Intensive Nutrition in Acute Lung Injury: A Clinical Trial (INTACT)

Braunschweig, Carol A.; Sheean, Patricia M.; Peterson, Sarah J.; Gomez Perez, Sandra; Freels, Sally; Lateef, Omar; Gurka, David; Fantuzzi, Giamila

doi:10.1177/0148607114528541

Cited by 199Clinical Nutrition and GastroenterologyNosocomial Infections in ICURespiratory Support and Mechanisms

Intensive Nutrition in Acute Lung Injury: A Clinical Trial (INTACT)

Open access

Braunschweig, Carol A., Sheean, Patricia M., Peterson, Sarah J., Gomez Perez, Sandra, Freels, Sally, Lateef, Omar, Gurka, David, Fantuzzi, Giamila·2015·Journal of Parenteral and Enteral Nutrition

DOI 10.1177/0148607114528541PMC PMC4205213

Open this paper in CoChat — free account

Abstract

Background: Despite extensive use of enteral (EN) and parenteral nutrition (PN) in intensive care unit (ICU) populations for 4 decades, evidence to support their efficacy is extremely limited. Methods : A prospective randomized trial was conducted evaluate the impact on outcomes of intensive medical nutrition therapy (IMNT; provision of >75% of estimated energy and protein needs per day via EN and adequate oral diet) from diagnosis of acute lung injury (ALI) to hospital discharge compared with standard nutrition support care (SNSC; standard EN and ad lib feeding). The primary outcome was infections; secondary outcomes included number of days on mechanical ventilation, in the ICU, and in the hospital and mortality. Results : Overall, 78 patients (40 IMNT and 38 SNSC) were recruited. No significant differences between groups for age, body mass index, disease severity, white blood cell count, glucose, C‐reactive protein, energy or protein needs occurred. The IMNT group received significantly higher percentage of estimated energy (84.7% vs 55.4%, P < .0001) and protein needs (76.1 vs 54.4%, P < .0001) per day compared with SNSC. No differences occurred in length of mechanical ventilation, hospital or ICU stay, or infections. The trial was stopped early because of significantly greater hospital mortality in IMNT vs SNSC (40% vs 16%, P = .02). Cox proportional hazards models indicated the hazard of death in the IMNT group was 5.67 times higher ( P = .001) than in the SNSC group. Conclusions : Provision of IMNT from ALI diagnosis to hospital discharge increases mortality.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1177/0148607114528541

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Studies (134, 138) and the meta-analysis derived from them (144, 145, 146) concluded there was no difference between normocaloric and hypocaloric diets in critically ill patients.
“These studies (134, 138) and the metaanalysis derived from them (144, 145, 146) concluded that there was no difference between normocaloric versus hypocaloric diets in critically ill patients.”
From ESPEN guideline on clinical nutrition in the intensive care unit. (2019) · cites this paper as [134]
The Results (page unavailable) report significantly higher mortality with intensive nutrition than with standard care (39% versus 16%), and the Discussion says the trial was stopped early because of that difference. Although several other outcomes did not differ, this study did not conclude that the feeding approaches were equivalent. (LLM, conf=0.88)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

