Anhedonia in substance use disorders: a systematic review of its nature, course and clinical correlates
Abstract
OBJECTIVE: There is growing evidence that anhedonia is a commonly experienced symptom among substance-using populations. This systematic review synthesises findings across a range of substances to address questions regarding the time course of anhedonia, how anhedonia relates to other symptoms of substance dependence and whether it is similarly prevalent across all addictive drugs. METHOD: A literature search was conducted on PubMed, PsycINFO and MEDLINE, yielding 32 studies that used self-report measures of anhedonia among participants with a history of a substance abuse, dependence or long-term daily use of addictive substances. RESULTS: Findings from these studies indicate that anhedonia (1) is elevated in samples dependent on a range of substances; (2) typically appears as a consequence of substance abuse or dependence, and diminishes with abstinence; and (3) predicts increased drug cravings and the likelihood of relapse in those attempting abstinence. CONCLUSIONS: The common experience of anhedonia in substance-dependent populations, and its relationship to relapse, emphasises the importance of developing therapeutic interventions that specifically target anhedonia in the treatment of all substance use disorders.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The experience of anhedonia may be a consequence of substance use.
“Those correlations have been reproduced through several studies; research on the subject identifies, in a somewhat paradoxical way, that the experience of anhedonia may be a consequence of substance use (48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
In substance use disorders, the search for stimulation through consumption of substances aims to lessen the experience of anhedonia.
“The emotional processes observed in substance use disorders suggest that the search for stimulation through the consumption of substances would aim to lessen the experience of anhedonia, an often-reported state in this population (47, 48).”
From Mobile intervention for individuals with psychosis, dual disorders, and their common comorbidities: A literature review (2019) · cites this paper as [48]
Deficits in reward processing occur in major depressive disorder, substance use disorders, posttraumatic stress disorder, schizophrenia, and ADHD.
“Deficits in reward processing are found in MDD (Admon and Pizzagalli, 2015), substance use disorders (Garfield et al., 2014; Tobler et al., 2016), posttraumatic stress disorder (PTSD) (Kalebasi et al., 2015), schizophrenia (McCarthy et al., 2016), and ADHD (van Hulst et al., 2016).”
From The effects of early life stress on reward processing (2018) · cites this paper as Garfield et al., 2014
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
An inventory for measuring depression
BECK, A. T. (1961) · Archives of General Psychiatry · doi:10.1001/archpsyc.1961.01710120031004 · Cited by 38,032 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
Grant, B. F., Stinson, F. S., Dawson, D. A., Chou, S. P., Dufour, M. C., Compton, W., Pickering, R. P., & Kaplan, K. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.8.807 · Cited by 2,889 · see citing works
Negative Symptoms in Schizophrenia: Definition and Reliability
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070020005 · Cited by 2,247 · see citing works
A scale for the assessment of hedonic tone the Snaith-Hamilton pleasure scale
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., & Trigwell, P. (1995) · British Journal of Psychiatry · doi:10.1192/bjp.167.1.99 · Cited by 1,778 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.85.4.374 · Cited by 1,557 · see citing works
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523 · see citing works
Scales for physical and social anhedonia.
Chapman, L. J., Chapman, J. P., & Raulin, M. L. (1976) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.85.4.374 · Cited by 1,234 · see citing works
Dramatic decreases in brain reward function during nicotine withdrawal
Epping-Jordan, M. P., Watkins, S. S., Koob, G. F., & Markou, A. (1998) · Nature · doi:10.1038/30001 · Cited by 674 · see citing works
Postcocaine anhedonia. An animal model of cocaine withdrawal.
Markou, A., & Koob, G. F. (1991) · PubMed · Cited by 505 · see citing works
The nature, time course and severity of methamphetamine withdrawal
McGregor, C., Srisurapanont, M., Jittiwutikarn, J., Laobhripatr, S., Wongtan, T., & White, J. M. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01160.x · Cited by 458 · cited 5× · see citing works
“, 2008), methamphetamine (McGregor et al., 2005) and opioid (Stevens et al.”
