Functional imaging and pain: behavior, perception, and modulation.
Open accessAbstract
Time-dependent increases of local metabolic or blood flow rates have been described in spinal cord and brain during acute and chronic pain states in experimental animals, in parallel with changes of different behavioral endpoints of pain and hyperalgesia. In healthy human volunteers, pain intensity-related hemodynamic changes have been identified in a widespread, bilateral brain system including parietal, insular, cingulate, and frontal cortical areas, as well as thalamus, amygdala, and midbrain. Specific patterns of activity may characterize hyperalgesic states and some chronic pain conditions. Forebrain nociceptive systems are under inhibitory control by endogenous opioids and can be affected by acute administration of mu-opioid receptor agonists. Anticipation of pain may in itself induce changes in brain nociceptive networks. Moreover, pain-related cortical activity can be modulated by hypnotic suggestions, focusing or diverting attention, and placebo. These findings begin to disclose the spatio-temporal dynamics of brain networks underlying pain perception and modulation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The results of fMRI experiment I replicate and extend previous findings by showing stronger involvement of neural structures involved in action anticipation and somatosensation when focusing on the sensory consequences of mechanically induced pain.
“Taken together, the results of fMRI experiment I replicate and extend previous findings concerning empathy for pain by showing a stronger involvement of neural structures involved in action anticipation and somatosensation when focusing on the sensory consequences of mechanically induced pain [34], [54], [55].”
From What are you feeling? Using functional magnetic resonance imaging to assess the modulation of sensory and affective responses during empathy for pain (2007) · cites this paper as [54]
Cites
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190 · see citing works
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Mesulam, M. (1998) · Brain · doi:10.1093/brain/121.6.1013 · Cited by 3,072 · see citing works
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629 · see citing works
Placebo and Opioid Analgesia-- Imaging a Shared Neuronal Network
Petrovic, P., Kalso, E., Petersson, K. M., & Ingvar, M. (2002) · Science · doi:10.1126/science.1067176 · Cited by 1,488 · see citing works
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia
Gracely, R. H., Petzke, F., Wolf, J. M., & Clauw, D. J. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10225 · Cited by 1,263 · see citing works
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151 · see citing works
The cortical representation of pain
Treede, R.-D., Kenshalo, D. R., Gracely, R. H., & Jones, A. K. P. (1999) · Pain · doi:10.1016/s0304-3959(98)00184-5 · Cited by 1,077 · see citing works
Pain intensity processing within the human brain: a bilateral, distributed mechanism
Coghill, R. C., Sang, C. N., Maisog, J. M., & Iadarola, M. J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.4.1934 · Cited by 1,077 · see citing works
Imaging how attention modulates pain in humans using functional MRI
Bantick, S. J., Wise, R. G., Ploghaus, A., Clare, S., Smith, S. M., & Tracey, I. (2002) · Brain · doi:10.1093/brain/awf022 · Cited by 888 · see citing works
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Zubieta, J.-K., Smith, Y. R., Bueller, J. A., Xu, Y., Kilbourn, M. R., Jewett, D. M., Meyer, C. R., Koeppe, R. A., & Stohler, C. S. (2001) · Science · doi:10.1126/science.1060952 · Cited by 842 · see citing works
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-24-09896.2001 · Cited by 822 · see citing works
Pain perception: Is there a role for primary somatosensory cortex?
Bushnell, M. C., Duncan, G. H., Hofbauer, R. K., Ha, B., Chen, J.-I., & Carrier, B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7705 · Cited by 736 · see citing works
Cognitive modulation of pain: how do attention and emotion influence pain processing?
Villemure, C., & Bushnell, C. M. (2002) · Pain · doi:10.1016/s0304-3959(02)00007-6 · Cited by 728 · see citing works
Derbyshire, S. W. G., Jones, A. K. P., Gyulai, F., Clark, S., Townsend, D., & Firestone, L. L. (1997) · Pain · doi:10.1016/s0304-3959(97)00138-3 · Cited by 629 · see citing works
Cortical Representation of the Sensory Dimension of Pain
Hofbauer, R. K., Rainville, P., Duncan, G. H., & Bushnell, M. C. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.1.402 · Cited by 611 · see citing works
Bornhövd, K., Quante, M., Glauche, V., Bromm, B., Weiller, C., & Büchel, C. (2002) · Brain · doi:10.1093/brain/awf137 · Cited by 584 · see citing works
Haemodynamic brain responses to acute pain in humans
Peyron, R., Garcı́a-Larrea, L., Grégoire, M., Costes, N., Convers, P., Lavenne, F., Mauguı̀ere, F., Michel, D., & Laurent, B. (1999) · Brain · doi:10.1093/brain/122.9.1765 · Cited by 576 · see citing works
Imaging attentional modulation of pain in the periaqueductal gray in humans
Tracey, I., Ploghaus, A., Gati, J. S., Clare, S., Smith, S., Menon, R. S., & Matthews, P. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02748.2002 · Cited by 569 · see citing works
Sawamoto, N., Honda, M., Okada, T., Hanakawa, T., Kanda, M., Fukuyama, H., Konishi, J., & Shibasaki, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07438.2000 · Cited by 522 · see citing works
Reward Circuitry Activation by Noxious Thermal Stimuli
Becerra, L. R., Breiter, H. C., Wise, R. A., González, R., & Borsook, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00533-5 · Cited by 489 · see citing works
Does anticipation of pain affect cortical nociceptive systems?