APACHE II
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,333 · see citing works
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379 · see citing works
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure: On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine (see contributors to the project in the appendix)
Vincent, J. L., Moreno, R., Takala, J., Willatts, S., De Mendonça, A., Bruining, H., Reinhart, C. K., Suter, P. M., & Thijs, L. G. (1996) · Intensive Care Medicine · doi:10.1007/bf01709751 · Cited by 11,674 · see citing works
The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
Bernard, G. R., Artigas, A., Brigham, K. L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J. R., Morris, A., & Spragg, R. (1994) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.149.3.7509706 · Cited by 6,746 · see citing works
APACHE II: a severity of disease classification system.
Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034 · see citing works
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119 · see citing works
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
McClave, S. A., Taylor, B. E., Martindale, R. G., Warren, M. M., Johnson, D. R., Braunschweig, C., McCarthy, M. S., Davanos, E., Rice, T. W., Cresci, G. A., et al. (2016) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115621863 · Cited by 3,982 · see citing works
Self-citation
Modelling for Survival Data in Medical Research
(1995) · Technometrics · doi:10.1080/00401706.1995.10485920 · Cited by 2,159 · see citing works
Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial
Girard, T. D., Kress, J. P., Fuchs, B. D., Thomason, J. W. W., Schweickert, W. D., Pun, B. T., Taichman, D. B., Dunn, J., Pohlman, A. S., Kinniry, P. A., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60105-1 · Cited by 2,051 · see citing works
ESPEN guidelines on parenteral nutrition: intensive care
Singer, P., Berger, M. M., Van den Berghe, G., Biolo, G., Calder, P., Forbes, A., Griffiths, R., Kreyman, G., Leverve, X., & Pichard, C. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.04.024 · Cited by 1,907 · see citing works
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.)
McClave, S. A., Martindale, R. G., Vanek, V. W., McCarthy, M., Roberts, P., Taylor, B., Ochoa, J. B., Napolitano, L., Cresci, G., the A.S.P.E.N. Board of Directors, et al. (2009) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607109335234 · Cited by 1,873 · see citing works
Early versus late parenteral nutrition in critically ill adults
Casaer, M. P., Mesotten, D., Hermans, G., Wouters, P. J., Schetz, M., Meyfroidt, G., Van Cromphaut, S., Ingels, C., Meersseman, P., Muller, J., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102662 · Cited by 1,696 · cited 1× · see citing works
“89 Protein received per day, g 82 (23) 60.”
Canadian clinical practice guidelines for nutrition support in mechanically ventilated, critically ill adult patients
Heyland, D., Dhaliwal, R., Drover, J., Gramlich, L. M., & Dodek, P. (2003) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607103027005355 · Cited by 1,471 · see citing works
The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study
Moreno, R. P., Vincent, J., Matos, R., de Mendonça, A., Cantraine, F. R. L., THIJS, L. G., Takala, J., Sprung, C. L., Antonelli, M. M., Bruining, H. A., et al. (1999) · Intensive Care Medicine · doi:10.1007/s001340050931 · Cited by 1,050 · see citing works
Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial
The National Heart, L., Rice, T. W., Wheeler, A. P., Thompson, B. T., Steingrub, J., Hite, R. D., Moss, M., Morris, A., Dong, N., & Rock, P. (2012) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.2012.137 · Cited by 935 · see citing works
The International Sepsis Forum Consensus Conference on Definitions of Infection in the Intensive Care Unit
Calandra, T., & Cohen, J. D. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000168253.91200.83 · Cited by 840 · see citing works
Benefits of Immediate Jejunostomy Feeding after Major Abdominal Trauma???A Prospective, Randomized Study
Moore, E. E., & Jones, T. N. (1986) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-198610000-00003 · Cited by 717 · see citing works
The tight calorie control study (TICACOS): a prospective, randomized, controlled pilot study of nutritional support in critically ill patients
Singer, P., Anbar, R., Cohen, J., Shapiro, H., Shalita-Chesner, M., Lev, S., Grozovski, E., Theilla, M., Frishman, S., & Madar, Z. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2146-z · Cited by 566 · see citing works
Early Parenteral Nutrition in Critically Ill Patients With Short-term Relative Contraindications to Early Enteral Nutrition: A Randomized Controlled Trial
Doig, G. S. (2013) · JAMA · doi:10.1001/jama.2013.5124 · Cited by 526 · see citing works
Modelling survival data
Collett, D. (1994) · Springer eBooks · doi:10.1007/978-1-4899-3115-3_3 · Cited by 524 · see citing works
Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit*
Rubinson, L., Diette, G. B., Song, X., Brower, R. G., & Krishnan, J. A. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000089641.06306.68 · Cited by 384 · see citing works
Randomized trial of initial trophic versus full-energy enteral nutrition in mechanically ventilated patients with acute respiratory failure
Rice, T. W., Mogan, S., Hays, M. A., Bernard, G. R., Jensen, G. L., & Wheeler, A. P. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e31820a905a · Cited by 351 · see citing works
Permissive underfeeding and intensive insulin therapy in critically ill patients: a randomized controlled trial
Arabi, Y. M., Tamim, H., Dhar, G. S., Al‐Dawood, A., Al-Sultan, M., Sakkijha, M. H., Kahoul, S. H., & Brits, R. J. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005074 · Cited by 351 · see citing works
Role of Disease and Macronutrient Dose in the Randomized Controlled EPaNIC Trial
Casaer, M. P., Wilmer, A., Hermans, G., Wouters, P. J., Mesotten, D., & Van den Berghe, G. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-0999oc · Cited by 307 · see citing works
Tube Feedings in Elderly Patients
Ciocon, J. O. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380020173022 · Cited by 292 · see citing works
The Canadian Critical Care Nutrition Guidelines in 2013: An Update on Current Recommendations and Implementation Strategies
Dhaliwal, R., Cahill, N., Lemieux, M., & Heyland, D. K. (2014) · Nutrition in Clinical Practice · doi:10.1177/0884533613510948 · Cited by 282 · see citing works
Whole Body Protein Kinetics in Severely Septic Patients
SHAW, J. H. F., WILDBORE, M., & Wolfe, R. R. (1987) · Annals of Surgery · doi:10.1097/00000658-198703000-00012 · Cited by 276 · see citing works
Optimal protein requirements during the first 2 weeks after the onset of critical illness
Ishibashi, N., Plank, L. D., Sando, K., & Hill, G. L. (1998) · Critical Care Medicine · doi:10.1097/00003246-199809000-00020 · Cited by 245 · see citing works
Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients
Vanhorebeek, I., Gunst, J., Derde, S., Derese, I., Boussemaere, M., Güiza, F., Martinet, W., Timmermans, J.-P., D'Hoore, A., Wouters, P. J., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2563 · Cited by 241 · see citing works
Early Enteral Nutrition Support in Patients Undergoing Liver Transplantation
Hasse, J. M., Blue, L. S., Liepa, G. U., Goldstein, R. M., Jennings, L. W., Mor, E., Husberg, B. S., Levy, M. F., Gonwa, T. A., & Klintmalm, G. B. G. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607195019006437 · Cited by 236 · see citing works
Modelling Survival Data in Medical Research.
D’Agostino, R. B., & Collett, D. (1995) · Journal of the American Statistical Association · doi:10.2307/2291354 · Cited by 224 · see citing works
Does Enteral Nutrition Affect Clinical Outcome? A Systematic Review of the Randomized Trials
Koretz, R. L., Avenell, A., Lipman, T. O., Braunschweig, C. L., & Milne, A. C. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.01024.x · Cited by 213 · see citing works
Self-citation
Adequacy of Oral Intake in Critically Ill Patients 1 Week after Extubation
Peterson, S. J., Tsai, A., Scala, C., Sowa, D. C., Sheean, P., & Braunschweig, C. L. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2009.11.020 · Cited by 204 · see citing works
Self-citation
Early Parenteral Nutrition Evokes a Phenotype of Autophagy Deficiency in Liver and Skeletal Muscle of Critically Ill Rabbits
Derde, S., Vanhorebeek, I., Güiza, F., Derese, I., Gunst, J., Fahrenkrog, B., Martinet, W., Vervenne, H. B. V. K., Ververs, E.-J., Larsson, L., et al. (2012) · Endocrinology · doi:10.1210/en.2011-2068 · Cited by 164 · see citing works
Adjusted Body Weight, Pro: Evidence to Support the Use of Adjusted Body Weight in Calculating Calorie Requirements
Krenitsky, J. (2005) · Nutrition in Clinical Practice · doi:10.1177/0115426505020004468 · Cited by 112 · see citing works
A comparison of the predictive value of nutritional assessment techniques.
Baker, J. P., Detsky, A., Whitwell, J., Langer, B., & Jeejeebhoy, K. N. (1982) · PubMed · Cited by 80 · see citing works
Early versus Late Enteral Feeding in Patients with Acute Cervical Spinal Cord Injury
Dvorak, M. F., Noonan, V. K., Bélanger, L. M., Bruun, B., WING, P. C., Boyd, M. C., & Fisher, C. G. (2004) · Spine · doi:10.1097/00007632-200405010-00020 · Cited by 74 · see citing works
Randomised clinical trials.
Pocock, S. (1977) · BMJ · doi:10.1136/bmj.1.6077.1661 · Cited by 57 · see citing works
Complications of Enteral Feeding
Cabré, E., & Gassull, M. A. (1998) · Nutrition in Clinical Practice · doi:10.1177/088453369801300312 · Cited by 35 · see citing works
Microbiological and immunological effects of enteral feeding on the upper gastrointestinal tract
Smith, A. R., Macfarlane, S., Furrie, E., Ahmed, S., Bahrami, B., Reynolds, N., & Macfarlane, G. T. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.026401-0 · Cited by 29 · see citing works
Enteral alimentation: administration and complications.
Benya, R., & Mobarhan, S. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718147 · Cited by 28 · see citing works
Intranasal Retraction of Nasogastric Feeding Tube: Case Report and Suggestion for Design Modification
Bohnker, B. K., Artman, L. E., & Hoskins, W. J. (1985) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860718500900153 · Cited by 3 · see citing works

