Targeted Rejection Predicts Hastened Onset of Major Depression
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Although severe life stress frequently precipitates the onset of major depression, little is known about the basic nature of stressors in this general category of adversity and how exposure to different life events might be related to clinical aspects of the disorder. We addressed this issue by introducing, and examining the effects of, targeted rejection (TR), which involves the exclusive, active, and intentional social rejection of an individual by others. Twenty-seven adults with major depressive disorder were administered an interview-based measure of life stress. Severe life events that occurred prior to the onset of depression were subsequently coded as TR or as non-TR. Participants who experienced a pre-onset severe TR event became depressed approximately three times faster than did their non-TR counterparts. These findings highlight the potential importance of TR as a marker of hastened depression onset and demonstrate how refining characterizations of stress may advance our understanding of depression.
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Individuals who experienced a recent major life event involving targeted rejection became depressed 3 times faster (i.e., in one third as many days) than their counterparts who experienced other forms of severe life stress.
“individuals who experienced a recent major life event involving targeted rejection became depressed 3 times faster (i.e., in one third as many days) than their counterparts who experienced other forms of severe life stress”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Slavich et al., 2009
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- Authors
- Slavich, G. M., Thornton, T., Torres, L. D., Monroe, S. M., & Gotlib, I. H.
- Affiliations
- University of Notre Dame (US)
- Corresponding author
- Slavich, George M.
- Venue
- Journal of Social and Clinical Psychology
- Publisher
- Guilford Publications
- Published
- 2009-02
- Volume
- 28
- Issue
- 2
- Pages
- 223-243
- ISSN
- 0736-7236 (ISSN-L)
- PMC
- PMC2847269
- OpenAlex
- W2148138637
- Cited by
- 154
- References
- 71
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 10 · 2023: 12 · 2022: 8 · 2021: 21 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 5 · 2016: 7 · 2015: 14 · 2014: 4 · 2013: 10 · 2012: 3
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Social and Clinical Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH-60802, MH019391, T32MH019391, MH59259, R01MH060802, R01MH059259)
- Topics
- Social Sciences › Psychology › Social Psychology › Death Anxiety and Social Exclusion
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- social rejection, major depressive disorder, depression onset, life events, stressors
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