BackgroundMethodInfluentialCannabis Abuse as a Risk Factor for Depressive Symptoms
BOVASSO, G. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2033 · Cited by 455 · see citing works
Assessing Anhedonia in Psychiatric Patients
FAWCETT, J. A. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790010081010 · Cited by 419 · see citing works
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389 · see citing works
Franken, I. H. A., Rassin, E., & Muris, P. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.08.020 · Cited by 373 · see citing works
Decreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345 · see citing works
Anhedonia and Substance Dependence: Clinical Correlates and Treatment Options
Hatzigiakoumis, D. S., Martinotti, G., Giannantonio, M. D., & Janiri, L. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00010 · Cited by 238 · see citing works
Methamphetamine Abstinence Syndrome: Preliminary Findings
Newton, T. F., Kalechstein, A. D., Duran, S., Vansluis, N., & Ling, W. W. (2004) · American Journal on Addictions · doi:10.1080/10550490490459915 · Cited by 216 · see citing works
Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales
Leventhal, A. M., Chasson, G. S., Tapia, E., Miller, E. K., & Pettit, J. W. (2006) · Journal of Clinical Psychology · doi:10.1002/jclp.20327 · Cited by 211 · see citing works
Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents
Cryan, J. F., Hoyer, D., & Markou, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01730-4 · Cited by 199 · see citing works
Affect dysregulation in cannabis abusers
Dorard, G., Berthoz, S., Phan, O., Corcos, M., & Bungener, C. (2008) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-0663-7 · Cited by 181 · see citing works
Anhedonia: a neglected symptom of psychopathology
Snaith, P. R. (1993) · Psychological Medicine · doi:10.1017/s0033291700026428 · Cited by 179 · see citing works
Janiri, L., Martinotti, G., Dario, T., Reina, D., Paparello, F., Pozzi, G., Addolorato, G., Giannantonio, M. D., & Risio, S. D. (2005) · Neuropsychobiology · doi:10.1159/000086176 · Cited by 147 · see citing works
Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model
Powell, J. E., Dawkins, L., & Davis, R. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01208-2 · Cited by 137 · see citing works
Alcohol Protracted Withdrawal Syndrome: The Role of Anhedonia
Martinotti, G., Nicola, M. D., Reina, D., Andreoli, S., Focà, F., Cunniff, A. L., Tonioni, F., Bria, P., & Janiri, L. (2008) · Substance Use & Misuse · doi:10.1080/10826080701202429 · Cited by 136 · see citing works
Martinotti, G., Cloninger, C. R., & Janiri, L. (2008) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990701877078 · Cited by 116 · cited 11× · see citing works
“…tobacco smokers attempting to quit (Cook et al., 2010; Leventhal et al., 2009), and positively correlates with drug cravings in detoxified alcohol(Martinotti et al., 2008a, 2008b) and opioid-dependent (Janiri et al., 2005; Martinotti et al., 2008a) users, as well as recently abstinent tobacco…”
BackgroundMethodResultInfluentialWithdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds
Wise, R. A., & Munn, E. M. (1995) · Psychopharmacology · doi:10.1007/bf02245178 · Cited by 115 · see citing works
Zijlstra, F., Booij, J., van den Brink, W., & Franken, I. H. A. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.11.002 · Cited by 109 · see citing works
Leventhal, A. M., Brightman, M., Ameringer, K. J., Greenberg, J. B., Mickens, L., Ray, L. A., Sun, P., & Sussman, S. Y. (2010) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0021964 · Cited by 109 · see citing works
Paterson, N. E., Myers, C., & Markou, A. (2000) · Psychopharmacology · doi:10.1007/s002130000559 · Cited by 103 · see citing works
Martinotti, G., Andreoli, S., Reina, D., Nicola, M. D., Ortolani, I., Tedeschi, D., Fanella, F., Pozzi, G., Iannoni, E., D'Iddio, S., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.01.013 · Cited by 98 · see citing works
Schmidt, K., Nolte-Zenker, B., Patzer, J., Bauer, M., Schmidt, L. G., & Heinz, A. (2001) · Pharmacopsychiatry · doi:10.1055/s-2001-15184 · Cited by 97 · see citing works
A double-blind placebo controlled experimental study of nicotine: I—effects on incentive motivation
Dawkins, L., Powell, J. H., West, R., Powell, J., & Pickering, A. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0588-8 · Cited by 97 · see citing works
Skjei, K. L., & Markou, A. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1414-1 · Cited by 93 · see citing works
