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Prevalence and Incidence Studies of Mood Disorders: A Systematic Review of the Literature
Open accessAbstract
This is the second in a series of papers that present systematic reviews of the prevalence and incidence of psychiatric disorders drawn from studies published in English literature in the years 1980 to 2000. The series discusses the implications of these epidemiologic findings to mental health policy and practice. Objective: To present the results of a systematic review of literature published between January 1, 1980, and December 31, 2000, that reports findings on the prevalence and incidence of mood disorders in both general population and primary care settings. Method: We conducted a literature search of epidemiologic studies of mood disorders, using Medline and HealthSTAR databases and canvassing English-language publications. Eligible publications were restricted to studies that examined subjects aged at least 15 years and over. We used a set of predetermined inclusion and exclusion criteria to identify relevant studies. We extracted and analyzed prevalence and incidence data for heterogeneity. Results: Of general population studies, a total of 18 prevalence and 5 incidence studies met eligibility criteria. We found heterogeneity across 1-year and lifetime prevalence of major depressive disorder (MDD), dysthymic disorder, and bipolar I disorder. The corresponding pooled rates for 1-year prevalence were 4.1 per 100, 2.0 per 100, and 0.72 per 100, respectively. For lifetime prevalence, the corresponding pooled rates were 6.7 per 100, 3.6 per 100, and 0.8 per 100, respectively. Significant variation was observed among 1-year incidence rates of MDD, with a corresponding pooled rate of 2.9 per 100. Conclusions: The prevalence of mood disorders reported in high-quality studies is generally lower than rates commonly reported in the general psychiatric literature. When controlled for common methodological confounds, variation in prevalence rates persists across studies and deserves continued study. Methodological variation among studies that have examined the prevalence of depression in primary health care services is so large that comparative analyses cannot be achieved.
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“Depression is more common in RA than in the general population [1]”
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“Depressive disorders are highly prevalent in the general [1-3] and working [4,5] population and lead to excessive costs [6,7].”
From Short-Term Effects of a Web-Based Guided Self-Help Intervention for Employees With Depressive Symptoms: Randomized Controlled Trial (2014) · cites this paper as [3]
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“These prevalence estimates are considerably higher than those observed in the general population [1] and are similar to, or higher than, those observed in patients with diabetes [24], Parkinson’s disease [25] and cancer [26].”
From The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis (2013) · cites this paper as [1]
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“This is compared with the lifetime risk of depression in the general population of approximately 7% (44).”
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Nixon, N. L., Liddle, P. F., Nixon, E., Worwood, G., Mario Liotti, A., & Palaniyappan, L. K. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.129965 · Cited by 80
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“8% prevalence of depression (2), while the estimated prevalence in general population is 5% (3).”
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“Waraich et al. (2004) showed that there was remarkable stability in the lifetime prevalence of bipolar disorder across adulthood, thereby demonstrating the chronicity of this condition across the lifespan.”
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Prevalence of Bipolar I and II Disorder in Canada
McDonald, K. C., Bulloch, A. G. M., Duffy, A., Bresee, L., Williams, J. V. A., Lavorato, D. H., & Patten, S. B. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000310 · Cited by 45
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Cognition and Aging in Psychopathology: Focus on Schizophrenia and Depression
Harvey, P. D., Reichenberg, A., & Bowie, C. R. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095206 · Cited by 44
The epidemiological modelling of dysthymia: Application for the Global Burden of Disease Study 2010
Charlson, F. J., Ferrari, A. J., Flaxman, A. D., & Whiteford, H. A. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.05.060 · Cited by 44
Indirect prevention and treatment of depression: an emerging paradigm?
Cuijpers, P. (2021) · Clinical Psychology in Europe · doi:10.32872/cpe.6847 · Cited by 44
“, 2004; Kessler & Bromet, 2013), have a high incidence (Waraich et al., 2004), and are associated with a substantial loss of quality of life for patients and their relatives (Saarni et al.”
BackgroundUse of benzodiazepine and risk of cancer: A meta-analysis of observational studies
Kim, H.-B., Myung, S., Park, Y. C., & Park, B. (2016) · International Journal of Cancer · doi:10.1002/ijc.30443 · Cited by 43
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Higher prevalence of major depressive symptoms in Brazilians aged 14 and older
Coelho, C. L. D. S., Crippa, J. A. S., Santos, J. L. F., Pinsky, I., Zaleski, M., Caetano, R., & Laranjeira, R. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2012-0875 · Cited by 42
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Tay, C. T., Teede, H. J., Loxton, D. J., Kulkarni, J., & Joham, A. E. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104678 · Cited by 42
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“Recent meta-analyses have found the prevalence of depression in patients with cancer to be as high as 24% [68, 94], much higher than the 8% annual prevalence in the general population [119, 128].”
BackgroundVerrotti, A., Agostinelli, S., Mohn, A., Manco, R., Coppola, G., Franzonı, E., Cerminara, C., Parisi, P., Iannetti, P., Spalice, A., et al. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0107-x · Cited by 40
“In the general population, the prevalence of major depressive disorders in these age groups is approximately 2–5% [26, 27].”
