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Cited by 103Attention Deficit Hyperactivity DisorderPharmaceutical studies and practicesBehavioral and Psychological Studies

The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.

A Randomized, Double-Blind, Placebo-Controlled, Laboratory Classroom Assessment of Methylphenidate Transdermal System in Children With ADHD

McGough, James J., Wigal, Sharon B., Abikoff, Howard, Turnbow, John M., Posner, Kelly, Moon, Eliot·2006·Journal of Attention Disorders
DOI 10.1177/1087054705284089
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Abstract

Objective: This study evaluates the efficacy, duration of action, and tolerability of methylphenidate transdermal system (MTS) in children with ADHD. Method: Participants were dose optimized over 5 weeks utilizing patch doses of 10, 16, 20, and 27 mg applied in the morning and worn for 9 hours. Following optimization, 80 participants were randomized to 1 week of MTS or placebo followed by 1 week of the opposite treatment. Laboratory classroom sessions conducted after each randomized week included blinded ratings of attention, behavior, and academic performance. Results: MTS was well tolerated and displayed significant improvement compared with placebo. Improvements were seen at the first postdose time point measured and continued through 12 hours. Conclusions: Treatment with MTS resulted in statistically significant improvements on all efficacy measures. Time course and therapeutic effects of MTS suggest that this novel methylphenidate delivery system is an efficacious once-daily treatment for ADHD.

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Crossref · 10.1177/1087054705284089

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Citations

Cites

Research works printed but not linked: 2

  1. SAS Institute, Inc, 2001, SAS (Version 8.2) [Computer software]
  2. Wigal, S. B., 1998, Psychopharmacology Bulletin, 34, 47

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Metadata

Authors
McGough, J. J., Wigal, S. B., Abikoff, H., Turnbow, J. M., Posner, K., & Moon, E.
Affiliations
  • University of California, Los Angeles (US)
  • University of California, Irvine (US)
  • New York University (US)
  • Texas Tech University (US)
  • New York State Psychiatric Institute (US)
  • Clinical Trials of Texas (US)
Corresponding author
McGough, James J.
ORCID
Venue
Journal of Attention Disorders
Publisher
SAGE Publications
Published
2006-02
Volume
9
Issue
3
Pages
476-485
ISSN
  • 1087-0547 (ISSN-L)
  • 1557-1246
DOI
10.1177/1087054705284089
OpenAlex
W2056663519
Cited by
103
References
31
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 7
FWCI
8.92
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Attention Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
  • Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
Keywords
attention deficit hyperactivity disorder, children, transdermal drug delivery, attention, academic performance, treatment tolerability, duration of action, dose optimization, placebo comparison
MeSH terms
Administration, Cutaneous, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Double-Blind Method, Drug Administration Schedule, Drug Tolerance, Female, Humans, Male, Methylphenidate

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