Cited by 138Genetic Associations and EpidemiologyCognitive Abilities and TestingGenetic Mapping and Diversity in Plants and Animals

Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities

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Plomin, Robert, Haworth, Claire M. A., Meaburn, Emma L., Price, Thomas S., Wellcome Trust Case Control Consortium 2, Davis, Oliver S. P.·2013·Psychological Science

Abstract

For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal, and general) with GCTA estimates captured by 1.7 million DNA markers. We found that DNA markers tagged by the array accounted for .66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities.

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  • Heritability estimates from genome-wide data on unrelated individuals generally support large and increasing heritability of intelligence.

    “findings generally supported by heritability estimates from genome-wide data on unrelated individuals (Davies et al., 2011; Plomin et al., 2013).”

    From Large Cross-National Differences in Gene × Socioeconomic Status Interaction on Intelligence (2016) · cites this paper as Plomin et al., 2013

    The Discussion reports a substantial GCTA estimate for general cognitive ability, and the Genomewide Complex-Trait Analysis section reports estimates from unrelated adults and children. The paper describes increasing heritability from childhood to adulthood as a finding from developmental research, but does not show that genome-wide estimates establish that increase. (LLM, conf=0.86)

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Research works printed but not linked: 4

  1. Deary I. J. (2012). Intelligence. Annual Review of Psychology, 63, 453– 482 21943169
  2. Kovas Y. Haworth C. M. A. Dale P. S. Plomin R. (2007). The genetic and environmental origins of learning abilities and disabilities in the early school years. Monographs of the Society for Research in Child Development, 72(3), 1– 144 17995572 PMC2784897
  3. Plomin R. DeFries J. C. Knopik V. S. Neiderhiser J. M. (2013). Behavioral genetics (6th ed.). New York, NY: Worth
  4. Speliotes E. K. Willer C. J. Berndt S. I. Monda K. L. Thorleifsson G. Jackson A. U.... Loos R. J. F. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42, 937– 948 20935630 PMC3014648

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Authors
Plomin, R., Haworth, C. M. A., Meaburn, E. L., Price, T. S., Wellcome Trust Case Control Consortium 2, & Davis, O. S. P.
Affiliations
  • King's College London (GB)
  • University of London (GB)
  • Pennsylvania State University (US)
  • University of Bristol (GB)
Corresponding author
Plomin, Robert
Venue
Psychological Science
Published
2013-03-15
Volume
24
Issue
4
Pages
562-568
ISSN
  • 0956-7976 (ISSN-L)
  • 1467-9280
OpenAlex
W2098272018
Cited by
138
References
39
Citations by year
2026: 2 · 2025: 6 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 20 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 15 · 2015: 19 · 2014: 27 · 2013: 19 · 2012: 1
FWCI
17.69
Type
journal article
Language
en
Open access
Locations
  • Psychological Science (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • BIROn (Birkbeck, University of London) (acceptedVersion)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Portal (King's College London) (submittedVersion, other-oa)
  • Bristol Research (University of Bristol) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
  • Wellcome Trust (085475/Z/08/Z, WT088984, 085475/B/08/Z)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD044454, R01HD046167, HD046167, R01HD044454)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
cognitive ability, heritability, missing heritability, twin studies, language skills, verbal ability, nonverbal ability, genetic variants, genotyping arrays
MeSH terms
Child, Cognition, Genetic Markers, Genotype, Humans, Intelligence, Phenotype, Twins, Dizygotic, Twins, Monozygotic, Polymorphism, Single Nucleotide, Genome-Wide Association Study

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