Flagged first, then by citations

1 of the 43 references couldn’t be matched to a known paper.

Sorted by citations

ESPEN guideline on clinical nutrition in the intensive care unit.
Singer, P., Blaser, A. R., Berger, M. M., Alhazzani, W., Calder, P. C., Casaer, M. P., Hiesmayr, M., Mayer, K., Montejo, J. C., Pichard, C., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.08.037 · Cited by 2,904 · see citing works
Guidelines for the provision of nutrition support therapy in the adult critically ill patient: the American Society for Parenteral and Enteral Nutrition
Compher, C., Bingham, A. L., McCall, M., Patel, J., Rice, T. W., Braunschweig, C., & McKeever, L. (2022) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.2267 · Cited by 747 · see citing works
Self-citation
Energy-dense versus routine enteral nutrition in the critically ill
The TARGET Investigators (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1811687 · Cited by 345 · see citing works
Greater protein and energy intake may be associated with improved mortality in higher risk critically ill patients: a multicenter, multinational observational study
Compher, C., Chittams, J., Sammarco, T., Nicolo, M., & Heyland, D. K. (2017) · Critical Care Medicine · doi:10.1097/ccm.0000000000002083 · Cited by 264 · see citing works
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020)
Egi, M., Ogura, H., Yatabe, T., Atagi, K., Inoue, S., Iba, T., Kakihana, Y., Kawasaki, T., Kushimoto, S., Kuroda, Y., et al. (2021) · Journal of Intensive Care · doi:10.1186/s40560-021-00555-7 · Cited by 226 · see citing works
Pathophysiology of Critical Illness and Role of Nutrition
Sharma, K., Mogensen, K., & Robinson, M. (2019) · Nutrition in clinical practice · doi:10.1002/ncp.10232 · Cited by 153 · see citing works
Monitoring nutrition in the ICU
Berger, M. M., Reintam-Blaser, A., Calder, P. C., Casaer, M., Hiesmayr, M. J., Mayer, K., Montejo, J. C., Pichard, C., Preiser, J.-C., van Zanten, A. R. H., et al. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.07.009 · Cited by 171 · see citing works
Adequate Nutrition May Get You Home
Yeh, D. D., Fuentes, E., Quraishi, S. A., Cropano, C. M., Kaafarani, H. M. A., Lee, J., King, D. R., DeMoya, M. A., Fagenholz, P. J., Butler, K. L., et al. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607115585142 · Cited by 150 · see citing works
Clinical Nutrition in Critical Care Medicine – Guideline of the German Society for Nutritional Medicine (DGEM)
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2019) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2019.05.002 · Cited by 150 · see citing works
Energy expenditure and indirect calorimetry in critical illness and convalescence: current evidence and practical considerations
Moonen, H. P. F. X., Beckers, K. J. H., & van Zanten, A. R. H. (2021) · Journal of Intensive Care · doi:10.1186/s40560-021-00524-0 · Cited by 120 · see citing works
Nutrition support in hospitalised adults at nutritional risk
Feinberg, J. B., Nielsen, E. E., Korang, S. K., Engell, K. H., Nielsen, M. S., Zhang, K., Didriksen, M., Lund, L., Lindahl, N., Hallum, S., et al. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011598.pub2 · Cited by 133 · see citing works
Normocaloric versus hypocaloric feeding on the outcomes of ICU patients: a systematic review and meta-analysis
Marik, P. E., & Hooper, M. H. (2016) · Intensive Care Medicine · doi:10.1007/s00134-015-4131-4 · Cited by 109 · see citing works
Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults
Padilla, P. F., Martínez, G., Vernooij, R. W. M., Urrútia, G., Figuls, M. R. I., & Bonfill, X. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012340.pub2 · Cited by 110 · see citing works
Supplemental parenteral nutrition improves immunity with unchanged carbohydrate and protein metabolism in critically ill patients: The SPN2 randomized tracer study
Berger, M. M., Pantet, O., Jacquelin-Ravel, N., Charrière, M., Schmidt, S., Becce, F., Audran, R., Spertini, F., Tappy, L., & Pichard, C. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2018.10.023 · Cited by 92 · see citing works
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020)
Egi, M., Ogura, H., Yatabe, T., Atagi, K., Inoue, S., Iba, T., Kakihana, Y., Kawasaki, T., Kushimoto, S., Kuroda, Y., et al. (2021) · Acute Medicine & Surgery · doi:10.1002/ams2.659 · Cited by 86 · see citing works
Nutrition in the intensive care unit: from the acute phase to beyond
de Man, A., Gunst, J., & Blaser, A. R. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07458-9 · Cited by 94 · see citing works
Enteral Nutrition in the Mechanically Ventilated Patient
Allen, K. S., & Hoffman, L. (2019) · Nutrition in Clinical Practice · doi:10.1002/ncp.10242 · Cited by 85 · see citing works
Preserving the quality of life: nutrition in the ICU
Singer, P. (2019) · Critical Care · doi:10.1186/s13054-019-2415-8 · Cited by 84 · see citing works
Metabolic support in the critically ill: a consensus of 19
Wernerman, J., Christopher, K. B., Annane, D., Casaer, M. P., Coopersmith, C. M., Deane, A. M., Waele, E. D., Elke, G., Ichaï, C., Karvellas, C. J., et al. (2019) · Critical Care · doi:10.1186/s13054-019-2597-0 · Cited by 85 · see citing works
Nutrition Risk in Critically Ill Versus the Nutritional Risk Screening 2002: Are They Comparable for Assessing Risk of Malnutrition in Critically Ill Patients?
Canales, C., Elsayes, A., Yeh, D. D., Belcher, D. M., Nakayama, A., McCarthy, C. M., Chokengarmwong, N., & Quraishi, S. A. (2018) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1181 · Cited by 78 · see citing works
Malnutrition and its effects in severely injured trauma patients
Dijkink, S., Meier, K., Krijnen, P., Yeh, D. D., Velmahos, G. C., & Schipper, I. B. (2020) · European Journal of Trauma and Emergency Surgery · doi:10.1007/s00068-020-01304-5 · Cited by 75 · see citing works
DGEM-Leitlinie: „Klinische Ernährung in der Intensivmedizin“
Elke, G., Hartl, W. H., Kreymann, K. G., Adolph, M., Felbinger, T. W., Graf, T., de Heer, G., Heller, A. R., Kampa, U., Mayer, K., et al. (2018) · Aktuelle Ernährungsmedizin · doi:10.1055/a-0713-8179 · Cited by 76 · see citing works
Lower versus higher dose of enteral caloric intake in adult critically ill patients: a systematic review and meta-analysis
Al-Dorzi, H. M., Albarrak, A., Ferwana, M., Murad, M. H., & Arabi, Y. M. (2016) · Critical Care · doi:10.1186/s13054-016-1539-3 · Cited by 74 · see citing works
Autophagy and Its Implications Against Early Full Nutrition Support in Critical Illness
Van Dyck, L., Casaer, M. P., & Gunst, J. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10084 · Cited by 70 · see citing works
Japanese Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients 2023 (J-ReCIP 2023)
Unoki, T., Hayashida, K., Kawai, Y., Taito, S., Ando, M., Iida, Y., Kasai, F., Kawasaki, T., Kozu, R., Kondo, Y., et al. (2023) · Journal of Intensive Care · doi:10.1186/s40560-023-00697-w · Cited by 73 · see citing works