Porro, C. A., Baraldi, P., Pagnoni, G., Serafini, M., Facchin, P., Maieron, M., & Nichelli, P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03206.2002 · Cited by 469 · see citing works
Self-citationFunctional MRI of Pain- and Attention-Related Activations in the Human Cingulate Cortex
Davis, K. D., Taylor, S. J., Crawley, A. P., Wood, M. L., & Mikulis, D. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.6.3370 · Cited by 426 · see citing works
Pain-related cerebral activation is altered by a distracting cognitive task
Petrović, P., Petersson, K. M., Ghatan, P. H., Stone‐Elander, S., & Ingvar, M. (2000) · Pain · doi:10.1016/s0304-3959(99)00232-8 · Cited by 419 · see citing works
fMRI of Thermal Pain: Effects of Stimulus Laterality and Attention
Brooks, J. C. W., Nurmikko, T. J., Bimson, W. E., Singh, K. D., & Roberts, N. (2002) · NeuroImage · doi:10.1006/nimg.2001.0974 · Cited by 402 · see citing works
Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET
Iadarola, M. (1998) · Brain · doi:10.1093/brain/121.5.931 · Cited by 397 · see citing works
Büchel, C., Bornhövd, K., Quante, M., Glauche, V., Bromm, B., & Weiller, C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00970.2002 · Cited by 380 · see citing works
Neural Mechanisms of Antinociceptive Effects of Hypnosis
Faymonville, M. E., Laureys, S., Degueldre, C., DelFiore, G., Luxen, A., Franck, G., Lamy, M., & Maquet, P. (2000) · Anesthesiology · doi:10.1097/00000542-200005000-00013 · Cited by 370 · see citing works
Imaging cognitive modulation of pain processing
Petrovic, P., & Ingvar, M. (2002) · Pain · doi:10.1016/s0304-3959(01)00467-5 · Cited by 318 · see citing works
Hemispheric lateralization of somatosensory processing
Coghill, R. C., Gilron, I., & Iadarola, M. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.6.2602 · Cited by 257 · see citing works
Relationship of spikes, synaptic activity, and local changes of cerebral blood flow
Lauritzen, M. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200112000-00001 · Cited by 253 · see citing works
Temporal and Intensity Coding of Pain in Human Cortex
Porro, C. A., Cettolo, V., Francescato, M. P., & Baraldi, P. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.6.3312 · Cited by 253 · see citing works
Self-citationA unique representation of heat allodynia in the human brain
Lorenz, J., Cross, D. J., Minoshima, S., Morrow, T. J., Paulson, P. E., & Casey, K. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00767-5 · Cited by 233 · see citing works
Distraction Modulates Anterior Cingulate Gyrus Activations during the Cold Pressor Test
Frankenstein, U. N., Richter, W., McIntyre, M. C., & Rémy, F. (2001) · NeuroImage · doi:10.1006/nimg.2001.0883 · Cited by 198 · see citing works
Allodynia after lateral-medullary (Wallenberg) infarct. A PET study
Peyron, R. (1998) · Brain · doi:10.1093/brain/121.2.345 · Cited by 193 · see citing works
Wise, R. G. (2002) · NeuroImage · doi:10.1006/nimg.2002.1146 · Cited by 192 · see citing works
Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model.
