Identification of Distinct Psychosis Biotypes Using Brain-Based Biomarkers
Open accessAbstract
OBJECTIVE: Clinical phenomenology remains the primary means for classifying psychoses despite considerable evidence that this method incompletely captures biologically meaningful differentiations. Rather than relying on clinical diagnoses as the gold standard, this project drew on neurobiological heterogeneity among psychosis cases to delineate subgroups independent of their phenomenological manifestations. METHOD: A large biomarker panel (neuropsychological, stop signal, saccadic control, and auditory stimulation paradigms) characterizing diverse aspects of brain function was collected on individuals with schizophrenia, schizoaffective disorder, and bipolar disorder with psychosis (N=711), their first-degree relatives (N=883), and demographically comparable healthy subjects (N=278). Biomarker variance across paradigms was exploited to create nine integrated variables that were used to capture neurobiological variance among the psychosis cases. Data on external validating measures (social functioning, structural magnetic resonance imaging, family biomarkers, and clinical information) were collected. RESULTS: Multivariate taxometric analyses identified three neurobiologically distinct psychosis biotypes that did not respect clinical diagnosis boundaries. The same analysis procedure using clinical DSM diagnoses as the criteria was best described by a single severity continuum (schizophrenia worse than schizoaffective disorder worse than bipolar psychosis); this was not the case for biotypes. The external validating measures supported the distinctiveness of these subgroups compared with clinical diagnosis, highlighting a possible advantage of neurobiological versus clinical categorization schemes for differentiating psychotic disorders. CONCLUSIONS: These data illustrate how multiple pathways may lead to clinically similar psychosis manifestations, and they provide explanations for the marked heterogeneity observed across laboratories on the same biomarker variables when DSM diagnoses are used as the gold standard.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Clusters of individuals with neural network alterations have been identified in depression, psychotic disorders, and ADHD.
“Indeed, clusters of individuals with neural network alterations have been identified in depression [7–8], psychotic disorders [9] and attention-deficit/hyperactivity disorder (ADHD [10]).”
From Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder (2021) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369 · see citing works
Data clustering: 50 years beyond K-means
Jain, A. K. (2009) · Pattern Recognition Letters · doi:10.1016/j.patrec.2009.09.011 · Cited by 9,622 · see citing works
Insel, T., Cuthbert, B., Garvey, M., Heinssen, R., Pine, D. S., Quinn, K., Sanislow, C., & Wang, P. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091379 · Cited by 7,067 · see citing works
Estimating the Number of Clusters in a Data Set Via the Gap Statistic
Tibshirani, R., Walther, G., & Hastie, T. (2001) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00293 · Cited by 6,205 · see citing works
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
METABRIC Group, Curtis, C., Shah, S. P., Chin, S.-F., Turashvili, G., Rueda, O. M., Dunning, M. J., Speed, D., Lynch, A. G., Samarajiwa, S., et al. (2012) · Nature · doi:10.1038/nature10983 · Cited by 6,097 · see citing works
Leucht, S., Cipriani, A., Spineli, L., Mavridis, D., Örey, D., Richter, F., Samara, M., Barbui, C., Engel, R. R., Geddes, J. R., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60733-3 · Cited by 2,561 · see citing works
Preterm labor: One syndrome, many causes
Romero, R., Dey, S. K., & Fisher, S. J. (2014) · Science · doi:10.1126/science.1251816 · Cited by 1,984 · see citing works
The Family History Method Using Diagnostic Criteria
Andreasen, N. C. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770220111013 · Cited by 1,903 · see citing works
Keefe, R. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.09.011 · Cited by 1,573 · see citing works
K -means clustering via principal component analysis
Ding, C. H. Q., & He, X. (2004) · doi:10.1145/1015330.1015408 · Cited by 1,412 · see citing works
(1995) · PubMed · Cited by 1,320 · see citing works
Kapur, S., Phillips, A. G., & Insel, T. R. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.105 · Cited by 980 · see citing works
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
Malhotra, D., & Sebat, J. (2012) · Cell · doi:10.1016/j.cell.2012.02.039 · Cited by 854 · see citing works
Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update.
