doi:10.1177/1099800418776082 · Cited by 297
Opposite Molecular Signatures of Depression in Men and Women
Seney, M. L., Huo, Z., Cahill, K., French, L., Puralewski, R., Zhang, J., Logan, R. W., Tseng, G., Lewis, D. A., & Sibille, E. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.017 · Cited by 272
Self-citation
Hyperactivity of Anterior Cingulate Cortex Areas 24a/24b Drives Chronic Pain-Induced Anxiodepressive-like Consequences
Sellmeijer, J., Mathis, V., Hugel, S., Li, X., Song, Q., Chen, Q., Barthas, F., Lutz, P.-É., Karatas, M., Lüthi, A., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3195-17.2018 · Cited by 246
Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders
Prévot, T. D., & Sibille, E. L. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0727-3 · Cited by 238
Self-citation
PI3K/AKT signaling pathway: Molecular mechanisms and therapeutic potential in depression
Guo, N., Wang, X., Xu, M., Bai, J., Yu, H., & Zhang, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107300 · Cited by 237
NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice
Song, A., Gao, B., Fan, J.-J., Zhu, Y., Zhou, J., Wang, Y., Xu, L.-Z., & Wu, W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01848-8 · Cited by 215
Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state
Fuchs, T., Jefferson, S. J., Hooper, A., Yee, P.-H., Maguire, J., & Luscher, B. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.188 · Cited by 204
BDNF at the synapse: why location matters
Song, M., Martinowich, K., & Lee, F. S. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.144 · Cited by 201
Self-citation
Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine
Deyama, S., & Duman, R. S. (2020) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.172837 · Cited by 186
Association of BDNF Val66Met Polymorphism and Brain BDNF Levels with Major Depression and Suicide
Youssef, M. M., Underwood, M. D., Huang, Y.-Y., Hsiung, S.-C., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., et al. (2018) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy008 · Cited by 183
Altered expression of BDNF, BDNF pro-peptide and their precursor proBDNF in brain and liver tissues from psychiatric disorders: rethinking the brain–liver axis
Yang, B., Ren, Q., Zhang, J.-C., Chen, Q.-X., & Hashimoto, K. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.95 · Cited by 187
Sex differences in mood disorders: Perspectives from humans and rodent models
Seney, M. L., & Sibille, E. (2014) · Biology of Sex Differences · doi:10.1186/s13293-014-0017-3 · Cited by 181
Self-citation
Sex differences in brain‐derived neurotrophic factor signaling and functions
Chan, C. B., & Ye, K. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23863 · Cited by 193
The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology
Homberg, J. R., Molteni, R., Calabrese, F., & Riva, M. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.012 · Cited by 177
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin, L., & Sibille, E. L. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.184 · Cited by 188
Self-citation
Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Stepanichev, M. Y., Дыгало, Н. Н., Grigoryan, G. A., Shishkina, G. T., & Gulyaeva, N. V. (2014) · BioMed Research International · doi:10.1155/2014/932757 · Cited by 180
New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases
Adachi, N. (2014) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v5.i4.409 · Cited by 171
Psychedelics and Other Psychoplastogens for Treating Mental Illness.
