Cited by 132Pain Mechanisms and TreatmentsPain Management and Placebo EffectPain Management and Treatment

Functional imaging and pain: behavior, perception, and modulation.

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Porro, Carlo A.·2003·The Neuroscientist

Abstract

Time-dependent increases of local metabolic or blood flow rates have been described in spinal cord and brain during acute and chronic pain states in experimental animals, in parallel with changes of different behavioral endpoints of pain and hyperalgesia. In healthy human volunteers, pain intensity-related hemodynamic changes have been identified in a widespread, bilateral brain system including parietal, insular, cingulate, and frontal cortical areas, as well as thalamus, amygdala, and midbrain. Specific patterns of activity may characterize hyperalgesic states and some chronic pain conditions. Forebrain nociceptive systems are under inhibitory control by endogenous opioids and can be affected by acute administration of mu-opioid receptor agonists. Anticipation of pain may in itself induce changes in brain nociceptive networks. Moreover, pain-related cortical activity can be modulated by hypnotic suggestions, focusing or diverting attention, and placebo. These findings begin to disclose the spatio-temporal dynamics of brain networks underlying pain perception and modulation.

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Crossref · 10.1177/1073858403253660

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  • The results of fMRI experiment I replicate and extend previous findings by showing stronger involvement of neural structures involved in action anticipation and somatosensation when focusing on the sensory consequences of mechanically induced pain.

    “Taken together, the results of fMRI experiment I replicate and extend previous findings concerning empathy for pain by showing a stronger involvement of neural structures involved in action anticipation and somatosensation when focusing on the sensory consequences of mechanically induced pain [34], [54], [55].”

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Authors
Porro, C. A.
Affiliations
University of Udine (IT)
Corresponding author
Porro, Carlo A.
Venue
The Neuroscientist
Published
2003-10
Volume
9
Issue
5
Pages
354-369
ISSN
  • 1073-8584 (ISSN-L)
  • 1089-4098
OpenAlex
W2136606402
Cited by
132
References
63
Citations by year
2026: 2 · 2025: 1 · 2023: 12 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
FWCI
0.90
Type
journal article
Language
en
Open access
Locations
  • The Neuroscientist (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
pain perception, chronic pain, hyperalgesia, brain imaging of pain, hemodynamic changes, endogenous opioids, mu-opioid receptor agonists, pain anticipation, hypnotic suggestion, attentional modulation, placebo effect, pain modulation
MeSH terms
Animals, Brain, Diagnostic Imaging, Humans, Pain, Pain Measurement, Perception

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