Lin, D. C.-H., Koob, G. F., & Markou, A. (1999) · Psychopharmacology · doi:10.1007/s002130051060 · Cited by 92 · see citing works
Relations between anhedonia and smoking motivation
Leventhal, A. M., Waters, A. J., Kahler, C. W., Ray, L. A., & Sussman, S. Y. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp098 · Cited by 92 · see citing works
Hedonic capacity, cigarette craving, and diminished positive mood
Cook, J. W., Spring, B. J., McChargue, D. E., & Hedeker, D. (2004) · Nicotine & Tobacco Research · doi:10.1080/14622200310001656849 · Cited by 89 · see citing works
Effects of anhedonia on days to relapse among smokers with a history of depression: A brief report
Cook, J. W., Spring, B. J., McChargue, D. E., & Doran, N. (2010) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntq118 · Cited by 89 · see citing works
Animal models and treatments for addiction and depression co-morbidity
Paterson, N. E., & Markou, A. (2007) · Neurotoxicity Research · doi:10.1007/bf03033479 · Cited by 84 · see citing works
Stevens, A., Peschk, I., & Schwarz, J. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01823.x · Cited by 82 · see citing works
Kenny, P. J., Polis, I. Y., Koob, G. F., & Markou, A. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02443.x · Cited by 80 · see citing works
Influence of nicotine on positive affect in anhedonic smokers
Cook, J. W., Spring, B. J., & McChargue, D. E. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0688-5 · Cited by 80 · see citing works
Kwapil, T. R. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.1.114 · Cited by 79 · see citing works
Dawkins, L., Powell, J. H., Pickering, A. D., Powell, J. F., & West, R. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02522.x · Cited by 74 · see citing works
Anhedonia and relapse in alcoholism
Marra, D., Warot, D., Payan, C., Hispard, É., Dally, S., & Puech, A. J. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00054-7 · Cited by 72 · see citing works
Cognitive and psychological correlates of smoking abstinence, and predictors of successful cessation
Powell, J. H., Pickering, A. D., Dawkins, L., West, R., & Powell, J. F. (2004) · Addictive Behaviors · doi:10.1016/j.addbeh.2004.06.006 · Cited by 72 · see citing works
Spielewoy, C., & Markou, A. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300124 · Cited by 72 · see citing works
Predictors of psychosis severity in individuals with primary stimulant addictions
Lichlyter, B., Purdon, S. E., & Tibbo, P. G. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.08.019 · Cited by 70 · see citing works
The Assessment of Post-Detoxification Anhedonia: Influence of Clinical and Psychosocial Variables
Pozzi, G., Martinotti, G., Reina, D., Dario, T., Frustaci, A., Janiri, L., & Bria, P. (2008) · Substance Use & Misuse · doi:10.1080/00952990701202954 · Cited by 64 · see citing works
Zhornitsky, S., Rizkallah, É., Pampoulova, T., Chiasson, J., Lipp, O., Stip, É., & Potvin, S. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.07.046 · Cited by 51 · see citing works
The relationship between reward-based learning and nicotine dependence in smokers with schizophrenia
AhnAllen, C. G., Liverant, G. I., Gregor, K. L., Kamholz, B. W., Levitt, J. J., Gulliver, S. B., Pizzagalli, D. A., Koneru, V. K., & Kaplan, G. B. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.09.011 · Cited by 42 · see citing works
Anhedonia: A Construct Validation Approach
Peterson, C. A., & Knudson, R. M. (1983) · Journal of Personality Assessment · doi:10.1207/s15327752jpa4705_16 · Cited by 40 · see citing works
Carton, S., Houezec, J. L., Lagrue, G., & Jouvent, R. (2000) · Addictive Behaviors · doi:10.1016/s0306-4603(00)00067-8 · Cited by 29 · see citing works
Martinotti, G., Reina, D., Nicola, M. D., Andreoli, S., Tedeschi, D., Ortolani, I., Pozzi, G., Iannoni, E., D'Iddio, S., & Janiri, L. (2010) · Alcohol and Alcoholism · doi:10.1093/alcalc/agq039 · Cited by 26 · see citing works
Anhedonia predicts altered processing of happy faces in abstinent cigarette smokers
Leventhal, A. M., Munafo, M. R., Tidey, J. W., Sussman, S. Y., Monterosso, J. R., Sun, P., & Kahler, C. W. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2649-5 · Cited by 24 · see citing works
D’Haenen, H. (1996) · European Psychiatry · doi:10.1016/s0924-9338(97)81056-5 · Cited by 24 · see citing works
Responsiveness to reward following cessation of smoking
Snuggs, S. J., & Hájek, P. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2874-y · Cited by 23 · see citing works
MMPI correlates of social and physical anhedonia.