Porro, C., & Cavazzuti, M. (1993) · Progress in neurobiology · doi:10.1016/0301-0082(93)90044-s · Cited by 187 · see citing works
Self-citationSelective Opiate Modulation of Nociceptive Processing in the Human Brain
Casey, K. L., Svensson, P., Morrow, T. J., Raz, J., Jone, C., & Minoshima, S. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.525 · Cited by 186 · see citing works
Brain processing of capsaicin-induced secondary hyperalgesia
Baron, R., Baron, Y., Disbrow, E. A., & Roberts, T. P. L. (1999) · Neurology · doi:10.1212/wnl.53.3.548 · Cited by 186 · see citing works
Kenshalo, D. R., Iwata, K., Sholas, M., & Thomas, D. A. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.719 · Cited by 184 · see citing works
Acupuncture Produces Central Activations in Pain Regions
Biella, G. E. M., Sotgiu, M. L., Pellegata, G., Paulesu, E., Castiglioni, I., & Fazio, F. (2001) · NeuroImage · doi:10.1006/nimg.2001.0798 · Cited by 184 · see citing works
Adler, L. J., Gyulai, F. E., Diehl, D. J., Mintun, M. A., Winter, P. M., & Firestone, L. L. (1997) · Anesthesia & Analgesia · doi:10.1213/00000539-199701000-00023 · Cited by 174 · see citing works
Adler, L. J., Gyulai, F. E., Diehl, D. J., Mintun, M. A., Winter, P. M., & Firestone, L. L. (1997) · Anesthesia & Analgesia · doi:10.1097/00000539-199701000-00023 · Cited by 174 · see citing works
Jones, A. K. P., Cunningham, V. J., Ha-Kawa, S., FUJIWARA, T., Luthra, S. K., SILVA, S., Derbyshire, S. W. G., & Jones, T. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.10.909 · Cited by 156 · see citing works
Patterns of increased brain activity indicative of pain in a rat model of peripheral mononeuropathy
Mao, J., Mayer, D. J., & Price, D. D. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-06-02689.1993 · Cited by 150 · see citing works
Derbyshire, S. W. G., Jones, A. K. P., Creed, F. H., Starz, T., MELTZER, C. C., Townsend, D. W., Peterson, A. M., & Firestone, L. L. (2002) · NeuroImage · doi:10.1006/nimg.2002.1066 · Cited by 136 · see citing works
Chen, J.-I., Ha, B., Bushnell, M. C., Pike, G. B., & Duncan, G. H. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.1.464 · Cited by 134 · see citing works
Dose-dependent Regional Cerebral Blood Flow Changes during Remifentanil Infusion in Humans
Wagner, K. J., Willoch, F., Kochs, E. F., Siessmeier, T., Tölle, T. R., Schwaiger, M., & Bartenstein, P. (2001) · Anesthesiology · doi:10.1097/00000542-200105000-00008 · Cited by 120 · see citing works
Neural correlates of prickle sensation: a percept-related fMRI study
Davis, K. D., Pope, G. E., Crawley, A. P., & Mikulis, D. J. (2002) · Nature Neuroscience · doi:10.1038/nn955 · Cited by 111 · see citing works
Mao, J., Mayer, D. J., Hayes, R. L., & Price, D. D. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.2.470 · Cited by 105 · see citing works
Apkarian, A. V., Darbar, A., Krauss, B. R., Gelnar, P. A., & Szeverenyi, N. M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.2956 · Cited by 104 · see citing works
Experimental brush-evoked allodynia activates posterior parietal cortex
Witting, N., Kupers, R. C., Svensson, P. J., Arendt‐Nielsen, L., GJEDDE, A. H., & Jensen, T. S. (2001) · Neurology · doi:10.1212/wnl.57.10.1817 · Cited by 104 · see citing works
Jones, A. K. P., Kitchen, N. D., Watabe, H., Cunningham, V. J., Jones, T., Luthra, S. K., & Thomas, D. G. T. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199907000-00011 · Cited by 100 · see citing works
Paulson, P. E., Casey, K. L., & Morrow, T. (2002) · Pain · doi:10.1016/s0304-3959(01)00370-0 · Cited by 80 · see citing works
Cortical activation by tactile and painful stimuli in hemispherectomized patients
Olausson, H. (2001) · Brain · doi:10.1093/brain/124.5.916 · Cited by 70 · see citing works
Global Cerebral Blood Flow Decreases during Pain
Coghill, R. C., Sang, C. N.-M., Berman, K. F., Bennett, G. J., & Iadarola, M. J. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199802000-00003 · Cited by 69 · see citing works
Metabolic activity changes in the rat spinal cord during adjuvant monoarthritis
Schadrack, J., Neto, F. L. M., Ableitner, A., Castro‐Lopes, J. M., Willoch, F., Bartenstein, P., Zieglgänsberger, W., & Tölle, T. R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00186-4 · Cited by 62 · see citing works
CNS pattern of metabolic activity during tonic pain: evidence for modulation by β‐endorphin