Effect of initial calorie intake via enteral nutrition in critical illness: a meta-analysis of randomised controlled trials
Tian, F., Wang, X., Gao, X., Wan, X., Wu, C., Zhang, L., Li, N., & Li, J. (2015) · Critical Care · doi:10.1186/s13054-015-0902-0 · Cited by 69 · see citing works
Calorie delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis
Parikh, H. G., Miller, A., Chapman, M., Moran, J. L., & Peake, S. L. (2016) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00927-4 · Cited by 69 · see citing works
A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient—the SPIRIT trial
Jakob, S. M., Bütikofer, L., Berger, D., Coslovsky, M., & Takala, J. A. (2017) · Critical Care · doi:10.1186/s13054-017-1730-1 · Cited by 63 · see citing works
Relationship Between Dietary Fiber Intake and Short‐Chain Fatty Acid–Producing Bacteria During Critical Illness: A Prospective Cohort Study
Fu, Y., Moscoso, D. I., Porter, J., Krishnareddy, S., Abrams, J. A., Seres, D. S., Chong, D. H., & Freedberg, D. E. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1682 · Cited by 58 · see citing works
Early high protein intake and mortality in critically ill ICU patients with low skeletal muscle area and -density
Looijaard, W. G. P. M., Dekker, I. M., Beishuizen, A., Girbes, A. R. J., Straaten, H. M. O., & Weijs, P. J. M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.09.007 · Cited by 57 · see citing works
Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults
Baldwin, C., de van der Schueren, M. A. E., Kruizenga, H. M., & Weekes, C. E. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002008.pub5 · Cited by 56 · see citing works
Role of timing and dose of energy received in patients with acute lung injury on mortality in the Intensive Nutrition in Acute Lung Injury Trial (INTACT): a post hoc analysis ,
Braunschweig, C. L., Freels, S. A., Sheean, P., Peterson, S. J., Gomez‐Perez, S. L., McKeever, L., Lateef, O., Gurka, D. P., & Fantuzzi, G. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.140764 · Cited by 54 · see citing works
Self-citation
Protein delivery and clinical outcomes in the critically ill: a systematic review and meta-analysis
Davies, M. L., Chapple, L. S., Chapman, M. J., Moran, J. L., & Peake, S. (2017) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00783-4 · Cited by 52 · see citing works
Autophagy and autophagic cell death in sepsis: friend or foe?
Iba, T., Helms, J., Maier, C. L., Ferrer, R., & Levy, J. H. (2024) · Journal of Intensive Care · doi:10.1186/s40560-024-00754-y · Cited by 52 · see citing works
Upregulation of miRNA‑140‑5p inhibits inflammatory cytokines in acute lung injury through the MyD88/NF‑κB signaling pathway by targeting TLR4
Yang, Y., Liu, D., Yin, X., Li, J., Liu, B., & Li, J. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6692 · Cited by 49 · see citing works
Expert consensus‑based clinical practice guidelines for nutritional support in the intensive care unit: the French Intensive Care Society (SRLF) and the French-Speaking Group of Pediatric Emergency Physicians and Intensivists (GFRUP)
Reignier, J., Roux, B. G., Dequin, P. F., Maluf, V. A. B., Bohé, J., Casaer, M. P., Delbove, A., Dupuis, C., Fontaine, E. M., Gamon, P., et al. (2025) · Annals of Intensive Care · doi:10.1186/s13613-025-01509-0 · Cited by 53 · see citing works
Association of PROtein and CAloric Intake and Clinical Outcomes in Adult SEPTic and Non‐Septic ICU Patients on Prolonged Mechanical Ventilation: The PROCASEPT Retrospective Study
de Koning, M.-S. L. Y., Koekkoek, W. A. C., Kars, J. C. N., & van Zanten, A. R. H. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1663 · Cited by 45 · see citing works
Controversies Surrounding Critical Care Nutrition: An Appraisal of Permissive Underfeeding, Protein, and Outcomes
Patel, J. J., Martindale, R. G., & McClave, S. A. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607117721908 · Cited by 41 · see citing works
Feeding the child with congenital heart disease: a narrative review
Herridge, J., Tedesco-Bruce, A., Gray, S., & Floh, A. A. (2021) · Pediatric Medicine · doi:10.21037/pm-20-77 · Cited by 41 · see citing works
Propofol sedation substantially increases the caloric and lipid intake in critically ill patients
Charrière, M., Ridley, E. J., Hastings, J., Bianchet, O., Scheinkestel, C. D., & Berger, M. M. (2017) · Nutrition · doi:10.1016/j.nut.2017.05.009 · Cited by 39 · see citing works
How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist
Blaser, A. R., Rooyackers, O., & Bear, D. E. (2023) · Critical Care · doi:10.1186/s13054-023-04543-1 · Cited by 40 · see citing works
Safety and efficacy of volume-based feeding in critically ill, mechanically ventilated adults using the ‘Protein & Energy Requirements Fed for Every Critically ill patient every Time’ (PERFECT) protocol: a before-and-after study
Brierley-Hobson, S., Clarke, G., & O’Keeffe, V. (2019) · Critical Care · doi:10.1186/s13054-019-2388-7 · Cited by 38 · see citing works
Systematic Review With Meta‐Analysis of Patient‐Centered Outcomes, Comparing International Guideline–Recommended Enteral Protein Delivery With Usual Care
Fetterplace, K., Gill, B. M. T., Chapple, L. S., Presneill, J., MacIsaac, C., & Deane, A. M. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1725 · Cited by 38 · see citing works
Nutrition in the ICU: new trends versus old-fashioned standard enteral feeding?
Koekkoek, K. W. A. C., & van Zanten, A. R. H. (2018) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000000571 · Cited by 38 · see citing works
Japanese Guidelines for Nutrition Support Therapy in the Adult and Pediatric Critically Ill Patients
日本集中治療医学会重症患者の栄養管理ガイドライン作成委員会 (2016) · Journal of the Japanese Society of Intensive Care Medicine · doi:10.3918/jsicm.23.185 · Cited by 35 · see citing works
Nutritional support in critical illness and recovery
Casaer, M. P., & Ziegler, T. R. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00222-3 · Cited by 34 · see citing works
Mitochondrial dysfunction in critical illness during acute metabolic stress and convalescence: consequences for nutrition therapy
Moonen, H. P. F. X., & van Zanten, A. R. H. (2020) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000741 · Cited by 34 · see citing works
Intermittent or continuous feeding: any difference during the first week?
Dyck, L. V., & Casaer, M. P. (2019) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000617 · Cited by 33 · see citing works
Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome
Wilson, B., & Typpo, K. (2016) · Frontiers in Pediatrics · doi:10.3389/fped.2016.00108 · Cited by 31 · see citing works
Delivery of full predicted energy from nutrition and the effect on mortality in critically ill adults: A systematic review and meta-analysis of randomised controlled trials.
Ridley, E., Davies, A., Hodgson, C., Deane, A., Bailey, M., & Cooper, D. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.09.026 · Cited by 24 · see citing works
Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study
Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., & Blaser, A. R. (2017) · World Journal of Critical Care Medicine · doi:10.5492/wjccm.v6.i1.56 · Cited by 30 · see citing works
Early Exposure to Recommended Calorie Delivery in the Intensive Care Unit Is Associated With Increased Mortality in Patients With Acute Respiratory Distress Syndrome
Peterson, S. J., Lateef, O., Freels, S. A., McKeever, L., Fantuzzi, G., & Braunschweig, C. A. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607117713483 · Cited by 31 · see citing works
Self-citation
Evaluation of the effect of high protein supply on diaphragm atrophy in critically ill patients receiving prolonged mechanical ventilation
Zhang, Q., Zhou, J., Zhu, D., & Zhou, S. (2021) · Nutrition in Clinical Practice · doi:10.1002/ncp.10672 · Cited by 29 · see citing works
Impact of withholding early parenteral nutrition on 2-year mortality and functional outcome in critically ill adults
Casaer, M. P., Stragier, H., Hermans, G., Hendrickx, A., Wouters, P. J., Dubois, J., Güiza, F., den Berghe, G. V., & Gunst, J. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07546-w · Cited by 26 · see citing works
Early or Late Feeding after ICU Admission?
Blaser, A. R., & Berger, M. M. (2017) · Nutrients · doi:10.3390/nu9121278 · Cited by 26 · see citing works
Should enteral nutrition be started in the first week of critical illness?
Martindale, R. G., & Warren, M. M. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000146 · Cited by 26 · see citing works
When timing and dose of nutrition support were examined, the modified Nutrition Risk in Critically Ill (mNUTRIC) score did not differentiate high-risk patients who would derive the most benefit from nutrition support: a prospective cohort study
Lew, C. C. H., Wong, G. J. Y., Cheung, K. P., Fraser, R. J., Chua, A. P., Chong, M. F., & Miller, M. (2018) · Annals of Intensive Care · doi:10.1186/s13613-018-0443-1 · Cited by 24 · see citing works
Should We Aim for Full Enteral Feeding in the First Week of Critical Illness?
McClave, S. A., Codner, P. A., Patel, J. J., Hurt, R. T., Allen, K. S., & Martindale, R. G. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616653809 · Cited by 23 · see citing works
Major publications in the critical care pharmacotherapy literature in 2015
Wong, A., Erdman, M. J., Hammond, D. A., Holt, T., Holzhausen, J. M., Horng, M., Huang, L. L., Jarvis, J., Kram, B., Kram, S. J., et al. (2017) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp160144 · Cited by 24 · see citing works
Effects of early energy intake on neonatal cerebral growth of preterm newborn: an observational study
Boscarino, G., Chiara, M. D., Cellitti, R., Nardo, M. C. D., Conti, M. G., Parisi, P., Spalice, A., Mario, C. D., Ronchi, B., Russo, A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98088-4 · Cited by 24 · see citing works
Early Enteral Nutrition in Mechanically Ventilated Patients With COVID‐19 Infection
Farina, N., Nordbeck, S., Montgomery, M., Cordwin, L., Blair, F., Cherry‐Bukowiec, J. R., Kraft, M. D., Pleva, M. R., & Raymond, E. (2021) · Nutrition in Clinical Practice · doi:10.1002/ncp.10629 · Cited by 23 · see citing works
Targeted Energy Intake Is the Important Determinant of Clinical Outcomes in Medical Critically Ill Patients with High Nutrition Risk
Wang, C.-Y., Fu, P., Huang, C.-T., Chen, C., Lee, B., & Huang, Y. (2018) · Nutrients · doi:10.3390/nu10111731 · Cited by 23 · see citing works
Is early starvation beneficial for the critically ill patient?
Marik, P. E. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000256 · Cited by 21 · see citing works
Impact of Energy and Protein Delivery to Critically Ill Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nakanishi, N., Matsushima, S., Tatsuno, J., Liu, K., Tamura, T., Yonekura, H., Yamamoto, N., Unoki, T., Kondo, Y., & Nakamura, K. (2022) · Nutrients · doi:10.3390/nu14224849 · Cited by 21 · see citing works
Gastrointestinal dysmotility in the critically ill
Weimann, A., & Felbinger, T. W. (2016) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000300 · Cited by 21 · see citing works
A Novel Risk Score to Predict the Need for Nutrition Support After Cardiac Surgery
Ohkuma, R., Crawford, T. C., Brown, P. M., Grimm, J. C., Magruder, J. T., Kilic, A., Suarez‐Pierre, A., Snyder, S., Wood, J. D., Schneider, E. B., et al. (2017) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2017.03.013 · Cited by 21 · see citing works
Allicin attenuates lipopolysaccharide‑induced acute lung injury in neonatal rats via the PI3K/Akt pathway
Wang, X., Zhang, C., Chen, C., Guo, Y. C., Meng, X., & Kan, C. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8693 · Cited by 21 · see citing works
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality
Sartini, C., Ломиворотов, В. В., Pieri, M., Delgado, J. C. L., Redaelli, M. B., Hajjar, L. A., Pisano, A., Likhvantsev, V. V., Fominskiy, E. V., Bradic, N., et al. (2018) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2018.11.026 · Cited by 21 · see citing works
TLR4/NF-κB signaling pathway gene single nucleotide polymorphisms alter gene expression levels and affect ARDS occurrence and prognosis outcomes
Ding, Y., Feng, Q., Chen, J., & Song, J. (2019) · Medicine · doi:10.1097/md.0000000000016029 · Cited by 21 · see citing works
High‐Protein Hypocaloric Nutrition for Non‐Obese Critically Ill Patients
Hoffer, L. J. (2018) · Nutrition in Clinical Practice · doi:10.1002/ncp.10091 · Cited by 18 · see citing works
Perioperative gastrointestinal problems in the ICU
Blaser, A. R., Starkopf, J., Moonen, P.-J., Malbrain, M. L. N. G., & Straaten, H. M. O. (2014) · Anaesthesiology Intensive Therapy · doi:10.5603/ait.a2017.0064 · Cited by 19 · see citing works
Parenteral nutrition in the critically ill
Gunst, J., & den Berghe, G. V. (2017) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000385 · Cited by 18 · see citing works
Efficacy of permissive underfeeding for critically ill patients: an updated systematic review and trial sequential meta-analysis
Yue, H.-Y., Peng, W. J., Zeng, J., Zhang, Y., Wang, Y., & Jiang, H. (2024) · Journal of Intensive Care · doi:10.1186/s40560-024-00717-3 · Cited by 19 · see citing works
Updates in Nutrition Support for Critically III Adult Patients
Mulherin, D. W., & Cogle, S. V. (2017) · Hospital Pharmacy · doi:10.1310/hpj5201-17 · Cited by 18 · see citing works
Impact of differences in acute respiratory distress syndrome randomised controlled trial inclusion and exclusion criteria: systematic review and meta-analysis
Saha, R., Assouline, B., Mason, G., Douiri, A., Summers, C., & Shankar‐Hari, M. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.02.027 · Cited by 18 · see citing works
Feeding During Phases of Altered Mitochondrial Activity: A Theory