Penk, W. E., Carpenter, J., & Rylee, K. (1979) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.47.6.1046 · Cited by 20 · see citing works
Dawes, G. M., Sitharthan, T., Conigrave, K. M., Phung, N., & Weltman, M. (2011) · Journal of Substance Use · doi:10.3109/14659891.2010.499491 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Connor, J. P., Haber, P. S., & Hall, W. D. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00122-1 · Cited by 389 · see citing works
Alcohol use disorder relapse factors: A systematic review.
Sliedrecht, W., de Waart, R., Witkiewitz, K., & Roozen, H. G. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.05.038 · Cited by 358 · see citing works
Secondary negative symptoms — A review of mechanisms, assessment and treatment
Kirschner, M., Aleman, A., & Kaiser, S. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.05.003 · Cited by 215 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“, 2016), substance use disorder (CastellanosRyan et al., 2011; Garfield et al., 2014), and conduct disorder (Rubia et al.”
BackgroundLawn, W., Freeman, T. P., Pope, R. A., Joye, A., Harvey, L. A., Hindocha, C., Mokrysz, C., Moss, A., Wall, M. B., Bloomfield, M., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4383-x · Cited by 175 · see citing works
Assessment of Anhedonia in Adults With and Without Mental Illness
Trøstheim, M., Eikemo, M., Meir, R., Hansen, I., Paul, E. R., Kroll, S. L., Garland, E. L., & Leknes, S. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.13233 · Cited by 160 · see citing works
Mapping inflammation onto mood: inflammatory mediators of anhedonia
Swardfager, W., Rosenblat, J. D., Benlamri, M., & McIntyre, R. S. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.017 · Cited by 125 · see citing works
The adverse health effects and harms related to marijuana use: an overview review.
Memedovich, K. A., Dowsett, L., Spackman, E., Noseworthy, T., & Clement, F. (2018) · CMAJ Open · doi:10.9778/cmajo.20180023 · Cited by 111 · see citing works
Positive affect and reward processing in the treatment of depression, anxiety and trauma
Craske, M. G., Dunn, B. D., Meuret, A. E., Rizvi, S. J., & Taylor, C. T. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00355-4 · Cited by 105 · see citing works
Huhn, A. S., Meyer, R. E., Harris, J., Ayaz, H., Deneke, E., Stankoski, D. M., & Bunce, S. C. (2015) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2015.12.004 · Cited by 100 · see citing works
Boness, C. L., Watts, A. L., Moeller, K. N., & Sher, K. J. (2021) · Psychological Bulletin · doi:10.1037/bul0000333 · Cited by 95 · see citing works
Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review
Destoop, M., Morrens, M., Coppens, V., & Dom, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00311 · Cited by 85 · see citing works
Vujanovic, A. A., Meyer, T. D., Heads, A. M. B., Stotts, A. L., Villarreal, Y. R., & Schmitz, J. M. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1199697 · Cited by 83 · see citing works
Symptoms of anhedonia, not depression, predict the outcome of treatment of cocaine dependence
Crits-Christoph, P. F., Wadden, S., Gaines, A. N., Rieger, A., Gallop, R., McKay, J. R., & Gibbons, M. B. C. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.06.010 · Cited by 81 · see citing works
Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder
Wardle, M. C., Vincent, J. N., Suchting, R., Green, C. E., Lane, S. D., & Schmitz, J. M. (2016) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2016.08.020 · Cited by 80 · see citing works
Evidence that anhedonia is a symptom of opioid dependence associated with recent use
Garfield, J. B. B., Cotton, S., Allen, N. B., Cheetham, A., Kras, M., Yücel, M., & Lubman, D. I. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.03.012 · Cited by 79 · see citing works
Dynamic associations between opioid use and anhedonia: A longitudinal study in opioid dependence
Lubman, D. I., Garfield, J. B. B., Gwini, S. M., Cheetham, A., Cotton, S., Yücel, M., & Allen, N. B. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118791741 · Cited by 67 · see citing works
COMTVal158Met genotype is associated with reward learning: a replication study and meta‐analysis
Corral-Frías, N. S., Pizzagalli, D. A., Carré, J. M., Michalski, L. J., Nikolova, Y. S., Perlis, R. H., Fagerness, J. A., Lee, M. R., Drabant, E. M., Lancaster, T. M., et al. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12296 · Cited by 65 · see citing works
The Cambridge Handbook of Substance and Behavioral Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591 · Cited by 63 · see citing works
Lee, Y. L., Subramaniapillai, M., Brietzke, E. M., Mansur, R. B., Ho, R., Yim, S. J., & McIntyre, R. S. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125318791944 · Cited by 65 · see citing works
