Cited by 198Fatty Acid Research and HealthAttention Deficit Hyperactivity DisorderSchizophrenia research and treatment

Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder: A Randomized Placebo-Controlled Trial in Children and Adolescents

Johnson, Mats, Östlund, Sven, Fransson, Gunnar, Kadesjö, Björn, Gillberg, Christopher·2009·Journal of Attention Disorders

Abstract

Objective: The aim of the study was to assess omega 3/6 fatty acids (eye q) in attention deficit hyperactivity disorder (ADHD). Method: The study included a randomized, 3-month, omega 3/6 placebo-controlled, one-way crossover trial with 75 children and adolescents (8—18 years), followed by 3 months with omega 3/6 for all. Investigator-rated ADHD Rating Scale—IV and Clinical Global Impression (CGI) scale were outcome measures. Results: A majority did not respond to omega 3/6 treatment. However, a subgroup of 26% responded with more than 25% reduction of ADHD symptoms and a drop of CGI scores to the near-normal range. After 6 months, 47% of all showed such improvement. Responders tended to have ADHD inattentive subtype and comorbid neurodevelopmental disorders. Conclusion: A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months responded with meaningful reduction of ADHD symptoms. (J. of Att. Dis. 2009; 12(5) 394-401)

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Crossref · 10.1177/1087054708316261

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  • Short-chain fatty acids and omega-3/omega-6 fatty acids have not been found to be efficacious in treating ADHD.

    “Short-chain fatty acids [108] and omega-3/omega-6 fatty acids [109] have not been found to be efficacious.”

    From Advances in understanding and treating ADHD (2011) · cites this paper as [109]

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Authors
Johnson, M., Östlund, S., Fransson, G., Kadesjö, B., & Gillberg, C.
Affiliations
University of Gothenburg (SE)
Corresponding author
Johnson, Mats
Venue
Journal of Attention Disorders
Published
2009-03
Volume
12
Issue
5
Pages
394-401
ISSN
  • 1087-0547 (ISSN-L)
  • 1557-1246
OpenAlex
W2096024129
Cited by
198
References
28
Citations by year
2026: 4 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 11 · 2018: 10 · 2017: 13 · 2016: 12 · 2015: 11 · 2014: 22 · 2013: 12 · 2012: 19
FWCI
17.78
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Attention Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
omega-3 fatty acids, omega-6 fatty acids, attention deficit hyperactivity disorder, dietary supplementation, children and adolescents, inattentive subtype, neurodevelopmental comorbidities, treatment response, ADHD Rating Scale-IV, Clinical Global Impression Scale
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Child, Double-Blind Method, Dyslexia, Follow-Up Studies, Humans, Learning Disabilities, Personality Assessment, Writing, Fatty Acids, Omega-3, Comorbidity, Cross-Over Studies, Motor Skills Disorders, Fatty Acids, Omega-6

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