Bethune, G. C., Bethune, D. C. G., Ridgway, N. D., & Xu, Z. (2010) · Europe PMC (PubMed Central) · Cited by 449 · see citing works
Yang, Y., Han, L., Yuan, Y., Li, J., Hei, N., & Liang, H. (2014) · Nature Communications · doi:10.1038/ncomms4231 · Cited by 423 · see citing works
Yang, J. C., Shih, J., Su, W., Hsia, T., Tsai, C., Ou, S. I., Yu, C., Chang, G., Ho, C., Sequist, L. V. D., et al. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70086-4 · Cited by 410 · see citing works
Tamminga, C. A., Ivleva, E. I., Keshavan, M. S., Pearlson, G. D., Clementz, B. A., Witte, B. P., Morris, D. W., Bishop, J. R., Thaker, G. K., & Sweeney, J. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12101339 · Cited by 361 · see citing works
Self-citationHill, S. K., Reilly, J. L., Keefe, R. S. E., Gold, J. M., Bishop, J. R., Gershon, E. S., Tamminga, C. A., Pearlson, G. D., Keshavan, M. S., & Sweeney, J. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12101298 · Cited by 355 · see citing works
Self-citationProbing genetic overlap among complex human phenotypes
Rzhetsky, A., Wajngurt, D., Park, N., & Zheng, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704820104 · Cited by 298 · see citing works
Hyman, S. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003142 · Cited by 260 · see citing works
Meda, S. A., Ruaño, G., Windemuth, A., O’Neil, K., Berwise, C., Dunn, S. M., Boccaccio, L. E., Narayanan, B., Kocherla, M., Sprooten, E., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313093111 · Cited by 242 · see citing works
Self-citationKhadka, S., Meda, S. A., Stevens, M. C. G., Glahn, D. C., Calhoun, V. D., Sweeney, J. A., Tamminga, C. A., Keshavan, M. S., O'Neil, K. M., Schretlen, D. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.024 · Cited by 221 · see citing works
Self-citationKeshavan, M. S., Morris, D. W., Sweeney, J. A., Pearlson, G. D., Thaker, G. K., Seidman, L. J., Eack, S. M., & Tamminga, C. A. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.09.005 · Cited by 210 · see citing works
Self-citationNeurophysiological Endophenotypes Across Bipolar and Schizophrenia Psychosis
Thaker, G. K. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn049 · Cited by 204 · see citing works
After GWAS: Searching for Genetic Risk for Schizophrenia and Bipolar Disorder
Gershon, E. S., Alliey‐Rodriguez, N., & Liu, C. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10091340 · Cited by 200 · see citing works
Skudlarski, P., Schretlen, D. J., Thaker, G. K., Stevens, M. C. G., Keshavan, M. S., Sweeney, J. A., Tamminga, C. A., Clementz, B. A., O'Neil, K. M., & Pearlson, G. D. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12111448 · Cited by 188 · see citing works
Self-citationGenetics of schizophrenia: new findings and challenges
Gejman, P. V., Sanders, A. R., & Kendler, K. S. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082410-101459 · Cited by 183 · see citing works
Ivleva, E. I., Bidesi, A. S., Keshavan, M. S., Pearlson, G. D., Meda, S. A., Dodig, D., Moates, A. F., Lu, H., Francis, A., Tandon, N., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13010126 · Cited by 164 · see citing works
Self-citationGenetics and intermediate phenotypes of the schizophrenia—bipolar disorder boundary
Ivleva, E. I., Morris, D. W., Moates, A. F., Suppes, T. M., Thaker, G. K., & Tamminga, C. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.022 · Cited by 150 · see citing works
Self-citationMeasuring liability for schizophrenia using optimized antisaccade stimulus parameters
McDowell, J. E., Myles‐Worsley, M., Coon, H. H., Byerley, W., & Clementz, B. A. (1999) · Psychophysiology · doi:10.1017/s0048577299980836 · Cited by 119 · see citing works
Self-citationYanagi, M., Joho, R. H., Southcott, S. A., Shukla, A. A., Ghose, S., & Tamminga, C. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.49 · Cited by 102 · see citing works
Self-citationReilly, J. L., Frankovich, K., Hill, S. K., Gershon, E. S., Keefe, R. S. E., Keshavan, M. S., Pearlson, G. D., Tamminga, C. A., & Sweeney, J. A. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt132 · Cited by 88 · see citing works
Self-citationEthridge, L. E., Hamm, J. P., Pearlson, G. D., Tamminga, C. A., Sweeney, J. A., Keshavan, M. S., & Clementz, B. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.032 · Cited by 86 · see citing works
Self-citationReimagining psychoses: An agnostic approach to diagnosis