Anhedonia as a Key Clinical Feature in the Maintenance and Treatment of Opioid Use Disorder
Kiluk, B. D., Yip, S. W., DeVito, E. E., Carroll, K. M., & Sofuoglu, M. (2019) · Clinical Psychological Science · doi:10.1177/2167702619855659 · Cited by 63 · see citing works
Dopamine, endocannabinoids and their interaction in fear extinction and negative affect in PTSD
Ney, L. J., Akhurst, J., Bruno, R., Laing, P. A. F., Matthews, A. J., & Felmingham, K. L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110118 · Cited by 61 · see citing works
“Don't [ruminate], be happy”: A cognitive perspective linking depression and anhedonia
Rutherford, A. V., McDougle, S. D., & Joormann, J. (2023) · Clinical Psychology Review · doi:10.1016/j.cpr.2023.102255 · Cited by 57 · see citing works
Huhn, A. S., Harris, J., Cleveland, H. H., Lydon, D. M., Stankoski, D., Cleveland, M. J., Deneke, E., & Bunce, S. C. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.01.012 · Cited by 53 · see citing works
Webber, H. E., Lopez-Gamundi, P., Stamatovich, S. N., de Wit, H., & Wardle, M. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.11.004 · Cited by 52 · see citing works
Spano, M. C., Lorusso, M., Pettorruso, M., Zoratto, F., Di Giuda, D., Martinotti, G., & di Giannantonio, M. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13230 · Cited by 52 · see citing works
Reed, D. D., Naudé, G. P., Gelino, B. W., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.011 · Cited by 48 · see citing works
Benefits of Exercise for the Quality of Life of Drug-Dependent Patients
Giménez-Meseguer, J., Tortosa‐Martínez, J., & Fernández-Valenciano, M. D. L. R. (2015) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2015.1102991 · Cited by 49 · see citing works
Association between prescription opioid misuse and dimensions of suicidality among college students
Davis, R. E., Doyle, N. A., & Nahar, V. K. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.07.002 · Cited by 49 · see citing works
The Prevention and Treatment of Gambling Disorders: Some Art, Some Science
Derevensky, J. L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.024 · Cited by 45 · see citing works
Considering the Overlap and Nonoverlap of Compulsivity, Impulsivity, and Addiction
Blum, A. W., & Grant, J. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.038 · Cited by 44 · see citing works
Neurobiological Foundations of Behavioral Addictions
Vaccaro, A. G., & Potenza, M. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.016 · Cited by 45 · see citing works
Neurobiology of Substance Addictions
Christie, N. C., & Bechara, A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.015 · Cited by 44 · see citing works
Sensitization of Incentive Salience and the Transition to Addiction
Warlow, S. M., Baumgartner, H. M., Freeland, C. M., Naffziger, E. E., Olney, J. J., Berridge, K. C., & Robinson, M. J. F. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.006 · Cited by 45 · see citing works
Guessoum, S. B., Strat, Y. L., Dubertret, C., & Mallet, J. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109862 · Cited by 45 · see citing works
Hien, D. A., López‐Castro, T., Fitzpatrick, S., Ruglass, L. M., Fertuck, E. A., & Melara, R. D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.022 · Cited by 45 · see citing works
Mindfulness-Based Interventions Applied to Addiction Treatments
Kechter, A., & Black, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.040 · Cited by 43 · see citing works
Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
Stacy, A. W., Pike, J. R., & Lee, A. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.017 · Cited by 43 · see citing works
Tanning as an Addiction: The State of the Research and Implications for Intervention
Miller, K. A., & Mays, D. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.037 · Cited by 43 · see citing works
Schulte, E. M., Schiestl, E. T., & Gearhardt, A. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.035 · Cited by 43 · see citing works
Behavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42 · see citing works
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42 · see citing works
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42 · see citing works
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42 · see citing works
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42 · see citing works
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42 · see citing works
Meier, I. M., Eikemo, M., & Leknes, S. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00366-8 · Cited by 44 · see citing works