Porro, C. A., Cavazzuti, M., Baraldi, P., Giuliani, D., Panerai, A. E., & Corazza, R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00494.x · Cited by 62 · see citing works
Self-citationSupraspinal metabolic activity changes in the rat during adjuvant monoarthritis
Neto, F. L. M., Schadrack, J., Ableitner, A., Castro‐Lopes, J. M., Bartenstein, P., Zieglgänsberger, W., & Tölle, T. R. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00185-2 · Cited by 59 · see citing works
Porro, C. A., Cavazzuti, M., Lui, F., Giuliani, D., Pellegrini, M., & Baraldi, P. (2003) · Pain · doi:10.1016/s0304-3959(03)00015-0 · Cited by 40 · see citing works
Self-citationMara Fabri, C. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.4.446 · Cited by 26 · see citing works
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1
Flagged first, then by citations
Cited by
Sorted by citations
Legrain, V., Iannetti, G. D., Plaghki, L., & Mouraux, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.005 · Cited by 854 · see citing works
Bair, M. J., Wu, J., Damush, T. M., Sutherland, J. M., & Kroenke, K. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318185c510 · Cited by 572 · see citing works
From the neuromatrix to the pain matrix (and back)
Iannetti, G. D., & Mouraux, A. (2010) · Experimental Brain Research · doi:10.1007/s00221-010-2340-1 · Cited by 554 · see citing works
Lamm, C., Nusbaum, H. C., Meltzoff, A. N., & Decety, J. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001292 · Cited by 411 · see citing works
Lerman, S. F., Rudich, Z., Brill, S., Shalev, H., & Shahar, G. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000158 · Cited by 408 · see citing works
Determinants of Laser-Evoked EEG Responses: Pain Perception or Stimulus Saliency?
Iannetti, G. D., Hughes, N. P., Lee, M., & Mouraux, A. (2008) · Journal of Neurophysiology · doi:10.1152/jn.00097.2008 · Cited by 400 · see citing works
Nociceptive Laser-Evoked Brain Potentials Do Not Reflect Nociceptive-Specific Neural Activity
Mouraux, A., & Iannetti, G. D. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91181.2008 · Cited by 373 · see citing works
Brain imaging of neuropathic pain
Moisset, X., & Bouhassira, D. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.054 · Cited by 338 · see citing works
George, O., & Koob, G. F. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.05.002 · Cited by 312 · see citing works
Assessing pain objectively: the use of physiological markers
Cowen, R., Stasiowska, M., Laycock, H. C., & Bantel, C. (2015) · Anaesthesia · doi:10.1111/anae.13018 · Cited by 285 · see citing works
Iannetti, G. D., Zambreanu, L., Wise, R. G., Buchanan, T. J., Huggins, J. P., Smart, T. S., Vennart, W., & Tracey, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506624102 · Cited by 267 · see citing works
Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia
Ducreux, D., Attal, N., Parker, F., & Bouhassira, D. (2006) · Brain · doi:10.1093/brain/awl016 · Cited by 257 · see citing works
Burgmer, M., Gaubitz, M., Konrad, C., Wrenger, M., Hilgart, S., Heuft, G., & Pfleiderer, B. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a32da0 · Cited by 237 · see citing works
Iannetti, G. D., Zambreanu, L., Cruccu, G., & Tracey, I. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.035 · Cited by 222 · see citing works
An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients
Schweinhardt, P., Glynn, C. J., Brooks, J. C. W., McQuay, H., Jack, T., Chessell, I. P., Bountra, C., & Tracey, I. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.03.024 · Cited by 190 · see citing works
Simmons, A. N., Paulus, M. P., Thorp, S. R., Matthews, S. C., Norman, S. B., & Stein, M. B. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.027 · Cited by 191 · see citing works
Pain in the body. Altered interoception in chronic pain conditions: a systematic review
Di Lernia, D., Serino, S., & Riva, G. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.015 · Cited by 190 · see citing works
Does It Look Painful or Disgusting? Ask Your Parietal and Cingulate Cortex
Benuzzi, F., Lui, F., Duzzi, D., Nichelli, P., & Porro, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4012-07.2008 · Cited by 178 · see citing works
Self-citationA comparison of the effects of preferred music, arithmetic and humour on cold pressor pain
Mitchell, L., MacDonald, R., & Brodie, E. E. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2005.03.005 · Cited by 178 · see citing works
How does distraction work in the management of pain?