McKeever, L., Bonini, M. G., & Braunschweig, C. L. (2017) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1010 · Cited by 18 · see citing works
Self-citation
Are Current Protein Recommendations for the Critically Ill Adequate for Patients on VV ECMO: Experience From a High-Volume Center.
Pelekhaty, S. L., Galvagno, S., Lantry, J., Dolly, K., Herr, D., Kon, Z., Deatrick, K., Cornachione, C. R., Scalea, T., & Menaker, J. (2020) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1602 · Cited by 15 · see citing works
Le concept du « Baby stomach » appliqué à la nutrition du patient agressé
Preiser, J., Fraipont, V., & Lheureux, O. (2019) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2019.05.003 · Cited by 18 · see citing works
Effect of calories delivered on clinical outcomes in critically ill patients: Systemic review and meta-analysis
Chelkeba, L., Mojtahedzadeh, M., & Mekonnen, Z. (2017) · Indian Journal of Critical Care Medicine · doi:10.4103/ijccm.ijccm_453_16 · Cited by 17 · see citing works
Update on nutritional assessment and therapy in critical care
Blaser, A. R., Rice, T. W., & Deane, A. M. (2020) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000694 · Cited by 16 · see citing works
Protein and Energy Intake Assessment and Their Association With In-Hospital Mortality in Critically Ill COVID-19 Patients: A Prospective Cohort Study
Hajimohammadebrahim‐Ketabforoush, M., Shariatpanahi, Z. V., Shariatpanahi, M. V., Shahbazi, E., & Shahbazi, S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.708271 · Cited by 18 · see citing works
Pros and Cons of Feeding the Septic Intensive Care Unit Patient
Fremont, R. D., & Rice, T. W. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615578457 · Cited by 17 · see citing works
Considerations When Using Predictive Equations to Estimate Energy Needs Among Older, Hospitalized Patients: A Narrative Review
Parker, E. A. D., Feinberg, T., Wappel, S. R., & Verceles, A. C. (2017) · Current Nutrition Reports · doi:10.1007/s13668-017-0196-8 · Cited by 16 · see citing works
Perspectives: on Precision Nutrition Research in Heart, Lung, and Blood Diseases and Sleep Disorders
PRATT, C. A., Brown, A. G. M., Dixit, S., Farmer, N. M., Natarajan, A. R., Boyington, J., Shi, S., Lu, Q., & Cotton, P. A. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac053 · Cited by 15 · see citing works
Study protocol for the Augmented versus Routine Approach to Giving Energy Trial (TARGET)
Williams, P. J. (2018) · Critical Care and Resuscitation · doi:10.1016/s1441-2772(23)00734-2 · Cited by 15 · see citing works
Combination of High-Calorie Delivery and Organ Failure Increases Mortality Among Patients With Acute Respiratory Distress Syndrome
Peterson, S. J., McKeever, L., Lateef, O., Freels, S. A., Fantuzzi, G., & Braunschweig, C. A. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003476 · Cited by 14 · see citing works
Self-citation
Intensive Care Nutrition and Post–Intensive Care Recovery
Gunst, J., & den Berghe, G. V. (2018) · Critical Care Clinics · doi:10.1016/j.ccc.2018.06.004 · Cited by 14 · see citing works
Concordance of Computed Tomography Regional Body Composition Analysis Using a Fully Automated Open-Source Neural Network versus a Reference Semi-Automated Program with Manual Correction
Gomez‐Perez, S. L., Zhang, Y., Byrne, C. A., Wakefield, C., Geesey, T., Sclamberg, J. S., & Peterson, S. J. (2022) · Sensors · doi:10.3390/s22093357 · Cited by 15 · see citing works
Self-citation
The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation
Huang, S., Lin, H., Chou, Y.-F., Lin, T., Lo, C., Huang, H.-Y., Fang, Y., Hsieh, M., Lin, S., Lo, Y., et al. (2022) · Nutrients · doi:10.3390/nu14204395 · Cited by 13 · see citing works
Nutritional support of critically ill adults and children with acute respiratory distress syndrome: A clinical review
Loi, M. V., Wang, J. L., Ong, C., & Lee, J. H. (2017) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2017.02.005 · Cited by 13 · see citing works
Impact of early protein provision on the mortality of acute critically ill stroke patients
Wang, D., Lin, Z., Xie, L., Huang, K., Ji, Z., Gu, C., & Wang, S. (2021) · Nutrition in Clinical Practice · doi:10.1002/ncp.10768 · Cited by 12 · see citing works
Effect of Hypocaloric Normoprotein Or Trophic Feeding versus Target Full Feeding on Patient Outcomes in Critically Ill Adults: A Systematic Review
Phan, K. A., Dux, C., Osland, E., & Reade, M. C. (2017) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1704500604 · Cited by 12 · see citing works
Critical Care Nutrition: Where's the Evidence?
Patel, J. J., Hurt, R., McClave, S., & Martindale, R. (2017) · Critical care clinics · doi:10.1016/j.ccc.2016.12.006 · Cited by 24 · see citing works
A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Increasing Mortality
Sartini, C., Ломиворотов, В. В., Pisano, A., Říha, H., Redaelli, M. B., Delgado, J. C. L., Pieri, M., Hajjar, L. A., Fominskiy, E. V., Likhvantsev, V. V., et al. (2019) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2019.03.022 · Cited by 11 · see citing works
Nutritional support for critically ill patients by the Korean Society for Parenteral and Enteral Nutrition — part I: a clinical practice guideline
Lee, S. H., Lee, J. G., Kwon, M. K., Kim, M., Kim, M., Park, J. Y., Lee, J. Y., Sung, Y. W., Kim, B., Kim, S. E., et al. (2024) · 한국정맥경장영양학회지 · doi:10.15747/acnm.2024.16.3.89 · Cited by 11 · see citing works
Effect of hypocaloric versus standard enteral feeding on clinical outcomes in critically ill adults – A meta-analysis of randomized controlled trials with trial sequential analysis
Zhou, X., Fang, H., Hu, C., Xu, J., Wang, H., Pan, J., Sha, Y., & Xu, Z. (2019) · Medicina Intensiva · doi:10.1016/j.medin.2019.10.003 · Cited by 11 · see citing works
Enteral feeding, even when the gut does not feel very good?
Blaser, A. R., & Hiesmayr, M. (2022) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000817 · Cited by 10 · see citing works
Initial energy supplementation in critically ill patients receiving enteral nutrition: a systematic review and meta-analysis of randomized controlled trials.
Tian, F., Gao, X.-J., Wu, C., Zhang, L., Xia, X.-F., & Wang, X.-Y. (2015) · Asia Pacific Journal of Clinical Nutrition · doi:10.6133/apjcn.102015.11 · Cited by 11 · see citing works
The Systemic Metabolic Profile Early after Allogeneic Stem Cell Transplantation: Effects of Adequate Energy Support Administered through Enteral Feeding Tube
Tvedt, T. H. A., Skaarud, K. J., Tjønnfjord, G. E., Gedde‐Dahl, T., Iversen, P. O., & Bruserud, Ø. (2019) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2019.10.005 · Cited by 10 · see citing works
Real‐Time Energy Exposure Is Associated With Increased Oxidative Stress Among Feeding‐Tolerant Critically Ill Patients: Results From the FEDOX Trial
McKeever, L., Peterson, S. J., Cienfuegos, S., Rizzie, J., Lateef, O., Freels, S. A., & Braunschweig, C. A. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1776 · Cited by 10 · see citing works
Self-citation