Vargas, M. V., Meyer, R., Avanes, A. A., Rus, M., & Olson, D. E. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.727117 · Cited by 166
Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction
Pehrson, A. L., & Sanchez, C. (2014) · CNS Spectrums · doi:10.1017/s1092852913000540 · Cited by 161
Major Depression: One Brain, One Disease, One Set of Intertwined Processes
Filatova, E. V., Shadrina, M. I., & Slominsky, P. A. (2021) · Cells · doi:10.3390/cells10061283 · Cited by 186
Decreased BDNF and TrkB mRNA expression in multiple cortical areas of patients with schizophrenia and mood disorders
Ray, M. T., Shannon Weickert, C., & Webster, M. J. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.26 · Cited by 161
Use of Nanoparticle Contrast Agents for Cell Tracking with Computed Tomography
Kim, J., Chhour, P., Hsu, J. C., Litt, H. I., Ferrari, V. A., Popovtzer, R., & Cormode, D. P. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00194 · Cited by 157
Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review
Sălcudean, A., Bodo, C.-R., Popovici, R. A., Lica, M. M., Păcurar, M., Crăciun, R.-E., Crișan, A., ENĂTESCU, V. R., Marinescu, I. P., Cîmpian, D. M., et al. (2025) · Biomolecules · doi:10.3390/biom15040502 · Cited by 179
GABAergic Control of Depression-Related Brain States
Luscher, B., & Fuchs, T. (2015) · Advances in Pharmacology · doi:10.1016/bs.apha.2014.11.003 · Cited by 149
The serum protein levels of the tPA–BDNF pathway are implicated in depression and antidepressant treatment
Jiang, H., Chen, S., Li, C., Lu, N., Yue, Y., Yin, Y., Zhang, Y., Zhi, X., Zhang, D., & Yuan, Y. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.43 · Cited by 148
Why are cortical GABA neurons relevant to internal focus in depression? A cross-level model linking cellular, biochemical and neural network findings
Northoff, G., & Sibille, E. L. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.68 · Cited by 148
Self-citation
Afferents to anterior cingulate areas 24a and 24b and midcingulate areas 24a′ and 24b′ in the mouse
Fillinger, C., Yalçın, İ., Barrot, M., & Veinante, P. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1290-1 · Cited by 144
BDNF promoter methylation and genetic variation in late-life depression
Januar, V, Ancelin, M.-L., Ritchie, K., Saffery, R., & Ryan, J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.114 · Cited by 139
Gene expression links functional networks across cortex and striatum
Anderson, K. M., Krienen, F. M., Choi, E. Y., Reinen, J. M., Yeo, B. T. T., & Holmes, A. J. (2018) · Nature Communications · doi:10.1038/s41467-018-03811-x · Cited by 138
A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder
Hing, B., Sathyaputri, L., & Potash, J. B. (2018) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32616 · Cited by 137
Opposing effects of acute versus chronic blockade of frontal cortex somatostatin-positive inhibitory neurons on behavioral emotionality in mice
Soumier, A., & Sibille, E. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.76 · Cited by 136
Self-citation
Characterization of GABAergic Marker Expression in the Chronic Unpredictable Stress Model of Depression
Banasr, M., Lepack, A., Fee, C., Duric, V., Maldonado-Aviles, J., DiLeone, R., Sibille, E., Duman, R. S., & Sanacora, G. (2017) · Chronic Stress · doi:10.1177/2470547017720459 · Cited by 135
Self-citation
Brain-derived neurotrophic factor
Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001507 · Cited by 138
Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders
Sibille, E. L. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.1/esibille · Cited by 131
Self-citation
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses
Fogaça, M. V., Wu, M., Li, C., Li, X.-Y., Picciotto, M. R., & Duman, R. S. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00916-y · Cited by 129
Neurobiology of Major Depressive Disorder
Villanueva, R. (2013) · Neural Plasticity · doi:10.1155/2013/873278 · Cited by 127
Brain-wide changes in excitation-inhibition balance of major depressive disorder: a systematic review of topographic patterns of GABA- and glutamatergic alterations
Hu, Y.-T., Tan, Z.-L., Hirjak, D., & Northoff, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02193-x · Cited by 127
Increased BDNF levels after electroconvulsive therapy in patients with major depressive disorder: A meta-analysis study
Rocha, R. B., Dondossola, E. R., Grande, A. J., Colonetti, T., Ceretta, L. B., Passos, I. C., Quevedo, J., & da Rosa, M. I. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.004 · Cited by 119
Estrogenic mediation of serotonergic and neurotrophic systems: Implications for female mood disorders
Borrow, A. P., & Cameron, N. M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.009 · Cited by 126
Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?