Johnson, M. H. (2005) · Current Pain and Headache Reports · doi:10.1007/s11916-005-0044-1 · Cited by 175 · see citing works
Altered brain activity during pain processing in fibromyalgia
Burgmer, M., Pogatzki-Zahn, E. M., Gaubitz, M., Wessoleck, E., Heuft, G., & Pfleiderer, B. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.008 · Cited by 165 · see citing works
Using fMRI to Study the Neural Correlates of Virtual Reality Analgesia
Hoffman, H. G., Richards, T. L., Bills, A. R., Oostrom, T. V., Magula, J., Seibel, E. J., & Sharar, S. R. (2006) · CNS Spectrums · doi:10.1017/s1092852900024202 · Cited by 152 · see citing works
Neural bases of conditioned placebo analgesia
Lui, F., Colloca, L., Duzzi, D., Anchisi, D., Benedetti, F., & Porro, C. A. (2010) · Pain · doi:10.1016/j.pain.2010.09.021 · Cited by 149 · see citing works
“Because noxious-evoked responses in the parietal operculum, cingulate and insular cortex are often bilateral [2,35], we performed the analysis on the whole group of 31 volunteers, even if they received noxious stimulation on to one foot only.”
MethodSelf-citationLabus, J. S., Naliboff, B. N., Fallon, J., Berman, S. M., Suyenobu, B. Y., Bueller, J. A., Mandelkern, M. A., & Mayer, E. A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.009 · Cited by 139 · see citing works
Vaseghi, B., Zoghi, M., & Jaberzadeh, S. J. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.01.020 · Cited by 134 · see citing works
Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis
Farrell, M. J., Laird, A. R., & Egan, G. F. (2005) · Human Brain Mapping · doi:10.1002/hbm.20125 · Cited by 124 · see citing works
Milde, T., Leistritz, L., Laura Astolfi, A., Miltner, W. H. R., Weiß, T., Babiloni, F., & Witte, H. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.110 · Cited by 120 · see citing works
Representation of cold allodynia in the human brain–a functional MRI study
Seifert, F., & Maihöfner, C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.021 · Cited by 105 · see citing works
Schneider, G., Ständer, S., Burgmer, M., Driesch, G., Heuft, G., & Weckesser, M. (2008) · European Journal of Pain · doi:10.1016/j.ejpain.2007.12.003 · Cited by 105 · see citing works
Objective Correlate of Subjective Pain Perception by Contact Heat-Evoked Potentials
Granovsky, Y., Granot, M., Nir, R., & Yarnitsky, D. (2007) · Journal of Pain · doi:10.1016/j.jpain.2007.08.010 · Cited by 101 · see citing works
Functional brain imaging of trigeminal neuralgia
Moisset, X., Villain, N., Ducreuxl, D., Serriel, A., Cuninl, G., Valadel, D., Calvinol, B., & Bouhassiral, D. (2010) · European Journal of Pain · doi:10.1016/j.ejpain.2010.06.006 · Cited by 99 · see citing works
Pâquet, M., Rosen, N. O., Steben, M., Mayrand, M., Santerre-Baillargeon, M., & Bergeron, S. (2018) · Journal of Pain · doi:10.1016/j.jpain.2017.12.264 · Cited by 88 · see citing works
Touch or pain? Spatio-temporal patterns of cortical fMRI activity following brief mechanical stimuli
Lui, F., Duzzi, D., Corradini, M., Serafini, M., Baraldi, P., & Porro, C. A. (2008) · Pain · doi:10.1016/j.pain.2008.01.010 · Cited by 86 · see citing works
Self-citationSheng, K., Fang, W., Su, M., Li, R., Zou, D., Han, Y., Wang, X., & Cheng, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084705 · Cited by 82 · see citing works
Nociception and autonomic nervous system
Cortelli, P., Giannini, G., Favoni, V., Cevoli, S., & Pierangeli, G. (2013) · Neurological Sciences · doi:10.1007/s10072-013-1391-z · Cited by 81 · see citing works
Overview of orofacial pain: epidemiology and gender differences in orofacial pain
Shinal, R. M., & Fillingim, R. B. (2007) · Dental Clinics of North America · doi:10.1016/j.cden.2006.09.004 · Cited by 80 · see citing works
Liang, M., Mouraux, A., & Iannetti, G. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6207-10.2011 · Cited by 77 · see citing works
Pain-Evoked Reorganization in Functional Brain Networks
Zheng, W., Woo, C., Yao, Z., Goldstein, P., Atlas, L. Y., Roy, M., Schmidt, L., Krishnan, A., Jepma, M., Hu, B., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz276 · Cited by 79 · see citing works
Leite‐Almeida, H., Valle‐Fernandes, A., & Almeida, A. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.022 · Cited by 75 · see citing works