Enduring disruption of reward and stress circuit activities by early-life adversity in male rats
Levis, S. C., Birnie, M. T., Bolton, J. L., Perrone, C. R., Montesinos, J. S., Baram, T. Z., & Mahler, S. V. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01988-w · Cited by 42 · see citing works
Anhedonia in Posttraumatic Stress Disorder: Prevalence, Phenotypes, and Neural Circuitry
Vinograd, M., Stout, D. M., & Risbrough, V. B. (2021) · Current topics in behavioral neurosciences · doi:10.1007/7854_2021_292 · Cited by 39 · see citing works
Reward functioning in posttraumatic stress and substance use disorders
Vujanovic, A. A., Wardle, M. C., Smith, L. J., & Berenz, E. C. (2016) · Current Opinion in Psychology · doi:10.1016/j.copsyc.2016.11.004 · Cited by 40 · see citing works
The effects of early life stress on motivated behaviors: A role for gonadal hormones
Eck, S. R., & Bangasser, D. A. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.09.014 · Cited by 38 · see citing works
Psychedelic-Assisted Therapy for Substance Use Disorders and Potential Mechanisms of Action
Rieser, N. M., Herdener, M., & Preller, K. H. (2021) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2021_284 · Cited by 37 · see citing works
Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis
Schaub, A.-C., Kirschner, M., Schweinfurth, N., Mählmann, L., Kettelhack, C., Engeli, E., Doll, J. P. K., Borgwardt, S., Lang, U. E., Kaiser, S., et al. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102825 · Cited by 37 · see citing works
Wellan, S. A., Daniels, A., & Walter, H. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.682824 · Cited by 35 · see citing works
Structural connectivity and risk for anhedonia after trauma: A prospective study and replication
Fani, N., Michopoulos, V., van Rooij, S. J. H., Clendinen, C., Hardy, R. A., Jovanović, T., ROTHBAUM, B. O., Ressler, K. J., & Stevens, J. S. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.009 · Cited by 35 · see citing works
Neural circuit adaptations during drug withdrawal — Spotlight on the lateral habenula
Meye, F. J., Trusel, M., Soiza‐Reilly, M., & Mameli, M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.08.007 · Cited by 35 · see citing works
Pennou, A., Lecomte, T., Potvin, S., & Khazaal, Y. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00302 · Cited by 34 · see citing works
Tao, Y., Tang, Q., Zou, X., Wang, S., Ma, Z., Zhang, L., & Liu, X. (2023) · Computers in Human Behavior · doi:10.1016/j.chb.2023.107920 · Cited by 41 · see citing works
From apathy to addiction: Insights from neurology and psychiatry.
Kirschner, M., Rabinowitz, A. G., Singer, N., & Dagher, A. (2020) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109926 · Cited by 33 · see citing works
Sheynin, J., Moustafa, A. A., Beck, K. D., Servatius, R. J., Casbolt, P., Haber, P., Elsayed, M., Hogarth, L., & Myers, C. E. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09284 · Cited by 32 · see citing works
Development and validation of the Reward Deficiency Syndrome Questionnaire (RDSQ-29)
Kótyuk, E., Urbán, R., Hende, B., Richman, M. J., Mägi, A., Király, O., Barta, C., Griffiths, M. D., Potenza, M. N., Badgaiyan, R. D., et al. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811211069102 · Cited by 30 · see citing works
Tsilosani, A., Chan, K., Steffens, A., Bolton, T., & Kowalczyk, W. J. (2023) · Addictive Behaviors · doi:10.1016/j.addbeh.2023.107781 · Cited by 29 · see citing works
Ethridge, P., Sandre, A., Dirks, M. A., & Weinberg, A. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy091 · Cited by 29 · see citing works
Predicting Predischarge Anhedonia Among Inpatients With Schizophrenia and Schizoaffective Disorders
Ritsner, M. S., & Ratner, Y. (2018) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000923 · Cited by 29 · see citing works
Costumero, V., Bustamante, J. C., Rosell‐Negre, P., Fuentes‐Claramonte, P., Llopis, J. J., Ávila, C., & Barrós‐Loscertales, A. (2015) · Addiction Biology · doi:10.1111/adb.12329 · Cited by 26 · see citing works
Muench, C., Schwandt, M. L., Jung, J., Cortes, C. R., Momenan, R., & Lohoff, F. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0184-9 · Cited by 25 · see citing works
Duque-Quintero, M., Hooijmans, C. R., Hurowitz, A., Ahmed, A., Barris, B., Homberg, J. R., Hen, R., Harris, A. Z., Balsam, P. D., & Atsak, P. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104849 · Cited by 24 · see citing works
Using the Beck Depression Inventory to Assess Anhedonia: A Scale Validation Study
Cogan, A. B., Persons, J. B., & Kring, A. M. (2023) · Assessment · doi:10.1177/10731911231164628 · Cited by 23 · see citing works
A behavioral economic analysis of marijuana and other drug use among heavy drinking young adults.