Lin, L., & Sibille, E. L. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00110 · Cited by 122
Self-citation
Beyond genotype: serotonin transporter epigenetic modification predicts human brain function
Nikolova, Y. S., Koenen, K. C., Galea, S., Wang, C., Seney, M. L., Sibille, E. L., Williamson, D. E., & Hariri, A. R. (2014) · Nature Neuroscience · doi:10.1038/nn.3778 · Cited by 114
Self-citation
Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling
Maynard, K. R., Hill, J. L., Calcaterra, N. E., Palko, M. E., Kardian, A., Paredes, D., Sukumar, M., Adler, B. D., Jimenez, D. V., Schloesser, R. J., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.349 · Cited by 115
Self-citation
Activity-Dependent Brain-Derived Neurotrophic Factor Release Is Required for the Rapid Antidepressant Actions of Scopolamine
Ghosal, S., Bang, E., Yue, W., Hare, B. D., Lepack, A. E., Girgenti, M. J., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.017 · Cited by 111
The Role of BDNF in Age-Dependent Changes of Excitatory and Inhibitory Synaptic Markers in the Human Prefrontal Cortex
Oh, H., Lewis, D. A., & Sibille, E. L. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.126 · Cited by 113
Self-citation
Neuropathological relationship between major depression and dementia: A hypothetical model and review
Kim, H. K., Nunes, P. V., de Oliveira, K. C., Young, L. T., & Lafer, B. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.008 · Cited by 112
Value of peripheral neurotrophin levels for the diagnosis of depression and response to treatment: A systematic review and meta-analysis
Shi, Y., Luan, D., Song, R., & Zhang, Z. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.09.633 · Cited by 105
Interplay between pro-inflammatory cytokines and growth factors in depressive illnesses
Audet, M., & Anisman, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00068 · Cited by 107
A Conserved BDNF, Glutamate- and GABA-Enriched Gene Module Related to Human Depression Identified by Coexpression Meta-Analysis and DNA Variant Genome-Wide Association Studies
Chang, L., Jamain, S., Lin, C., Rujescu, D., Tseng, G. C., & Sibille, E. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090980 · Cited by 103
Self-citation
Mechanism of Repetitive Transcranial Magnetic Stimulation for Depression.
Peng, Z., Zhou, C., Xue, S., Bai, J., Yu, S.-F., Li, X., Wang, H., & Tan, Q. (2018) · Europe PMC (PubMed Central) · doi:10.11919/j.issn.1002-0829.217047 · Cited by 100
Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression
Seney, M. L., Glausier, J. R., & Sibille, E. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.12.025 · Cited by 100
Self-citation
Laminar and cellular analyses of reduced somatostatin gene expression in the subgenual anterior cingulate cortex in major depression
Seney, M. L., Tripp, A. C., McCune, S., Lewis, D. A., & Sibille, E. L. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.10.005 · Cited by 97
Self-citation
Meta-analysis of central and peripheral γ-aminobutyric acid levels in patients with unipolar and bipolar depression
Romeo, B., Choucha, W., Fossati, P., & Rotge, J.-Y. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.160228 · Cited by 94
A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder
Yin, H., Pantazatos, S. P., Galfalvy, H., Huang, Y., Rosoklija, G. B., Dwork, A. J., Burke, A., Arango, V., Oquendo, M. A., & Mann, J. J. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32423 · Cited by 91
Roles of olfactory system dysfunction in depression
Yuan, T., & Slotnick, B. M. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.05.013 · Cited by 99
Diversity and Function of Somatostatin-Expressing Interneurons in the Cerebral Cortex
Riedemann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20122952 · Cited by 103
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
Samsom, J., & Wong, A. H. C. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00013 · Cited by 88
The Role of Genetic Sex in Affect Regulation and Expression of GABA-Related Genes Across Species
Seney, M. L., Chang, L.-C., Oh, H., Wang, X., Tseng, G. C., Lewis, D. A., & Sibille, E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00104 · Cited by 78
Self-citation
Abnormal Retinoid and TrkB Signaling in the Prefrontal Cortex in Mood Disorders
Qi, X., Zhao, J. Y., Liu, J., Fang, H., Swaab, D. F., & Zhou, J. (2013) · Cerebral Cortex · doi:10.1093/cercor/bht203 · Cited by 82
Optogenetic and chemogenetic insights into the neurocircuitry of depression‐like behaviour: A systematic review
Biselli, T., Lange, S. S., Sablottny, L., Steffen, J., & Walther, A. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14603 · Cited by 77