Keshavan, M. S., Clementz, B. A., Pearlson, G. D., Sweeney, J. A., & Tamminga, C. A. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.02.022 · Cited by 84 · see citing works
Self-citationPhenomenology of First-Episode Psychosis in Schizophrenia, Bipolar Disorder, and Unipolar Depression
Rosen, C., Marvin, R. W., Reilly, J. L., León, O. A. D., Harris, M. S. H., Keedy, S., Solari, H., Weiden, P. J., & Sweeney, J. A. (2012) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.6.3.6 · Cited by 73 · see citing works
Self-citationSeveriano, A., Carriço, J. A., Robinson, D. A., Ramirez, M., & Pinto, F. R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019539 · Cited by 71 · see citing works
Ethridge, L. E., Soilleux, M., Nakonezny, P. A., Reilly, J. L., Hill, S. K., Keefe, R. S. E., Gershon, E. S., Pearlson, G. D., Tamminga, C. A., Keshavan, M. S., et al. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.08.025 · Cited by 69 · see citing works
Self-citationReilly, J. L., Harris, M. S. H., Khine, T. T., Keshavan, M. S., & Sweeney, J. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.009 · Cited by 66 · see citing works
Self-citationAugmented gamma band auditory steady-state responses: Support for NMDA hypofunction in schizophrenia
Hamm, J. P., Gilmore, C. S., & Clementz, B. A. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.04.003 · Cited by 66 · see citing works
Self-citationHarvey, P. D., Keefe, R. S. E., Patterson, T. L., Heaton, R. K., & Bowie, C. R. (2008) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390802251386 · Cited by 64 · see citing works
Shinn, A. K., Pfaff, D. L., Young, S., Lewandowski, K. E., Cohen, B. M., & Öngür, D. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.11.003 · Cited by 57 · see citing works
Closing in on Genes for Manic-Depressive Illness and Schizophrenia
Gershon, E. S. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00145-0 · Cited by 50 · see citing works
A twin study of schizoaffective‐mania, schizoaffective‐depression, and other psychotic syndromes
Cardno, A. G., Rijsdijk, F. V., West, R. M., Gottesman, I. I., Craddock, N. J., Murray, R. M., & McGuffin, P. (2011) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32011 · Cited by 41 · see citing works
Hamm, J. P., Ethridge, L. E., Boutros, N. N., Keshavan, M. S., Sweeney, J. A., Pearlson, G. D., Tamminga, C. A., & Clementz, B. A. (2014) · Psychophysiology · doi:10.1111/psyp.12185 · Cited by 37 · see citing works
Self-citationDiagnosing the DSM: Diagnostic Classification Needs Fundamental Reform.
Hyman, S. E. (2011) · PubMed · Cited by 37 · see citing works
Iacono, W., & Ba, C. (1993) · PubMed · Cited by 37 · see citing works
The ability to produce express saccades as a function of gap interval among schizophrenia patients
Clementz, B. (1996) · Experimental Brain Research · doi:10.1007/bf00229561 · Cited by 36 · see citing works
Self-citationComplication begets clarification in classification
Barkovich, A. J. (2013) · Brain · doi:10.1093/brain/awt001 · Cited by 25 · see citing works
Clementz, B. A., Sweeney, J. A., Keshavan, M. S., Pearlson, G. D., & Tamminga, C. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.012 · Cited by 15 · see citing works
Self-citationInterpreter of Maladies: Redescription Mining Applied to Biomedical Data Analysis
Waltman, P., Pearlman, A., & Mishra, B. (2006) · Pharmacogenomics · doi:10.2217/14622416.7.3.503 · Cited by 5 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [7]National Research Council (US) Committee on a Framework for Developing a New Taxonomy of Disease: Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease 2011 Washington, DC National Academies Press 22536618
- [50]Rosenberg RN Pascual JN Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Diseases 2014 5th Waltham, Mass Academic Press
Cited by
Sorted by citations
Resting-state connectivity biomarkers define neurophysiological subtypes of depression
Drysdale, A. T., Grosenick, L., Downar, J., Dunlop, K., Mansouri, F., Meng, Y., Fetcho, R. N., Zebley, B., Oathes, D. J., Etkin, A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4246 · Cited by 2,170 · see citing works
Building better biomarkers: brain models in translational neuroimaging
Woo, C.-W., Chang, L. J., Lindquist, M. A., & Wager, T. D. (2017) · Nature Neuroscience · doi:10.1038/nn.4478 · Cited by 1,056 · see citing works
Machine Learning Approaches for Clinical Psychology and Psychiatry
Dwyer, D. B., Falkai, P., & Koutsouleris, N. (2018) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032816-045037 · Cited by 966 · see citing works