Meshesha, L. Z., Utzelmann, B., Dennhardt, A. A., & Murphy, J. G. (2018) · Translational Issues in Psychological Science · doi:10.1037/tps0000144 · Cited by 23 · see citing works
Possible New Symptoms of Tobacco Withdrawal II: Anhedonia—A Systematic Review
Hughes, J. R., Klemperer, E. M., & Peasley‐Miklus, C. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/nty171 · Cited by 23 · see citing works
Garfield, J. B. B., Cotton, S., & Lubman, D. I. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.02.011 · Cited by 22 · see citing works
Puhl, M. D., Desai, R. I., Takagi, S., Presti, K. T., Doyle, M. R., Donahue, R. J., Landino, S. M., Bergman, J., Carlezon, W. A., & Coyle, J. T. (2017) · Addiction Biology · doi:10.1111/adb.12577 · Cited by 22 · see citing works
Maher, J. P., Ra, C. K., Leventhal, A. M., Hedeker, D., Huh, J., Chou, C., & Dunton, G. F. (2018) · Journal of Abnormal Psychology · doi:10.1037/abn0000374 · Cited by 22 · see citing works
Nicola, M. D., Pepe, M., Panaccione, I., Moccia, L., Dattoli, L., Molinaro, M., Sani, G., Janiri, L., & McIntyre, R. S. (2020) · CNS Spectrums · doi:10.1017/s109285292000173x · Cited by 22 · see citing works
Filippis, S. D., Martinotti, G., Nicoletti, F., Mastrostefano, A., Trovini, G., Pugliese, A., & Nicola, M. D. (2024) · Current Neuropharmacology · doi:10.2174/1570159x22666240827165327 · Cited by 20 · see citing works
Emery, N. N., Carpenter, R. W., Meisel, S. N., & Miranda, R. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05925-5 · Cited by 18 · see citing works
Shevorykin, A., Carl, E. M., Mahoney, M. C., Hanlon, C. A., Liskiewicz, A., Rivard, C., Alberico, R. A., Belal, A., Bensch, L., Vantucci, D., et al. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.920383 · Cited by 18 · see citing works
Self-evaluation of negative symptoms in adolescent and young adult first psychiatric episodes.
Mallet, J., Guessoum, S., Tebeka, S., Strat, Y. L., & Dubertret, C. (2020) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.109988 · Cited by 14 · see citing works
Intact responses to non-drug rewards in long-term opioid maintenance treatment
Eikemo, M., Lobmaier, P. P. K., Pedersen, M. L., Kunøe, N., Matziorinis, A. M., Leknes, S., & Sarfi, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0377-9 · Cited by 16 · see citing works
Fani, N., Jain, J., Hudak, L. A., ROTHBAUM, B. O., Ressler, K. J., & Michopoulos, V. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112777 · Cited by 16 · see citing works
Anhedonia in cocaine use disorder is associated with inflammatory gene expression
Fries, G. R., Khan, S. H., Stamatovich, S. N., Dyukova, E., Walss‐Bass, C., Lane, S. D., Schmitz, J. M., & Wardle, M. C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207231 · Cited by 14 · see citing works
Guerrin, C. G. J., Tesselaar, D. R. M., Booij, J., Schellekens, A., & Homberg, J. R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106311 · Cited by 15 · see citing works
I feel good? Anhedonia might not mean “without pleasure” for people treated for opioid use disorder.