Mainero, C., Zhang, W., Kumar, A., Rosen, B. R., & Sorensen, A. G. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.024 · Cited by 71 · see citing works
Cerebral Activation and Catastrophizing During Pain Anticipation in Patients With Fibromyalgia
Burgmer, M., Petzke, F. W., Giesecke, T., Gaubitz, M., Heuft, G., & Pfleiderer, B. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318236588a · Cited by 71 · see citing works
Haefeli, J., Vögeli, S., Michel, J., & Dietz, V. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07494.x · Cited by 75 · see citing works
Effect of pain and pain expectation on primary motor cortex excitability
Dubé, J. A., & Mercier, C. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.03.026 · Cited by 69 · see citing works
The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI
Wise, R. G., Lujan, B. J., Schweinhardt, P., Peskett, G. D., Rogers, R., & Tracey, I. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.03.016 · Cited by 67 · see citing works
Increased cortical activation upon painful stimulation in fibromyalgia syndrome
Üçeyler, N., Zeller, J. B. M., Kewenig, S., Kittel‐Schneider, S., Fallgatter, A. J., & Sommer, C. (2015) · BMC Neurology · doi:10.1186/s12883-015-0472-4 · Cited by 66 · see citing works
Simmons, A., Strigo, I. A., Matthews, S. C., Paulus, M. P., & Stein, M. B. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181a56ed8 · Cited by 64 · see citing works
Functional Neuroimaging and the Law: Trends and Directions for Future Scholarship
Tovino, S. A. (2007) · The American Journal of Bioethics · doi:10.1080/15265160701518714 · Cited by 64 · see citing works
Ahmad, A. H., & Zakaria, R. (2015) · Europe PMC (PubMed Central) · Cited by 63 · see citing works
Bungert, M., Koppe, G., Niedtfeld, I., Vollstädt-Klein, S., Schmahl, C., Lis, S., & Bohus, M. (2015) · PLOS ONE · doi:10.1371/journal.pone.0133693 · Cited by 62 · see citing works
Porro, C. A., Lui, F., Facchin, P., Maieron, M., & Baraldi, P. (2004) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.003 · Cited by 61 · see citing works
Self-citationAnxiety but Not Social Stressors Predict 12-Month Depression and Pain Severity
Bair, M. J., Poleshuck, E. L., Wu, J., Krebs, E. E., Damush, T. M., Tu, W., & Kroenke, K. (2012) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e3182652ee9 · Cited by 62 · see citing works
Castro, M. M. C., Quarantini, L. C., Daltro, C., Caldas, M. P., Koenen, K. C., Kraychete, D. C., & de Oliveira, I. R. (2011) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/s0101-60832011000400002 · Cited by 59 · see citing works
Evidence-based pain management: is the concept of integrative medicine applicable?
Bubnov, R. V. (2012) · The EPMA Journal · doi:10.1186/1878-5085-3-13 · Cited by 51 · see citing works
Ranking brain areas encoding the perceived level of pain from fMRI data
Favilla, S., Huber, A., Pagnoni, G., Lui, F., Facchin, P., Cocchi, M., Baraldi, P., & Porro, C. A. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.01.001 · Cited by 50 · see citing works
Self-citationEndogenous opiates and behavior: 2003
Bodnar, R. J., & Klein, G. E. (2004) · Peptides · doi:10.1016/j.peptides.2004.09.005 · Cited by 49 · see citing works
Independent effects of emotion and attention on sensory and affective pain perception
Kenntner‐Mabiala, R., Weyers, P., & Pauli, P. (2007) · Cognition & Emotion · doi:10.1080/02699930701252249 · Cited by 46 · see citing works
The Relationship Between Pain Perception and Interoception
Werner, N. S., Duschek, S., Mattern, M., & Schandry, R. (2009) · Journal of Psychophysiology · doi:10.1027/0269-8803.23.1.35 · Cited by 45 · see citing works
Pain Detection and the Privacy of Subjective Experience
Kolber, A. J. (2007) · American Journal of Law & Medicine · doi:10.1177/009885880703300212 · Cited by 38 · see citing works
Somatosensory cortex stimulation for deafferentation pain
Ridder, D. A., Mulder, G., Verstraeten, E., Sunaert, S. G., & Møller, A. R. (2007) · Springer eBooks · doi:10.1007/978-3-211-33081-4_8 · Cited by 36 · see citing works
Monconduit, L., & Villanueva, L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04160.x · Cited by 36 · see citing works