Clark, L. A., Cuthbert, B., Lewis-Fernández, R., Narrow, W. E., & Reed, G. M. (2017) · Psychological Science in the Public Interest · doi:10.1177/1529100617727266 · Cited by 688 · see citing works
Nonsocial and social cognition in schizophrenia: current evidence and future directions
Green, M. F., Horan, W. P., & Lee, J. (2019) · World Psychiatry · doi:10.1002/wps.20624 · Cited by 612 · see citing works
Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models
Wolfers, T., Doan, N. T., Kaufmann, T., Alnæs, D., Moberget, T., Agartz, I., Buitelaar, J. K., Ueland, T., Melle, I., Franke, B., et al. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.2467 · Cited by 508 · see citing works
Linked dimensions of psychopathology and connectivity in functional brain networks
Xia, C. H., Ma, Z., Ciric, R., Gu, S., Betzel, R. F., Kaczkurkin, A. N., Calkins, M. E., Cook, P. A., García de la Garza, A., Vandekar, S. N., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05317-y · Cited by 437 · see citing works
Lee, E., Torous, J. B., Choudhury, M. D., Depp, C. A., Graham, S. A., Kim, H., Paulus, M. P., Krystal, J. H., & Jeste, D. V. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.02.001 · Cited by 477 · see citing works
Rashid, B., Arbabshirani, M. R., Damaraju, E., Cetin, M. S., Miller, R. L., Pearlson, G. D., & Calhoun, V. D. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.04.051 · Cited by 328 · see citing works
Self-citationDu, Y., Fu, Z., & Calhoun, V. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00525 · Cited by 326 · see citing works
Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia
Brugger, S. P., & Howes, O. D. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2663 · Cited by 332 · see citing works
Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning
Chand, G. B., Dwyer, D., Erus, G., Sotiras, A., Varol, E., Srinivasan, D., Doshi, J. J., Pomponio, R., Pigoni, A., Dazzan, P., et al. (2020) · Brain · doi:10.1093/brain/awaa025 · Cited by 271 · see citing works
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Alnæs, D., Kaufmann, T., van der Meer, D., Córdova‐Palomera, A., Rokicki, J., Moberget, T., Bettella, F., Agartz, I., Barch, D. M., Bertolino, A., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0257 · Cited by 261 · see citing works
Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder
Shephard, E., Stern, E. R., van den Heuvel, O. A., Costa, D. L. C., Batistuzzo, M. C., Godoy, P. B. G., Lopes, A. C., Brunoni, A. R., Hoexter, M. Q., Shavitt, R. G., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-01007-8 · Cited by 250 · see citing works
A Transdiagnostic Review of Negative Symptom Phenomenology and Etiology
Strauss, G. P., & Cohen, A. S. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx066 · Cited by 222 · see citing works
Altered Cortical Ensembles in Mouse Models of Schizophrenia
Hamm, J. P., Peterka, D. S., Gogos, J. A., & Yuste, R. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.019 · Cited by 175 · see citing works
Self-citationPillinger, T., Osimo, E. F., Brugger, S., Mondelli, V., McCutcheon, R. A., & Howes, O. D. (2019) · Schizophrenia Bulletin · doi:10.1093/schbul/sby160 · Cited by 190 · see citing works
Research Domain Criteria (RDoC): Progress and Potential
Cuthbert, B. N. (2022) · Current Directions in Psychological Science · doi:10.1177/09637214211051363 · Cited by 208 · see citing works
Characterizing cognitive heterogeneity on the schizophrenia–bipolar disorder spectrum
Rheenen, T. E. V., Lewandowski, K. E., Tan, E. J., Ospina, L. H., Öngür, D., Neill, E., Gurvich, C., Pantelis, C., Malhotra, A. K., Rossell, S. L., et al. (2017) · Psychological Medicine · doi:10.1017/s0033291717000307 · Cited by 192 · see citing works
Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions
Miller, B. J., & Goldsmith, D. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.211 · Cited by 182 · see citing works
Grisanzio, K. A., Goldstein‐Piekarski, A. N., Wang, M. Y., Ahmed, A. P. R., Samara, Z., & Williams, L. M. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.3951 · Cited by 184 · see citing works
Lynch, C. J., Gunning, F. M., & Liston, C. M. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.012 · Cited by 181 · see citing works
Revisiting the seven pillars of RDoC
Morris, S. E., Sanislow, C. A., Pacheco, J., Vaidyanathan, U., Gordon, J. A., & Cuthbert, B. N. (2022) · BMC Medicine · doi:10.1186/s12916-022-02414-0 · Cited by 173 · see citing works