Stull, S. W., Bertz, J. W., Panlilio, L. V., Kowalczyk, W. J., Phillips, K. A., Moran, L. M., Lin, J., Vahabzadeh, M., Finan, P. H., Preston, K. L., et al. (2021) · Journal of Abnormal Psychology · doi:10.1037/abn0000674 · Cited by 14 · see citing works
Effects of an acute bout of physical exercise on reward functioning in healthy adults
Wardle, M. C., Lopez-Gamundi, P., & LaVoy, E. C. P. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.07.010 · Cited by 14 · see citing works
Izadpanah, M., Najafi, M., & Khosravani, V. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106656 · Cited by 14 · see citing works
Gorostowicz, A., Rizvi, S. J., Kennedy, S. H., Chrobak, A. A., Dudek, D., CYRANKA, K. M., Piekarska, J., Krawczyk, E., & Siwek, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1268290 · Cited by 13 · see citing works
Cannabis packaging: An opportunity for facilitating informed decisions
Al-Hamdani, M., Joyce, K., Park, T., Cowie, M. E., & Stewart, S. (2020) · Journal of Consumer Affairs · doi:10.1111/joca.12325 · Cited by 11 · see citing works
Emery, N. N., Stanton, K. J., Baumgardner, S., Simons, J. S., Douglass, M. A., & Prince, M. A. (2023) · Behaviour Research and Therapy · doi:10.1016/j.brat.2023.104356 · Cited by 13 · see citing works
Hussain, M., Iudicello, J., Morgan, E., Kamat, R., Heaton, R., & Grant, I. (2021) · Addictive Behaviors Reports · doi:10.1016/j.abrep.2020.100331 · Cited by 13 · see citing works
Evaluating the item-level factor structure of anhedonia
Case, J. A. C., Sullivan‐Toole, H., Mattoni, M., Jacobucci, R., Forbes, E. E., & Olino, T. M. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.11.069 · Cited by 13 · see citing works
Roos, C. R., Kiluk, B., Carroll, K. M., Bricker, J. B., Mun, C. J., Sala, M., Kirouac, M., Stein, E., John, M., Palmer, R., et al. (2024) · Annals of Medicine · doi:10.1080/07853890.2024.2315228 · Cited by 12 · see citing works
Link Between Anhedonia and Depression During Early Alcohol Abstinence: Gender Matters
Petit, G., Deschietere, G., Loas, G., Luminet, O., & de Timary, P. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz090 · Cited by 12 · see citing works
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12 · see citing works
Chiappini, S., Mosca, A., Semeraro, F., Amerio, A., Berardelli, I., Cremaschi, L., Bernardo, I. D., Pettorruso, M., Serafini, G., Dell’Osso, B. M., et al. (2025) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2025.152616 · Cited by 14 · see citing works
Parikh, A., Moeller, S. J., & Garland, E. L. (2022) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2021.2007258 · Cited by 9 · see citing works
Mackesy‐Amiti, M. E., & Donenberg, G. R. (2020) · Psychology of Addictive Behaviors · doi:10.1037/adb0000577 · Cited by 10 · see citing works
The Reward Deficiency Syndrome and Links with Addictive and Related Behaviors
Kótyuk, E., Potenza, M. N., Blum, K., & Demetrovics, Z. (2021) · Springer eBooks · doi:10.1007/978-3-030-67928-6_3-1 · Cited by 10 · see citing works
Petrie, D. J., Knapp, K. S., Freet, C. S., Deneke, E., Brick, T. R., Cleveland, H. H., & Bunce, S. C. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.09.012 · Cited by 10 · see citing works
Yi, J. Y., Dichter, G. S., Reese, E. D., Bell, R. P., Bartuska, A. D., Stein, J. R., & Daughters, S. B. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.01.047 · Cited by 10 · see citing works
Yu, Q., Wang, X., Cao, Y., Lu, J., Gao, F., Fan, J., & Zhu, X. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.01.039 · Cited by 9 · see citing works
- Authors
- Garfield, J. B. B., Lubman, D. I., & Yücel, M.
- Affiliations
- Eastern Health (AU)
- Monash University (AU)
- Venue
- Australian & New Zealand Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2013-11-22
- Volume
- 48
- Issue
- 1
- Pages
- 36-51
- ISSN
- 0004-8674 (ISSN-L)
- 1440-1614
- OpenAlex
- W2148297013
- Cited by
- 213
- References
- 61
- Citations by year
- 2026: 17 · 2025: 27 · 2024: 11 · 2023: 22 · 2022: 11 · 2021: 18 · 2020: 58 · 2019: 13 · 2018: 14 · 2017: 3 · 2016: 12 · 2015: 6 · 2013: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Australian & New Zealand Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anhedonia, substance use disorders, substance dependence, abstinence, relapse, drug craving, drugs of abuse, therapeutic interventions
- MeSH terms
- Humans, Substance-Related Disorders, Anhedonia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