Understanding epigenetic architecture of suicide neurobiology: A critical perspective
Roy, B., & Dwivedi, Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.031 · Cited by 70
Sex-dependent anti-stress effect of an α5 subunit containing GABAA receptor positive allosteric modulator
Piantadosi, S. C., French, B. J., Poe, M. M., Timić, T., Marković, B. D., Pabba, M., Seney, M. L., Oh, H., Orser, B. A., Savić, M. M., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00446 · Cited by 67
Self-citation
Hormonal regulation of circuit function: sex, systems and depression
Thériault, R.-K., & Perreault, M. L. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0226-x · Cited by 73
Gender and brain regions specific differences in brain derived neurotrophic factor protein levels of depressed individuals who died through suicide
Hayley, S. P., Du, L., Litteljohn, D., Palkovits, M., Faludi, G., Merali, Z., Poulter, M. O., & Anisman, H. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.052 · Cited by 72
Parvalbumin interneuron alterations in stress-related mood disorders: A systematic review
Perlman, G., Tanti, A., & Mechawar, N. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100380 · Cited by 71
Neural Mechanisms of Exercise: Anti-Depression, Neurogenesis, and Serotonin Signaling
Yuan, T., Paes, F., Arias-Carrión, Ó., Rocha, N., Filho, A. S. S., & Machado, S. E. D. C. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666151111124402 · Cited by 65
Molecular and Genetic Characterization of Depression: Overlap with Other Psychiatric Disorders and Aging
Ding, Y., Chang, L.-C., Wang, X., Guilloux, J.-P., Parrish, J., Oh, H., French, B. J., Lewis, D. A., Tseng, G. C., & Sibille, E. (2015) · Complex Psychiatry · doi:10.1159/000369974 · Cited by 61
Self-citation
Transcriptional Evidence for the Role of Chronic Venlafaxine Treatment in Neurotrophic Signaling and Neuroplasticity Including also Glutatmatergic- and Insulin-Mediated Neuronal Processes
Tamási, V., Petschner, P., Ádori, C., Kirilly, E., Andó, R. D., Tóthfalusi, L., Juhász, G., & Bagdy, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113662 · Cited by 60
Sex chromosome complement regulates expression of mood-related genes
Seney, M. L., Ekong, K. I., Ding, Y., Tseng, G. C., & Sibille, E. L. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-20 · Cited by 62
Self-citation
Epigenetics, nutrition and mental health. Is there a relationship?
Stevens, A. J., Rucklidge, J. J., & Kennedy, M. A. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1331524 · Cited by 61
A Role of BDNF in the Depression Pathogenesis and a Potential Target as Antidepressant: The Modulator of Stress Sensitivity “Shati/Nat8l-BDNF System” in the Dorsal Striatum
Miyanishi, H., & Nitta, A. (2021) · Pharmaceuticals · doi:10.3390/ph14090889 · Cited by 57
Inflammatory Pathogenesis of Post-stroke Depression
Feng, X., Ma, X., Li, J., Zhou, Q., Liu, Y., Song, J., Liu, J., Situ, Q., Wang, L., Zhang, J., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0203 · Cited by 63
Prefrontal cortical parvalbumin and somatostatin expression and cell density increase during adolescence and are modified by BDNF and sex
Du, X., Serena, K., Hwang, W. J., Grech, A. M., Wu, Y., Schroeder, A., & Hill, R. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.02.001 · Cited by 58
BDNF plasma levels and genotype in depression and the response to electroconvulsive therapy
Ryan, K. M., Dunne, R. A., & McLoughlin, D. M. (2018) · Brain stimulation · doi:10.1016/j.brs.2018.05.011 · Cited by 58
Sex Differences in Depression and Anxiety
Pavlidi, P., Kokras, N., & Dalla, C. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_375 · Cited by 60
Biological markers of sex-based differences in major depressive disorder and in antidepressant response
Silva, R. C., Pisanu, C., Maffioletti, E., Menesello, V., Bortolomasi, M., Gennarelli, M., Baune, B. T., Squassina, A., & Minelli, A. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.07.012 · Cited by 53
The Role of Dendritic Brain-Derived Neurotrophic Factor Transcripts on Altered Inhibitory Circuitry in Depression
Oh, H., Piantadosi, S. C., Rocco, B. R., Lewis, D. A., Watkins, S. C., & Sibille, E. L. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.026 · Cited by 55
Self-citation
Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
Aldoghachi, A. F., Tor, Y. S., Redzun, S. Z., Lokman, K. A. B., Razaq, N. A. A., Shahbudin, A. F., Badamasi, I. M., Cheah, P.-S., Stanslas, J., Veerakumarasivam, A., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0211241 · Cited by 54