Bora, E., & Özerdem, A. (2017) · Psychological Medicine · doi:10.1017/s0033291717001490 · Cited by 173 · see citing works
Somatostatin Interneurons Control a Key Component of Mismatch Negativity in Mouse Visual Cortex
Hamm, J. P., & Yuste, R. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.037 · Cited by 169 · see citing works
Self-citationCadinu, D., Grayson, B., Podda, G., Harte, M., Doostdar, N., & Neill, J. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.045 · Cited by 166 · see citing works
A multi-site, multi-disorder resting-state magnetic resonance image database
Tanaka, S., Yamashita, A., Yahata, N., Itahashi, T., Lisi, G., Yamada, T., Ichikawa, N., Takamura, M., Yoshihara, Y., Kunimatsu, A., et al. (2021) · Scientific Data · doi:10.1038/s41597-021-01004-8 · Cited by 169 · see citing works
Towards a brain‐based predictome of mental illness
Rashid, B., & Calhoun, V. D. (2020) · Human Brain Mapping · doi:10.1002/hbm.25013 · Cited by 160 · see citing works
Conus, P., Seidman, L. J., Fournier, M., Xin, L., Cleusix, M., Baumann, P., Ferrari, C., Cousins, A., Alameda, L., Gholam‐Rezaee, M., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx093 · Cited by 163 · see citing works
Self-citationFunctional connectomics of affective and psychotic pathology
Baker, J. T., Dillon, D. G., Patrick, L. M., Roffman, J. L., Brady, R. O., Pizzagalli, D. A., Öngür, D., & Holmes, A. J. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820780116 · Cited by 155 · see citing works
Haukvik, U. K., Tamnes, C. K., Söderman, E., & Agartz, I. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.08.012 · Cited by 220 · see citing works
Keshavan, M. S., Collin, G., Guimond, S., Kelly, S., Prasad, K. M. R., & Lizano, P. L. (2019) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2019.09.007 · Cited by 152 · see citing works
Self-citationIdentification of depression subtypes and relevant brain regions using a data-driven approach
Tokuda, T., Yoshimoto, J., Shimizu, Y., Okada, G., Takamura, M., Okamoto, Y., Yamawaki, S., & Doya, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-32521-z · Cited by 136 · see citing works
Ivleva, E. I., Clementz, B. A., Dutcher, A. M., Arnold, S. J. M., Jeon‐Slaughter, H., Aslan, S., Witte, B. P., Poudyal, G., Lu, H., Meda, S. A., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.08.030 · Cited by 143 · see citing works
Self-citationReynolds, L. M., Pokinko, M., Torres-Berrío, A., Cuesta, S., Lambert, L. C., Del Cid Pellitero, E., Wodzinski, M., Manitt, C., Krimpenfort, P., Kolb, B., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.009 · Cited by 129 · see citing works
The role of RDoC in future classification of mentaldisorders
Cuthbert, B. N. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.1/bcuthbert · Cited by 135 · see citing works
Reininghaus, U., Boehnke, J. R., Chavez‐Baldini, U., Gibbons, R. D., Ivleva, E. I., Clementz, B. A., Pearlson, G. D., Keshavan, M. S., Sweeney, J. A., & Tamminga, C. A. (2019) · World Psychiatry · doi:10.1002/wps.20607 · Cited by 130 · see citing works
Self-citationGallo, S., El-Gazzar, A., Zhutovsky, P., Thomas, R. M., Javaheripour, N., Li, M., Bartova, L., Bathula, D. R., Dannlowski, U., Davey, C. G., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01977-5 · Cited by 128 · see citing works
Lizano, P. L., Lutz, O., Xu, Y., Rubin, L. H., Paskowitz, L., Lee, A. M., Eum, S., Keedy, S., Hill, S. K., Reilly, J. L., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00914-0 · Cited by 126 · see citing works
Self-citationPsychosis Biotypes: Replication and Validation from the B-SNIP Consortium
Clementz, B. A., Parker, D., Trotti, R. L., McDowell, J. E., Keedy, S., Keshavan, M. S., Pearlson, G. D., Gershon, E. S., Ivleva, E. I., Huang, L.-Y., et al. (2021) · Schizophrenia Bulletin · doi:10.1093/schbul/sbab090 · Cited by 127 · see citing works
Self-citationCurrent findings and perspectives on aberrant neural oscillations in schizophrenia
Hirano, Y., & Uhlhaas, P. J. (2021) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13300 · Cited by 121 · see citing works
Yamada, T., Hashimoto, R., Yahata, N., Ichikawa, N., Yoshihara, Y., Okamoto, Y., Kato, N., Takahashi, H., & Kawato, M. (2017) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx059 · Cited by 133 · see citing works
Du, Y., Pearlson, G. D., Lin, D., Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, N. Q. U. O. S. A. T., Chen, J., Salman, M. S., Tamminga, C. A., Ivleva, E. I., Sweeney, J. A., Keshavan, M. S., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23553 · Cited by 118 · see citing works