BackgroundPsychosocial factors associated with impact of cancer in longterm haematological cancer survivors
Korszun, A., Sarker, S., Chowdhury, K., Clark, C., Greaves, P., Johnson, R., Kingston, J. E., Levitt, G., Matthews, J., White, P. D., et al. (2013) · British Journal of Haematology · doi:10.1111/bjh.12698 · Cited by 40
“In our group of survivors, 24 3% reported a previous history of depression, which is higher than the lifetime prevalence of depressive disorders reported for the general population both in Europe [6 7% (Waraich et al, 2004)] and in USA [16 2% (Kessler et al, 2005)].”
ResultToschi‐Dias, E., Tobaldini, E., Solbiati, M., Costantino, G., Sanlorenzo, R., Doria, S., Irtelli, F., Mencacci, C., & Montano, N. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.017 · Cited by 42
“Besides being common lifelong, affective spectrum disorders are some of the most burdensome diseases with respect to their global impact on morbidity, mortality, and loss of quality of life (Baxter et al., 2013; De Wilde et al., 2007; Pavlova et al., 2015; Waraich et al., 2004).”
BackgroundKolovos, S., Bosmans, J. E., van Dongen, J. M., van Esveld, B., Magai, D. N., van Straten, A., Feltz-Cornelis, C. M. V. D., van Steenbergen-Weijenburg, K. M., Huijbregts, K. M. L., van Marwijk, H., et al. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1536-2 · Cited by 40
Metyrapone in treatment-resistant depression
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“It has been reported to have a 1-year prevalence of 3–5% [Hasin et al. 2005; Waraich et al. 2004] and a lifetime prevalence varying from 10 to 30% [Hasin et al. 2005; Waraich et al. 2004].”
BackgroundWork impairment in bipolar disorder patients – results from a two-year observational study (EMBLEM)
Reed, C. C., GOETZ, I. A., Vieta, E., Bassi, M., Haro, J. M., & the EMBLEM Advisory Board (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2010.01.001 · Cited by 44
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“Studies have shown how individual sociodemographic factors are associated with depression and use of mental health services [1-3].”
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“5% [2], higher than the general population [3], even higher than www.”
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“Bratisl Lek Listy 2008; 109(12): 568−72.”
Diagnosis and treatment in the early illness phase of bipolar disorders
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A study on mental disorders: 5-year retrospective study
Celine, T., & Antony, J. (2014) · Journal of Family Medicine and Primary Care · doi:10.4103/2249-4863.130260 · Cited by 39
“8% for bipolar I disorder.[22] In the United States it was 20.”
BackgroundHuang, K., Lu, W., Wang, Y.-Y., Hu, G., Lu, C.-H., Lee, W., & Hsu, C. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414525837 · Cited by 36
“The global lifetime prevalence of major depressive disorder (MDD) is an estimated 6.7% (Waraich et al., 2004).”
BackgroundInfluentialMenear, M., Doré, I., Cloutier, A., Perrier, L., Roberge, P., Duhoux, A., Houle, J., & Fournier, L. (2014) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.11.016 · Cited by 35
Psychotrichology: psychosomatic aspects of hair diseases
Harth, W., & Blume‐Peytavi, U. (2012) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2012.08034.x · Cited by 36
Ebert, D. D., Lehr, D., Baumeister, H., Boß, L., Riper, H. M., Cuijpers, P. J., Reins, J. A., Buntrock, C., & Berking, M. (2014) · Trials · doi:10.1186/1745-6215-15-39 · Cited by 37
“Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders with a lifetime prevalence of more than 16% [1-3].”
BackgroundLife negative events and depressive symptoms: the China longitudinal ageing social survey
Wang, Z., Yang, H., Zheng, P., Liu, B., Guo, Z., Geng, S., & Hong, S. (2020) · BMC Public Health · doi:10.1186/s12889-020-09119-0 · Cited by 39
Environmental manipulation affects depressive-like behaviours in female Wistar-Kyoto rats
Mileva, G. R., & Bielajew, C. H. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.07.035 · Cited by 37
“Depression is one of the most prevalent mental health disorders in the world today and places an enormous burden on the economy and healthcare systems worldwide [13,33,64].”
Metadata
- Authors
- Waraich, P., Goldner, E. M., Somers, J. M., & Hsu, L.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Waraich, Paul
- ORCID
- Somers, Julian M
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2004-02
- Volume
- 49
- Issue
- 2
- Pages
- 124-138
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- OpenAlex
- W4237251694
- Cited by
- 522
- References
- 83
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 21 · 2023: 21 · 2022: 28 · 2021: 26 · 2020: 16 · 2019: 27 · 2018: 29 · 2017: 31 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 39 · 2012: 29
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health, British Columbia
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- mood disorders, prevalence, incidence, major depressive disorder, dysthymia, bipolar I disorder, primary care, lifetime prevalence, methodological heterogeneity
- MeSH terms
- Analysis of Variance, Bipolar Disorder, Cross-Sectional Studies, Cross-Cultural Comparison, Major Depressive Disorder, Depressive Disorder, Major, Humans, Incidence, Dysthymic Disorder, Mood Disorders
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