Intensive Nutrition in Acute Lung Injury: \n\nA Clinical Trial (INTACT)
(7918178), C. A. B., (7918181), P. M. S., (7918184), S. J. P., & (7918187), S. G. P. (2014) · Figshare
Role of timing and dose of energy received in patients with acute lung injury on mortality in the Intensive Nutrition in Acute Lung Injury Trial (INTACT): a post hoc analysis ,
Braunschweig, C. L., Freels, S. A., Sheean, P., Peterson, S. J., Gomez‐Perez, S. L., McKeever, L., Lateef, O., Gurka, D. P., & Fantuzzi, G. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.140764 · Cited by 54 · see citing works
Self-citation
A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill
Atkinson, S., Sieffert, E., & Bihari, D. J. (1998) · Critical Care Medicine · doi:10.1097/00003246-199807000-00013 · Cited by 285 · see citing works
Effects of Immune-Enhancing Enteral Nutrition on Mortality and Oxygenation in Acute Lung Injury and Acute Respiratory Distress Syndrome: A Meta-Analysis
Dee, B. M., Bruno, J. J., Lal, L. S., & Canada, T. W. (2011) · Hospital Pharmacy · doi:10.1310/hpj4601-33 · Cited by 8 · see citing works
Does intensive medical nutrition therapy (IMNT) reduce overall mortality in comparison to standard nutrition support care (SNSC) in intensive care unit (ICU) patients?
RCHSR (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.18456994