Self-citationParkes, L., Satterthwaite, T. D., & Bassett, D. S. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.10.016 · Cited by 116 · see citing works
Parsing Heterogeneity in the Brain Connectivity of Depressed and Healthy Adults During Positive Mood
Price, R. B., Lane, S., Gates, K., Kraynak, T. E., Horner, M. S., Thase, M. E., & Siegle, G. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.023 · Cited by 106 · see citing works
Keifer, J., & Summers, C. H. (2016) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2016.00069 · Cited by 112 · see citing works
Brain Subtyping Enhances The Neuroanatomical Discrimination of Schizophrenia
Dwyer, D., Cabral, C., Kambeitz‐Ilankovic, L., Sanfelici, R., Kambeitz, J. P., Calhoun, V. D., Falkai, P., Pantelis, C., Meisenzahl, E. M., & Koutsouleris, N. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby008 · Cited by 114 · see citing works
Auditory EEG Biomarkers in Fragile X Syndrome: Clinical Relevance
Ethridge, L. E., Stefano, L. A. D., Schmitt, L., Woodruff, N., Brown, K. L., Tran, M., Wang, J., Pedapati, E. V., Erickson, C. A., & Sweeney, J. A. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00060 · Cited by 114 · see citing works
Self-citationGreen, M. J., Girshkin, L., Kremerskothen, K., Watkeys, O. J., & Quidé, Y. (2019) · Neuropsychology Review · doi:10.1007/s11065-019-09422-7 · Cited by 117 · see citing works
Wada, M., Noda, Y., Iwata, Y., Tsugawa, S., Yoshida, K., Tani, H., Hirano, Y., Koike, S., Sasabayashi, D., Katayama, H., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01572-0 · Cited by 109 · see citing works
Calhoun, V. D., & de Lacy, N. (2017) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2017.06.012 · Cited by 110 · see citing works
A Reckoning and Research Agenda for Neuroimaging in Psychiatry
Etkin, A. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19050521 · Cited by 108 · see citing works
RDoC-based categorization of amygdala functions and its implications in autism
Hennessey, T., Andari, E., & Rainnie, D. G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.007 · Cited by 105 · see citing works
Pasion, R., & Barbosa, F. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.06.013 · Cited by 107 · see citing works
Data-Driven Subgroups in Depression Derived from Directed Functional Connectivity Paths at Rest
Price, R. B., Gates, K., Kraynak, T. E., Thase, M. E., & Siegle, G. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.97 · Cited by 98 · see citing works
Shan, X., Uddin, L. Q., Xiao, J., He, C., Ling, Z., Li, L., Huang, X., Chen, H., & Duan, X. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.01.011 · Cited by 100 · see citing works
Ibrahim, G. M., Sharma, P., Hyslop, A. E., Guillen, M. R., Morgan, B. R., Wong, S. M., Abel, T. J., Elkaim, L. M., Cajigas, I., Shah, A. H., et al. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.09.015 · Cited by 99 · see citing works
Chang, M., Womer, F. Y., Gong, X., Chen, X., Tang, L., Feng, R., Dong, S., Duan, J., Chen, Y., Zhang, R., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00892-3 · Cited by 92 · see citing works
Adams, R. A., Pinotsis, D., Tsirlis, K., Unruh, L., Mahajan, A., Horas, A. M., Convertino, L., Summerfelt, A., Sampath, H., Du, X. M., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.024 · Cited by 98 · see citing works
Toward personalized medicine in connectomic deep brain stimulation
Hollunder, B., Rajamani, N., Siddiqi, S., Finke, C., Kühn, A. A., Mayberg, H. S., Fox, M., Neudorfer, C., & Horn, A. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102211 · Cited by 89 · see citing works
Dhamala, E., Yeo, B. T. T., & Holmes, A. J. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.024 · Cited by 91 · see citing works
Personalized Transcranial Magnetic Stimulation in Psychiatry
Cocchi, L., & Zalesky, A. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.01.008 · Cited by 89 · see citing works
Bishop, J. R., Zhang, L., & Lizano, P. L. (2022) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000321 · Cited by 90 · see citing works
A meta-analysis of neurocognition in youth with familial high risk for bipolar disorder
Bora, E., & Özerdem, A. (2017) · European psychiatry · doi:10.1016/j.eurpsy.2017.02.483 · Cited by 80 · see citing works
Yamashita, M., Yoshihara, Y., Hashimoto, R., Yahata, N., Ichikawa, N., Sakai, Y., Yamada, T., Matsukawa, N., Okada, G., Tanaka, S., et al. (2018) · eLife · doi:10.7554/elife.38844 · Cited by 87 · see citing works