Tracing Toothache Intensity in the Brain
Brügger, M., Lutz, K., Brönnimann, B., Meier, M. L., Luechinger, R., Barlow, A., Jäncke, L., & Ettlin, D. A. (2011) · Journal of Dental Research · doi:10.1177/0022034511431253 · Cited by 35 · see citing works
Fujisawa, H., Ohtani‐Kaneko, R., Naiki, M., Okada, T., Masuko, K., Yudoh, K., Suematsu, N., Okamoto, K., Nishioka, K., & Kato, T. (2008) · PROTEOMICS · doi:10.1002/pmic.200700928 · Cited by 33 · see citing works
Lenz, F. A., Casey, K. L., Jones, E. G., & Willis, W. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770579 · Cited by 47 · see citing works
Pontari, M. A., Mohamed, F. B., Lebovitch, S., Moonat, S., Lebed, B. D., Ruggieri, M. R., & Faro, S. H. (2010) · The Journal of Urology · doi:10.1016/j.juro.2010.01.009 · Cited by 32 · see citing works
Influence of Body Position on Cortical Pain-Related Somatosensory Processing: An ERP Study
Spironelli, C., & Angrilli, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024932 · Cited by 28 · see citing works
Attention and pain: merging behavioural and neuroscience investigations
Eccleston, C., & Crombez, G. (2004) · Pain · doi:10.1016/j.pain.2004.09.006 · Cited by 27 · see citing works
Casey, K., Geisser, M., Lorenz, J., Morrow, T., Paulson, P., & Minoshima, S. (2011) · Pain · doi:10.1016/j.pain.2011.10.029 · Cited by 25 · see citing works
Neuropsychopharmacological effects of midazolam on the human brain
Wang, J., Sun, P., & Liang, P. (2020) · Brain Informatics · doi:10.1186/s40708-020-00116-y · Cited by 28 · see citing works
Pharmacological modulation of brain activity in a preclinical model of osteoarthritis
Upadhyay, J., Baker, S. J., Rajagovindan, R., Hart, M., Chandran, P., Hooker, B. A., Cassar, S. L., Mikusa, J. P., Tovcimak, A. E., Wald, M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.084 · Cited by 26 · see citing works
Rizzolatti, G., & Sinigaglia, C. (2023) · doi:10.1093/oso/9780198871705.001.0001 · Cited by 26 · see citing works
Pain, Affect, Nonlinear Dynamical Systems, and Chronic Pain: Bringing Order to Disorder
Young, G. C., & Chapman, C. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-36445-2_8 · Cited by 23 · see citing works
The Brain Stem Reticular Formation
Traurig, H. H. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-455-5_17 · Cited by 23 · see citing works
The Perception of Pain and its Management in Disorders of Consciousness
Pistoia, F., Sacco, S., Sarà, M., & Carolei, A. (2013) · Current Pain and Headache Reports · doi:10.1007/s11916-013-0374-3 · Cited by 23 · see citing works
Drug Discovery and Evaluation: Methods in Clinical Pharmacology
(2017) · Springer eBooks · doi:10.1007/978-3-319-56637-5 · Cited by 22 · see citing works
Karaş, H., Çetingök, H., İlişer, R., Çarpar, E., & Kaşer, M. (2020) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651501.2020.1764585 · Cited by 22 · see citing works
A regularization algorithm for decoding perceptual temporal profiles from fMRI data
Prato, M., Favilla, S., Zanni, L., Porro, C. A., & Baraldi, P. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.01.074 · Cited by 21 · see citing works
Self-citationThe Role of Endogenous Opioids in the Placebo Effect in Post-Traumatic Stress Disorder
Sher, L. (2004) · Complementary Medicine Research · doi:10.1159/000082817 · Cited by 19 · see citing works
Vadalouca, A., Μoka, Ε., Chatzidimitriou, A., Siafaka, I., Sikioti, P., & Argyra, E. (2009) · Pain Practice · doi:10.1111/j.1533-2500.2009.00271.x · Cited by 18 · see citing works
Manresa, J. A. B., Sörensen, J., Andersen, O. K., Arendt‐Nielsen, L., & Gerdle, B. U. C. (2015) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000209 · Cited by 17 · see citing works
Lin, C., Yen, Y., Chen, M., & Chen, C. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.08.003 · Cited by 16 · see citing works
Karp, J. F., DiNapoli, E. A., Wetherell, J. L., Bolon, C. A., Rodríguez, E., Shega, J. W., & Weiner, D. K. (2016) · Pain Medicine · doi:10.1093/pm/pnw135 · Cited by 15 · see citing works
Brain networks responsive to aversive visual stimuli in humans
Benuzzi, F., Lui, F., Duzzi, D., Nichelli, P., & Porro, C. A. (2009) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2009.05.037 · Cited by 13 · see citing works
Self-citationAmylin modulates the formalin‐induced tonic pain behaviours in rats
Potes, C. S., Pestana, A., Pontes, M. C., Caramelo, A., & Neto, F. L. M. (2016) · European Journal of Pain · doi:10.1002/ejp.898 · Cited by 13 · see citing works
Chen, W., Li, H., Hou, X., & Jia, X. (2022) · Brain Imaging and Behavior · doi:10.1007/s11682-022-00634-9 · Cited by 10 · see citing works
Wellness of patients with chronic pain is not only about pain intensity
Gershoni, T., Pud, D., Aviram, J., & Eisenberg, E. (2022) · Pain Practice · doi:10.1111/papr.13168 · Cited by 9 · see citing works
da Silva, F. T. G., do Rêgo, J. T. P., Raulino, F. R., da Silva, M. R., Reynaud, F., do Egito, E. S. T., & Dantas, P. M. S. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.08.007 · Cited by 9 · see citing works
Molin, B., Zwedberg, S., Berger, A.-K., Sand, A., & Georgsson, S. (2021) · Midwifery · doi:10.1016/j.midw.2021.103098 · Cited by 6 · see citing works
Urayama, Y., Yamada, Y., Nakamura, E., Koga, T., & Fukuda, H. (2009) · Autonomic Neuroscience · doi:10.1016/j.autneu.2009.08.022 · Cited by 6 · see citing works
Strittmatter, M., Ostertag, D., Hoffmann, K. H., Paulus, C., Fischer, C., & Meyer, S. (2004) · Der Nervenarzt · doi:10.1007/s00115-004-1746-z · Cited by 5 · see citing works
Supraspinal Mechanisms Underlying Ocular Pain
Pondelis, N. J., & Moulton, E. A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.768649 · Cited by 5 · see citing works
Pharmacodynamic Evaluation: Pain Methodologies
Siebenga, P. S., Okkerse, P., van Amerongen, G., Doll, R. J., Mentink, A., Hay, J. L., & Groeneveld, G. J. (2017) · Springer eBooks · doi:10.1007/978-3-319-56637-5_56-1 · Cited by 4 · see citing works
Duerden, E. G., Messina, R., Rocca, M. A., Filippi, M., & Duncan, G. H. (2016) · Neuromethods · doi:10.1007/978-1-4939-5611-1_16 · Cited by 3 · see citing works
Spinothalamocortical Projections to Ventromedial and Parafascicular Nuclei
Monconduit, L., & Villanueva, L. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_4181 · Cited by 3 · see citing works
Psychological Assessment and Management of Post-Traumatic Pain
Martelli, M. F., Nicholson, K., & Zasler, N. D. (2012) · Springer Publishing Company eBooks · doi:10.1891/9781617050572.0058 · Cited by 2 · see citing works
Diers, M., & Milde, C. (2017) · Springer eBooks · doi:10.1007/978-3-319-48046-6_8 · Cited by 2 · see citing works
O impacto da dor crônica na saúde mental
de Paiva, A. R., Ribeiro, B. M., Marra, L. J. V., Borges, P. S., & Barbosa, S. R. A. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n2-159 · Cited by 2 · see citing works
Jabbar, R., Pettersson, S. D., Pawełczyk, A. M., & Radek, M. (2026) · Brain Sciences · doi:10.3390/brainsci16060587 · Cited by 1 · see citing works
Neuroimaging in Understanding Chronic Pain Mechanisms and the Development of New Therapies
Wartolowska, K. A., & Tracey, I. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0134-7_16 · Cited by 1 · see citing works
Duerden, E. G., & Duncan, G. H. (2009) · Neuromethods · doi:10.1007/978-1-60327-919-2_15 · Cited by 1 · see citing works
Pharmacodynamic Evaluation: Pain Methodologies
Siebenga, P. S., Okkerse, P., van Amerongen, G., Doll, R. J., Mentink, A., Hay, J. L., & Groeneveld, G. J. (2020) · Springer eBooks · doi:10.1007/978-3-319-68864-0_56 · Cited by 1 · see citing works
- Authors
- Porro, C. A.
- Affiliations
- University of Udine (IT)
- Corresponding author
- Porro, Carlo A.
- ORCID
- Porro, Carlo A.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2003-10
- Volume
- 9
- Issue
- 5
- Pages
- 354-369
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2136606402
- Cited by
- 132
- References
- 63
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 12 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- The Neuroscientist (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain perception, chronic pain, hyperalgesia, brain imaging of pain, hemodynamic changes, endogenous opioids, mu-opioid receptor agonists, pain anticipation, hypnotic suggestion, attentional modulation, placebo effect, pain modulation
- MeSH terms
- Animals, Brain, Diagnostic Imaging, Humans, Pain, Pain Measurement, Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review