Authors: Braunschweig, C. A., Sheean, P. M., Peterson, S. J., Gomez Perez, S., Freels, S., Lateef, O., Gurka, D., & Fantuzzi, G.
Affiliations: University of Illinois Chicago (US)
Loyola University Chicago (US)
Rush University Medical Center (US)
Corresponding author: Braunschweig, Carol A.
ORCID: Braunschweig, Carol A.
Sheean, Patricia M.
Peterson, Sarah J.
Freels, Sally
Lateef, Omar
Fantuzzi, Giamila
Venue: Journal of Parenteral and Enteral Nutrition
Publisher: Wiley
Published: 2014-04-09
Volume: 39
Issue: 1
Pages: 13-20
ISSN: 0148-6071 (ISSN-L)
1941-2444
DOI: 10.1177/0148607114528541
PMC: PMC4205213
OpenAlex: W1999372553
Cited by: 199
References: 43
Citations by year: 2026: 6 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 14 · 2021: 25 · 2020: 9 · 2019: 24 · 2018: 27 · 2017: 29 · 2016: 19 · 2015: 11 · 2014: 2 · 2013: 1
FWCI: 18.94
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Parenteral and Enteral Nutrition (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL093142)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
Keywords: acute lung injury, enteral nutrition, parenteral nutrition, nutritional support, in-hospital mortality, mechanical ventilation duration, infection, ICU length of stay, energy and protein requirements
MeSH terms: Adult, Aged, Blood Cell Count, Blood Glucose, Body Weight, C-Reactive Protein, Energy Intake, Dietary Proteins, Enteral Nutrition, Female, Humans, Intensive Care Units, Male, Middle Aged, Parenteral Nutrition, Prospective Studies, Respiration, Artificial, Body Mass Index, Proportional Hazards Models, Treatment Outcome, Hospital Mortality, APACHE, Acute Lung Injury

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intensive Nutrition in Acute Lung Injury: A Clinical Trial (INTACT)

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks