Neural Basis of Δ-9-Tetrahydrocannabinol and Cannabidiol: Effects During Response Inhibition
Abstract
Background This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task. Methods Functional magnetic resonance imaging and behavioural measures were recorded while 15 healthy volunteers performed a Go/No-Go task following administration of either THC or CBD or placebo in a double-blind, pseudo-randomized, placebo-controlled repeated measures within-subject design. Results Relative to placebo, THC attenuated activation in the right inferior frontal and the anterior cingulate gyrus. In contrast, CBD deactivated the left temporal cortex and insula. These effects were not related to changes in anxiety, intoxication, sedation, and psychotic symptoms. Conclusions These data suggest that THC attenuates the engagement of brain regions that mediate response inhibition. CBD modulated function in regions not usually implicated in response inhibition.
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The plasma peak of an oral dose of CBD usually occurs 1-2 h after ingestion.
“the plasma peak of an oral dose of CBD usually occurs 1–2 h after ingestion (Agurell et al, 1981; Crippa et al, 2004, 2010, 2011; Borgwardt et al, 2008; Fusar-Poli et al, 2009a, 2009b)”
From Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients (2011) · cites this paper as Borgwardt et al, 2008
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- Authors
- Borgwardt, S. J., Allen, P., Bhattacharyya, S., Fusar-Poli, P., Crippa, J. A., Seal, M. L., Fraccaro, V., Atakan, Z., Martin-Santos, R., O'Carroll, C., Rubia, K., & McGuire, P. K.
- Affiliations
- King's College London (GB)
- The University of Melbourne (AU)
- Corresponding author
- Borgwardt, Stefan J.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 64
- Issue
- 11
- Pages
- 966-973
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2017062859
- Cited by
- 195
- References
- 7
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 7 · 2023: 3 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 7 · 2018: 15 · 2017: 23 · 2016: 11 · 2015: 12 · 2014: 14 · 2013: 11 · 2012: 20
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Keywords
- delta-9-tetrahydrocannabinol, cannabidiol, response inhibition, go/no-go task, brain activation, inferior frontal gyrus, anterior cingulate cortex, temporal cortex, insula
- MeSH terms
- Adult, Analysis of Variance, Brain, Brain Mapping, Cannabidiol, Decision Making, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Photic Stimulation, Psychotropic Drugs, Reaction Time, Dronabinol, Young Adult
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