The miRNome of Depression
Żurawek, D., & Turecki, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111312 · Cited by 62
Neurotrophin receptors in the pathogenesis, diagnosis and therapy of neurodegenerative diseases
Meldolesi, J. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.04.024 · Cited by 53
BDNF receptor TrkB as the mediator of the antidepressant drug action
Casarotto, P. C., Umemori, J., & Ċastrén, E. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1032224 · Cited by 53
Agmatine, a potential novel therapeutic strategy for depression
Freitas, A. E., Neis, V. B., & Rodrigues, A. L. S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.10.013 · Cited by 54
Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
Alcaide, J., Guirado, R., Crespo, C., Blasco-Ibáñez, J. M., Varea, E., Sanjuan, J., & Nacher, J. (2019) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0161-0 · Cited by 51
Biological substrates underpinning diagnosis of major depression
Sibille, E. L., & French, B. J. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000436 · Cited by 53
Self-citation
Autophagy dysfunction contributes to NLRP1 inflammasome-linked depressive-like behaviors in mice
Zhu, Y., Huang, J., Chen, R., Zhang, Y., He, X., Duan, W.-X., Zou, Y.-L., Sun, M.-M., Sun, H., Cheng, S.-M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02995-4 · Cited by 52
Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex
Lomazzo, E., König, F., Abassi, L., Jelinek, R., & Lutz, B. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.10.008 · Cited by 50
Role of neurotrophic and growth factors in the rapid and sustained antidepressant actions of ketamine
Deyama, S., & Kaneda, K. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109335 · Cited by 46
Post-stroke depression: epigenetic and epitranscriptomic modifications and their interplay with gut microbiota
Jeong, S., Chokkalla, A. K., Davis, C. K., & Vemuganti, R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02099-8 · Cited by 50
Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice
Ren, Z., Sahir, N., Murakami, S., Luellen, B. A., Earnheart, J. C., Lal, R., Kim, J. Y., Song, H., & Lüscher, B. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.019 · Cited by 47
Transcranial Magnetic Stimulation Modulates Resting EEG Functional Connectivity Between the Left Dorsolateral Prefrontal Cortex and Limbic Regions in Medicated Patients With Treatment-Resistant Depression.
Kito, S., Hasegawa, T., Takamiya, A., Noda, T., Nakagome, K., Higuchi, T., & Koga, Y. (2017) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15120419 · Cited by 42
Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation
Fee, C., Prévot, T. D., Misquitta, K. A., Knutson, D. E., Li, G., Mondal, P., Cook, J. M., Banasr, M., & Sibille, E. L. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab002 · Cited by 50
Self-citation

Authors: Tripp, A., Oh, H., Guilloux, J.-P., Martinowich, K., Lewis, D. A., & Sibille, E.
Affiliations: Université Paris-Sud (FR)
ORCID: Oh, Hyunjung
Guilloux, Jean-Philippe
Martinowich, Keri
Lewis, David A.
Sibille, Etienne
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2012-11
Volume: 169
Issue: 11
Pages: 1194-1202
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2012.12020248
PMC: PMC3638149
OpenAlex: W2161401578
Cited by: 273
References: 40
Citations by year: 2026: 10 · 2025: 12 · 2024: 32 · 2023: 18 · 2022: 18 · 2021: 24 · 2020: 24 · 2019: 24 · 2018: 21 · 2017: 18 · 2016: 18 · 2015: 19 · 2014: 24 · 2013: 10 · 2012: 1
FWCI: 12.70
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (P50MH084053, MH084060, MH084053, MH085111, R21MH085111, R01MH077159, K02MH084060)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: major depressive disorder, brain-derived neurotrophic factor, subgenual anterior cingulate cortex, TrkB receptor, GABAergic interneurons, GABA synthesis, gene expression, sex differences, postmortem brain, amygdala, neuropeptides
MeSH terms: Animals, Major Depressive Disorder, Depressive Disorder, Major, Dominance, Cerebral, Exons, Female, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Gyrus Cinguli, Genetic Carrier Screening, Humans, Male, Mice, Inbred C57BL, RNA, Messenger, Sex Factors, Signal Transduction, Down-Regulation, Gene Expression, Case-Control Studies, Polymerase Chain Reaction, Mice, Knockout, Brain-Derived Neurotrophic Factor, Receptor, trkB, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Brain-Derived Neurotrophic Factor Signaling and Subgenual Anterior Cingulate Cortex Dysfunction in Major Depressive Disorder

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks