Cannabidiol for the treatment of psychosis in Parkinson's disease
Abstract
The management of psychosis in Parkinson's disease (PD) has been considered a great challenge for clinicians and there is a need for new pharmacological intervention. Previously an antipsychotic and neuroprotective effect of Cannabidiol (CBD) has been suggested. Therefore, the aim of the present study was to directly evaluate for the first time, the efficacy, tolerability and safety of CBD on PD patients with psychotic symptoms. This was an open-label pilot study. Six consecutive outpatients (four men and two women) with the diagnosis of PD and who had psychosis for at least 3 months were selected for the study. All patients received CBD in flexible dose (started with an oral dose of 150 mg/day) for 4 weeks, in addition to their usual therapy. The psychotic symptoms evaluated by the Brief Psychiatric Rating Scale and the Parkinson Psychosis Questionnaire showed a significant decrease under CBD treatment. CBD did not worsen the motor function and decreased the total scores of the Unified Parkinson's Disease Rating Scale. No adverse effect was observed during the treatment. These preliminary data suggest that CBD may be effective, safe and well tolerated for the treatment of the psychosis in PD.
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In an open clinical trial with six PD outpatients, CBD (150-600 mg/day) added to usual treatment produced a significant reduction in BPRS and PPQ scores.
“In an open clinical trial with six PD outpatients, we found a significant reduction in the BPRS and the Parkinson Psychosis Questionnaire (PPQ) scores with CBD (150–600 mg/day) added to the usual treatment.”
From Translational investigation of the therapeutic potential of Cannabidiol (CBD): Toward a new age (2018) · cites this paper as [73]
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Self-citation
- Authors
- Zuardi, A., Crippa, J., Hallak, J., Pinto, J., Chagas, M., Rodrigues, G., Dursun, S., & Tumas, V.
- Affiliations
- Universidade de São Paulo (BR)
- Department of Neuropsychiatry and Medical Psychology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil
- Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
- Corresponding author
- Zuardi, AW
- ORCID
- Tumas, V.
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2008-09-18
- Volume
- 23
- Issue
- 8
- Pages
- 979-983
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W1967281437
- Cited by
- 355
- References
- 30
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 28 · 2023: 34 · 2022: 28 · 2021: 33 · 2020: 39 · 2019: 29 · 2018: 21 · 2017: 20 · 2016: 17 · 2015: 12 · 2014: 14 · 2013: 8 · 2012: 9
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health
- National Institute of Mental Health
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cannabidiol, Parkinson's disease, psychosis, antipsychotic drugs, neuroprotection, motor function, drug safety and tolerability, Brief Psychiatric Rating Scale
- MeSH terms
- Adult, Aged, Cannabidiol, Female, Humans, Male, Middle Aged, Parkinson Disease, Pilot Projects, Psychotic Disorders
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