A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome
Lee, M., Martin, G. E., Berry‐Kravis, E., & Losh, M. C. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9179-0 · Cited by 88 · see citing works
Kernbach, J. M., Satterthwaite, T. D., Bassett, D. S., Smallwood, J., Margulies, D., Krall, S., Shaw, P., Varoquaux, G., Thirion, B., Konrad, K., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0179-6 · Cited by 81 · see citing works
Liu, L., Zhou, X., Zhang, Y., Pu, J., Yang, L., Yuan, S., Zhao, L., Zhou, C., Zhang, H., & Xie, P. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0018-1 · Cited by 87 · see citing works
Ross, C. A., & Margolis, R. L. (2019) · Complex Psychiatry · doi:10.1159/000501797 · Cited by 84 · see citing works
Artificial intelligence applications in psychoradiology
Li, F. Y., Sun, H., Biswal, B. B., Sweeney, J. A., & Gong, Q. (2021) · Psychoradiology · doi:10.1093/psyrad/kkab009 · Cited by 86 · see citing works
Self-citationCummings, J. L., Pinto, L. C., de la Cruz, M. P., Fischer, C. E., Gerritsen, D. L., Grossberg, G. T., Hwang, T., Ismail, Z., Jeste, D. V., Koopmans, R. T. C. M., et al. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.09.002 · Cited by 85 · see citing works
Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects
Murray, K. N., Edye, M. E., Manca, M., Vernon, A. C., Oladipo, J. M., Fasolino, V., Harte, M., Mason, V., Grayson, B., McHugh, P., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.005 · Cited by 84 · see citing works
Generalizable brain network markers of major depressive disorder across multiple imaging sites
Yamashita, A., Sakai, Y., Yamada, T., Yahata, N., Kunimatsu, A., Okada, N., Itahashi, T., Hashimoto, R., Mizuta, H., Ichikawa, N., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000966 · Cited by 82 · see citing works
Evolving Notions of Schizophrenia as a Developmental Neurocognitive Disorder
Seidman, L. J., & Mirsky, A. F. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717001114 · Cited by 84 · see citing works
Precision psychiatry roadmap: towards a biology-informed framework for mental disorders
Kas, M. J., Penninx, B. W. J. H., Knudsen, G. M., Cuthbert, B. N., Falkai, P., Sachs, G. S., Ressler, K. J., Bałkowiec-Iskra, E., Butlen‐Ducuing, F., Leboyer, M., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03070-5 · Cited by 83 · see citing works
Koutsouleris, N., Wobrock, T., Guse, B., Langguth, B., Landgrebe, M., Eichhammer, P., Frank, E., Cordes, J., Wölwer, W., Musso, F., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx114 · Cited by 83 · see citing works
Data-Driven Phenotypic Categorization for Neurobiological Analyses: Beyond DSM-5 Labels
Dam, N. T. V., O’Connor, D. A., Marcelle, E. T., Ho, E. J., Craddock, R. C., Tobe, R. H., Gabbay, V., Hudziak, J. J., Castellanos, F. X., LEVENTHAL, B. L., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.027 · Cited by 83 · see citing works
Longitudinal trajectory of early functional recovery in patients with first episode psychosis
Hall, M., Holton, K. M., Öngür, D., Montrose, D. M., & Keshavan, M. S. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.02.003 · Cited by 80 · see citing works
Self-citationDopamine, fronto-striato-thalamic circuits and risk for psychosis
Dandash, O., Pantelis, C., & Fornito, A. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.08.020 · Cited by 78 · see citing works
Cortical ensembles selective for context
Hamm, J. P., Shymkiv, Y., Han, S., Yang, W., & Yuste, R. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2026179118 · Cited by 78 · see citing works
Self-citationBavato, F., Cathomas, F., Klaus, F., Guetter, K., Barro, C., Maceski, A. M., Seifritz, E., Kühle, J., Kaiser, S., & Quednow, B. B. (2021) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2021.05.072 · Cited by 77 · see citing works
A symptom network structure of the psychosis spectrum
van Rooijen, G., Isvoranu, A., Meijer, C. J., van Borkulo, C. D., Ruhé, H. G., & de Haan, L. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.018 · Cited by 77 · see citing works
New drug developments in psychosis: Challenges, opportunities and strategies
Keshavan, M. S., Lawler, A. N., Nasrallah, H. A., & Tandon, R. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.004 · Cited by 75 · see citing works
Self-citationRecent advances in psychoradiology
Luo, L., You, W., Delbello, M., Gong, Q., & Li, F. (2022) · Physics in Medicine and Biology · doi:10.1088/1361-6560/ac9d1e · Cited by 67 · see citing works
Neurocognitive subtypes in patients with bipolar disorder and their unaffected siblings
Russo, M., Rheenen, T. E. V., Shanahan, M. R., Mahon, K., Pérez-Rodríguez, M. M., Cuesta‐Diaz, A., Larsen, E. M., Malhotra, A. K., & Burdick, K. E. (2017) · Psychological Medicine · doi:10.1017/s003329171700143x · Cited by 74 · see citing works
Viviano, J. D., Buchanan, R. W., Calarco, N., Gold, J. M., Foussias, G., Bhagwat, N., Stefanik, L., Hawco, C. S., DeRosse, P., Árgyelán, M., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.03.013 · Cited by 73 · see citing works
Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects
Orsolini, L., Pompili, S., & Volpe, U. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11175040 · Cited by 73 · see citing works
Schnack, H. G. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.10.023 · Cited by 73 · see citing works
Voineskos, A. N., Jacobs, G. R., & Ameis, S. H. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.09.004 · Cited by 71 · see citing works
Woods, R. M., Lorusso, J. M., Potter, H. G., Neill, J. C., Glazier, J. D., & Hager, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.015 · Cited by 72 · see citing works
Palaniyappan, L. K. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.028 · Cited by 73 · see citing works
Miller, A. H., & Raison, C. L. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01887-y · Cited by 67 · see citing works
Voineskos, A. N., Hawco, C. S., Neufeld, N. H., Turner, J. A., Ameis, S. H., Anticevic, A., Buchanan, R. W., Cadenhead, K. S., Dazzan, P., Dickie, E. W., et al. (2024) · World Psychiatry · doi:10.1002/wps.21159 · Cited by 73 · see citing works
Shafee, R., Nanda, P., Padmanabhan, J. L., Tandon, N., Alliey‐Rodriguez, N., Kalapurakkel, S. S., Weiner, D. J., Gur, R. E., Keefe, R. S. E., Hill, S. K., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0124-8 · Cited by 72 · see citing works
Self-citationTamminga, C. A., Pearlson, G. D., Stan, A. D., Gibbons, R. D., Padmanabhan, J. L., Keshavan, M. S., & Clementz, B. A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.07.005 · Cited by 70 · see citing works
Self-citationEwen, J. B., Sweeney, J. A., & Potter, W. Z. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00045 · Cited by 68 · see citing works
Self-citationBrain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma
Stevens, J. S., Harnett, N. G., Lebois, L. A. M., van Rooij, S. J. H., Ely, T. D., Roeckner, A. R., Vincent, N., Beaudoin, F. L., An, X., Zeng, D., et al. (2021) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2021.20101526 · Cited by 70 · see citing works
Iacono, W. G., Malone, S. M., & Vrieze, S. I. (2016) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2016.07.516 · Cited by 68 · see citing works
Research Domain Criteria (RDoC)
Walter, H. (2017) · Der Nervenarzt · doi:10.1007/s00115-017-0284-4 · Cited by 69 · see citing works
Zhang, W., Sweeney, J. A., Bishop, J. R., Gong, Q., & Lui, S. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00019-x · Cited by 67 · see citing works
Self-citation
- Authors
- Clementz, B. A., Sweeney, J. A., Hamm, J. P., Ivleva, E. I., Ethridge, L. E., Pearlson, G. D., Keshavan, M. S., & Tamminga, C. A.
- Affiliations
- Hartford Hospital (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2016-04-01
- Volume
- 173
- Issue
- 4
- Pages
- 373-384
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC5314432
- OpenAlex
- W2190536949
- Cited by
- 768
- References
- 50
- Citations by year
- 2026: 64 · 2025: 59 · 2024: 58 · 2023: 61 · 2022: 70 · 2021: 78 · 2020: 72 · 2019: 122 · 2018: 68 · 2017: 75 · 2016: 40
- FWCI
- 49.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH077852, MH‐077945, MH 077852, R01MH077851, MH-078113, MH077851, R01MH096913, MH‐077862, R01MH078113, R01MH077862, R01MH077945)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- schizophrenia, schizoaffective disorder, taxometric analysis, neuropsychological assessment, stop-signal task, auditory stimulation, first-degree relatives, social functioning, structural MRI
- MeSH terms
- Acoustic Stimulation, Adult, Bipolar Disorder, Brain, Electroencephalography, Evoked Potentials, Auditory, Family, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Phenotype, Psychotic Disorders, Saccades, Schizophrenia, Schizophrenic Psychology, Case-Control Studies, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
